{"paper_id":"4668817d-1223-47d9-b8f7-fe46a5691eee","body_text":"Abnormal uterine bleeding (AUB) accounts for 33% of outpatient referrals and 69% of referrals in the peri-menopausal and postmenopausal ages [ 1 ,  2 ]. AUB is a common cause of iron deficiency anemia (IDA), especially in the reproductive age group [ 3 ]. Polyps, adenomyosis, leiomyoma, malignancy and hyperplasia are the structural causes of AUB [ 3 ]. Endometrial biopsy is an important step in the assessment of AUB to rule out endometrial carcinoma, so that medical treatment can be offered, and unnecessary radical surgery can be avoided [ 1 ,  2 ].\nHysterectomy is the definitive, widely accepted treatment for fibroids, adenomyosis not responding to medical treatment and/or associated with endometrial hyperplasia [ 3 ,  4 ].\nThis case report represents a rare case of a perimenopausal woman who presented with a pelvi-abdominal enlarged uterus due to severe adenomyosis and high CA-125 to highlight that unexpectedly high CA-125 over 1000 IU/ml can be seen in benign gynecologic conditions other than malignancy.\n\nA 46-year-old woman, with 4 previous normal vaginal deliveries, diabetic on oral hypoglycemic medications, presented to the emergency department of Ahmadi Hospital, Kuwait Oil Company (KOC), with abdominal pain and AUB over the last year.\nShe had received cyclic progesterone (cyclic medroxyprogesterone acetate 10 mg daily for 10 days each month) with tranexamic acid (anti-fibrinolysis) 1-1.5 g 3 times/day during the bleeding episodes for the last 3 months without any response [ 5 ].\nShe had a tender pelvi-abdominal mass reaching two fingers breadth above the umbilicus (28 weeks’ gestation). She was admitted to the hospital with the provisional diagnosis of complicated fibroid uterus for further laboratory and radiological evaluations [ 6 ].\nTherapeutic curettage was performed because of the current bleeding attack, which was heavy and associated with a hemoglobin drop from 11 to 8.8 g/dl [ 1 ,  2 ].\nThe histological examination of the endometrial tissue taken during the therapeutic curettage showed cystic glandular hyperplasia without atypia.\nIntravenous iron was given for correction of the patient’s IDA according to the hospital protocol [ 7 ,  8 ].\nThe departmental trans-abdominal ultrasound of the pelvi-abdominal mass showed asymmetrical myometrial thickening, predominantly its anterior wall, with myometrial hyperechoic regions surrounded by hypoechoic areas suggestive of adenomyosis for magnetic resonance imaging (MRI) confirmation [ 3 ].\nThe pelvi-abdominal T2-weighted MRI confirmed the diagnosis of adenomyosis and showed a normal elongated cervix with small Nabothian follicle, diffuse asymmetrical uterine adenomyosis, predominantly its anterior myometrial wall, with an ill-defined endo-myometrial junction and both ovaries normal ( Fig. 1 ).\nElongated cervix with small Nabothian follicle and dif- fuse asymmetrical uterine adenomyosis (predominantly its anterior myometrial wall)\nTotal abdominal hysterectomy with bilateral salpingectomy and bilateral ovarian conservation was performed after departmental approval and the patient’s consent.\nThe routine pre-operative investigations including Pap smear were completely normal except the cancer antigen (CA-125), which was unexpectedly high (1658 and 1046 IU/ml repeated twice two days apart) ( Fig. 2 ).\nPre-operative CA-125 was unexpectedly high (1658 and 1046 IU/ml repeated twice two days apart)\nThe histological examination of the surgically removed uterus showed pinpoint/small cystic areas of hemorrhage seen within the myometrium with the presence of endometrial glands and stroma within the myometrium away from the endo-myometrial junction, confirming the diagnosis of adenomyosis uterus [ 3 ], and the preoperative high CA-125 decreased to 22 IU/ml (normal range 0-35 IU/ml) one week after surgery.\n\nAdenomyosis is a common pathology detected in hysterectomy specimens, characterized by the presence of endometrial glands and stroma within the myometrium [ 3 ]. Patients with adenomyosis uteri typically present with AUB at pre- or perimenopausal age.\nDiagnosis of adenomyosis on clinical findings alone is usually difficult. Ultrasound is the primary imaging tool used in the evaluation of myometrial lesions [ 3 ].\nThe ultrasound criteria used for the diagnosis of adenomyosis are asymmetrical myometrial thickening, heterogenous area within the myometrium, hyperechoic regions surrounded by hypoechoic areas and unaltered uterine contour [ 3 ]. Myometrial cyst has been cited as the most sensitive and specific feature for the diagnosis of adenomyosis [ 9 ].\nThe sensitivity and specificity of transabdominal ultrasound in diagnosing adenomyosis are 32-63% and 95-97%, respectively, while MRI has 78-88% sensitivity and 67-93% specificity in diagnosing adenomyosis [ 3 ]. MRI findings of adenomyosis include diffuse uterine wall enlargement with hyperintense foci, cystically dilated glands and sites of microhemorrhages [ 10 ].\nA retrospective study was conducted by Rizvi  et al . on hysterectomy specimens of patients with AUB, and they concluded that adenomyosis was the most common cause of AUB in perimenopausal age (46.34% [38/82]) [ 3 ].\nThe studied woman was surgically managed by total hysterectomy and bilateral salpingectomy with bilateral ovarian conservation (because of her age of 46 years and both normal ovaries detected by pre-operative MRI and intra-operative examination) after correction of her anemia using intravenous iron, departmental approval and the patient’s consent. The decision of hysterectomy was based on failed cyclic progesterone with tranexamic acid over the last 3 months to control the studied woman’s bleeding attacks [ 5 ] and presence of cystic glandular hyperplasia detected after histological examination of the endometrial biopsy taken during the therapeutic curettage.\nThe studied patient had unexpectedly high preoperative CA-125 (1658 and 1046 IU/ml repeated twice two days apart) and the pre-operative high CA-125 decreased to 22 IU/ml (normal range 0-35 IU/ml) one week after surgery.\nCancer antigen 125 (CA-125) is a high-molecular weight glycoprotein, traditionally associated with ovarian cancers, and it can be elevated in other benign conditions [ 11 ]. Kojima  et al . reported elevated CA-125 (256 IU/l) in a case of adenomyosis uterus with mosaic Turner syndrome [ 10 ]. Ghaemmaghami  et al . reported 3 cases scheduled for laparotomy as ovarian cancer and leiomyosarcoma due to high levels of CA-125 (> 1,000 IU/ml), and the histologic results after laparotomy showed uterine myoma in two patients and endometrioma in the third patient [ 12 ]. Ghaemmaghami  et al . concluded that high levels of CA-125 (> 1,000 IU/ml) can be seen in benign gynecological condition other than malignancy [ 12 ].\nZhou  et al . found that women with adenomyosis had a higher CA-125 positive rate than normal controls or those with leiomyoma and the CA-125 levels were positively correlated with uterine size [ 13 ]. In addition, Zhou  et al . found that the mean CA-125 level decreased significantly one week after surgery [ 13 ].\nFifty women having uterine enlargement of > 12 weeks’ size due to severe adenomyosis and raised CA-125 were studied by Sheth and Ray, and they concluded that the greater the enlargement of the uterus over 240 cm 3  volume or > 12 weeks’ uterine size due to severe adenomyosis, the greater was the rise of CA-125 levels [ 14 ].\nThis case report presents a rare case of a perimenopausal woman who presented with a pelvi-abdominal enlarged uterus due to severe adenomyosis and high CA-125 to highlight that unexpectedly high CA-125 over 1000 IU/ml can be seen in benign gynecologic conditions other than malignancy.\n\nUnexpectedly high CA-125 over 1000 IU/ml can be seen in benign gynecologic conditions such as severe adenomyosis. The high CA-125 level is positively correlated with the uterine size in severe adenomyosis.","source_license":"CC0","license_restricted":false}