{"paper_id":"3ff02144-27c6-4a74-9e5b-5752720d5c1b","body_text":"Abstract\nAdenomyosis refers to the presence of endometrial stroma and glands within the myometrium, whereas the ectopic location of endometrium outside the uterus identifies the condition of endometriosis. Both benign and gynecological conditions originate from a menstruation-related dysfunction, and they are typically observed in reproductive age women. Common pathogenetic mechanisms, shared risk factor profile, and their frequent coexistence support their similarities, despite each disease has its own features. Dysmenorrhea, dyspareunia, pelvic pain, and infertility resulting from relative hyperestrogenism, progesterone resistance, and inflammation are frequently observed in both diseases. Conversely, abnormal uterine bleeding (AUB) and heavy menstrual bleeding (HMB) are mostly associated with adenomyosis, and resulting iron deficiency anemia is commonly reported. Endometriosis, instead, is a disease often accompanied by systemic comorbidities, along with a chronic pain syndrome. However, common pathogenetic mechanisms and factors support the use of similar hormonal treatment approaches.\nAccess this chapter\nTax calculation will be finalised at checkout\nPurchases are for personal use only\nSimilar content being viewed by others\nReferences\nNezhat C, Nezhat F, Nezhat C. Endometriosis: ancient disease, ancient treatments. Fertil Steril. 2012;98(6):S1–S62.\nBenagiano G, Brosens I. Adenomyosis and endometriosis have a common origin. J Obstet Gynecol India. 2011;61(2):146–52.\nLoring M, Chen TY, Isaacson KB. A systematic review of adenomyosis: it is time to reassess what we thought we knew about the disease. J Minim Invasive Gynecol. 2021;28(3):644–55.\nStratopoulou CA, Donnez J, Dolmans M-M. Origin and pathogenic mechanisms of uterine adenomyosis: what is known so far. Reprod Sci. 2021;28(8):2087–97.\nBrosens I, Gordts S, Habiba M, Benagiano G. 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Best Pract Res Clin Obstet Gynaecol. 2018;51:119–37.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG\nAbout this chapter\nCite this chapter\nVannuccini, S., Aslan, B., Petraglia, F. (2024). Endometriosis and Adenomyosis. In: Genazzani, A.R., Goldstein, S.R., Simoncini, T. (eds) Menstrual Bleeding and Pain Disorders from Adolescence to Menopause. ISGE Series. Springer, Cham. https://doi.org/10.1007/978-3-031-55300-4_9\nDownload citation\nDOI: https://doi.org/10.1007/978-3-031-55300-4_9\nPublished:\nPublisher Name: Springer, Cham\nPrint ISBN: 978-3-031-55299-1\nOnline ISBN: 978-3-031-55300-4\neBook Packages: MedicineMedicine (R0)","source_license":"CC0","license_restricted":false}