{"paper_id":"548928fe-d624-4da1-8617-de71026b6003","body_text":"Abstract\nBackground\nVarious studies have been conducted on the role of leptin in the different types of infertility, including endometriosis, polycystic ovaries and male infertility; however, only a few studies have been conducted on the effect of leptin on unexplained infertility. The purpose of the present study was therefore to compare serum leptin levels in women with unexplained infertility and fertile women as a contributing factor to female infertility in Iran.\nMethods\nThe present case–control study was conducted on 40 women with unexplained infertility and 30 fertile women who met the inclusion criteria (FSH < 10, BMI < 30, normal AMH and AFC and age under 35). Serum leptin levels were analyzed on the third day of menstruation by ELISA method.\nResults\nAlthough the mean serum leptin level was higher in women with unexplained infertility (31.20 ± 2.83 ng/ml) than in fertile women (24.89 ± 2.93 ng/ml), no statistically significant differences were observed between the two groups (P = 0.13).\nConclusions\nNo statistically significant relationship was found between serum leptin levels in the two groups. In addition, there were no significant relationships between leptin and other predisposing factors such as hormone profile and antral follicle count.\nSimilar content being viewed by others\nReferences\nAkbarian A, Haghighi L. Update on unexplained infertility. Razi J Med Sci. 1995;2:165–72 (in Persian).\nFritz MA, Speroff L. Clinical gynecologic endocrinology and infertility. 8th ed. Tehran: Golban Publishers; 2010.\nDemir B, Guven S, Guven ES, et al. Serum leptin level in women with unexplained infertility. 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Neuro Endocrinol Lett. 2004;25:381–5.\nGyton AC, Hall JE. Textbook of medical physiology. 11th ed. Philadelphia: Saunders Company; 2006.\nUnal M, Unal DO, Baltaci AK, et al. Investigation of serum leptin levels in professional male football players and healthy sedentary males. Neuro Endocrinol Lett. 2005;26:148–51.\nFarooqi IS, Matarese G, Lord GM, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest. 2002;110:1093–103.\nAcknowledgments\nThe authors are grateful to the individuals who accepted to participate in this study. We are indebted to personnel of Vali-e-asr infertility clinic for their assistance in sample collection.\nAuthors’ contribution\nFarzaneh Tafvizi contributed to project development, data collection and manuscript writing. Masomeh Masomi collected and analyzed data.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEthics declarations\nConflict of interest\nThe authors declare that they have no conflict of interest.\nEthical Approval\nThe present case–control study was conducted after obtaining written informed consent from qualified patients interested in participating in the study.\nAdditional information\nDr. Farzaneh Tafvizi is Assistant Professor in Department of Biology at Islamic Azad University; Masomeh Masomi is the M.Sc. student in Department of Biology at Islamic Azad University.\nRights and permissions\nAbout this article\nCite this article\nTafvizi, F., Masomi, M. Comparison of Serum Leptin Level in Women with Unexplained Infertility and Fertile Women in Iran. J Obstet Gynecol India 66 (Suppl 1), 466–470 (2016). https://doi.org/10.1007/s13224-016-0843-9\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s13224-016-0843-9","source_license":"public-domain-us","license_restricted":false}