{"paper_id":"4aea77c4-eab9-49fc-a7e5-bdf53f630fd6","body_text":"Risk of vaso-occlusive crisis requiring hospitalization in sickle cell disease patients in Brazil: retrospective cohort study of real-world data | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Risk of vaso-occlusive crisis requiring hospitalization in sickle cell disease patients in Brazil: retrospective cohort study of real-world data Vanessa Maia Almeida Barros, Ana Cristina Silva-Pinto, Patricia Gomes Moura, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7576339/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 19 Feb, 2026 Read the published version in Annals of Hematology → Version 1 posted 7 You are reading this latest preprint version Abstract Background: Sickle cell disease (SCD) is associated with several complications, high health-care-related costs and reduced life expectancy. This study addresses the high incidence of vaso-occlusive crises (VOC) in patients with SCD in Brazil, a condition that significantly impacts public health and healthcare costs. Objective: To describe clinical characteristics, healthcare resource utilization, incidence risk, and complications due to VOCs requiring hospitalization among Brazilian patients with SCD. Methods: Between January 2016 to December 2018, we involved 404 SCD patients aged 5-67, we utilized routinely collected data from four referral centers in Brazil. We characterized the cohort regarding healthcare resource utilization (disease complications, mortality, pharmacological treatments, blood transfusions, laboratory and imaging tests, emergency department visits, hospitalizations, and surgeries). Results: Of the 404 participants, 312 (77%) were aged ≥18 and 228 (56%) were female. The most common genotype was HbSS (n=289, 72%). At baseline, 66.6% used hydroxyurea; osteonecrosis was the most prevalent SCD complication (82 patients, 21%). During the 3-year follow-up, 240 (59.4%, 95% confidence interval [95% CI], 55 to 64%) of the 404 participants developed VOCs requiring hospitalization. The incidence rate was 812 events per 1000 person-years (95 CI: 758 to 869). Overall, the cohort was associated with considerable healthcare utilization regarding pharmacological treatments, blood transfusions, laboratory and imaging tests, emergency department visits, and hospitalizations. Conclusion: SCD continues to cause substantial morbidity and utilization of the Brazilian healthcare system. New strategies and therapies are needed to prevent VOCs and improve clinical outcomes, thereby reducing VOC-related healthcare utilization in Brazil. Sickle Cell Disease Vaso-occlusive Crises Hospitalization Disease Burden Figures Figure 1 Figure 2 Introduction Sickle cell disease (SCD) is a group of genetic disorders characterized by a single mutation in the HBB gene which encodes the β-globin subunit of hemoglobin[ 1 , 2 ]. Although considered a rare condition, it is estimated that 7.74 million individuals were living with sickle cell disorders globally in 2021[ 3 ]. In Brazil, it ranks among the most prevalent hereditary diseases, yet epidemiological data on its occurrence within the country remain limited [ 4 ]. SCD is a group of inherited blood disorders that include sickle cell anemia (HbSS), sickle cell/β-thalassemia, HbSC, and other less common variants [ 1 , 2 , 5 , 6 ]. Based on a recent meta-analysis, the global prevalence of HbSS and the severe form of sickle cell/β-thalassemia was estimated to be 112 per 100,000 live births, with a prevalence rate approximately 26 times higher among African children than European children (1,125 vs 43 cases per 100,000 live births, respectively) [ 7 ]. Clinically, SCD is associated with numerous vaso-occlusive symptoms, including episodes of intense pain, acute chest syndrome, and stroke [ 1 , 2 , 5 ]. Vaso-occlusive crisis (VOC) is the primary reason for hospital emergency room visits and hospitalization among patients with SCD, resulting in high healthcare-related costs [ 8 , 9 ]. For example, in the United States, data from 2012 revealed that the average cost per emergency room visit due to a VOC was $ 1,072, and the corresponding average cost per hospitalization due to a VOC was greater than $ 11,398 in Medicare patients [ 10 ]. Remarkably, while the pathophysiology and new therapeutic approaches for SCD have been widely studied [ 6 , 11 , 12 ], there have been limited data regarding the risk of VOCs requiring hospitalization among patients with SCD, making it hard to predict its clinical and economic consequences. It is important to consider that the clinical course and symptoms of SCD are multifactorial manifestations that can be modulated by the genetic background of patients [ 12 ]. Latin American populations, such as Brazilians, show an important miscegenation between African, European, and Native American populations, which can contribute to a singular clinical profile of SCD [ 13 ]. However, there is a paucity of information on the current characteristics of Latin American patients with SCD. In this study, we performed a real-world investigation to describe a cohort of patients with SCD treated in four referral centers in Brazil. The objective was to describe the clinical characteristics, healthcare resource utilization (HCRU), incidence risk, and complications associated with VOCs requiring hospitalization among Brazilian patients with SCD. Methods This was a multicenter, retrospective cohort study. The institutional review boards at the participating institutions approved the study protocol, and written informed consent was obtained from all participants. However, two sites granted a waiver of informed consent. This observational study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki and adheres to the reporting standards established by the Strengthening Reporting of Observational Studies in Epidemiology Statement (STROBE) [ 14 ]. The study was conducted in four referral centers for blood diseases, all located in the Southeastern region of Brazil. We reviewed the medical records of patients with SCD who received healthcare at the participating centers between January 2016 and December 2018. Follow-up continued until the end of the study period, patient death, or until they could no longer be contacted (lost to follow-up), whichever occurred first. We applied pre-specified inclusion criteria, enrolling bothpediatric patients (aged 5–17 years) and adult patients (18 years or older) of any gender. Eligible participants had a confirmed diagnosis of SCD (genotype HbSS, HbSC, HbSβ 0 -thalassemia, HbSβ + -thalassemia) established at baseline (defined as January 01, 2016), and had at least three outpatient visits during the first year of follow-up. Patients who did not meet these criteria were excluded from the study. The primary outcome was the incidence risk of VOC requiring hospitalization during the 3-year follow-up (2016–2018). VOC was defined as an acute onset of pain crisis for which there is no other medically determined explanation other than vaso-occlusion which requires therapy with oral or parenteral opioids or non-steroidal anti-inflammatory drugs (NSAIDs). We estimated the incidence rate of a VOC requiring hospitalization for the secondary outcomes. Results were presented as events per 1000 person-years to facilitate interpretation. Furthermore, we assessed the cumulative proportion of participants with complications presented by the patient at the start of the observation period, including mortality, leg ulcer, retinopathy, iron overload, pulmonary hypertension, hepatic disease, renal disease, chronic heart failure, essential hypertension, acute myocardial infarction, cardiac disease, and osteonecrosis. We also evaluated healthcare utilization considering the following domains: pharmacological interventions in the outpatient setting, immunizations, blood transfusions at the outpatient setting, laboratory and imaging tests during medical visits, hospitalizations and emergency room visits. Study size Given the paucity of previous evidence, we assumed that the incidence risk of patients with sickle cell disease developing a VOC requiring hospitalization during the 3-year follow-up would be 50%. Based on this conservative assumption, 384 participants were required to estimate the expected proportion with 5% absolute precision and a 95% confidence interval [ 15 ]. The main analysis involved all participants, but we also conducted subgroup analyses considering pediatric and adult populations separately when clinically relevant. We summarized continuous variables with an approximately normal distribution using means and standard deviations (SD). Continuous variables with a skewed distribution were presented as medians (minimum and maximum). Categorical variables were summarized as numbers (percentages). We did not employ multiple imputations for missing data. Because results are considered descriptive and exploratory, we did not adjust for multiple testing. All statistical analyses were performed using SAS 9.4 software (SAS Institute Inc., Cary, NC, USA). All tests are two-sided, and a P < 0.05 was considered statistically significant. Results Between January 2016 and December 2018, 420 individuals were identified through patient registries at the participating centers and assessed for eligibility. Following review, 404 pediatric and adult participants met all inclusion criteria and were enrolled in the study (Figure 1). Of these, 312 (77.2%) were aged 18 years or older, and 228 (56.4%) were female. During a three-year follow-up period, 14 participants (3.5%) died, and 34 (8.4%) were lost to follow-up (Table 1, Figure 1). Of the 404 participants included, only 166 (41.1%) had sufficient information regarding disease duration. Based on this sub-sample (both pediatric and adult cohorts included), the mean (SD) disease duration was 21.9 (11.7) years. The corresponding estimates for the pediatric and adult cohorts were 10.5 years (3.0) and 25.5 years (11.1), respectively. The most common genotype among included participants was HbSS (n=289, 71.5%), followed by HbSC (n=66, 16.3%). Table 1 shows the clinical and sociodemographic characteristics of the study participants at baseline. Incidence rate and risk of VOC requiring hospitalization. Over the 3-year follow-up period, 240 patients (59.4%) experienced at least one VOC requiring hospitalization. There is a gradual increase in the incidence of VOC-related hospitalization from 2016 to 2018, with the highest risk observed in 2018 (38.4%) (p= 0.02) (Figure 2, panel A). The incidence rate of VOCs requiring hospitalization was 812 events per 1,000 person-years during the observation period, with a notable increase in 2018 with 985 events per 1,000 person-years (p= 0.07) (Figure 2, panel B). Healthcare resource utilization: Emergency Room or Hospitalization Among 404 participants, 265 (65.6%) were hospitalized or admitted to an emergency room, and the reasons for emergency room visits or hospitalization in the cohort are summarized in Table 2. Of the 404 participants, 50 (12.4%) underwent any surgery during the follow-up, resulting in 52 surgical procedures. Of the 52 surgeries, 24 (48.0%) were cholecystectomies (Table 3) . Sickle cell disease complications At the start of the observation period, among 398 patients with complete data, 219 (55.0%) presented at least one SCD-related complication on their first visit. Osteonecrosis was the most prevalent (82 patients, 20.6%), followed by iron overload (57 patients, 14.3%). The diagnosis of new complications during the follow-up period was uncommon, with only 34 patients (8.4%) developing a new complication. The most frequently diagnosed new complication was retinopathy (9 patients, 2.2%), followed by iron overload (7 patients, 1.7%) (Table 4). Mortality Fourteen patients (3.5%) died during the follow-up period, of whom 12 (85.7%) were adults (≥18 years) and 2 (14.3%) were pediatric patients. Among adults, the most common cause of death was acute chest syndrome (3 patients, 25.0%), followed by hemorrhagic stroke and sepsis (2 patients each, 16.7%). The two pediatric deaths were due to other causes (Table 5) Healthcare resource utilization: pharmacological interventions at the outpatient setting Folic acid was the most used treatment in the outpatient setting (386 [95.5%] of 404 participants). In addition, 248 (61.4%) of the 404 participants received oral NSAIDs at least once to control pain intensity in VOCs not requiring hospitalization. An overview presented in Table 6 describes the number of participants who required other pharmacological interventions in the outpatient setting. Hydroxyurea use in the cohort is described in Table 7. Overall, 269 (66.6%) of the 404 participants received hydroxyurea treatment at least once during the 3-year follow-up period. A total of 755 treatment courses of hydroxyurea were recorded. Continuous use of hydroxyurea was confirmed in 207 patients (77%). The mean (SD) dose was 21.4 (6.9) mg/kg per day among 481 treatment courses with complete information. Healthcare resource utilization: immunizations at the outpatient setting At baseline, only 172 participants had complete data regarding immunizations. Of these, 129 (75.0%) had been vaccinated against pneumococcal disease, 106 (61.6%) for meningococcal disease, 120 (69.8%) for influenza and 120 (69.8%) for hepatitis B. During the follow-up, data on immunizations was available for 404 participants (Table 8). Healthcare resource utilization: blood transfusions at the outpatient setting Of the 404 participants, 185 (45.8%) received blood transfusions during the 3-year follow-up period. A total of 2,578 blood transfusions were recorded, with a mean of 6.4 transfusions per patient (range: 0 to 74). Exchange transfusions were the most frequently performed procedure (1,733 transfusions, 67.2%). Prophylactic treatment was the most common indication for transfusion, accounting for 2,229 cases (86.5%) (Table 9). Healthcare resource utilization: laboratory and imaging tests at the outpatient setting During the 3-year follow-up, the 404 participants had 8,344 medical visits. Of 8,344 visits, 6,008 (72.0%) visits had requests for biochemical tests, and 1,136 (13.6%) had requests for imaging exams. A total of 1.589(19.0%) visits had requests for oximetry and /or ophthalmoscopy, with 1,302 (81.9%) oximetry and 306 (19.3%) ophthalmoscopy. The most frequently requested laboratory test was a hemogram of 5,810 (96.7%). The most requested imaging tests were ultrasound 350 (30.8%) and echocardiogram 312 (27.5%). Table 10 describes the use of laboratory and imaging tests in the cohort. Discussion In this retrospective study, we described the characteristics of a cohort of Brazilian patients with SCD, focusing on hospital admission due to a VOC Approximately 240 out of 404 patients with SCD developed VOCs requiring hospitalization during a 3-year follow-up. The incidence rate of a VOC requiring hospitalization was 812 per 1000 person-years, representing a critical issue regarding healthcare utilization and costs in Brazil. To our knowledge, this is one of the few investigations employing real-world data that explored the epidemiology of VOCs requiring hospitalization among Latin American populations. Overall, our results provide an updated panorama of the healthcare burden associated with SCD in Brazil and can inform parameters for future health economic evaluations. These results corroborate previous evidence regarding the substantial economic burden of sickle cell disease in Brazil. For example, a recent analysis indicated that SCD could inflict nearly half a billion US dollars yearly in direct and indirect costs in Brazil[ 16 ]. Notably, most previous investigations assessing the clinical course of SCD in Brazilian patients focused on all-cause hospital admission [ 17 ], blood utilization [ 18 ] and genetic background [ 13 ], used smaller cohorts or investigated populations treated earlier than 2012 [ 19 ]. Recently, Oliveira et al. presented preliminary data from the most extensive study to date, focusing on clinical predictors of VOC among Brazilian SCD patients [ 20 ]. The authors found that treatment with hydroxyurea, a previous history of acute chest syndrome, and elevated white blood cell count were independent risk factors for three or more episodes of vaso-occlusive events requiring hospitalization. Similarly, Padrão et al. employed clustering techniques to identify the characteristics of SCD patients admitted to intensive care units, demonstrating that Brazilian patients with SCD can exhibit high heterogeneity, with distinct profiles and clinical outcomes [ 21 ]. In the international scenario, recent advances in antibiotic and vaccine protocols[ 22 ] have led to a shift in the leading cause of death among patients with SCD, which changed from infectious diseases[ 23 ] to cardiopulmonary events [ 24 , 25 ]. Our results corroborate these observations, indicating a very high vaccination coverage among the studied participants, with available immunization data. Interestingly, however, a recent analysis showed that the leading underlying cause of death among Brazilian patients with SCD (2000–2018) was septicemia, pneumonia, and respiratoryfailure [ 26 ]. The reason why our results align more closely with the international scenario than the Brazilian one remains unclear. Possible explanations are the small number of deaths observed in our study (only 14 events), recent time-dependent changes [ 27 ], which could not be detected in an analysis that considered all years between 2000–2018 jointly[ 26 ] and the fact that the four participating institutions in our study are national referral centers located in the Southeast part of the country, the richest one. Limitations This study has many limitations that should be acknowledged. First, our cohort reflected the real-world characteristics of patients with sickle cell disease served by four referral institutions in Brazil. The data reflect only the reality of referral centers in the Southeast, limiting generalization to other regions of Brazil. In addition, no causal relationships can be inferred. Second, our retrospective design is prone to selection bias and estimation bias. Although we adopted only a few inclusion criteria to increase the clinical spectrum of the studied cohort, it is plausible that missing data could lead to a downward bias in our findings, resulting in more conservative estimates regarding the epidemiology of VOCs requiring hospitalization. Importantly, the estimation of VOC requiring hospitalization is likely conservative in retrospective studies performed in the context of routine clinical care in Brazil. The costs and known logistic difficulties associated with hospital admission (hospital queues, transportation and absenteeism, for instance) can restrict access to healthcare, reducing the number of patients seeking medical attention at the hospital. Third, our regression models were limited by the few clinical and sociodemographic variables routinely collected in real-world settings, which may have led to potential residual confounding. Thus, these analyses should be considered exploratory only and employed as hypothesis-generating results for further investigations. Large, prospective cohort studies with pre-specified analyses are needed to adequately control residual confounding and pinpoint better risk factors for VOCs requiring hospitalization in Brazilian patients with SCD. Conclusion This study highlights the urgent need for preventive strategies and innovative therapies to reduce the burden of vaso-occlusive crises in patients with sickle cell disease in Brazil. ​ Investments in multicenter and prospective studies are crucial for informing public policies and enhancing clinical outcomes. Declarations Data Sharing Statement: All data may be found in a data supplement available with the online version of this article. Acknowledgments We thank all participating institutions and healthcare professionals for their valuable contributions to data collection and patient care. Special appreciation to the patients and families whose data made this study possible. This research was supported by Novartis Biociências SA. The authors are grateful for the collaborative efforts that enabled this real-world investigation. Authorship contributions ACSP and RDC participated in the study design, data collection and reviewed the manuscript. ACPS, PGM, SFMG and RDC contributed to the screening and inclusion of patients in the study, their clinical follow-up, compilation, review and analysis of the data and revision of the final manuscript. VMAB critically reviewed the manuscript. Conflict of Interest Disclosures VMAB is an employee of Novartis Biociências SA. ACSP has participated in some advisory boards sponsored by Novartis. Funding Declaration This study was funded by Novartis Biociências SA. 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Pediatr Blood Cancer 60(9):1482–1486. 10.1002/pbc.24557 Tables Table 1 . Sociodemographic and genetic characteristics of the participants at baseline (n =404) Variable n (%) Age (years), mean (SD)* 29.0 (14.1) Age group, No. (%) Pediatric (<18 years) ** 92 (22.8%) Adult (≥18 years) 312 (77.2%) Sex, No. (%) Female 228 (56.4%) Male 176 (43.6%) Race/Ethnicity, No. (%)† White 96 (24.9%) Black 151 (39.2%) Brown 138 (35.8%) Missing 19 Educational level, No. (%) Primary school 104 (41.8%) Secondary school 77 (30.9%) Higher education 15 (6.0%) Not applicable†† 53 (21.3%) Missing 155 Sickle cell disease genotype, No. (%) HbSS 289 (71.5%) HbSC 66 (16.3%) HbSβ 0 thalassemia 45 (11.1%) HbSβ + thalassemia 4 (1.0%) * The median age was 27 years (min = 5, max = 67). **Among the 92 pediatric participants, there were 35 (38%) aged 5-11 years and 57 (62%) aged 12-17 years. † Self-reported. †† Children who have not yet completed primary school. ¶Among adults, the distribution of genotypes HbSS, HbSC, HbSβ0 thalassemia and HbSβ+ thalassemia was 209 (67%), 58 (18.6%), 42 (13.5%)and 3 (1.0%) respectively. Among pediatric participants, the corresponding distribution was 80 (87%), 8 (8.7%), 3 (3.3%) and 1 (1.1%), respectively. Fisher’s exact test, P = 0.002 comparing adults vs pediatric participants. Table 2 – Hospitalizations during the observation period Hospitalization at other facilities Hospitalization at the study site Overall Patient admitted to the emergency room or hospitalized during the observation period, n (%) Yes 99 (24.5%) 216 (53.5%) 265 (65.6%) No 305 (75.5%) 188 (46.5%) 139 (34.4%) Total 404 404 404 Conditions of interest, n (%) Uncomplicated pain crisis (VOC) 82 (20.3%) 194 (48.0%) 240 (59.4%) N 404 404 404 Mean 0.42 1.64 2.06 Median 0.00 0.00 1.00 Standard deviation 1.16 3.02 3.22 Minimum 0.00 0.00 0.00 Maximum 9.00 25.00 25.00 <=1 368 (91.1%) 286 (70.8%) 246 (60.9%) 2 - 5 29 (7.2%) 79 (19.6%) 107 (26.5%) >5 7 (1.7%) 39 (9.7%) 51 (12.6%) Acute chest syndrome 13 (3.2%) 36 (8.9%) 47 (11.6%) N 404 404 404 Mean 0.03 0.13 0.16 Median 0.00 0.00 0.00 Standard deviation 0.20 0.47 0.51 Minimum 0.00 0.00 0.00 Maximum 2.00 4.00 4.00 Splenic sequestration 0 3 (0.7%) 3 (0.7%) N 404 404 404 Mean 0.00 0.01 0.01 Median 0.00 0.00 0.00 Standard deviation 0.00 0.09 0.09 Minimum 0.00 0.00 0.00 Maximum 0.00 1.00 1.00 Hepatic sequestration 0 4 (1.0%) 4 (1.0%) N 404 404 404 Mean 0.00 0.01 0.01 Median 0.00 0.00 0.00 Standard deviation 0.00 0.10 0.10 Table 2 – Hospitalizations during the observation period (Continuation) Hospitalization at other facilities Hospitalization at the study site Overall Minimum 0.00 0.00 0.00 Maximum 0.00 1.00 1.00 Priapism * 0 2 (1.1%) 2 (1.1%) N 176 176 176 Mean 0.00 0.01 0.01 Median 0.00 0.00 0.00 Standard deviation 0.00 0.14 0.14 Minimum 0.00 0.00 0.00 Maximum 0.00 2.00 2.00 Ischemic stroke 0 5 (1.2%) 5 (1.2%) N 404 404 404 Mean 0.00 0.02 0.02 Median 0.00 0.00 0.00 Standard deviation 0.00 0.26 0.26 Minimum 0.00 0.00 0.00 Maximum 0.00 4.00 4.00 Hemorrhagic stroke 2 (0.5%) 2 (0.5%) 4 (1.0%) N 404 404 404 Mean 0.00 0.00 0.01 Median 0.00 0.00 0.00 Standard deviation 0.07 0.07 0.10 Minimum 0.00 0.00 0.00 Maximum 1.00 1.00 1.00 Cholelithiasis 2 (0.5%) 12 (3.0%) 14 (3.5%) N 404 404 404 Mean 0.00 0.04 0.04 Median 0.00 0.00 0.00 Standard deviation 0.07 0.25 0.26 Minimum 0.00 0.00 0.00 Maximum 1.00 3.00 3.00 Cholecystitis 2 (0.5%) 5 (1.2%) 7 (1.7%) N 404 404 404 Mean 0.00 0.01 0.02 Median 0.00 0.00 0.00 Standard deviation 0.07 0.11 0.13 Minimum 0.00 0.00 0.00 Hospitalization at other facilities Hospitalization at the study site Overall Maximum 1.00 1.00 1.00 Pneumonia 15 (3.7%) 58 (14.4%) 70 (17.3%) N 404 404 404 Mean 0.05 0.26 0.31 Median 0.00 0.00 0.00 Standard deviation 0.26 0.87 0.90 Minimum 0.00 0.00 0.00 Maximum 3.00 8.00 8.00 Acute myocardial infarction 0 0 0 N 404 404 404 Mean 0.00 0.00 0.00 Median 0.00 0.00 0.00 Standard deviation 0.00 0.00 0.00 Minimum 0.00 0.00 0.00 Maximum 0.00 0.00 0.00 Chronic renal disease 0 4 (1.0%) 4 (1.0%) N 404 404 404 Mean 0.00 0.01 0.01 Median 0.00 0.00 0.00 Standard deviation 0.00 0.16 0.16 Minimum 0.00 0.00 0.00 Maximum 0.00 2.00 2.00 Osteonecrosis 0 5 (1.2%) 5 (1.2%) N 404 404 404 Mean 0.00 0.11 0.11 Median 0.00 0.00 0.00 Standard deviation 0.00 1.95 1.95 Minimum 0.00 0.00 0.00 Maximum 0.00 39.00 39.00 Overall N 404 404 404 Mean 0.50 2.09 2.60 Median 0.00 1.00 1.00 Standard deviation 1.26 3.90 4.06 Minimum 0.00 0.00 0.00 Maximum 10.00 40.00 40.00 *Número de participantes do sexo masculino. Table 3 – Surgeries during the observation period Total (n=404) Surgery during the observation period, n (%) Yes 50 (12.4%) No 354 (87.6%) Total 404 If yes, specify a) , n (%) Adenoidectomy 0 Tonsillectomy 0 Splenectomy 1 (2.0%) Cholecystectomy 24 (48.0%) Hip arthroplasty 3 (6.0%) Neurosurgery 1 (2.0%) Heart surgery 1 (2.0%) Other 22 (44.0%) Surgery performed during a hospitalization due to a condition of interest b) , n (%) Yes 20 (38.5%) No 32 (61.5%) Total 52 a) Patients could have been submitted to more than one surgery. b) Statistical analysis performed by surgery. Table 4 – SCD complications First visit a) (n=404) During Observation period (n=404) SCD complications b) , n (%) 219 (55.0%) 34 (8.4%) Leg ulcer 40 (10.1%) 6 (1.5%) Retinopathy 40 (10.1%) 9 (2.2%) Iron overload 57 (14.3%) 7 (1.7%) Pulmonary hypertension 7 (1.8%) 4 (1.0%) Hepatic disease 11 (2.8%) 3 (0.7%) Renal disease 37 (9.3%) 5 (1.2%) Chronic heart failure 3 (0.8%) 0 Hypertension 35 (8.8%) 3 (0.7%) Acute myocardial infarction 0 0 Cardiac disease 33 (8.3%) 3 (0.7%) Osteonecrosis 82 (20.6%) 1 (0.2%) None of the above 179 (45.0%) 7 (1.7%) Unknown 6 1 a) Conditions presented by the patient at the start of the observation period. b) Patients could have had more than one SCD complication. Table 5 – Mortality data per age-group Pediatric (<18 years) Adult (≥18 years) (n=312) Death, n (%) No 90 (97.8%) 300 (96.2%) Yes 2 (2.2%) 12 (3.8%) Ischemic stroke 0 1 (8.3%) Hemorrhagic stroke 0 2 (16.7%) Sepsis 0 2 (16.7%) Acute Chest Syndrome 0 3 (25.0%) Other 2 (100.0%) 4 (33.3%) Cardiorespiratory arrest - 1 Unspecified pneumonia - 1 Cardiorespiratory arrest, refractory sepsis - 1 Complications from cholecystectomy surgery - 1 Death by firearm projectile in an attempted robbery 1 - Unknown 1 - Total 92 312 Table 6 – Treatments of interest (ambulatory) During Observation period (n=404) Treatments, n (%) Iron chelation 91 (22.5%) Folic acid 386 (95.5%) Prophylactic penicillin 74 (18.3%) Hydration therapy 73 (18.1%) Pain medication for VOC not requiring hospitalization: NSAID - oral 248 (61.4%) Pain medication for VOC not requiring hospitalization: Opioid - oral 163 (40.3%) None of the above 4 (1.0%) a) Treatments received by the patient since the start of the observation period. Table 7 – Hydroxyurea use (ambulatory) during the observation period Total Patients (n=404) n (%) nTrt (n=755) Patient treated with hydroxyurea, n (%) No 135 (33.4%) - Yes 269 (66.6%) - Total 404 - Missing values 0 - Adherence (%) N 269 - Mean 87.17 - Median 100.00 - Standard deviation 23.21 - Minimum 2.94 - Maximum 100.00 - Missing values 135 - <70% of continuous use 62 (23.0%) - ≥70% of continuous use 207 (77.0%) - Dose (mg/kg/day) N - 481 Mean - 21.40 Median - 21.00 Standard deviation - 6.86 Minimum - 3.51 Maximum - 41.67 Missing values - 274 15 mg/kg/day - 22 (9.3%) 20 mg/kg/day - 24 (10.1%) 25 mg/kg/day - 24 (10.1%) 30 mg/kg/day - 13 (5.5%) 35 mg/kg/day - 4 (1.7%) Other - 150 (63.3%) n (%) = Number (percent) of patients. nTrt = Number of treatment courses. Table 8 – Immunization First visit a) – immunization history (n=404) During Observation period (n=404) Immunization b) , n (%) Antipneumococcal 129 (75.0%) 9 (2.3%) N - 9 Mean - 1.00 Median - 1.00 Standard deviation - 0.00 Minimum - 1.00 Maximum - 1.00 Missing values - 0 Anti-meningococcal 106 (61.6%) 5 (1.3%) N - 5 Mean - 1.00 Median - 1.00 Standard deviation - 0.00 Minimum - 1.00 Maximum - 1.00 Missing values - 0 Influenza 120 (69.8%) 41 (10.3%) N - 41 Mean - 1.07 Median - 1.00 Standard deviation - 0.26 Minimum - 1.00 Maximum - 2.00 Missing values - 0 Hepatitis B 120 (69.8%) 6 (1.5%) N - 6 Mean - 1.00 Median - 1.00 Standard deviation - 0.00 Minimum - 1.00 Maximum - 1.00 Missing values - 0 None of the above 9 (5.2%) 0 Unknown 232 4 a) Immunizations received by the patient before the start of the observation period. b) Patients could have received more than one immunization. Table 9 – Blood transfusions (outpatient) During Observation period (n=404) Blood transfusions, n (%) No 219 (54.2%) Yes 185 (45.8%) Total 404 Number of blood transfusions N 404 Mean 6.38 Median 0.00 Standard deviation 13.49 Minimum 0.00 Maximum 74.00 Reason for blood transfusion a) , n (%) Prophylactic treatment 2229 (86.5%) Symptomatic treatment 340 (13.2%) Other 9 (0.3%) Pulmonary Hypertension 1 Surgical preparation 8 Total 2578 Type of blood transfusion a) , n (%) Simple transfusion 845 (32.8%) Exchange transfusion 1733 (67.2%) Total 2578 Number of blood bags used a) N 2578 Mean 1.46 Median 1.00 Standard deviation 1.50 Minimum 1.00 Maximum 44.00 a) Statistical analysis performed by blood transfusion. Table 10 – Exams and tests (ambulatory) Total (n=8344) Biochemistry tests specified in the protocol, n (%) Yes 6008 (72.0%) No 2336 (28.0%) Total 8344 If yes: Hemogram, n (%) No 198 (3.3%) Yes 5810 (96.7%) Total 6008 MCV (fL) N 5524 Mean 94.99 Median 94.00 Standard deviation 14.52 Minimum 24.60 Maximum 151.00 LDH, n (%) No 3920 (65.2%) Yes 2088 (34.8%) Total 6008 LDH result, n (%) <240 U/L 104 (5.0%) 240 - 480 U/L 566 (27.1%) >480 U/L 1418 (67.9%) Total 2088 Reticulocytes, n (%) No 3602 (60.0%) Yes 2406 (40.0%) Total 6008 Ferritin, n (%) No 5046 (84.0%) Yes 962 (16.0%) Total 6008 Biochemistry a) , n (%) No 2507 (41.7%) Yes 3501 (58.3%) Total 6008 Urine, n (%) MCV: Mean Corpuscular Volume. LDH: Lactate dehydrogenase. Table 10 – Exams and tests (ambulatory) Total (n=8344) No 5136 (85.5%) Yes 872 (14.5%) Total 6008 B HCG test, n (%) No 5730 (95.4%) Yes 278 (4.6%) Positive 16 (5.8%) Negative 262 (94.2%) Total 6008 Any image exams, n (%) Yes 1136 (13.6%) No 7208 (86.4%) Total 8344 If yes, n (%) Magnetic resonance imaging 89 (7.8%) Computed tomography 65 (5.7%) Transcranial doppler 120 (10.6%) Chest X-Ray 212 (18.7%) Ultrasound 350 (30.8%) Densitometry 99 (8.7%) Scintigraphy 5 (0.4%) Echocardiogram 312 (27.5%) Other 71 (6.3%) Bone X-Ray 11 Hip X-Ray 3 Mammography 3 Quadriceps X-Ray 3 Simple Jaw X-Ray 3 knee X-Ray 3 Foot X-Ray 2 Jaw X-Ray 2 Pelvic X-Ray 2 Sacrum X-Ray 2 Shoulder X-Ray 2 Abdomen X-Ray 1 Angioresonance 1 Ankle X-Ray; Foot X-Ray 1 Ankle X-Ray; Foot X-Ray; Hip X-Ray 1 Arm X-Ray 1 MCV: Mean Corpuscular Volume. LDH: Lactate dehydrogenase. a) Any of the following: creatinine, sodium, potassium, gamma-glutamyl transferase, alanine aminotransferase, aspartate aminotransferase. Table 10 – Exams and tests (ambulatory) Total (n=8344) Bone Age X-Ray 1 Cavum X-Ray 1 Cineangiocoronariography 1 Costal Arch X-Ray; Knee X-Ray 1 Coxofemoral Joint X-Ray 1 Coxofemoral Joint X-Ray; Knee X-Ray; Thigh X-Ray 1 Fluorescein Angiography 1 Foot X-Ray; Shoulder X-Ray 1 Hip X-Ray; Knee X-Ray 1 Left Foot X-Ray 1 Left Knee X-Ray 1 Legs Venous Doppler 1 Lower Member Venous Doppler 1 Lumbosacral Spine X-Ray 1 Pelvis X-Ray 1 Pelvis X-Ray; Sinuses X-Ray 1 Sacral Column X-Ray 1 Shoulders X-Ray 1 Simple Forearm X-Ray 1 Sinuses X-Ray 1 Spine X-Ray 1 Oximetry and/or fundoscopy, n (%) Yes 1589 (19.0%) No 6755 (81.0%) Total 8344 If yes, n (%) Oximetry 1302 (81.9%) Fundoscopy 306 (19.3%) MCV: Mean Corpuscular Volume. LDH: Lactate dehydrogenase. Any of the following: creatinine, sodium, potassium, gamma-glutamyl transferase, alanine aminotransferase, aspartate aminotransferase. Additional Declarations Competing interest reported. VMAB is an employee of Novartis Biociências SA. ACSP has participated in some advisory boards sponsored by Novartis. Cite Share Download PDF Status: Published Journal Publication published 19 Feb, 2026 Read the published version in Annals of Hematology → Version 1 posted Editorial decision: Revision requested 21 Nov, 2025 Reviews received at journal 21 Sep, 2025 Reviewers agreed at journal 13 Sep, 2025 Reviewers invited by journal 13 Sep, 2025 Editor assigned by journal 12 Sep, 2025 Submission checks completed at journal 12 Sep, 2025 First submitted to journal 09 Sep, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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06:52:20\",\"extension\":\"html\",\"order_by\":18,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":192812,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"earlyproof.html\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-7576339/v1/b46a941380ae2464e706510a.html\"},{\"id\":91952593,\"identity\":\"b58a38d3-c128-4aaa-b4ec-c356f9e7683c\",\"added_by\":\"auto\",\"created_at\":\"2025-09-23 06:52:20\",\"extension\":\"png\",\"order_by\":1,\"title\":\"Figure 1\",\"display\":\"\",\"copyAsset\":false,\"role\":\"figure\",\"size\":202615,\"visible\":true,\"origin\":\"\",\"legend\":\"\\u003cp\\u003eFlowchart of the selection and follow-up process of participants in a retrospective study carried out at four centers between January 2016 and December 2018. Out of the 420 evaluated, 404 were included. After three years, 356 completed the follow-up, while 48 had incomplete follow-up (14 deaths and 34 losses of contact). All 404 were included in the final analysis.\\u003c/p\\u003e\",\"description\":\"\",\"filename\":\"1.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-7576339/v1/1897c0da0d1ba6edc8965cd1.png\"},{\"id\":91953670,\"identity\":\"326bcaf7-79ce-4ed0-8ca8-4a0bde93c287\",\"added_by\":\"auto\",\"created_at\":\"2025-09-23 07:00:20\",\"extension\":\"png\",\"order_by\":2,\"title\":\"Figure 2\",\"display\":\"\",\"copyAsset\":false,\"role\":\"figure\",\"size\":169001,\"visible\":true,\"origin\":\"\",\"legend\":\"\\u003cp\\u003eEstimates of incidence risk of a vaso-occlusive crisis requiring hospitalization (panel A). Incidence rates of a vaso-occlusive crisis requiring hospitalization (panel B). P-values denote tests assessing the trend over the years (via generalized estimating equations models).\\u003c/p\\u003e\",\"description\":\"\",\"filename\":\"2.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-7576339/v1/acde29b4d13b71d87798e729.png\"},{\"id\":103251237,\"identity\":\"a6f173cb-3c62-4648-8554-84d04d6c7ea7\",\"added_by\":\"auto\",\"created_at\":\"2026-02-23 16:06:54\",\"extension\":\"pdf\",\"order_by\":0,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"manuscript-pdf\",\"size\":2695374,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"manuscript.pdf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-7576339/v1/d575da8f-7dda-45c9-94c7-222e78c6f8fe.pdf\"}],\"financialInterests\":\"Competing interest reported. VMAB is an employee of Novartis Biociências SA.\\nACSP has participated in some advisory boards sponsored by Novartis.\",\"formattedTitle\":\"Risk of vaso-occlusive crisis requiring hospitalization in sickle cell disease patients in Brazil: retrospective cohort study of real-world data\",\"fulltext\":[{\"header\":\"Introduction\",\"content\":\"\\u003cp\\u003eSickle cell disease (SCD) is a group of genetic disorders characterized by a single mutation in the HBB gene which encodes the β-globin subunit of hemoglobin[\\u003cspan citationid=\\\"CR1\\\" class=\\\"CitationRef\\\"\\u003e1\\u003c/span\\u003e, \\u003cspan citationid=\\\"CR2\\\" class=\\\"CitationRef\\\"\\u003e2\\u003c/span\\u003e]. Although considered a rare condition, it is estimated that 7.74\\u0026nbsp;million individuals were living with sickle cell disorders globally in 2021[\\u003cspan citationid=\\\"CR3\\\" class=\\\"CitationRef\\\"\\u003e3\\u003c/span\\u003e]. In Brazil, it ranks among the most prevalent hereditary diseases, yet epidemiological data on its occurrence within the country remain limited [\\u003cspan citationid=\\\"CR4\\\" class=\\\"CitationRef\\\"\\u003e4\\u003c/span\\u003e].\\u003c/p\\u003e\\u003cp\\u003eSCD is a group of inherited blood disorders that include sickle cell anemia (HbSS), sickle cell/β-thalassemia, HbSC, and other less common variants [\\u003cspan citationid=\\\"CR1\\\" class=\\\"CitationRef\\\"\\u003e1\\u003c/span\\u003e, \\u003cspan citationid=\\\"CR2\\\" class=\\\"CitationRef\\\"\\u003e2\\u003c/span\\u003e, \\u003cspan citationid=\\\"CR5\\\" class=\\\"CitationRef\\\"\\u003e5\\u003c/span\\u003e, \\u003cspan citationid=\\\"CR6\\\" class=\\\"CitationRef\\\"\\u003e6\\u003c/span\\u003e]. Based on a recent meta-analysis, the global prevalence of HbSS and the severe form of sickle cell/β-thalassemia was estimated to be 112 per 100,000 live births, with a prevalence rate approximately 26 times higher among African children than European children (1,125 vs 43 cases per 100,000 live births, respectively) [\\u003cspan citationid=\\\"CR7\\\" class=\\\"CitationRef\\\"\\u003e7\\u003c/span\\u003e].\\u003c/p\\u003e\\u003cp\\u003eClinically, SCD is associated with numerous vaso-occlusive symptoms, including episodes of intense pain, acute chest syndrome, and stroke [\\u003cspan citationid=\\\"CR1\\\" class=\\\"CitationRef\\\"\\u003e1\\u003c/span\\u003e, \\u003cspan citationid=\\\"CR2\\\" class=\\\"CitationRef\\\"\\u003e2\\u003c/span\\u003e, \\u003cspan citationid=\\\"CR5\\\" class=\\\"CitationRef\\\"\\u003e5\\u003c/span\\u003e]. Vaso-occlusive crisis (VOC) is the primary reason for hospital emergency room visits and hospitalization among patients with SCD, resulting in high healthcare-related costs [\\u003cspan citationid=\\\"CR8\\\" class=\\\"CitationRef\\\"\\u003e8\\u003c/span\\u003e, \\u003cspan citationid=\\\"CR9\\\" class=\\\"CitationRef\\\"\\u003e9\\u003c/span\\u003e]. For example, in the United States, data from 2012 revealed that the average cost per emergency room visit due to a VOC was \\u003cspan\\u003e$\\u003c/span\\u003e1,072, and the corresponding average cost per hospitalization due to a VOC was greater than \\u003cspan\\u003e$\\u003c/span\\u003e11,398 in Medicare patients [\\u003cspan citationid=\\\"CR10\\\" class=\\\"CitationRef\\\"\\u003e10\\u003c/span\\u003e]. Remarkably, while the pathophysiology and new therapeutic approaches for SCD have been widely studied [\\u003cspan citationid=\\\"CR6\\\" class=\\\"CitationRef\\\"\\u003e6\\u003c/span\\u003e, \\u003cspan citationid=\\\"CR11\\\" class=\\\"CitationRef\\\"\\u003e11\\u003c/span\\u003e, \\u003cspan citationid=\\\"CR12\\\" class=\\\"CitationRef\\\"\\u003e12\\u003c/span\\u003e], there have been limited data regarding the risk of VOCs requiring hospitalization among patients with SCD, making it hard to predict its clinical and economic consequences.\\u003c/p\\u003e\\u003cp\\u003eIt is important to consider that the clinical course and symptoms of SCD are multifactorial manifestations that can be modulated by the genetic background of patients [\\u003cspan citationid=\\\"CR12\\\" class=\\\"CitationRef\\\"\\u003e12\\u003c/span\\u003e]. Latin American populations, such as Brazilians, show an important miscegenation between African, European, and Native American populations, which can contribute to a singular clinical profile of SCD [\\u003cspan citationid=\\\"CR13\\\" class=\\\"CitationRef\\\"\\u003e13\\u003c/span\\u003e]. However, there is a paucity of information on the current characteristics of Latin American patients with SCD. In this study, we performed a real-world investigation to describe a cohort of patients with SCD treated in four referral centers in Brazil. The objective was to describe the clinical characteristics, healthcare resource utilization (HCRU), incidence risk, and complications associated with VOCs requiring hospitalization among Brazilian patients with SCD.\\u003c/p\\u003e\"},{\"header\":\"Methods\",\"content\":\"\\u003cp\\u003eThis was a multicenter, retrospective cohort study. The institutional review boards at the participating institutions approved the study protocol, and written informed consent was obtained from all participants. However, two sites granted a waiver of informed consent. This observational study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki and adheres to the reporting standards established by the Strengthening Reporting of Observational Studies in Epidemiology Statement (STROBE) [\\u003cspan citationid=\\\"CR14\\\" class=\\\"CitationRef\\\"\\u003e14\\u003c/span\\u003e].\\u003c/p\\u003e\\u003cp\\u003eThe study was conducted in four referral centers for blood diseases, all located in the Southeastern region of Brazil. We reviewed the medical records of patients with SCD who received healthcare at the participating centers between January 2016 and December 2018. Follow-up continued until the end of the study period, patient death, or until they could no longer be contacted (lost to follow-up), whichever occurred first.\\u003c/p\\u003e\\u003cp\\u003eWe applied pre-specified inclusion criteria, enrolling bothpediatric patients (aged 5\\u0026ndash;17 years) and adult patients (18 years or older) of any gender. Eligible participants had a confirmed diagnosis of SCD (genotype HbSS, HbSC, HbSβ\\u003csup\\u003e0\\u003c/sup\\u003e-thalassemia, HbSβ\\u003csup\\u003e+\\u003c/sup\\u003e-thalassemia) established at baseline (defined as January 01, 2016), and had at least three outpatient visits during the first year of follow-up. Patients who did not meet these criteria were excluded from the study.\\u003c/p\\u003e\\u003cp\\u003eThe primary outcome was the incidence risk of VOC requiring hospitalization during the 3-year follow-up (2016\\u0026ndash;2018). VOC was defined as an acute onset of pain crisis for which there is no other medically determined explanation other than vaso-occlusion which requires therapy with oral or parenteral opioids or non-steroidal anti-inflammatory drugs (NSAIDs).\\u003c/p\\u003e\\u003cp\\u003eWe estimated the incidence rate of a VOC requiring hospitalization for the secondary outcomes. Results were presented as events per 1000 person-years to facilitate interpretation. Furthermore, we assessed the cumulative proportion of participants with complications presented by the patient at the start of the observation period, including mortality, leg ulcer, retinopathy, iron overload, pulmonary hypertension, hepatic disease, renal disease, chronic heart failure, essential hypertension, acute myocardial infarction, cardiac disease, and osteonecrosis. We also evaluated healthcare utilization considering the following domains: pharmacological interventions in the outpatient setting, immunizations, blood transfusions at the outpatient setting, laboratory and imaging tests during medical visits, hospitalizations and emergency room visits.\\u003c/p\\u003e\\u003cp\\u003e\\u003cb\\u003eStudy size\\u003c/b\\u003e\\u003c/p\\u003e\\u003cp\\u003eGiven the paucity of previous evidence, we assumed that the incidence risk of patients with sickle cell disease developing a VOC requiring hospitalization during the 3-year follow-up would be 50%. Based on this conservative assumption, 384 participants were required to estimate the expected proportion with 5% absolute precision and a 95% confidence interval [\\u003cspan citationid=\\\"CR15\\\" class=\\\"CitationRef\\\"\\u003e15\\u003c/span\\u003e].\\u003c/p\\u003e\\u003cp\\u003eThe main analysis involved all participants, but we also conducted subgroup analyses considering pediatric and adult populations separately when clinically relevant. We summarized continuous variables with an approximately normal distribution using means and standard deviations (SD). Continuous variables with a skewed distribution were presented as medians (minimum and maximum). Categorical variables were summarized as numbers (percentages). We did not employ multiple imputations for missing data. Because results are considered descriptive and exploratory, we did not adjust for multiple testing. All statistical analyses were performed using SAS 9.4 software (SAS Institute Inc., Cary, NC, USA). All tests are two-sided, and a P\\u0026thinsp;\\u0026lt;\\u0026thinsp;0.05 was considered statistically significant.\\u003c/p\\u003e\"},{\"header\":\"Results\",\"content\":\"\\u003cp\\u003eBetween January 2016 and December 2018, 420 individuals were identified through patient registries at the participating centers and assessed for eligibility. Following review, 404 pediatric and adult participants met all inclusion criteria and were enrolled in the study (Figure 1). Of these, 312 (77.2%) were aged 18 years or older, and 228 (56.4%) were female. During a three-year follow-up period, 14 participants (3.5%) died, and 34 (8.4%) were lost to follow-up (Table 1, Figure 1).\\u003c/p\\u003e\\n\\u003cp\\u003eOf the 404 participants included, only 166 (41.1%) had sufficient information regarding disease duration. Based on this sub-sample (both pediatric and adult cohorts included), the mean (SD) disease duration was 21.9 (11.7) years. The corresponding estimates for the pediatric and adult cohorts were 10.5 years (3.0) and 25.5 years (11.1), respectively. The most common genotype among included participants was HbSS (n=289, 71.5%), followed by HbSC (n=66, 16.3%). Table 1 shows the clinical and sociodemographic characteristics of the study participants at baseline.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eIncidence\\u0026nbsp;\\u003c/strong\\u003e\\u003cstrong\\u003erate and\\u0026nbsp;\\u003c/strong\\u003e\\u003cstrong\\u003erisk of VOC requiring hospitalization.\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eOver the 3-year follow-up period, 240 patients (59.4%) experienced at least one VOC requiring hospitalization. There is a gradual increase in the incidence of VOC-related hospitalization from 2016 to 2018, with the highest risk observed in 2018 (38.4%) (p= 0.02) (Figure 2, panel A). The incidence rate of VOCs requiring hospitalization was 812 events per 1,000 person-years during the observation period, with a notable increase in 2018 with 985 events per 1,000 person-years (p= 0.07) (Figure 2, panel B).\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eHealthcare resource utilization: Emergency Room or Hospitalization\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eAmong 404 participants, 265 (65.6%) were hospitalized or admitted to an emergency room, and the reasons for emergency room visits or hospitalization in the cohort are summarized in Table 2. Of the 404 participants, 50 (12.4%) underwent any surgery during the follow-up, resulting in 52 surgical procedures. Of the 52 surgeries, 24 (48.0%) were cholecystectomies (Table 3)\\u003cstrong\\u003e.\\u0026nbsp;\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eSickle cell disease complications\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eAt the start of the observation period, among 398 patients with complete data, 219 (55.0%) presented at least one SCD-related complication on their first visit. Osteonecrosis was the most prevalent (82 patients, 20.6%), followed by iron overload (57 patients, 14.3%). The diagnosis of new complications during the follow-up period was uncommon, with only 34 patients (8.4%) developing a new complication. The most frequently diagnosed new complication was retinopathy (9 patients, 2.2%), followed by iron overload (7 patients, 1.7%) (Table 4).\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eMortality\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eFourteen patients (3.5%) died during the follow-up period, of whom 12 (85.7%) were adults (\\u0026ge;18 years) and 2 (14.3%) were pediatric patients. Among adults, the most common cause of death was acute chest syndrome (3 patients, 25.0%), followed by hemorrhagic stroke and sepsis (2 patients each, 16.7%). The two pediatric deaths were due to other causes (Table 5)\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eHealthcare resource utilization: pharmacological interventions at the outpatient setting\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eFolic acid was the most used treatment in the outpatient setting (386 [95.5%] of 404 participants). In addition, 248 (61.4%) of the 404 participants received oral NSAIDs at least once to control pain intensity in VOCs not requiring hospitalization. An overview presented in Table 6 describes the number of participants who required other pharmacological interventions in the outpatient setting.\\u003c/p\\u003e\\n\\u003cp\\u003eHydroxyurea use in the cohort is described in Table 7. Overall, 269 (66.6%) of the 404 participants received hydroxyurea treatment at least once during the 3-year follow-up period. A total of 755 treatment courses of hydroxyurea were recorded. Continuous use of hydroxyurea was confirmed in 207 patients (77%). The mean (SD) dose was 21.4 (6.9) mg/kg per day among 481 treatment courses with complete information.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eHealthcare resource utilization: immunizations at the outpatient setting\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eAt baseline, only 172 participants had complete data regarding immunizations. Of these, 129 (75.0%) had been vaccinated against pneumococcal disease, 106 (61.6%) for meningococcal disease, 120 (69.8%) for influenza and 120 (69.8%) for hepatitis B. During the follow-up, data on immunizations was available for 404 participants (Table 8).\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eHealthcare resource utilization: blood transfusions at the outpatient setting\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eOf the 404 participants, 185 (45.8%) received blood transfusions during the 3-year follow-up period. A total of 2,578 blood transfusions were recorded, with a mean of 6.4 transfusions per patient (range: 0 to 74). Exchange transfusions were the most frequently performed procedure (1,733 transfusions, 67.2%). Prophylactic treatment was the most common indication for transfusion, accounting for 2,229 cases (86.5%) (Table 9).\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eHealthcare resource utilization: laboratory and imaging tests at the outpatient setting\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eDuring the 3-year follow-up, the 404 participants had 8,344 medical visits. Of 8,344 visits, 6,008 (72.0%) visits had requests for biochemical tests, and 1,136 (13.6%) had requests for imaging exams. A total of \\u0026nbsp;1.589(19.0%) visits had requests for oximetry and /or ophthalmoscopy, with 1,302 (81.9%) \\u0026nbsp; oximetry and 306 (19.3%) ophthalmoscopy. The most frequently requested laboratory test was a hemogram of 5,810 (96.7%). The most requested imaging tests were ultrasound 350 (30.8%) and echocardiogram 312 (27.5%). Table 10 describes the use of laboratory and imaging tests in the cohort.\\u003c/p\\u003e\"},{\"header\":\"Discussion\",\"content\":\"\\u003cp\\u003eIn this retrospective study, we described the characteristics of a cohort of Brazilian patients with SCD, focusing on hospital admission due to a VOC Approximately 240 out of 404 patients with SCD developed VOCs requiring hospitalization during a 3-year follow-up. The incidence rate of a VOC requiring hospitalization was 812 per 1000 person-years, representing a critical issue regarding healthcare utilization and costs in Brazil. To our knowledge, this is one of the few investigations employing real-world data that explored the epidemiology of VOCs requiring hospitalization among Latin American populations. Overall, our results provide an updated panorama of the healthcare burden associated with SCD in Brazil and can inform parameters for future health economic evaluations.\\u003c/p\\u003e\\u003cp\\u003eThese results corroborate previous evidence regarding the substantial economic burden of sickle cell disease in Brazil. For example, a recent analysis indicated that SCD could inflict nearly half a billion US dollars yearly in direct and indirect costs in Brazil[\\u003cspan citationid=\\\"CR16\\\" class=\\\"CitationRef\\\"\\u003e16\\u003c/span\\u003e].\\u003c/p\\u003e\\u003cp\\u003eNotably, most previous investigations assessing the clinical course of SCD in Brazilian patients focused on all-cause hospital admission [\\u003cspan citationid=\\\"CR17\\\" class=\\\"CitationRef\\\"\\u003e17\\u003c/span\\u003e], blood utilization [\\u003cspan citationid=\\\"CR18\\\" class=\\\"CitationRef\\\"\\u003e18\\u003c/span\\u003e] and genetic background [\\u003cspan citationid=\\\"CR13\\\" class=\\\"CitationRef\\\"\\u003e13\\u003c/span\\u003e], used smaller cohorts or investigated populations treated earlier than 2012 [\\u003cspan citationid=\\\"CR19\\\" class=\\\"CitationRef\\\"\\u003e19\\u003c/span\\u003e]. Recently, Oliveira et al. presented preliminary data from the most extensive study to date, focusing on clinical predictors of VOC among Brazilian SCD patients [\\u003cspan citationid=\\\"CR20\\\" class=\\\"CitationRef\\\"\\u003e20\\u003c/span\\u003e]. The authors found that treatment with hydroxyurea, a previous history of acute chest syndrome, and elevated white blood cell count were independent risk factors for three or more episodes of vaso-occlusive events requiring hospitalization. Similarly, Padr\\u0026atilde;o et al. employed clustering techniques to identify the characteristics of SCD patients admitted to intensive care units, demonstrating that Brazilian patients with SCD can exhibit high heterogeneity, with distinct profiles and clinical outcomes [\\u003cspan citationid=\\\"CR21\\\" class=\\\"CitationRef\\\"\\u003e21\\u003c/span\\u003e].\\u003c/p\\u003e\\u003cp\\u003eIn the international scenario, recent advances in antibiotic and vaccine protocols[\\u003cspan citationid=\\\"CR22\\\" class=\\\"CitationRef\\\"\\u003e22\\u003c/span\\u003e] have led to a shift in the leading cause of death among patients with SCD, which changed from infectious diseases[\\u003cspan citationid=\\\"CR23\\\" class=\\\"CitationRef\\\"\\u003e23\\u003c/span\\u003e] to cardiopulmonary events [\\u003cspan citationid=\\\"CR24\\\" class=\\\"CitationRef\\\"\\u003e24\\u003c/span\\u003e, \\u003cspan citationid=\\\"CR25\\\" class=\\\"CitationRef\\\"\\u003e25\\u003c/span\\u003e]. Our results corroborate these observations, indicating a very high vaccination coverage among the studied participants, with available immunization data. Interestingly, however, a recent analysis showed that the leading underlying cause of death among Brazilian patients with SCD (2000\\u0026ndash;2018) was septicemia, pneumonia, and respiratoryfailure [\\u003cspan citationid=\\\"CR26\\\" class=\\\"CitationRef\\\"\\u003e26\\u003c/span\\u003e]. The reason why our results align more closely with the international scenario than the Brazilian one remains unclear. Possible explanations are the small number of deaths observed in our study (only 14 events), recent time-dependent changes [\\u003cspan citationid=\\\"CR27\\\" class=\\\"CitationRef\\\"\\u003e27\\u003c/span\\u003e], which could not be detected in an analysis that considered all years between 2000\\u0026ndash;2018 jointly[\\u003cspan citationid=\\\"CR26\\\" class=\\\"CitationRef\\\"\\u003e26\\u003c/span\\u003e] and the fact that the four participating institutions in our study are national referral centers located in the Southeast part of the country, the richest one.\\u003c/p\\u003e\\u003cdiv id=\\\"Sec12\\\" class=\\\"Section2\\\"\\u003e\\u003ch2\\u003eLimitations\\u003c/h2\\u003e\\u003cp\\u003eThis study has many limitations that should be acknowledged. First, our cohort reflected the real-world characteristics of patients with sickle cell disease served by four referral institutions in Brazil. The data reflect only the reality of referral centers in the Southeast, limiting generalization to other regions of Brazil. In addition, no causal relationships can be inferred. Second, our retrospective design is prone to selection bias and estimation bias. Although we adopted only a few inclusion criteria to increase the clinical spectrum of the studied cohort, it is plausible that missing data could lead to a downward bias in our findings, resulting in more conservative estimates regarding the epidemiology of VOCs requiring hospitalization. Importantly, the estimation of VOC requiring hospitalization is likely conservative in retrospective studies performed in the context of routine clinical care in Brazil. The costs and known logistic difficulties associated with hospital admission (hospital queues, transportation and absenteeism, for instance) can restrict access to healthcare, reducing the number of patients seeking medical attention at the hospital. Third, our regression models were limited by the few clinical and sociodemographic variables routinely collected in real-world settings, which may have led to potential residual confounding. Thus, these analyses should be considered exploratory only and employed as hypothesis-generating results for further investigations. Large, prospective cohort studies with pre-specified analyses are needed to adequately control residual confounding and pinpoint better risk factors for VOCs requiring hospitalization in Brazilian patients with SCD.\\u003c/p\\u003e\\u003c/div\\u003e\"},{\"header\":\"Conclusion\",\"content\":\"\\u003cp\\u003eThis study highlights the urgent need for preventive strategies and innovative therapies to reduce the burden of vaso-occlusive crises in patients with sickle cell disease in Brazil. ​ Investments in multicenter and prospective studies are crucial for informing public policies and enhancing clinical outcomes.\\u003c/p\\u003e\"},{\"header\":\"Declarations\",\"content\":\"\\u003cp\\u003e\\u003cstrong\\u003eData Sharing Statement:\\u0026nbsp;\\u003c/strong\\u003eAll data may be found in a data supplement available with the online version of this article.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eAcknowledgments\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eWe thank all participating institutions and healthcare professionals for their valuable contributions to data collection and patient care.\\u003cbr\\u003e\\u0026nbsp;Special appreciation to the patients and families whose data made this study possible.\\u003cbr\\u003e\\u0026nbsp;This research was supported by Novartis Bioci\\u0026ecirc;ncias SA.\\u003cbr\\u003e\\u0026nbsp;The authors are grateful for the collaborative efforts that enabled this real-world investigation.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eAuthorship contributions\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eACSP and RDC participated in the study design, data collection and reviewed the manuscript.\\u003c/p\\u003e\\n\\u003cp\\u003eACPS, PGM, SFMG and RDC contributed to the screening and inclusion of patients in the study, their clinical follow-up, compilation, review and analysis of the data and revision of the final manuscript.\\u003c/p\\u003e\\n\\u003cp\\u003eVMAB critically reviewed the manuscript.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003e\\u0026nbsp;Conflict of Interest Disclosures\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eVMAB is an employee of Novartis Bioci\\u0026ecirc;ncias SA.\\u003c/p\\u003e\\n\\u003cp\\u003eACSP has participated in some advisory boards sponsored by Novartis.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eFunding Declaration\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eThis study was funded by Novartis Bioci\\u0026ecirc;ncias SA.\\u003c/p\\u003e\"},{\"header\":\"References\",\"content\":\"\\u003col\\u003e\\u003cli\\u003e\\u003cspan\\u003eKavanagh PL, Fasipe TA, Wun T (2022) Sickle Cell Disease. 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Hematol Transfus Cell Ther 44(2):177\\u0026ndash;185. \\u003cspan class=\\\"ExternalRef\\\"\\u003e\\u003cspan class=\\\"RefSource\\\"\\u003e10.1016/j.htct.2020.09.154\\u003c/span\\u003e\\u003cspan address=\\\"10.1016/j.htct.2020.09.154\\\" targettype=\\\"DOI\\\" class=\\\"RefTarget\\\"\\u003e\\u003c/span\\u003e\\u003c/span\\u003e\\u003c/span\\u003e\\u003c/li\\u003e\\u003cli\\u003e\\u003cspan\\u003eHamideh D, Alvarez O (2013) Sickle cell disease related mortality in the United States (1999\\u0026ndash;2009). Pediatr Blood Cancer 60(9):1482\\u0026ndash;1486. \\u003cspan class=\\\"ExternalRef\\\"\\u003e\\u003cspan class=\\\"RefSource\\\"\\u003e10.1002/pbc.24557\\u003c/span\\u003e\\u003cspan address=\\\"10.1002/pbc.24557\\\" targettype=\\\"DOI\\\" class=\\\"RefTarget\\\"\\u003e\\u003c/span\\u003e\\u003c/span\\u003e\\u003c/span\\u003e\\u003c/li\\u003e\\u003c/ol\\u003e\"},{\"header\":\"Tables\",\"content\":\"\\u003cp\\u003e\\u003cstrong\\u003eTable\\u0026nbsp;\\u003c/strong\\u003e\\u003cstrong\\u003e1\\u003c/strong\\u003e\\u003cstrong\\u003e. Sociodemographic and genetic characteristics of the participants at baseline (n =404)\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003ctable border=\\\"0\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\" width=\\\"507\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eVariable\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e\\u0026nbsp; \\u0026nbsp; \\u0026nbsp; \\u0026nbsp; \\u0026nbsp; \\u0026nbsp; \\u0026nbsp; \\u0026nbsp; \\u0026nbsp; \\u0026nbsp; \\u0026nbsp; \\u0026nbsp; \\u0026nbsp; n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eAge (years), mean (SD)*\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e29.0 (14.1)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eAge group, No. (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003ePediatric (\\u0026lt;18 years)\\u003csup\\u003e**\\u003c/sup\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e92 (22.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003eAdult (\\u0026ge;18 years)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e312 (77.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eSex, No. (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003eFemale\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e228 (56.4%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003eMale\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e176 (43.6%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eRace/Ethnicity, No. (%)\\u0026dagger;\\u0026nbsp;\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003eWhite\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e96 (24.9%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003eBlack\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e151 (39.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp; \\u0026nbsp; \\u0026nbsp; \\u0026nbsp; \\u0026nbsp;Brown\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e138 (35.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003eMissing\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e19\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eEducational level, No. (%)\\u0026nbsp;\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003ePrimary school\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e104 (41.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003eSecondary school\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e77 (30.9%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003eHigher education\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e15 (6.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003eNot applicable\\u0026dagger;\\u0026dagger;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e53 (21.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003eMissing\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e155\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e\\u0026nbsp;\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eSickle cell disease \\u0026nbsp; \\u0026nbsp; \\u0026nbsp;genotype, No. (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003eHbSS\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e289 (71.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003eHbSC\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e66 (16.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e \\u0026nbsp;HbS\\u0026beta;\\u003csup\\u003e0\\u003c/sup\\u003e thalassemia\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e45 (11.1%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e \\u0026nbsp; HbS\\u0026beta;\\u003csup\\u003e+\\u003c/sup\\u003e thalassemia\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003e4 (1.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e* The median age was 27 years (min = 5, max = 67).\\u003c/p\\u003e\\n\\u003cp\\u003e**Among the 92 pediatric participants, there were 35 (38%) aged 5-11 years and 57 (62%) aged 12-17 years.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u0026dagger; Self-reported.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u0026dagger;\\u0026dagger; Children who have not yet completed primary school.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u0026para;Among adults, the distribution of genotypes HbSS, HbSC, HbS\\u0026beta;0 thalassemia and HbS\\u0026beta;+ thalassemia was 209 (67%), 58 (18.6%), 42 (13.5%)and 3 (1.0%) \\u0026nbsp; \\u0026nbsp; \\u0026nbsp; \\u0026nbsp; \\u0026nbsp; \\u0026nbsp; respectively. Among pediatric participants, the corresponding distribution was 80 (87%), 8 (8.7%), 3 (3.3%) and 1 (1.1%), \\u0026nbsp; \\u0026nbsp; \\u0026nbsp;respectively. Fisher\\u0026rsquo;s exact test, P = 0.002 comparing adults vs pediatric participants.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cbr\\u003e\\u003c/p\\u003e\\n\\u003ctable border=\\\"0\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"4\\\" valign=\\\"top\\\" style=\\\"width: 862px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eTable 2 \\u0026nbsp;\\u0026ndash; Hospitalizations during the observation period\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eHospitalization\\u0026nbsp;at\\u0026nbsp;other facilities\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eHospitalization\\u0026nbsp;at\\u0026nbsp;the\\u0026nbsp;study site\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eOverall\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"4\\\" valign=\\\"top\\\" style=\\\"width: 862px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003ePatient\\u0026nbsp;admitted\\u0026nbsp;to\\u0026nbsp;the\\u0026nbsp;emergency\\u0026nbsp;room\\u0026nbsp;or\\u0026nbsp;hospitalized\\u0026nbsp;during\\u0026nbsp;the observation period, n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e99 (24.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e216 (53.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e265 (65.6%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e305 (75.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e188 (46.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e139 (34.4%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eConditions\\u0026nbsp;of\\u0026nbsp;interest,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eUncomplicated\\u0026nbsp;pain\\u0026nbsp;crisis (VOC)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e82 (20.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e194 (48.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e240 (59.4%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e0.42\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e1.64\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e2.06\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e1.16\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e3.02\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e3.22\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e9.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e25.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e25.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026lt;=1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e368 (91.1%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e286 (70.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e246 (60.9%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e2\\u0026nbsp;- 5\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e29 (7.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e79 (19.6%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e107 (26.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026gt;5\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e7\\u0026nbsp;(1.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e39 (9.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e51 (12.6%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eAcute\\u0026nbsp;chest syndrome\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e13 (3.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e36 (8.9%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e47 (11.6%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e0.03\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.13\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.16\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e0.20\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.47\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.51\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e2.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e4.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e4.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eSplenic sequestration\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e3\\u0026nbsp;(0.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e3\\u0026nbsp;(0.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.01\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.01\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.09\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.09\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eHepatic sequestration\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e4\\u0026nbsp;(1.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e4\\u0026nbsp;(1.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.01\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.01\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.10\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.10\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003e\\u003cbr\\u003e\\u003c/p\\u003e\\n\\u003ctable border=\\\"0\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"4\\\" valign=\\\"top\\\" style=\\\"width: 862px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eTable 2 \\u0026nbsp;\\u0026ndash; Hospitalizations during the observation period (Continuation)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eHospitalization\\u0026nbsp;at\\u0026nbsp;other facilities\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eHospitalization\\u0026nbsp;at\\u0026nbsp;the\\u0026nbsp;study site\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eOverall\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003ePriapism\\u003c/strong\\u003e\\u003cstrong\\u003e*\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e2\\u0026nbsp;(1.1%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e2\\u0026nbsp;(1.1%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e176\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e176\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e176\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.01\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.01\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.14\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.14\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e2.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e2.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eIschemic stroke\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e5\\u0026nbsp;(1.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e5\\u0026nbsp;(1.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.02\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.02\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.26\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.26\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e4.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e4.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eHemorrhagic stroke\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e2\\u0026nbsp;(0.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e2\\u0026nbsp;(0.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e4\\u0026nbsp;(1.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.01\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.07\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.07\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.10\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eCholelithiasis\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e2\\u0026nbsp;(0.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e12 (3.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e14 (3.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.04\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.04\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.07\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.25\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.26\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e3.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e3.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eCholecystitis\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e2\\u0026nbsp;(0.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e5\\u0026nbsp;(1.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e7\\u0026nbsp;(1.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.01\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.02\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.07\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.11\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.13\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 250px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 279px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003ctable border=\\\"0\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eHospitalization\\u0026nbsp;at\\u0026nbsp;other facilities\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eHospitalization\\u0026nbsp;at\\u0026nbsp;the\\u0026nbsp;study site\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eOverall\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003ePneumonia\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e15 (3.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e58 (14.4%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e70 (17.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.05\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.26\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.31\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.26\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.87\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.90\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e3.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e8.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e8.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eAcute\\u0026nbsp;myocardial infarction\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eChronic\\u0026nbsp;renal disease\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e4\\u0026nbsp;(1.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e4\\u0026nbsp;(1.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.01\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.01\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.16\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.16\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e2.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e2.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eOsteonecrosis\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e5\\u0026nbsp;(1.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e5\\u0026nbsp;(1.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.11\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.11\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e1.95\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e1.95\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e39.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e39.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eOverall\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.50\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e2.09\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e2.60\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e1.26\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e3.90\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e4.06\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 266px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 263px;\\\"\\u003e\\n \\u003cp\\u003e10.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 167px;\\\"\\u003e\\n \\u003cp\\u003e40.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 166px;\\\"\\u003e\\n \\u003cp\\u003e40.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003e*N\\u0026uacute;mero de participantes do sexo masculino.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u0026nbsp;\\u003cstrong\\u003eTable 3 \\u0026nbsp;\\u0026ndash; Surgeries during the observation period\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003ctable border=\\\"0\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\" align=\\\"\\\" width=\\\"864\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eTotal (n=404)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eSurgery\\u0026nbsp;during\\u0026nbsp;the\\u0026nbsp;observation\\u0026nbsp;period,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e50 (12.4%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e354 (87.6%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eIf\\u0026nbsp;yes,\\u0026nbsp;specify\\u003csup\\u003ea)\\u003c/sup\\u003e,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003eAdenoidectomy\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003eTonsillectomy\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003eSplenectomy\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e1\\u0026nbsp;(2.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003eCholecystectomy\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e24 (48.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003eHip arthroplasty\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e3\\u0026nbsp;(6.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003eNeurosurgery\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e1\\u0026nbsp;(2.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003eHeart surgery\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e1\\u0026nbsp;(2.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003eOther\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e22 (44.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"2\\\" valign=\\\"top\\\" style=\\\"width: 864px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eSurgery\\u0026nbsp;performed\\u0026nbsp;during\\u0026nbsp;a\\u0026nbsp;hospitalization\\u0026nbsp;due\\u0026nbsp;to\\u0026nbsp;a\\u0026nbsp;condition\\u0026nbsp;of\\u0026nbsp;interest\\u003csup\\u003eb)\\u003c/sup\\u003e,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e20 (38.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e32 (61.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e52\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003ea)\\u0026nbsp;Patients\\u0026nbsp;could\\u0026nbsp;have\\u0026nbsp;been\\u0026nbsp;submitted\\u0026nbsp;to\\u0026nbsp;more\\u0026nbsp;than\\u0026nbsp;one surgery.\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 393px;\\\"\\u003e\\n \\u003cp\\u003eb)\\u0026nbsp;Statistical\\u0026nbsp;analysis\\u0026nbsp;performed\\u0026nbsp;by surgery.\\u003c/p\\u003e \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 471px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\u003cbr\\u003e\\n\\u003ctable border=\\\"0\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 267px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eTable 4 \\u0026ndash; SCD complications\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 271px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 267px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 271px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eFirst visit \\u003csup\\u003ea)\\u003c/sup\\u003e\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e(n=404)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eDuring\\u0026nbsp;Observation\\u0026nbsp;period (n=404)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 267px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eSCD\\u0026nbsp;complications\\u003c/strong\\u003e\\u003cstrong\\u003e\\u003csup\\u003eb)\\u003c/sup\\u003e\\u003c/strong\\u003e\\u003cstrong\\u003e,\\u0026nbsp;\\u003c/strong\\u003e\\u003cstrong\\u003en (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 271px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003cp\\u003e219 (55.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003cp\\u003e34 (8.4%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 267px;\\\"\\u003e\\n \\u003cp\\u003eLeg ulcer\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 271px;\\\"\\u003e\\n \\u003cp\\u003e40 (10.1%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e6\\u0026nbsp;(1.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 267px;\\\"\\u003e\\n \\u003cp\\u003eRetinopathy\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 271px;\\\"\\u003e\\n \\u003cp\\u003e40 (10.1%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e9\\u0026nbsp;(2.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 267px;\\\"\\u003e\\n \\u003cp\\u003eIron overload\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 271px;\\\"\\u003e\\n \\u003cp\\u003e57 (14.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e7\\u0026nbsp;(1.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 267px;\\\"\\u003e\\n \\u003cp\\u003ePulmonary hypertension\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 271px;\\\"\\u003e\\n \\u003cp\\u003e7\\u0026nbsp;(1.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e4\\u0026nbsp;(1.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 267px;\\\"\\u003e\\n \\u003cp\\u003eHepatic disease\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 271px;\\\"\\u003e\\n \\u003cp\\u003e11 (2.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e3\\u0026nbsp;(0.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 267px;\\\"\\u003e\\n \\u003cp\\u003eRenal disease\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 271px;\\\"\\u003e\\n \\u003cp\\u003e37 (9.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e5\\u0026nbsp;(1.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 267px;\\\"\\u003e\\n \\u003cp\\u003eChronic\\u0026nbsp;heart failure\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 271px;\\\"\\u003e\\n \\u003cp\\u003e3\\u0026nbsp;(0.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 267px;\\\"\\u003e\\n \\u003cp\\u003eHypertension\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 271px;\\\"\\u003e\\n \\u003cp\\u003e35 (8.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e3\\u0026nbsp;(0.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 267px;\\\"\\u003e\\n \\u003cp\\u003eAcute\\u0026nbsp;myocardial infarction\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 271px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 267px;\\\"\\u003e\\n \\u003cp\\u003eCardiac disease\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 271px;\\\"\\u003e\\n \\u003cp\\u003e33 (8.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e3\\u0026nbsp;(0.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 267px;\\\"\\u003e\\n \\u003cp\\u003eOsteonecrosis\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 271px;\\\"\\u003e\\n \\u003cp\\u003e82 (20.6%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e1\\u0026nbsp;(0.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 267px;\\\"\\u003e\\n \\u003cp\\u003eNone\\u0026nbsp;of\\u0026nbsp;the above\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 271px;\\\"\\u003e\\n \\u003cp\\u003e179 (45.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e7\\u0026nbsp;(1.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 267px;\\\"\\u003e\\n \\u003cp\\u003eUnknown\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 271px;\\\"\\u003e\\n \\u003cp\\u003e6\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"2\\\" valign=\\\"top\\\" style=\\\"width: 538px;\\\"\\u003e\\n \\u003cp\\u003ea)\\u0026nbsp;Conditions\\u0026nbsp;presented\\u0026nbsp;by\\u0026nbsp;the\\u0026nbsp;patient\\u0026nbsp;at\\u0026nbsp;the\\u0026nbsp;start\\u0026nbsp;of\\u0026nbsp;the\\u0026nbsp;observation period.\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"2\\\" valign=\\\"top\\\" style=\\\"width: 538px;\\\"\\u003e\\n \\u003cp\\u003eb)\\u0026nbsp;Patients\\u0026nbsp;could\\u0026nbsp;have\\u0026nbsp;had\\u0026nbsp;more\\u0026nbsp;than\\u0026nbsp;one\\u0026nbsp;SCD\\u0026nbsp;complication.\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n\\u003ctable border=\\\"0\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 337px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eTable 5 \\u0026ndash; Mortality data per age-group\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 224px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 300px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 337px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 224px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003ePediatric\\u0026nbsp;(\\u0026lt;18 years)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 300px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eAdult\\u0026nbsp;(\\u0026ge;18\\u0026nbsp;years) (n=312)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 337px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eDeath,\\u0026nbsp;n\\u0026nbsp;(%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 224px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 300px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 337px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 224px;\\\"\\u003e\\n \\u003cp\\u003e90 (97.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 300px;\\\"\\u003e\\n \\u003cp\\u003e300 (96.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 337px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 224px;\\\"\\u003e\\n \\u003cp\\u003e2\\u0026nbsp;(2.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 300px;\\\"\\u003e\\n \\u003cp\\u003e12 (3.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 337px;\\\"\\u003e\\n \\u003cp\\u003eIschemic stroke\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 224px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 300px;\\\"\\u003e\\n \\u003cp\\u003e1\\u0026nbsp;(8.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 337px;\\\"\\u003e\\n \\u003cp\\u003eHemorrhagic\\u0026nbsp;stroke\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 224px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 300px;\\\"\\u003e\\n \\u003cp\\u003e2\\u0026nbsp;(16.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 337px;\\\"\\u003e\\n \\u003cp\\u003eSepsis\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 224px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 300px;\\\"\\u003e\\n \\u003cp\\u003e2\\u0026nbsp;(16.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 337px;\\\"\\u003e\\n \\u003cp\\u003eAcute\\u0026nbsp;Chest Syndrome\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 224px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 300px;\\\"\\u003e\\n \\u003cp\\u003e3\\u0026nbsp;(25.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 337px;\\\"\\u003e\\n \\u003cp\\u003eOther\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 224px;\\\"\\u003e\\n \\u003cp\\u003e2\\u0026nbsp;(100.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 300px;\\\"\\u003e\\n \\u003cp\\u003e4\\u0026nbsp;(33.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 337px;\\\"\\u003e\\n \\u003cp\\u003eCardiorespiratory\\u0026nbsp;arrest\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 224px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 300px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 337px;\\\"\\u003e\\n \\u003cp\\u003eUnspecified\\u0026nbsp;pneumonia\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 224px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 300px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 337px;\\\"\\u003e\\n \\u003cp\\u003eCardiorespiratory\\u0026nbsp;arrest,\\u0026nbsp;refractory\\u0026nbsp;sepsis\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 224px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 300px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 337px;\\\"\\u003e\\n \\u003cp\\u003eComplications\\u0026nbsp;from\\u0026nbsp;cholecystectomy\\u0026nbsp;surgery\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 224px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 300px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 337px;\\\"\\u003e\\n \\u003cp\\u003eDeath\\u0026nbsp;by\\u0026nbsp;firearm\\u0026nbsp;projectile\\u0026nbsp;in\\u0026nbsp;an\\u0026nbsp;attempted robbery\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 224px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 300px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 337px;\\\"\\u003e\\n \\u003cp\\u003eUnknown\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 224px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 300px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 337px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 224px;\\\"\\u003e\\n \\u003cp\\u003e92\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 300px;\\\"\\u003e\\n \\u003cp\\u003e312\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n\\u003ctable border=\\\"0\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 511px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eTable \\u0026nbsp;6 \\u0026ndash; Treatments of interest (ambulatory)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 354px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 511px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 354px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eDuring\\u0026nbsp;Observation\\u0026nbsp;period (n=404)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 511px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eTreatments,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 354px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 511px;\\\"\\u003e\\n \\u003cp\\u003eIron chelation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 354px;\\\"\\u003e\\n \\u003cp\\u003e91 (22.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 511px;\\\"\\u003e\\n \\u003cp\\u003eFolic acid\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 354px;\\\"\\u003e\\n \\u003cp\\u003e386 (95.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 511px;\\\"\\u003e\\n \\u003cp\\u003eProphylactic penicillin\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 354px;\\\"\\u003e\\n \\u003cp\\u003e74 (18.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 511px;\\\"\\u003e\\n \\u003cp\\u003eHydration\\u0026nbsp;therapy\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 354px;\\\"\\u003e\\n \\u003cp\\u003e73 (18.1%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 511px;\\\"\\u003e\\n \\u003cp\\u003ePain\\u0026nbsp;medication\\u0026nbsp;for\\u0026nbsp;VOC\\u0026nbsp;not\\u0026nbsp;requiring\\u0026nbsp;hospitalization:\\u0026nbsp;NSAID\\u0026nbsp;- oral\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 354px;\\\"\\u003e\\n \\u003cp\\u003e248 (61.4%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 511px;\\\"\\u003e\\n \\u003cp\\u003ePain\\u0026nbsp;medication\\u0026nbsp;for\\u0026nbsp;VOC\\u0026nbsp;not\\u0026nbsp;requiring\\u0026nbsp;hospitalization:\\u0026nbsp;Opioid\\u0026nbsp;- oral\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 354px;\\\"\\u003e\\n \\u003cp\\u003e163 (40.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 511px;\\\"\\u003e\\n \\u003cp\\u003eNone\\u0026nbsp;of\\u0026nbsp;the above\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 354px;\\\"\\u003e\\n \\u003cp\\u003e4\\u0026nbsp;(1.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 511px;\\\"\\u003e\\n \\u003cp\\u003ea)\\u0026nbsp;Treatments\\u0026nbsp;received\\u0026nbsp;by\\u0026nbsp;the\\u0026nbsp;patient\\u0026nbsp;since\\u0026nbsp;the\\u0026nbsp;start\\u0026nbsp;of\\u0026nbsp;the\\u0026nbsp;observation period.\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 354px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n\\u003ctable border=\\\"0\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"3\\\" valign=\\\"top\\\" style=\\\"width: 861px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eTable 7 \\u0026ndash; Hydroxyurea use (ambulatory) during the observation period\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eTotal\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003ePatients (n=404)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003en (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003enTrt (n=755)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003ePatient\\u0026nbsp;treated\\u0026nbsp;with\\u0026nbsp;hydroxyurea,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e135 (33.4%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e269 (66.6%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eMissing values\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eAdherence (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e269\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e87.17\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e100.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e23.21\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e2.94\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e100.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eMissing values\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e135\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026lt;70%\\u0026nbsp;of\\u0026nbsp;continuous use\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e62 (23.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026ge;70%\\u0026nbsp;of\\u0026nbsp;continuous use\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e207 (77.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eDose (mg/kg/day)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e481\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e21.40\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e21.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e6.86\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e3.51\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e41.67\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eMissing values\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e274\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003e15 mg/kg/day\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e22 (9.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003e20 mg/kg/day\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e24 (10.1%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003e25 mg/kg/day\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e24 (10.1%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003e30 mg/kg/day\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e13 (5.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003e35 mg/kg/day\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e4\\u0026nbsp;(1.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 260px;\\\"\\u003e\\n \\u003cp\\u003eOther\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 278px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e150 (63.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"2\\\" valign=\\\"top\\\" style=\\\"width: 538px;\\\"\\u003e\\n \\u003cp\\u003en\\u0026nbsp;(%)\\u0026nbsp;=\\u0026nbsp;Number\\u0026nbsp;(percent)\\u0026nbsp;of\\u0026nbsp;patients.\\u0026nbsp;nTrt\\u0026nbsp;=\\u0026nbsp;Number\\u0026nbsp;of\\u0026nbsp;treatment\\u0026nbsp;courses.\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 323px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003e\\u0026nbsp;\\u003cstrong\\u003eTable 8 \\u0026ndash; Immunization\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003ctable border=\\\"0\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eFirst visit \\u003csup\\u003ea)\\u003c/sup\\u003e \\u0026ndash; immunization history (n=404)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eDuring\\u0026nbsp;Observation\\u0026nbsp;period (n=404)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eImmunization \\u003csup\\u003eb)\\u003c/sup\\u003e,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eAntipneumococcal\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e129 (75.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e9\\u0026nbsp;(2.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e9\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMissing values\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eAnti-meningococcal\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e106 (61.6%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e5\\u0026nbsp;(1.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e5\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMissing values\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eInfluenza\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e120 (69.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e41 (10.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e41\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e1.07\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e0.26\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e2.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMissing values\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eHepatitis B\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e120 (69.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e6\\u0026nbsp;(1.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e6\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003eMissing values\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eNone\\u0026nbsp;of\\u0026nbsp;the above\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e9\\u0026nbsp;(5.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e0\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 248px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eUnknown\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 349px;\\\"\\u003e\\n \\u003cp\\u003e232\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e4\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"2\\\" valign=\\\"top\\\" style=\\\"width: 597px;\\\"\\u003e\\n \\u003cp\\u003ea)\\u0026nbsp;Immunizations\\u0026nbsp;received\\u0026nbsp;by\\u0026nbsp;the\\u0026nbsp;patient\\u0026nbsp;before\\u0026nbsp;the\\u0026nbsp;start\\u0026nbsp;of\\u0026nbsp;the\\u0026nbsp;observation period.\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"2\\\" valign=\\\"top\\\" style=\\\"width: 597px;\\\"\\u003e\\n \\u003cp\\u003eb)\\u0026nbsp;Patients\\u0026nbsp;could\\u0026nbsp;have\\u0026nbsp;received\\u0026nbsp;more\\u0026nbsp;than\\u0026nbsp;one immunization.\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 264px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003e\\u0026nbsp;\\u003cstrong\\u003eTable 9 \\u0026ndash; Blood transfusions (outpatient)\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003ctable border=\\\"0\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eDuring\\u0026nbsp;Observation\\u0026nbsp;period (n=404)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eBlood\\u0026nbsp;transfusions,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e219 (54.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e185 (45.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eNumber\\u0026nbsp;of\\u0026nbsp;blood transfusions\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e404\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e6.38\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e13.49\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e74.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eReason for blood transfusion \\u003csup\\u003ea)\\u003c/sup\\u003e,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eProphylactic treatment\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e2229 (86.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eSymptomatic treatment\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e340 (13.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eOther\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e9\\u0026nbsp;(0.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003ePulmonary Hypertension\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eSurgical preparation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e8\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e2578\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eType of blood transfusion \\u003csup\\u003ea)\\u003c/sup\\u003e,\\u0026nbsp;n\\u0026nbsp;(%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eSimple transfusion\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e845 (32.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eExchange transfusion\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e1733 (67.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e2578\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eNumber of blood bags used \\u003csup\\u003ea)\\u003c/sup\\u003e\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e2578\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e1.46\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e1.50\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e44.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003ea)\\u0026nbsp;Statistical\\u0026nbsp;analysis\\u0026nbsp;performed\\u0026nbsp;by\\u0026nbsp;blood transfusion.\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 446px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n\\u003ctable border=\\\"0\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eTable\\u0026nbsp;10\\u0026nbsp;\\u0026ndash;\\u0026nbsp;Exams\\u0026nbsp;and\\u0026nbsp;tests\\u0026nbsp;(ambulatory)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eTotal (n=8344)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eBiochemistry\\u0026nbsp;tests\\u0026nbsp;specified\\u0026nbsp;in\\u0026nbsp;the\\u0026nbsp;protocol,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e6008 (72.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e2336 (28.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e8344\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eIf yes:\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eHemogram,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e198 (3.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e5810 (96.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e6008\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eMCV\\u0026nbsp;(fL)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eN\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e5524\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eMean\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e94.99\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eMedian\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e94.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eStandard deviation\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e14.52\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eMinimum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e24.60\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eMaximum\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e151.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eLDH,\\u0026nbsp;n\\u0026nbsp;(%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e3920 (65.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e2088 (34.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e6008\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eLDH\\u0026nbsp;result,\\u0026nbsp;n\\u0026nbsp;(%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026lt;240 U/L\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e104 (5.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003e240\\u0026nbsp;-\\u0026nbsp;480 U/L\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e566 (27.1%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026gt;480 U/L\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e1418 (67.9%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e2088\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eReticulocytes,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e3602 (60.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e2406 (40.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e6008\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eFerritin,\\u0026nbsp;n\\u0026nbsp;(%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e5046 (84.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e962 (16.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e6008\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eBiochemistry \\u003csup\\u003ea)\\u003c/sup\\u003e,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e2507 (41.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e3501 (58.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e6008\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eUrine,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 404px;\\\"\\u003e\\n \\u003cp\\u003eMCV: Mean Corpuscular Volume. LDH: Lactate dehydrogenase.\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 460px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n\\u003ctable border=\\\"0\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eTable\\u0026nbsp;10\\u0026nbsp;\\u0026ndash;\\u0026nbsp;Exams\\u0026nbsp;and\\u0026nbsp;tests\\u0026nbsp;(ambulatory)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eTotal (n=8344)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e5136 (85.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e872 (14.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e6008\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eB\\u0026nbsp;HCG\\u0026nbsp;test,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e5730 (95.4%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e278 (4.6%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003ePositive\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e16 (5.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eNegative\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e262 (94.2%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e6008\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eAny\\u0026nbsp;image\\u0026nbsp;exams,\\u0026nbsp;n\\u0026nbsp;(%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e1136 (13.6%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e7208 (86.4%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e8344\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eIf\\u0026nbsp;yes,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eMagnetic\\u0026nbsp;resonance imaging\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e89 (7.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eComputed\\u0026nbsp;tomography\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e65 (5.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eTranscranial\\u0026nbsp;doppler\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e120 (10.6%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eChest\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e212 (18.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eUltrasound\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e350 (30.8%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eDensitometry\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e99 (8.7%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eScintigraphy\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e5\\u0026nbsp;(0.4%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eEchocardiogram\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e312 (27.5%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eOther\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e71 (6.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eBone\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e11\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eHip\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e3\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eMammography\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e3\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eQuadriceps\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e3\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eSimple\\u0026nbsp;Jaw\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e3\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eknee\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e3\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eFoot\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e2\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eJaw\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e2\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003ePelvic\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e2\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eSacrum\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e2\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eShoulder\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e2\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eAbdomen\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eAngioresonance\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eAnkle\\u0026nbsp;X-Ray;\\u0026nbsp;Foot\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eAnkle\\u0026nbsp;X-Ray;\\u0026nbsp;Foot\\u0026nbsp;X-Ray;\\u0026nbsp;Hip\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eArm\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 447px;\\\"\\u003e\\n \\u003cp\\u003eMCV:\\u0026nbsp;Mean\\u0026nbsp;Corpuscular\\u0026nbsp;Volume.\\u0026nbsp;LDH:\\u0026nbsp;Lactate dehydrogenase.\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 418px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"2\\\" valign=\\\"top\\\" style=\\\"width: 864px;\\\"\\u003e\\n \\u003cp\\u003ea)\\u0026nbsp;Any\\u0026nbsp;of\\u0026nbsp;the\\u0026nbsp;following:\\u0026nbsp;creatinine,\\u0026nbsp;sodium,\\u0026nbsp;potassium,\\u0026nbsp;gamma-glutamyl\\u0026nbsp;transferase,\\u0026nbsp;alanine\\u0026nbsp;aminotransferase,\\u0026nbsp;aspartate aminotransferase.\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n\\u003ctable border=\\\"0\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eTable\\u0026nbsp;10\\u0026nbsp;\\u0026ndash;\\u0026nbsp;Exams\\u0026nbsp;and\\u0026nbsp;tests\\u0026nbsp;(ambulatory)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eTotal (n=8344)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eBone\\u0026nbsp;Age\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eCavum\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eCineangiocoronariography\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eCostal\\u0026nbsp;Arch\\u0026nbsp;X-Ray;\\u0026nbsp;Knee\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eCoxofemoral\\u0026nbsp;Joint\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eCoxofemoral\\u0026nbsp;Joint\\u0026nbsp;X-Ray;\\u0026nbsp;Knee\\u0026nbsp;X-Ray;\\u0026nbsp;Thigh\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eFluorescein\\u0026nbsp;Angiography\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eFoot\\u0026nbsp;X-Ray;\\u0026nbsp;Shoulder\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eHip\\u0026nbsp;X-Ray;\\u0026nbsp;Knee\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eLeft\\u0026nbsp;Foot\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eLeft\\u0026nbsp;Knee\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eLegs\\u0026nbsp;Venous Doppler\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eLower\\u0026nbsp;Member\\u0026nbsp;Venous Doppler\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eLumbosacral\\u0026nbsp;Spine\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003ePelvis\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003ePelvis\\u0026nbsp;X-Ray;\\u0026nbsp;Sinuses\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eSacral\\u0026nbsp;Column\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eShoulders\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eSimple\\u0026nbsp;Forearm\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eSinuses\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eSpine\\u0026nbsp;X-Ray\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eOximetry\\u0026nbsp;and/or\\u0026nbsp;fundoscopy,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1589 (19.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e6755 (81.0%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e8344\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003eIf\\u0026nbsp;yes,\\u0026nbsp;n (%)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eOximetry\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e1302 (81.9%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eFundoscopy\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e306 (19.3%)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 483px;\\\"\\u003e\\n \\u003cp\\u003eMCV:\\u0026nbsp;Mean\\u0026nbsp;Corpuscular\\u0026nbsp;Volume.\\u0026nbsp;LDH:\\u0026nbsp;Lactate dehydrogenase.\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 381px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"2\\\" valign=\\\"top\\\" style=\\\"width: 864px;\\\"\\u003e\\n \\u003col\\u003e\\n \\u003cli\\u003eAny of the following: creatinine, sodium, potassium, gamma-glutamyl transferase, alanine aminotransferase, aspartate aminotransferase.\\u003c/li\\u003e\\n \\u003c/ol\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\"}],\"fulltextSource\":\"\",\"fullText\":\"\",\"funders\":[],\"hasAdminPriorityOnWorkflow\":false,\"hasManuscriptDocX\":true,\"hasOptedInToPreprint\":true,\"hasPassedJournalQc\":\"\",\"hasAnyPriority\":false,\"hideJournal\":false,\"highlight\":\"\",\"institution\":\"\",\"isAcceptedByJournal\":true,\"isAuthorSuppliedPdf\":false,\"isDeskRejected\":\"\",\"isHiddenFromSearch\":false,\"isInQc\":false,\"isInWorkflow\":false,\"isPdf\":false,\"isPdfUpToDate\":true,\"isWithdrawnOrRetracted\":false,\"journal\":{\"display\":true,\"email\":\"info@researchsquare.com\",\"identity\":\"annals-of-hematology\",\"isNatureJournal\":false,\"hasQc\":true,\"allowDirectSubmit\":false,\"externalIdentity\":\"aohe\",\"sideBox\":\"Learn more about [Annals of Hematology](http://link.springer.com/journal/277)\",\"snPcode\":\"277\",\"submissionUrl\":\"https://submission.nature.com/new-submission/277/3\",\"title\":\"Annals of Hematology\",\"twitterHandle\":\"\",\"acdcEnabled\":true,\"dfaEnabled\":true,\"editorialSystem\":\"stoa\",\"reportingPortfolio\":\"Springer Hybrid\",\"inReviewEnabled\":true,\"inReviewRevisionsEnabled\":false},\"keywords\":\"Sickle Cell Disease, Vaso-occlusive Crises, Hospitalization, Disease Burden\",\"lastPublishedDoi\":\"10.21203/rs.3.rs-7576339/v1\",\"lastPublishedDoiUrl\":\"https://doi.org/10.21203/rs.3.rs-7576339/v1\",\"license\":{\"name\":\"CC BY 4.0\",\"url\":\"https://creativecommons.org/licenses/by/4.0/\"},\"manuscriptAbstract\":\"\\u003cp\\u003eBackground: Sickle cell disease (SCD) is associated with several complications, high health-care-related costs and reduced life expectancy. This study addresses the high incidence of vaso-occlusive crises (VOC) in patients with SCD in Brazil, a condition that significantly impacts public health and healthcare costs.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003eObjective: To describe clinical characteristics, healthcare resource utilization, incidence risk, and complications due to VOCs requiring hospitalization among Brazilian patients with SCD.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003eMethods: Between January 2016 to December 2018, we involved 404 SCD patients aged 5-67, we utilized routinely collected data from four referral centers in Brazil. We characterized the cohort regarding healthcare resource utilization (disease complications, mortality, pharmacological treatments, blood transfusions, laboratory and imaging tests, emergency department visits, hospitalizations, and surgeries).\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003eResults: Of the 404 participants, 312 (77%) were \\u0026nbsp;aged ≥18 and 228 (56%) were female. The most common genotype was HbSS (n=289, \\u0026nbsp;72%). At baseline, 66.6% used hydroxyurea; osteonecrosis was the most prevalent SCD complication (82 patients, 21%). \\u0026nbsp;During the 3-year follow-up, 240 (59.4%, 95% confidence interval [95% CI], 55 \\u0026nbsp;to 64%) of the 404 participants developed VOCs requiring hospitalization. The \\u0026nbsp;incidence rate was 812 events per 1000 person-years (95 CI: 758 to 869). \\u0026nbsp;Overall, the cohort was associated with considerable healthcare utilization \\u0026nbsp;regarding pharmacological treatments, blood transfusions, laboratory and \\u0026nbsp;imaging tests, emergency department visits, and hospitalizations.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003eConclusion: SCD continues to cause substantial morbidity and utilization of the Brazilian healthcare system. New strategies and therapies are needed to prevent VOCs and improve clinical outcomes, thereby reducing VOC-related healthcare utilization in Brazil.\\u003c/p\\u003e\",\"manuscriptTitle\":\"Risk of vaso-occlusive crisis requiring hospitalization in sickle cell disease patients in Brazil: retrospective cohort study of real-world data\",\"msid\":\"\",\"msnumber\":\"\",\"nonDraftVersions\":[{\"code\":1,\"date\":\"2025-09-23 06:52:15\",\"doi\":\"10.21203/rs.3.rs-7576339/v1\",\"editorialEvents\":[{\"type\":\"communityComments\",\"content\":0},{\"type\":\"decision\",\"content\":\"Revision requested\",\"date\":\"2025-11-21T15:18:54+00:00\",\"index\":\"\",\"fulltext\":\"\"},{\"type\":\"editorInvitedReview\",\"content\":\"\",\"date\":\"2025-09-21T18:40:53+00:00\",\"index\":\"hide\",\"fulltext\":\"\"},{\"type\":\"reviewerAgreed\",\"content\":\"99911213406142285505110636418923979339\",\"date\":\"2025-09-14T00:31:59+00:00\",\"index\":\"hide\",\"fulltext\":\"\"},{\"type\":\"reviewersInvited\",\"content\":\"\",\"date\":\"2025-09-13T14:52:25+00:00\",\"index\":\"\",\"fulltext\":\"\"},{\"type\":\"editorAssigned\",\"content\":\"\",\"date\":\"2025-09-12T08:38:08+00:00\",\"index\":\"\",\"fulltext\":\"\"},{\"type\":\"checksComplete\",\"content\":\"\",\"date\":\"2025-09-12T08:37:15+00:00\",\"index\":\"\",\"fulltext\":\"\"},{\"type\":\"submitted\",\"content\":\"Annals of Hematology\",\"date\":\"2025-09-09T17:55:26+00:00\",\"index\":\"\",\"fulltext\":\"\"}],\"status\":\"published\",\"journal\":{\"display\":true,\"email\":\"info@researchsquare.com\",\"identity\":\"annals-of-hematology\",\"isNatureJournal\":false,\"hasQc\":true,\"allowDirectSubmit\":false,\"externalIdentity\":\"aohe\",\"sideBox\":\"Learn more about [Annals of Hematology](http://link.springer.com/journal/277)\",\"snPcode\":\"277\",\"submissionUrl\":\"https://submission.nature.com/new-submission/277/3\",\"title\":\"Annals of Hematology\",\"twitterHandle\":\"\",\"acdcEnabled\":true,\"dfaEnabled\":true,\"editorialSystem\":\"stoa\",\"reportingPortfolio\":\"Springer Hybrid\",\"inReviewEnabled\":true,\"inReviewRevisionsEnabled\":false}}],\"origin\":\"\",\"ownerIdentity\":\"4390e7c3-08c9-4798-91dc-78061d081d1d\",\"owner\":[],\"postedDate\":\"September 23rd, 2025\",\"published\":true,\"recentEditorialEvents\":[],\"rejectedJournal\":[],\"revision\":\"\",\"amendment\":\"\",\"status\":\"published-in-journal\",\"subjectAreas\":[],\"tags\":[],\"updatedAt\":\"2026-02-23T16:04:06+00:00\",\"versionOfRecord\":{\"articleIdentity\":\"rs-7576339\",\"link\":\"https://doi.org/10.1007/s00277-026-06854-z\",\"journal\":{\"identity\":\"annals-of-hematology\",\"isVorOnly\":false,\"title\":\"Annals of Hematology\"},\"publishedOn\":\"2026-02-19 15:57:35\",\"publishedOnDateReadable\":\"February 19th, 2026\"},\"versionCreatedAt\":\"2025-09-23 06:52:15\",\"video\":\"\",\"vorDoi\":\"10.1007/s00277-026-06854-z\",\"vorDoiUrl\":\"https://doi.org/10.1007/s00277-026-06854-z\",\"workflowStages\":[]},\"version\":\"v1\",\"identity\":\"rs-7576339\",\"journalConfig\":\"researchsquare\"},\"__N_SSP\":true},\"page\":\"/article/[identity]/[[...version]]\",\"query\":{\"redirect\":\"/article/rs-7576339\",\"identity\":\"rs-7576339\",\"version\":[\"v1\"]},\"buildId\":\"8U1c8b4HqxoKbykW_rLl7\",\"isFallback\":false,\"isExperimentalCompile\":false,\"dynamicIds\":[84888],\"gssp\":true,\"scriptLoader\":[]}","source_license":"CC-BY-4.0","license_restricted":false}