{"paper_id":"41ddd80f-abaf-45dc-851c-3bf0c7327fee","body_text":"Endometriosis typified by the aberrant presence of functional endometrial glands and stroma outside the uterine cavity, affecting ~10% of reproductive-age women, with deep pelvic endometriosis occasionally extending its invasive reach to the intestinal wall. Intestinal endometriosis most frequently involves the rectum and sigmoid colon [ 1 ]. Although it’s classical, clinical manifestations encompass dysmenorrhea, chronic pelvic pain, and infertility. However, its polypoid variant poses unique diagnostic challenges and necessitating nuanced therapeutic strategies, particularly when involving the extra pelvic sites and masquerading as a rectal polyp. [ 2 ]. We report a rare and diagnostically challenging case of a 37-year-old female presenting with a 2-year history of non-cyclical rectal bleeding, significant unintentional weight loss, and spontaneous passage of polypoid tissue per rectal. Initial evaluations, including multiple biopsies, suggested hyperplastic or adenomatous rectal polyps with reactive atypia. However, a definitive diagnosis was only achieved following histopathological examination of the surgically resected specimen, which revealed polypoidal rectal endometriosis. This case highlights the diverse clinical and pathological presentations of rectal endometriosis and its potential to closely mimic malignancy, resulting in significant diagnostic uncertainty and therapeutic challenges.\n\nA 37-year-old female presented with a 2-year history of non-cyclical, recurrent rectal bleeding, significant weight loss, altered bowel habits, and spontaneous passage of polypoid tissue per rectum. Advanced imaging modalities, including computed tomography scan and contrast-enhanced MRI, demonstrated an aggressive local disease pattern with transmural rectal wall thickening, mesorectal fat stranding, and loss of intervening fat planes, features favoring a malignant lesion ( Fig. 1A  and  B ). Despite extensive diagnostic workup, including multiple biopsies, findings remained inconclusive, limited to nonspecific granulation tissue, inflammatory changes, and hyperplastic or adenomatous polyps with low-grade dysplasia. Pelvic imaging also revealed uterine fibroids and adnexal abnormalities. Ongoing diagnostic uncertainty necessitated a lower anterior resection with diversion loop ileostomy, which was complicated by persistent postoperative purulent discharge and poor clinical recovery, Gross examination of the resected rectal segment showed a diffusely thickened wall with multiple mucosal ulcerations and a well-circumscribed polypoid lesion measuring 3 cm in maximum dimension ( Fig. 1C ). Histological evaluation revealed ulceration with granulation tissue, along with multiple foci of ectopic endometrial glands and stroma within the submucosa and muscularis propria. Immunohistochemistry (IHC) confirmed the endometrial origin, with strong estrogen receptor (ER) positivity in both the glands and stromal component ( Fig. 2 ). These findings confirmed the rare diagnosis of polypoidal rectal endometriosis, illustrating the protean clinical and pathological manifestations of the disease and its potential to mimic malignancy, leading to significant diagnostic delay.\n(A) Sigmoidoscopy showing a polypoidal growth with surface ulceration (arrow) in the rectum involving more than 2/3 of the circumference. (B) CE MRI pelvis in a T2-weighted sequence reveals a heterogeneously enhanced hyperintense lesion with transmural involvement reaching up to the muscularis propria. (C) Gross specimen of proctosigmoidectomy showing a pedunculated polyp with petechial hemorrhages (arrow).\n(A) Micrograph from initial rectal polyp biopsy showing complete mucosal ulceration with underlying inflammatory granulation tissue (H&E 100×). (B) Micrograph from resection specimen showing colonic mucosa with ectopic endometrial glands and stroma traversing transmurally from the lamina propria to muscularis propria (H&E 200×). (C) Endometrial glands and stroma highlighted by estrogen receptor (ER, IHC 200×).\n\nIntestinal endometriosis is a rare, occurring in 3%–37% of females affected with endometriosis cases [ 1 ]. It often presents with nonspecific gastrointestinal symptoms such as intermittent rectal bleeding, abdominal cramping, constipation, or altered bowel habits mimicking more common colorectal pathologies, frequently leading to diagnostic challenges, particularly when cyclical patterns are absent [ 3 ,  4 ]. In more severe instances, the disease progression may lead to intestinal obstruction requiring emergency surgical intervention [ 5 ].\nRegardless of gynecologic history, clinicians should maintain a high index of suspicion for endometriosis in patients presenting with unexplained rectal bleeding. Colonoscopy remains a cornerstone of the diagnostic workup; however, endoscopic findings are highly variable and often mimic malignancies or submucosal tumors. Reported appearances include polypoid lesions, mucosal irregularities, and submucosal masses, as described by Shi  et al . and Lee  et al . [ 6–8 ]. For example, one case demonstrated a broad-based polypoid rectal lesion [ 3 ], while another revealed a partially obstructive bleeding sigmoid mass [ 4 ], both raising concern for malignancy similar to our patient.\nThis endoscopic variability contributes to diagnostic ambiguity, often necessitates adjunctive modalities for accurate diagnosis due to the subepithelial localization of endometriotic foci. Conventional forceps biopsies often yield nondiagnostic or misleading results due to limited mucosal involvement [ 8 ]. In such cases, endoscopic ultrasound-guided fine-needle aspiration offers superior diagnostic yield by enabling targeted sampling of deeper layers, including the submucosa and muscularis propria, and assessing lesion depth and adjacent structure involvement [ 7–9 ].\nHistopathological examination remains the gold standard for identification of ectopic endometrial glands and stroma, often accompanied by smooth muscle hyperplasia, fibrosis, and occasionally hemorrhagic cystic spaces [ 7 ,  9 ,  10 ]. Rarely, endometriotic lesions may undergo malignant transformation, resulting in endometrioid or clear cell carcinoma. This is confirmed histologically by the presence of malignant epithelial cells adjacent to benign endometriotic tissue, fulfilling the criteria for endometriosis-associated malignancy. Importantly, accurate histological recognition of these histological hallmarks is essential to differentiate endometriosis from other lesions such as gastrointestinal stromal tumors or colorectal carcinoma [ 11 ,  12 ].\nIHC serves as an invaluable adjuvant in challenging cases, particularly in atypical presentations or when malignancy is suspected. Endometriotic lesions typically express ER, progesterone receptor in the glandular component, and CD10 marking endometrial stromal components, helping to confirm diagnosis and distinguish from other pathologies. Miller  et al . established that ER as the most useful single to be used stain, where there was limited tissue or a resource constrained set up. It was documented that ER expressed in all cases highlighting both endometrial glandular and stromal components [ 1 ]. In our case also, ER is the only IHC used to establish the diagnosis highlighting the limited utility of immunostains.\n\nPolypoidal rectal endometriosis is a rare and elusive condition, often resulting in significant diagnostic complexity when chronic inflammatory changes obscuring underlying pathology. This case highlights the need to consider endometriosis in the differential diagnosis of rectal masses in women of reproductive age, especially when standard evaluations are inconclusive. Histopathology remains essential for definitive diagnosis, and a multidisciplinary approach is crucial for effective management.","source_license":"CC0","license_restricted":false}