{"paper_id":"55e6f268-4ae5-43fd-9ce5-ce556639f5fe","body_text":"Print ISSN: 1107-3756\nOnline ISSN: 1791-244X\nInternational Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.\nInternational Journal of Oncology is an international journal devoted to oncology research and cancer treatment.\nCovers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.\nOncology Reports is an international journal devoted to fundamental and applied research in Oncology.\nExperimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.\nOncology Letters is an international journal devoted to Experimental and Clinical Oncology.\nExplores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.\nInternational journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.\nMultidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.\nOpen-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.\nPublishes open-access research on using epigenetics to advance understanding and treatment of human disease.\nAn International Open Access Journal Devoted to General Medicine.\nArticle\n- Authors:\n-\nPages: 335-344|Published online on: March 1, 2008https://doi.org/10.3892/ijmm.21.3.335\n- Expand metrics +\nThe aim of the present study was to investigate whether endometriosis and cancer share common molecular characteristics. Tissue samples were collected prospectively during diagnostic laparoscopy of patients with primary infertility. Using high-density oligonucleotide microarrays, (Affymetrix Gene Chip HG-U133 Set) the genome-wide gene expression profile of advanced ovarian endometriosis was analyzed compared with matched normal endometrium. Expression of TERT, the gene encoding the telomerase reverse transcriptase subunit, and telomerase activity were analyzed in eutopic and ectopic endometrium. Genome-wide, high-resolution array-CGH was used to screen for genomic aberrations in endometriosis. Expression microarray data were validated quantitatively with RT-PCR. The genes RARRES1 and RARRES2 (retinoic acid receptor responder 1 and 2) were found to be up-regulated in endometriosis, suggesting a high degree of differentiation. Consistently, down-regulated genes included those involved in the cell cycle, cell metabolism and homeostasis. Expression of TERT and telomerase activity were present in eutopic but absent in ectopic endometrium. Array-CGH revealed a normal genomic pattern without gross amplifications and deletions. In conclusion, these data suggest that advanced ovarian endometriosis represents a highly differentiated tissue with minimal or no malignant potential.\nCopy and paste a formatted citation\nSpandidos Publications style\nZafrakas M, Tarlatzis BC, Streichert T, Pournaropoulos F, Wölfle U, Smeets SJ, Wittek B, Grimbizis G, Brakenhoff RH, Pantel K, Pantel K, et al: Genome-wide microarray gene expression, array-CGH analysis, and telomerase activity in advanced ovarian endometriosis: A high degree of differentiation rather than malignant potential. Int J Mol Med 21: 335-344, 2008.\nAPA\nZafrakas, M., Tarlatzis, B.C., Streichert, T., Pournaropoulos, F., Wölfle, U., Smeets, S.J. ... Günes, C. (2008). Genome-wide microarray gene expression, array-CGH analysis, and telomerase activity in advanced ovarian endometriosis: A high degree of differentiation rather than malignant potential. International Journal of Molecular Medicine, 21, 335-344. https://doi.org/10.3892/ijmm.21.3.335\nMLA\nZafrakas, M., Tarlatzis, B. C., Streichert, T., Pournaropoulos, F., Wölfle, U., Smeets, S. J., Wittek, B., Grimbizis, G., Brakenhoff, R. H., Pantel, K., Bontis, J., Günes, C.\"Genome-wide microarray gene expression, array-CGH analysis, and telomerase activity in advanced ovarian endometriosis: A high degree of differentiation rather than malignant potential\". International Journal of Molecular Medicine 21.3 (2008): 335-344.\nChicago\nZafrakas, M., Tarlatzis, B. C., Streichert, T., Pournaropoulos, F., Wölfle, U., Smeets, S. J., Wittek, B., Grimbizis, G., Brakenhoff, R. H., Pantel, K., Bontis, J., Günes, C.\"Genome-wide microarray gene expression, array-CGH analysis, and telomerase activity in advanced ovarian endometriosis: A high degree of differentiation rather than malignant potential\". International Journal of Molecular Medicine 21, no. 3 (2008): 335-344. https://doi.org/10.3892/ijmm.21.3.335","source_license":"CC0","license_restricted":false}