{"paper_id":"55ae6570-e910-491d-a961-9477ef746ff5","body_text":"Abstract\nIn order to investigate the mechanism of Nei-Yi Recipe (NYR) in treatment of endometriosis, the changes of plasma β-endorphin (β-EP) level in women with endometriosis treated by NYR were observed. It was found that in luteal phase β-EP concentrations in plasma were significantly reduced in moderate and severe dysmenorrhea groups compared with mild and control groups. Moreover, β-EP level in severe dysmenorrhea group was lower in the luteal phase than that in the follicular phase, and it was lower in patients with pelvic pain than that without it. In normal women, the β-EP level in plasma were not changed during menstrual cycle. It was also found that plasma β-EP levels were significantly increased in luteal phase and follicular phase after treatment by NYR. The therapeutical mechanism of NYR on dysmenorrhea and pelvic pain and the immunoenhancing function might be mediated by increase of plasma β-EP levels.\nSimilar content being viewed by others\nReference\nAndersch B, Milson I. An epidemiologic study of young women with dysmenorrhea. Am J Obstet Gynecol 1982;144:655.\nWybran J, Appelboom T, Fanaey JP, et al. Suggestive evidence of receptors for morphin and methionimenkephin on normal human blood T lymphocytes. J Immunol 1979;123:1068.\nOosterlynck DJ, Cornillie FJ, Waer M, et al. Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium. Fertil Steril 1991;56:45.\nGarzetti GG, Ciavattini A, Provinciali M, et al. Natural killer cell activity in endometriosis: Correlation between serum estradiol levels and cytotoxicity. Obstet Gynecol 1993;81(5):665.\nVercellini P, Sacerdote P, Alberto E, et al. Mononuclear cell β-endorphin concentration in women with and without endometriosis. Obstet Gynecol 1992;79:743.\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nYu, Cq., Zhai, Mf., Yao, Rm. et al. Effect of Nei-Yi Recipe (内异方) on plasma β-endorphin level during menstrual cycle in women with endometriosis. CJIM 1, 258–261 (1995). https://doi.org/10.1007/BF02940691\nIssue date:\nDOI: https://doi.org/10.1007/BF02940691","source_license":"CC0","license_restricted":false}