{"paper_id":"4886e662-f6b4-429f-9317-4bf18eebccf0","body_text":"Abstract\nEndometriosis remains a mysterious steadily progressing disease for reproductive medicine of the 21st century. About 10% of women (190 million) of childbearing age all over the world suffer from the disorder. Despite high prevalence, endometriosis is still diagnosed late. The time from first symptoms to the diagnosis varies between 5 and 12 years, depending on the geographic region. This is due to heterogeneity of symptoms and stigma of the issues related to menstrual health, as well as the lack of awareness about the disorder in both medical professionals and patients. In this regard, the review considers endometriosis retrospectively and notes the advances and paradigm shift in the early second quarter of the 21st century.\nKeywords: endometriosis, epidemiology, comorbidity, risk factors, diagnosis, dienogest, gonadotropin-releasing hormone antagonists, Relugolix.\nFor citation:Orazov M.R., Dolgov E.D. Endometriosis in the early second quarter of the 21st century: paradigm shift. Clinical review for general practice. 2026; 7 (5): 100–103 (In Russ.). DOI: 10.47407/kr2026.7.5.00848\nAll accepted articles publish licensed under a Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.","source_license":"CC0","license_restricted":false}