{"paper_id":"54e28962-74f6-4b23-be6b-97c5c6031747","body_text":"Print ISSN: 1792-0981\nOnline ISSN: 1792-1015\nInternational Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.\nInternational Journal of Oncology is an international journal devoted to oncology research and cancer treatment.\nCovers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.\nOncology Reports is an international journal devoted to fundamental and applied research in Oncology.\nExperimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.\nOncology Letters is an international journal devoted to Experimental and Clinical Oncology.\nExplores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.\nInternational journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.\nMultidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.\nOpen-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.\nPublishes open-access research on using epigenetics to advance understanding and treatment of human disease.\nAn International Open Access Journal Devoted to General Medicine.\nArticle\n- Authors:\n-\nPages: 2317-2322|Published online on: July 13, 2017https://doi.org/10.3892/etm.2017.4794\n- Expand metrics +\nCurrent data are inconsistent regarding the association between interleukin‑6 (IL‑6), a marker of acute phase inflammation, and pelvic endometriosis. The aim of the present study was to assess IL‑6 levels in serum and peritoneal fluid (PF), as well as IL‑6 gene expression in adipose tissue (AT) and endometrial samples in pelvic endometriosis. A total of 30 patients with endometriosis and 18 women with a normal pelvis were enrolled in this case‑control study. IL‑6 levels in PF and serum were determined using a human enzyme‑linked immunosorbent assay and IL‑6 gene expression was evaluated using reverse transcription‑quantitative polymerase chain reaction. It was observed that IL‑6 levels in the PF were higher in patients with endometriosis than in the control group (P=0.047) and patients with stage III/IV endometriosis exhibited higher IL‑6 levels in the PF than those with stage I/II endometriosis and the control group (P<0.001). Furthermore, a strong correlation between PF IL‑6 levels and the revised American Society for Reproductive Medicine score for endometriosis severity was identified (r=0.77; P<0.001). IL‑6 gene expression did not differ significantly between endometriosis and control groups in endometrial samples or in AT of both groups. The results of the current study suggest that there may be an association between IL‑6 and the presence and severity of pelvic endometriosis. The source of this higher IL‑6 seems not to be specifically related to regional AT.\nCopy and paste a formatted citation\nSpandidos Publications style\nDe Andrade VT, Nácul AP, Dos Santos BR, Lecke SB, Spritzer P and Morsch DM: Circulating and peritoneal fluid interleukin‑6 levels and gene expression in pelvic endometriosis. Exp Ther Med 14: 2317-2322, 2017.\nAPA\nDe Andrade, V.T., Nácul, A.P., Dos Santos, B.R., Lecke, S.B., Spritzer, P., & Morsch, D.M. (2017). Circulating and peritoneal fluid interleukin‑6 levels and gene expression in pelvic endometriosis. Experimental and Therapeutic Medicine, 14, 2317-2322. https://doi.org/10.3892/etm.2017.4794\nMLA\nDe Andrade, V. T., Nácul, A. P., Dos Santos, B. R., Lecke, S. B., Spritzer, P., Morsch, D. M.\"Circulating and peritoneal fluid interleukin‑6 levels and gene expression in pelvic endometriosis\". Experimental and Therapeutic Medicine 14.3 (2017): 2317-2322.\nChicago\nDe Andrade, V. T., Nácul, A. P., Dos Santos, B. R., Lecke, S. B., Spritzer, P., Morsch, D. M.\"Circulating and peritoneal fluid interleukin‑6 levels and gene expression in pelvic endometriosis\". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2317-2322. https://doi.org/10.3892/etm.2017.4794","source_license":"CC0","license_restricted":false}