{"paper_id":"40d61e9e-1b98-4628-ac8e-863ac4954880","body_text":"International Conference on Public Health, \nBest Western Premier Hotel, Solo, Indonesia, 6-7 September 2017 │257 \n https://doi.org/10.26911/theicph.2017.170 \nFACTORS AFFECTING VEGF EXPRESSION \nIN ENDOMETRIOSIS PATIENTS \n \nRochip Mursidi \n \nDepartment of Obstetrics and Gynecology, \nDr. Moewardi Hospital, Surakarta \n \nABSTRACT \n \nBackground: Patients with endometriosis have abnormal endometrial \nreceptivity that causes embryonic implantation failure. Some factors play role \nin endometrial receptivity, one of which is angiogenesis factor. VEGF is an \nangiogenesis factor that plays an important role in human body as well as in \npathological condition of endom etriosis. The purpose of this study was to \nexamine the effect of clinical and epidemiological factors on VEGF expression \nwith endometrial receptivity in endometriosis patients. \nSubjects and Method:  This was a cross sectional study. This study was \nconducted at Sekar Clinics, Dr. Moewardi Surakarta, and Islamic Hospital, \nKlaten, Central Java, from January to November 2014. A sample of 60 women \nundergoing sterilization consisting of 30 patients with infertile endometriosis \nand 30 patients with no endometriosis  who underwent laparoscopy or \nlaparotomy, were selected for this study. The dependent variable was VEGF \nexpression. The independent variables were menstrual disturbance, \ndysmenorrhea, and illness history. VEGF expression was measured by  \nimmunohistochemical (IHC) examination in the secretion phase as \nendometrial receptive marker. Hysterolaparoscopy was performed in the \nsecretion phase, i.e. the 19th day to the 24th day of the menstrual cycle. \nPatients with endometriosis underwent  biopsy of endometrial tiss ue during \nhysterolaparoscopy for IHC examination at Pathology Anatomy Laboratory, \nDr. Sardjito Hospital. The data were analyzed by logistic regression. \nResults: Menstrual disturbance (OR = 0.18; p = 0.071), dysmenorrhea (OR = \n0.22; p = 0.024), and illness history (OR = 0.70; p = 0.685) decreased VEGF \nexpression. \nConclusion: Menstrual disturbance, dysmenorrhea, and illness history, \ndecrease VEGF expression. \n \nKeywords: VEGF, clinical factor, epidemiological factor, endometriosis \n \nCorespondence: Rochip Mursidi . Department of Obstetrics and Gyneco -\nlogy, Dr. Moewardi Hospital, Surakarta.  \nEmail: rochip_10m@ymail.com. Mobile: +6285328222324.","source_license":"CC0","license_restricted":false}