{"paper_id":"4c868499-6c0c-4fbe-8fca-04b376a38837","body_text":"Abstract\nPurpose\nTo investigate the Homeobox genes HOXA-10 and HOXA-11 mediated endometrial molecular defects during implantation window in endometriosis-associated infertility cases.\nMethods\nEndometrial biopsies were obtained during implantation window from 31 infertile women with endometriosis (age < 35 years) and 26 age and BMI-matched infertile women without endometriosis were included in the study for comparison purposes. Endometrial expression of HOXA-10 and HOXA-11 genes, MMP-2, -9, αvβ3 integrin, leukemia inhibitory factor and surface characteristics including average roughness and topology were assessed.\nResults\nA significantly lower expression of HOXA-10 and HOXA-11 were observed in endometriotic women compared to non-endometriotic controls. Further, a significantly higher endometrial expression of MMP-2 and −9 were observed in women with endometriosis when compared with controls. Interestingly, endometrial surface were observed to be grossly affected in terms of average roughness and topology in women with endometriosis compared to controls.\nConclusions\nThe findings suggest that aberrant expression of HOXA-10 and −11 genes adversely affects endometrial remodelling and expression of receptivity markers.\nSimilar content being viewed by others\nAbbreviations\n- HOXA:\n-\nHomeobox genes A\n- MMP:\n-\nMatrix metalloproteinases\n- SEM:\n-\nScanning electron microscope\n- AFM:\n-\nAtomic force microscope\nReferences\nDutta M, Joshi M, Srivastava S, Lodh I, Chakravarty B, Chaudhury K. A metabonomics approach as a means for identification of potential biomarkers for early diagnosis of endometriosis. Mol Biosyst. 2012;8:3281–7. doi:10.1039/c2mb25353d.\nJana SK, Banerjee P, Thangaraju S, Chakravarty B, Chaudhury K (2012) Alteration in endometrial remodeling: a cause for implantation failure in endometriosis? 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The first author would like to acknowledge Vishmadeb Pramanik for helping with Real time PCR experiments.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nAdditional information\nCapsule Aberrant expression of Homeobox HOXA-10 and HOXA-11 genes causes excessive extracellular matrix degradation during implantation window in women with endometriosis. This results in impairment of endometrial remodeling affecting the receptive status of the endometrium.\nRights and permissions\nAbout this article\nCite this article\nJana, S.K., Banerjee, P., Mukherjee, R. et al. HOXA-11 mediated dysregulation of matrix remodeling during implantation window in women with endometriosis. J Assist Reprod Genet 30, 1505–1512 (2013). https://doi.org/10.1007/s10815-013-0088-9\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s10815-013-0088-9","source_license":"CC0","license_restricted":false}