{"paper_id":"51316a42-51e8-4053-9c68-ec9f47e93d90","body_text":"Genetic variations in UCA1, a lncRNA functioning as a miRNA sponge, determine endometriosis development and the potential associated infertility via regulating lipogenesis\nFig 8\nProposed pathogenesis model in the development of endometriosis and the associated infertility based on the findings of this study.\nElevated UCA1 in endometriosis patients via RNA stabilization by functional SNPs can disrupt lipogenesis regulation by sponging key miRNAs with target genes involved in lipid metabolism. Such epigenetic regulation can further lead to reduced biosynthesis of triacyglycerol for oocyte future maturation and increased lipotoxicity, resulting in infertility.","source_license":"CC0","license_restricted":false}