{"paper_id":"48b3c8b9-f36d-4f85-85d6-15cfd1cc7d62","body_text":"Critical Reviews™ in Eukaryotic Gene Expression\nPublished 8 issues per year\nISSN Print: 1045-4403\nISSN Online: 2162-6502\nDifferential Expression in Endometriosis Tissue versus Endometrium of the Uterine Adenogenesis Factors PRL-R, GH, IGF1, and IGF2\nABSTRACT\nEndometriosis is characterized by the presence of endometrial glandular and stromal structures outside the uterine cavity. It is an inflammatory estrogen dependent disease characterized by gene polymorphisms. This is a very frequent pathology and represents one of the most important causes of infertility, as well as having an important level of morbidity in patients. Recently, an alteration of the processes of organogenesis of the uterus has been proposed as a pathogenetic mechanism of endometriosis. In this article we have compared the expression in deep endometriotic lesions and in normal endometrial tissue of some of the molecular factors known to be involved in the embryonic development of the uterine glands. In detail, we found by immunohistochemistry a significant higher expression both for epithelium and stroma in the controls respect to the endometriosis samples for insulin growth factor 1 (IGF1) and IGF2, whereas for the prolactin receptor (PRL-R), this result was detected only for the epithelium. On the other hand, we found for growth hormone (GH) a significant higher expression in the epithelium of endometriosis samples respect to the controls. The correlation data generated can give indications on some of the molecular mechanisms responsible for the adenogenesis and survival of endometriosis structures outside of the uterus.\nFigures\n-\nGray CA, Bartol FF, Tarleton BJ, Wiley AA, Johnson GA, Bazer FW, Spencer TE. Developmental biology of uterine glands. 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Expression levels of MCP-1, HGF, and IGF-1 in endometriotic patients compared with non-endometriotic controls. BMC Womens Health. 2021;21: 422.\n-\nGregoraszczuk EL, Milewicz T, Kolodziejczyk J, Krzysiek J, Basta A, Sztefko K, Kurek S, Stachura J. Progesterone-induced secretion of growth hormone, in-sulin-like growth factor I and prolactin by human breast cancer explants. Gynecol Endocrinol. 2001;15:251-8.\n-\nSignorile Pietro G. , Baldi Alfonso, Viceconte Rosa , Vincenzi Bruno , Montella Marco , Adenogenesis Factors FGF7, FGF10, FGF23, IFN-τ and HGF in Endometriosis Tissue Respect to Eutopic Endometrium: An Immunohistochemical Study , Critical Reviews in Eukaryotic Gene Expression, 33, 4, 2023. Crossref","source_license":"public-domain-us","license_restricted":false}