{"paper_id":"4c912193-26ae-4c91-a2bb-7d89dc131274","body_text":"Abstract\nPurpose\nThe magnetic resonance imaging (MRI)-based classification of adenomyosis subtypes helps predict reproductive and obstetric outcomes; however, background factors associated with use of assisted reproductive technology (ART) and live birth within each individual subtype remain unclear.\nMethods\nWe conducted a multicenter retrospective study of 199 premenopausal women (32–49 years) who underwent pelvic MRI and laparoscopic surgery and had histopathologic confirmation of adenomyosis (January 2010–May 2023). Patients were classified as intrinsic (n = 58), extrinsic (n = 61), or indeterminate (n = 80) subtype. Within each subtype, multivariate logistic regression tested independent associations of age, ART history, gravidity, parity, lesion thickness, and intraoperative findings—including pelvic endometriosis—with ART use and live birth.\nResults\nThe extrinsic subtype had a higher proportion with ART history than the intrinsic subtype (32.8% vs 8.6%; p = 0.008). Live birth rate was lower in the indeterminate than the intrinsic subtype (60.0% vs 86.2%; p = 0.0048). In the extrinsic subtype, greater lesion thickness independently predicted lower odds of live birth (adjusted OR = 0.94 per 1-mm increase; 95% CI, 0.88–0.99; p = 0.048). In the indeterminate subtype, older age was associated with ART use (adjusted OR = 1.155 per year; 95% CI, 1.002–1.351; p = 0.047), and ovarian endometrioma was linked to reduced live birth (adjusted OR = 0.172; 95% CI, 0.054–0.508; p = 0.001). In the intrinsic subtype, women with live birth were older than those without, but age was not an independent factor.\nConclusion\nAdenomyosis lesion thickness and coexisting endometriosis are associated with ART indication and live birth outcomes in a subtype-specific manner and may support individualized counselling and management.\nSimilar content being viewed by others\nAcknowledgements\nWe thank all members of obstetricians and gynecologists in University of Yamanashi Hospital and Teine Keijinkai Hospital for their contributions to this study.\nFunding\nOpen Access funding provided by University of Yamanashi. None.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEthics declarations\nConflict of interest\nThe authors declare that this study was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. This article was approved by the hospital’s ethical committee, and it has duly received IRB approval.\nEthical approval\nHuman rights statements and informed consent: This study was conducted in accordance with the principles outlined in the Declaration of Helsinki, and it was approved by the Institutional Review Board of the University of Yamanashi (approval number: CS 0013).\nAdditional information\nPublisher's Note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nSupplementary Information\nBelow is the link to the electronic supplementary material.\nRights and permissions\nOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.\nAbout this article\nCite this article\nTanaka, K., Ono, Y., Ota, H. et al. Subtype-specific analysis of factors associated with assisted reproductive technology indication and live birth in patients with adenomyosis: a retrospective study. Arch Gynecol Obstet (2026). https://doi.org/10.1007/s00404-026-08490-4\nReceived:\nAccepted:\nPublished:\nDOI: https://doi.org/10.1007/s00404-026-08490-4","source_license":"public-domain-us","license_restricted":false}