{"paper_id":"579a51d0-ba24-4a5b-aaf4-80299e863d81","body_text":"Антимюллеровский гормон предиктор менопаузы?\nhttps://doi.org/10.33667/2078-5631-2023-3-37-41\nАннотация\nВ течение последних трех десятилетий считается, что в качестве потенциального маркера количества фолликулов в яичниках человека, известного как овариальный резерв, является антимюллеровский гормон (АМГ), который вырабатывается антральными фолликулами. Эта количественная мера, учитывая ее постепенное снижение с течением времени и ее невосполнимость, может быть предполагаемым маркером для предсказания окончательного истощения запасов яичников: постменопаузы. Во введении обобщаются современные знания о значении уровня АМГ в сыворотке в прогнозирование возраста нормальной менопаузы. Кроме того, обсуждается его прогностическая роль в контексте менопаузы в связи с несколькими часто встречающимися причинами нарушения фертильности, такими как преждевременная менопауза, синдром поликистозных яичников и эндометриоз. В целом маркеры овариального резерва, включая АМГ, безошибочно связаны с возрастом наступления менопаузы, но они недостаточно точны, чтобы информировать об индивидуальном пути старения яичников.\nОб авторе\nЯ. З. ЗайдиеваРоссия\nЗайдиева Яна Зайдилаевна, д.м.н., проф., в.н.с.\nСписок литературы\n1. Weinstein M., Gorrindo T., Riley A., Mormino J., Niedfeldt J., Singer B. Timing of Menopause and Patterns of Menstrual Bleeding. Am. J. Epidemiol (2003). 158:782–91. DOI: 10.1093/aje/kwg223\n2. Broekmans F. J., Kwee J., Hendriks D. J., Mol B. W., Lambalk C. B. A Systematic Review of Tests Predicting Ovarian Reserve and IVF Outcome. Hum. Reprod. Update (2006). 12:685–718. DOI: 10.1093/humupd/dml034\n3. Dolleman M., Depmann M., Eijkemans M.J., Heimensem J., Broer S.L., van der Stroom E.M. Anti-Mullerian Hormone Is a More Accurate Predictor of Individual Time to Menopause Than Mother’s Age at Menopause. Hum. Reprod. (2014). 29:584–91. DOI: 10.1093/humrep/det446\n4. Depmann M., Broer S. L., van der Schouw Y. T., Tehrani F. R., Eijkemans MJ., Mol B.W. Can We Predict Age at Natural Menopause Using Ovarian Reserve Tests or Mother’s Age at Menopause? A Systematic Literature Review. Menopause (2016). 23(2):224–32. DOI: 10.1097/GME.0000000000000509\n5. Sowers M. R., McConnell D., Yosef M., Jannausch M. L., Harlow S. D., Randolph J.F. Relating Smoking, Obesity, Insulin Resistance, and Ovarian Biomarker Changes to the Final Menstrual Period. Ann. NY Acad. Sci. (2010). 1204:95–103. DOI: 10.1111/j.1749–6632.2010.05523.x\n6. Tehrani F.R., Shakeri N., Solaymani-Dodaran M., Azizi F. Predicting Age at Menopause From Serum Antimullerian Hormone Concentration. Menopause (2011). 18:766–70. DOI: 10.1097/gme.0b013e318205e2ac\n7. Broer S. L., Eijkemans M. J., Scheffer G. J., van Rooij I. A., de Vet A., Themmen A.P. Anti-Mullerian Hormone Predicts Menopause: A Long-Term Follow-Up Study in Normoovulatory Women. J. Clin. Endocrinol. Metab. (2011). 96:2532–9. DOI: 10.1210/jc.2010–2776\n8. Freeman E.W., Sammel M.D., Lin H., Boorman D.W., Gracia C.R. Contribution of the Rate of Change of Antimullerian Hormone in Estimating Time to Menopause for Late Reproductive-Age Women. Fertil. Steril. (2012). 98:1254–9.e1. DOI: 10.1016/j.fertnstert.2012.07.1139\n9. Tehrani F.R., Solaymani-Dodaran M., Tohidi M., Gohari M.R., Azizi F. Modeling Age at Menopause Using Serum Concentration of Anti-Mullerian Hormone. J. Clin. Endocrinol. Metab. (2013). 98:729–35. DOI: 10.1210/jc.2012–3176\n10. Depmann M., Eijkemans M.J.C., Broer S.L., Tehrani F.R., Solaymani-Dodaran M., Azizi F. Does AMH Relate to Timing of Menopause? Results of an Individual Patient Data Meta- Analysis. J. Clin. Endocrinol. Metab. (2018). 103(10):3593–600. DOI:10.1016/j.maturitas.2017.03.325\n11. de Kat A.C., van der Schouw Y.T., Eijkemans M.J.C., Broer S.L., Verschuren W.M.M., Broekmans F.J.M. Can Menopause Prediction Be Improved With Multiple AMH Measurements? Results From the Prospective Doetinchem Cohort Study. J. Clin. Endocrinol. Metab. (2019). 104:5024–31. DOI: 10.1210/jc.2018–02607\n12. Ramezani Tehrani F., Bidhendi Yarandi R., Solaymani-Dodaran M., Tohidi M., Firouzi F., Azizi F. Improving Prediction of Age at Menopause Using Multiple Anti-Müllerian Hormone Measurements: The Tehran Lipid-Glucose Study. J. Clin. Endocrinol. Metab. (2020). 105: dgaa083. DOI: 10.1210/clinem/dgaa083\n13. Sowers M., Zheng H., Tomey K., Karvonen-Gutierrez C., Jannausch M., Li X. Changes in Body Composition in Women Over Six Years at Midlife: Ovarian and Chronological Aging. J. Clin. Endocrinol. Metab. (2007). 92:895–901. DOI: 10.1210/jc.2006–1393\n14. Freeman E.W., Sammel M.D., Lin H., Gracia C.R. Anti-Mullerian Hormone as a Predictor of Time to Menopause in Late Reproductive Age Women. J. Clin. Endocrinol. Metab. (2012). 97:1673–80. DOI: 10.1210/jc.2011–3032\n15. de Kat A.C., van der Schouw Y.T., Eijkemans M.J., Herber-Gast G.C., Visser J.A., Verschuren W.M. Back to the Basics of Ovarian Aging: A Population-Based Study on Longitudinal Anti-Mullerian Hormone Decline. BMC Med. (2016). 14:151. DOI:10.1186/s12916–016–0699-y\n16. Moolhuijsen L.M.E., Visser J.A. Anti-MÃllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function. J. Clin. Endocrinol. Metab. (2020). 105:3361–73. DOI: 10.1210/clinem/dgaa513\n17. Harlow S.D., Gass M., Hall J.E., Lobo R., Maki P., Rebar R.W. Executive Summary of the Stages of Reproductive Aging Workshop + 10: Addressing the Unfnished Agenda of Staging Reproductive Aging. J. Clin. Endocrinol. Metab. (2012). 97:1159–68. DOI: 10.1210/jc.2011–3362\n18. Lambalk C.B., van Disseldorp J., de Koning C.H.., Broekmans FJ. Testing Ovarian Reserve to Predict Age at Menopause. Maturitas (2009). 63:280–91. DOI: 10.1016/j.maturitas.2009.06.007\n19. van Rooij I.A., Broekmans F.J., Scheffer G.J., Looman C.W., Habbema J.D., de Jong F. H. Serum Antimullerian Hormone Levels Best Reflect the Reproductive Decline With Age in Normal Women With Proven Fertility: A Longitudinal Study. Fertil. Steril. (2005). 83:979–87. DOI: 10.1016/j.fertnstert.2004.11.029\n20. Bertone-Johnson E.R., Manson J.E., Purdue-Smithe A.C., Steiner A.Z., Eliassen A.H., Hankinson S. E. Anti-Müllerian Hormone Levels and Incidence of Early Natural Menopause in a Prospective Study. Hum. Reprod. (2018). 33:1175–82. DOI: 10.1093/humrep/dey077\n21. Anderson R.A., Nelson S.M. Anti-Müllerian Hormone in the Diagnosis and Prediction of Premature Ovarian Insuffciency. Semin. Reprod. Med. (2020). 38:263–9. DOI: 10.1055/s-0040–1722319\n22. Elting M. W., Korsen T. J., Rekers-Mombarg L.T., Schoemaker J. Women With Polycystic Ovary Syndrome Gain Regular Menstrual Cycles When Ageing. Hum. Reprod. (2000). 15:24–8. DOI: 10.1093/humrep/15.1.24\n23. van den Berg M.H., Overbeek A., Lambalk C.B., Kaspers G.J.L., Bresters D., van den Heuvel-Eibrink M.M. Long-Term Effects of Childhood Cancer Treatment on Hormonal and Ultrasound Markers of Ovarian Reserve. Hum. Reprod. (2018). 33:1474–88. DOI: 10.1093/humrep/dey229\n24. Minooee S., Ramezani Tehrani F., Rahmati M., Mansournia M.A., Azizi F. Prediction of Age at Menopause in Women With Polycystic Ovary Syndrome. Climacteric. (2018). 21:29–34. DOI: 10.1080/13697137.2017.1392501\n25. Streuli I., de Ziegler D., Gayet V., Santulli P., Bijaoui G., de Mouzon J. In Women With Endometriosis Anti-Müllerian Hormone Levels are Decreased Only in Those With Previous Endometrioma Surgery. Hum. Reprod. (2012). 27:3294–303. DOI: 10.1093/humrep/des274\n26. Uncu G., Kasapoglu I., Ozerkan K., Seyhan A., Oral Yilmaztepe A., Ata B. Prospective Assessment of the Impact of Endometriomas and Their Removal on Ovarian Reserve and Determinants of the Rate of Decline in Ovarian Reserve. Hum. Reprod. (2013). 28:2140–5. DOI: 10.1093/humrep/det123\n27. Younis J. S., Shapso N., Fleming R., Ben-Shlomo I., Izhaki I. Impact of Unilateral Versus Bilateral Ovarian Endometriotic Cystectomy on Ovarian Reserve: A Systematic Review and Meta-Analysis. Hum. Reprod. Update. (2019). 25:375–91. DOI: 10.1093/humupd/dmy049\n28. Coccia M.E., Rizzello F., Mariani G., Bulletti C., Palagiano A., Scarselli G. Ovarian Surgery for Bilateral Endometriomas Influences Age at Menopause. Hum. Reprod. (2011) 26:3000–7. DOI: 10.1093/humrep/der286\n29. Nielsen S.N., Andersen A.N., Schmidt K.T., Rechnitzer C., Schmiegelow K., Bentzen J.G. A 10-Year Follow Up of Reproductive Function in Women Treated for Childhood Cancer. Reprod BioMed Online (2013). 27:192–200. DOI: 10.1016/j.rbmo.2013.04.003\n30. van der Kooi A.L., van den Heuvel-Eibrink M.M., van Noortwijk A., Neggers S.J., Pluijm S.M., van Dulmen-den Broeder E. Longitudinal Follow-Up in Female Childhood Cancer Survivors: No Signs of Accelerated Ovarian Function Loss. Hum. Reprod. (2017). 32:193–200. DOI: 10.1093/humrep/dew278\n31. van Dorp W., van den Heuvel-Eibrink M.M., de Vries A. C., Pluijm S. M., Visser J. A., Pieters R. Decreased Serum Anti-Müllerian Hormone Levels in Girls With Newly Diagnosed Cancer. Hum. Reprod. (2014). 29:337–42. DOI: 10.1093/humrep/det442\n32. Ruth K.S., Day F.R., Hussain J., Martínez-Marchal A., Aiken C.E., Azad A. Genetic Insights Into Biological Mechanisms Governing Human Ovarian Ageing. Nature (2021). 596(7872):393–7. DOI: 10.1038/s41586–021–03779–7\n33. Laven J. S.E. Genetics of Menopause and Primary Ovarian Insuffciency: Time for a Paradigm Shift? Semin. Reprod. Med. (2020). 38:256–62. DOI: 10.1055/s-0040–1721796\n34. Grootenhuis A., van den Hoogen A., Broekmans F., Torrance H., van Os-Medendorp H., Ockhuijsen H. Young Women’s Opinions on the Use of a Blood Test to Predict the Possibility of Premature Ovarian Failure: A Qualitative Study. Hum. Fertil. (Camb) (2019). 1–11. DOI: 10.1080/14647273.2019.1665198\n35. Habbema J. D., Eijkemans M. J., Leridon H., te Velde E. R. Realizing a Desired Family Size: When Should Couples Start? Hum. Reprod. (2015). 30:2215–21. DOI:10.1093/humrep/dev148\n36. de Kat A.C., Broekmans F.J.M., Lambalk C.B. Role of AMH in Prediction of Menopause Front Endocrinol (Lausanne). Published online 2021 Sep 14. DOI: 10.3389/fendo.2021.733731\nРецензия\nДля цитирования:\nЗайдиева Я.З. Антимюллеровский гормон предиктор менопаузы? Медицинский алфавит. 2023;(3):37-41. https://doi.org/10.33667/2078-5631-2023-3-37-41\nFor citation:\nZaydieva Ya.Z. Is AMH Prediction of Menopause? Medical alphabet. 2023;(3):37-41. (In Russ.) https://doi.org/10.33667/2078-5631-2023-3-37-41\nJATS XML","source_license":"CC0","license_restricted":false}