{"paper_id":"451c42a6-92ae-4514-b38a-985910dc48d5","body_text":"Submit Manuscript | http://medcraveonline.com\nIntroduction\nMost often with endometriosis, the so-called chronic pain syndrome \nin the pelvic region is noted. For the early diagnosis of endometriosis, \nalong with the analysis of clinical data, using ultrasound, endoscopic \nand magnetic resonance studies, a method for identifying tumor \nantigens is very promising. 1‒3 Therefore, the tumor antigen CA-125 \nis currently the method of choice in the diagnosis of endometriosis. \nDiagnosis of endometriosis using this test without a full range of \nlaboratory and instrumental studies is not legitimate. The aim of the \nwork was to study in women with endometriotic ovarian cysts the \nmethod of early non-invasive diagnosis through tumor markers CA-\n125 and the assessment of the ovarian reserve after treatment with \nantimuller hormone.\nMaterial and methods \nUnder our supervision, there were 47 women of reproductive \nage with signs of endometriotic ovarian cysts diagnosed within 1-2 \nmonths after visiting a gynecologist. Each patient underwent an \nanalysis of development factors in comparison with healthy ones. For \na comprehensive clinical and laboratory diagnosis of endometriotic \novarian cysts, ultrasound, quantitative analyzes for tumor markers \nCA-125 and for antimuller hormone were used. At the same time, the \nstudy in the blood of SA-125 tumor markers was carried out in the \nfollicular phase and on the days of menstruation for early diagnosis of \novarian endometriosis with subsequent verification by ultrasound, and \nthe determination of the anti-Mühller hormone to assess the ovular \nreserve was performed before and after surgical treatment on the \novary.\nResearch results \nThe age of women ranged from 21 to 27 years. In a prospective \nstudy, we managed in 41 women with endometriotic ovarian cysts \nto diagnose twice the oncomarkers of CA-125 (in the 1st phase and \nduring menstruation), and twice the measurement of the antimuller \nhormone before and after surgical treatment. The ratio of indicators \nof the level of CA-125 during menstruation to the indicator during \nthe follicular phase of the cycle exceeded 1.5 times the average \nnormal values, which indicated the presence of endometriosis during \nultrasound verification (Figure 1). It should be noted that among 41 \npatients in 9 (22.4%) patients, the endometriotic cyst was not verified \nby ultrasound due to the small shape (diameter less than 2.5-3cm). In \noutpatient practice, a gynecologist faces a difficult question regarding \nthe routing and management tactics of such patients, especially \nif there is an acute issue of pregnancy. The surgical approach for \nendometriotic ovarian cysts is generally consistent with that for any \nbenign ovarian tumor. In the treatment of our patients of reproductive \nage, the most important was the preservation of fertility. At the same \ntime, all the principles of microsurgical surgery were not always \nobserved in all hospitals using the gentle effects of modern surgical \nenergies on the ovarian tissue (enucleation of only the affected areas) \nto maximize the preservation of the ovarian reserve.\nFigure 1  Diagnostic comparative increase in patients with ovarian \nendometriosis of the tumor marker CA-125.\nThe scope of the operation must have been designed to reduce the \nrisk of relapse. Our research data showed a significant decrease in \nserum concentration of AMH (anti-Müller hormone) after surgical \nremoval of the endometrioma compared to average values   (Figure 2).\nIt was shown that surgical treatment of ovarian endometrioma \nis accompanied by a decrease in serum AMH level by 2.36 times. \nThus, the results of the study indicate the negative impact of surgical \nremoval of ovarian endometrioma on ovarian reserve in women of \nreproductive age. In our study, an AMG study was conducted in 47 \npatients after surgical treatment, in which a low mean level of 2.1+-\n1.5ng\\l was determined.\nJ Pediatr Neonatal Care. 2019;9(6):165‒166. 165\n©2019 Askerov et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which \npermits unrestricted use, distribution, and build upon your work non-commercially.\nNon-invasive research in ovarian endometriosis\nVolume 9 Issue 6 - 2019\nAskerov AA,1 Satybaldieva AJ2\n1Department of Obstetrics and Gynecology of KRSU, \nKyrgyzstan\n2Department of Obstetrics and Gynecology KSMA, Kyrgyzstan\nCorrespondence: Askerov AA, professor of the Department \nof Obstetrics and Gynecology of KRSU, 0550331731, \nEmail \nReceived: November 13, 2019 | Published: December 03, \n2019\nAbstract\nThe article presents the results of a study on noninvasive early diagnosis of the \nendometriosis ovarian cyst via ultrasound and on-markers CA-125. The effectiveness of \nusing antimulyler hormone in predicting the reserve capacity of the ovary after surgical \ntreatment of endometriosis cyst.\nKeywords: endometriosis, cyst, ovary, oncomarkers, hormone, surgical treatment\nJournal of Pediatrics and Neonatal Care\nMini Review \n Open Access\n\n\nNon-invasive research in ovarian endometriosis\n166\nCopyright:\n©2019 Askerov et al.\nCitation: Askerov AA, Satybaldieva AJ. Non-invasive research in ovarian endometriosis. J Pediatr Neonatal Care. 2019;9(6):165‒166. \nDOI: 10.15406/jpnc.2019.09.00400\nFigure 2 Dynamics of AMH level in patients with ovarian endometriosis before and after surgical treatment.\nAcknowledgments \nNone.\nConflicts of interest \nThe authors declared there is no conflict of interest.\nFunding \nNone.\nReferences\n1. Matveeva NV . The effect of endosurgical coagulating effects on ovarian \nreserve. Doktor Ru. 2013;1(79):18‒20.\n2. Tikhomirov AL. Endometriosis - modern possibilities of \npharmacotherapy. Russian Medical Journal. 2013;21(23):1134‒1136.\n3. Burney RO. The genetics and biochemistry of endometriosis. Curr Opin \nObstet Gynecol. 2013;25(4):280‒286.","source_license":"CC0","license_restricted":false}