{"paper_id":"493a792e-f80b-461d-9243-6ff73f48b40a","body_text":"Abstract\nObjective\nDexpanthenol (Dxp), antioxidant and anti-inflammatory agent, plays an important role in the repair systems against oxidative stress and inflammatory response. The objective of this study is to determine the effect of Dxp on experimental endometriosis model.\nStudy Design\nA prospective experimental study was conducted in Experimental Animal Laboratory of Mustafa Kemal University, Hatay. Twenty nonpregnant female Wistar albino rats, in which experimental model of endometriosis was surgically induced, were randomly divided into 2 groups. Group 1 was administered 500 mg/kg/d Dxp intraperitoneally for 14 days, and group 2 was given the same amount of saline solution. After 2 weeks of medication, the rats were killed and implant volumes, histopathologic scores; and levels of serum total antioxidant status, total oxidant status (TOS), and oxidative stress index (OSI) were evaluated. Plasma and peritoneal fluid levels of tumor necrosis factor α (TNF-α) were analyzed.\nResults\nThe endometriotic implant volumes, histopathologic scores, and serum TOS and OSI values were significantly decreased (P <.05) in the Dxp group compared to the control group. Plasma and peritoneal fluid TNF-α levels were significantly decreased (P <.05) in the Dxp group compared to the control group.\nConclusion\nDexpanthenol has free radical scavenger effects, and antioxidant properties has significantly regressed endometriotic implant volumes, histopathologic scores, and serum TOS and OSI values. Serum and peritoneal fluid TNF-α levels were significantly decreased in the Dxp group. So Dxp decreased oxidative stress.\nSimilar content being viewed by others\nReferences\nBenagiano G, Brosens I. Who identified endometriosis? Fertil Steril. 2011;95(1):13–1.\nYilmaz N, Ozaksit G, Keskin R, et al. The effect of formoterol on peritoneal VEGF levels in rats with endometriosis. 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The Protective Role of Dexpanthenol on the Endometrial Implants in an Experimentally Induced Rat Endometriosis Model. Reprod. Sci. 24, 285–290 (2017). https://doi.org/10.1177/1933719116653682\nPublished:\nIssue date:\nDOI: https://doi.org/10.1177/1933719116653682","source_license":"CC0","license_restricted":false}