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Chavan\" }, { \"@type\": \"Person\", \"name\": \"Raghumahanti Raghuveer\" } ], \"publisher\": { \"@type\": \"Organization\", \"name\": \"F1000Research\", \"logo\": { \"@type\": \"ImageObject\", \"url\": \"https://f1000research.com/img/AMP/F1000Research_image.png\", \"height\": 480, \"width\": 60 } }, \"image\": { \"@type\": \"ImageObject\", \"url\": \"https://f1000research.com/img/AMP/F1000Research_image.png\", \"height\": 1200, \"width\": 150 }, \"description\": \" Background A stroke is described by the World Health Organization as “a clinical syndrome with rapidly developing symptoms that consist of a focal (or global, in a situation of coma) disruption of cerebral function that lasts more than 24 hours or leads to mortality without a known cause other than a vascular origin”. Stroke is the most prevalent cause of impairment and mortality on a global scale. Modified constraint-induced movement therapy (mCIMT) is an approach to therapy for motor disabilities that involves constraining the movements of the nonparetic limb, diligent practice and behaviour modification to extend the time the paretic limb is utilized for daily tasks. The motor relearning program (MRP) method involves many aspects of motor learning theory and is helpful in providing instructions for retraining practical skills (including walking, standing and sitting in balance and transferring abilities). So, the objective of this study is to assess the impact of the MRP and mCIMT on balance and gait in sub-acute hemiplegic stroke patients. Methods In this study, each group will consist of 17 people in total. The randomization procedure will be conducted using a computer-generated random number system. For sample distribution, we will use the sequentially numbered opaque sealed envelope technique. Outcome measures will be as follows: Berg balance scale, Dynamic gait index, Trunk impairment scale, Functional reach test, 10 Meter walk test and Fall efficacy test. Each patient will be evaluated prior to and during treatment at baseline and six weeks later. Conclusions There is sufficient evidence to derive the conclusion that the functional mobility and balance of stroke victims can be improved with physiotherapy. Therefore, this study will try to seek the comparison of mCIMT (group A) and MRP (group B) in sub-acute stroke subjects and compare the two regimes to determine which one will be superior. Registration CTRI (CTRI/2023/05/052674; 16/05/2023). \" } { \"@context\": \"http://schema.org\", \"@type\": \"BreadcrumbList\", \"itemListElement\": [ { \"@type\": \"ListItem\", \"position\": \"1\", \"item\": { \"@id\": \"https://f1000research.com/\", \"name\": \"Home\" } }, { \"@type\": \"ListItem\", \"position\": \"2\", \"item\": { \"@id\": \"https://f1000research.com/browse/articles\", \"name\": \"Browse\" } }, { \"@type\": \"ListItem\", \"position\": \"3\", \"item\": { \"@id\": \"https://f1000research.com/articles/12-1098\", \"name\": \"Lower limb rehabilitation using modified constraint-induced movement...\" } } ] } Home Browse Lower limb rehabilitation using modified constraint-induced movement... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Chavan NS and Raghuveer R. Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . F1000Research 2024, 12 :1098 ( https://doi.org/10.12688/f1000research.138127.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Study Protocol Clinical trial Revised Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] Nitika S. Chavan https://orcid.org/0009-0007-0640-5729 1 , Raghumahanti Raghuveer 1 Nitika S. Chavan https://orcid.org/0009-0007-0640-5729 1 , Raghumahanti Raghuveer 1 PUBLISHED 28 Mar 2024 Author details Author details 1 Department of Neurophysiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra, 442004, India Nitika S. Chavan Roles: Conceptualization, Writing – Original Draft Preparation Raghumahanti Raghuveer Roles: Supervision, Validation OPEN PEER REVIEW DETAILS REVIEWER STATUS This article is included in the Datta Meghe Institute of Higher Education and Research collection. Abstract Background A stroke is described by the World Health Organization as “a clinical syndrome with rapidly developing symptoms that consist of a focal (or global, in a situation of coma) disruption of cerebral function that lasts more than 24 hours or leads to mortality without a known cause other than a vascular origin”. Stroke is the most prevalent cause of impairment and mortality on a global scale. Modified constraint-induced movement therapy (mCIMT) is an approach to therapy for motor disabilities that involves constraining the movements of the nonparetic limb, diligent practice and behaviour modification to extend the time the paretic limb is utilized for daily tasks. The motor relearning program (MRP) method involves many aspects of motor learning theory and is helpful in providing instructions for retraining practical skills (including walking, standing and sitting in balance and transferring abilities). So, the objective of this study is to assess the impact of the MRP and mCIMT on balance and gait in sub-acute hemiplegic stroke patients. Methods In this study, each group will consist of 17 people in total. The randomization procedure will be conducted using a computer-generated random number system. For sample distribution, we will use the sequentially numbered opaque sealed envelope technique. Outcome measures will be as follows: Berg balance scale, Dynamic gait index, Trunk impairment scale, Functional reach test, 10 Meter walk test and Fall efficacy test. Each patient will be evaluated prior to and during treatment at baseline and six weeks later. Conclusions There is sufficient evidence to derive the conclusion that the functional mobility and balance of stroke victims can be improved with physiotherapy. Therefore, this study will try to seek the comparison of mCIMT (group A) and MRP (group B) in sub-acute stroke subjects and compare the two regimes to determine which one will be superior. Registration CTRI (CTRI/2023/05/052674; 16/05/2023). READ ALL READ LESS Keywords Hemiplegic Stroke, Modified constraint-induced movement therapy, Motor relearning program, Berg balance scale, Dynamic gait index Corresponding Author(s) Nitika S. Chavan ( [email protected] ) Close Corresponding author: Nitika S. Chavan Competing interests: No competing interests were disclosed. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2024 Chavan NS and Raghuveer R. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Chavan NS and Raghuveer R. Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . F1000Research 2024, 12 :1098 ( https://doi.org/10.12688/f1000research.138127.2 ) First published: 01 Sep 2023, 12 :1098 ( https://doi.org/10.12688/f1000research.138127.1 ) Latest published: 28 Mar 2024, 12 :1098 ( https://doi.org/10.12688/f1000research.138127.2 ) Revised Amendments from Version 1 I have mentioned the groups in the abstract and added a few sentences about balance and mobility in hemiplegic patients. I have mentioned the groups in the abstract and added a few sentences about balance and mobility in hemiplegic patients. To read any peer review reports and author responses for this article, follow the \"read\" links in the Open Peer Review table. READ REVIEWER RESPONSES Introduction Stroke, which is deemed by the World Health Organization (WHO) to be the “quickly growing clinical evidence of a permanent (or worldwide) brain function impairment with sign and symptoms lasting 24 hours or more or causing mortality with no apparent cause other than the vascular origin”. 1 Stroke incidence ranges from 105 to 152/100,000 per year, making it the third most prevalent cause of impairment and the second-leading cause of mortality worldwide. 2 , 3 In India, the prevalence of stroke considerably rises with age; compared to younger persons, the risk is higher for those over 55 years old and lower for those between 45 and 54 years old (0.80% vs. 1.97%, respectively). Stroke risk is higher in men than in women. African Americans, Hispanics, and Americans have a higher risk of stroke compared to other races. Americans are more likely to have a stroke. 4 Stroke is divided into two distinct subtypes based on its aetiology: ischemic and haemorrhagic. The ischemic type of stroke, which affects 85% of patients, arises whenever the vascularity of the brain tissue is damaged as the blood clot blocks or plugs a blood vessel in the brain. However, 15% of acute strokes are haemorrhagic strokes, which are brought on by a burst blood vessel or an abrupt haemorrhage. Subarachnoid and intracerebral haemorrhage are the two main forms of haemorrhagic attacks. 5 There are numerous causes of stroke. Common risk factors include smoking (12%), heredity, hypertension, diabetes mellitus, high cholesterolemia (15%) and lack of physical activity. 4 Alcohol consumption that is mild to moderate carries a slightly lower risk of ischemic stroke, however higher drinking significantly boosts the risk. 6 Common stroke problems include gait impairment that makes it difficult to maintain postural alignment as well as stiffness, fatigue, and loss of balance on the affected side. One of the most frequent problems following a stroke is paralysis. Usually, opposing the brain side of the body that has been harmed by a stroke undergoes the paralysis. It can affect the overall side of the body, the face, upper limb, lower limb or even one of the legs. Hemiplegia refers to this type of unilateral paralysis. There are several anatomical and functional abnormalities that are followed by hemiplegia. These people frequently have functional mobility and balance issues as a result of their movement paralysis. 7 Balance is the ability to maintain the line of gravity within the base of support with minimal postural sway. Balance impairment is characterised by short supporting time and differences between two sides of the body and slow walking speed, which may increase the risk of falls. Without using more resources, a planned program can considerably raise documented patient activity levels during inpatient stroke therapy. The main goal of stroke treatment is to promote activity in daily life (ADL) independence while restoring function. 8 There are numerous physiotherapy approach treatments for stroke, including body weight supported treadmill training, electromechanical-assisted training, virtual reality therapy, constraint-induced movement therapy, motor relearning program, robot-assisted training, mirror therapy and proprioceptive neuromuscular facilitation. All methods for restoring voluntary control and mobility after a stroke operates according to its own principles. 9 Major studies have revealed that muscle weakness is the main thing preventing physical function from recovering. 9 Conventional exercises are ones that are performed all around the world. These include exercises such as passive motion, exercise at the gym, gait training, electrical stimulation, and functional re-education. 10 Modified constraint-induced movement therapy (mCIMT) is a type of therapeutic intervention for those with motor disabilities. The established method for treating the paretic upper limb enhances the functional usage by preventing “learned disuse” that occurs after a stroke. 11 , 12 Three main elements of mCIMT include the use of repetitive, structured, practice-intensive therapy in the more paretic limb, constraint of the non-paretic limb and a variety of behavioural strategies that translate improvements made in a clinical setting to everyday life. Recently, mCIMT has also been used to the paretic lower limb with the goal of improving neurological function and prevent “learned misuse”. One of the rehabilitation techniques utilised predominantly with the post-stroke population is the motor relearning program (MRP). This technique incorporates several elements of motor learning theory and includes practical advice for retraining practical abilities (such as a balanced sitting position, sitting and standing, skill transfer, and walking). 13 With good feedback and practise, this approach focuses on the growth of active movement control and task-specific learning. It is less frequently encountered to use facilitation tactics in preference for verbal direction, demonstrations and manual recommendation. 14 Three main elements of mCIMT include the use of repetitive, structured, practice-intensive therapy in the more paretic limb, constraint of the non-paretic limb and a variety of behavioural strategies that translate improvements made in a clinical setting to everyday life. Recently, mCIMT has also been used to the paretic lower limb with the goal of improving neurological function and prevent “learned misuse”. One of the rehabilitation techniques utilised predominantly with the post-stroke population is the motor relearning program (MRP). This technique incorporates several elements of motor learning theory and includes practical advice for retraining practical abilities (such as a balanced sitting position, sitting and standing, skill transfer, and walking). 13 With good feedback and practise, this approach focuses on the growth of active movement control and task-specific learning. It is less frequently encountered to use facilitation tactics in preference for verbal direction, demonstrations and manual recommendation. 14 Aims and objectives 1. To study the effect of mCIMT in addition to conventional therapy on balance (using the Berg Balance Scale (BBS)) and gait (using the Dynamic Gait Index (DGI)) in sub-acute hemiplegic stroke. 2. To study the effectiveness of MRP along with conventional therapy on balance (BBS) and gait (DGI) in sub-acute hemiplegic stroke. 3. To compare mCIMT and the MRP in improving balance and gait in sub-acute hemiplegic stroke patients along with conventional therapy. Trial design A single-centre, two arm, parallel group, comparative open labelled superiority trial will be conducted. Methods Protocol The model consent form, data collection form and schedule of enrolment, interventions and assessments can be found as Extended data. 24 This protocol adheres to the SPIRIT guidelines. 25 After gaining clearance from the Institutional Ethics Committee (IEC) of Datta Meghe Institute of Higher Education and Research (Deemed to be University), participants will be enrolled from the Physiotherapy Outpatient Department of Acharya Vinoba Bhave Rural Hospital Sawangi, Meghe, Wardha, Maharashtra. A total of 34 participants will be made aware of the study’s objectives and procedures and will be asked to sign written patient consent forms. All hemiplegic stroke patients who meet the inclusion and exclusion parameter will be included in the study. They will be further separated into Group A and Group B by means of simple random selection. Each group will consist of 17 people in total. The randomization procedure will be conducted using a computer-generated random number system. For sample distribution, we will use the sequentially numbered opaque sealed envelope technique. There will be no blinding procedure in this study. The principal investigator will generate allocation, enrol participants and assign participants to interventions. A departmental committee made up of the Post Graduate (PG), Guide, the Head of Department (HOD), the Principal of the Ravi Nair Physiotherapy College (RNPC) and a member of the Research Guidance Cell will oversee the project. Through routine treatment sessions, we will make sure that the patients follow the suggested treatment plan closely. If necessary, individuals will receive counselling or telephone reminders about their therapy appointments. Prior to and following the analysis, the outcome measures will be assessed. The study’s outcome indicators are as follows: The BBS, DGI, Trunk Impairment Scale (TIS), Functional Reach Test (FRT), 10 Meter Walk Test (10MWT) and Fall Efficacy Scale (FES) along with conventional treatment for balance and gait. mCIMT will be given in Group A in addition to conventional therapy, whereas Group B will receive the MRP in addition to conventional therapy. Figure 1 and Figure 2 depict the study design. Figure 1. Summary of study process. Figure 2. Schedule of enrolment, interventions and assessments. Inclusion criteria Patients will be included if they fulfil the following inclusion criteria: i) Sub-acute stroke in both men and women between the ages of 45 and 65 years; ii) Mini-Mental State Examination score ≥24; iii) Modified Rankin Scale ≤3; iv) patients with Brunnstrom stage for hand and leg ≥4; v) Modified Ashworth Scale ≤2; and vi) be able to comprehend and adhere to instructions. Exclusion criteria The exclusion criteria will be as follows: i) Individuals who are experiencing balance problems as a result of neurological conditions other than stroke (for instance cerebellar impairment, inner ear dysfunction, or Parkinson’s disease); ii) individuals suffering from unstable angina, symptomatic heart failure, or uncontrolled hypertension; iii) acute stroke (flaccid stage); iv) physician determined unstable cardiovascular conditions; v) the patient has been diagnosed as having organ failure, including the heart, kidneys, and lungs; and iv) patients with any traumatic musculoskeletal injury to lower limbs. Interventions Criteria for discontinuing allocated interventions for a given trial participant If any patients in any of the allocated groups develop any complication ( e.g. , deep venous thrombosis), their participation will be discontinued in the study. The patients will then receive appropriate care and offered outpatient rehabilitation as needed. Study participants will be retained in the trial (unless they withdraw their consent) to enable follow-up data collection and to prevent missing data. Adherence and concomitant care During the first consultation, the importance of following the study guidelines and adhering to the allocated group will be highlighted. Exercise adherence will be recorded as a percentage of completed exercises during the first follow up (after the six-week intervention) for both groups. Exercise adherence will be taken into consideration when performing the pre-protocol analysis. All enrolled patients will be encouraged to contact the principal investigator directly if experiencing problems related to their allocated group intervention. The principal investigator will then fill out a standardized form at these calls. Patients can use medicines and nutritional products as needed, prescribed by their physician. To avoid study-contamination, patients will be asked to adhere to the allocated rehabilitation intervention and not to seek alternative health-care services during the course of the study. Patients will be advised to contact their general practitioner or the principal investigator as needed. The physiotherapy intervention will be given to Groups A and B for six weeks. The intervention will be provided for 60 minutes, five days each week. Both Group A and Group B will receive conventional treatment. Group A will receive mCIMT along with the conventional therapy, while Group B will receive the motor relearning program along with the conventional therapy. Treatment will be provided to both groups for six weeks. Modified constraint-induced movement therapy (mCIMT) Exercises will be given to participants that have a functional focus and will be under supervision. The affected lower extremity will be the focus of these exercises. Based on the desired movements, the therapist (principal investigator) recommended these exercises. The 30-minute mCIMT approach will consist of the following movements: Transfer package (10 minutes per session), side stepping, ball kicking, stair climbing, and knee control on a step. Motor Relearning program (MRP) Participants receive task-specific guidance based on the MRP. This method will be applied for 30 minutes. The actions will be practiced in both sitting and standing and should target an individual’s particular deficits: supine to side-lying to sitting, looking up at ceiling (ensure that centre of body mass does not move back when head is tilted back), without moving one’s feet, turning to gaze over each other’s shoulders and scanning the surroundings for specific items, reaching motions in multiple directions while moving the head and trunk, scooting in bed, altering the base of support (standing with your feet together, in tandem, with one foot on a step, or on one leg), squatting to pick up an object and cross over stepping. Conventional therapy Conventional therapy includes: i) Passive and active assisted range of motion exercises for upper and lower extremities; ii) stretching exercises for flexor synergy component shown in Table 1 ; iii) strengthening exercises with the help of THERABAND shown in Table 2 ; iv) balance training including practicing reaching beyond arm’s length while sitting and standing; and v) walking training that includes challenge to dynamic balance ( e.g. , obstacle courses). Table 1. Stretching exercises for upper extremities, pelvic position and lower extremities. Action of the muscles Major muscles targeted Procedure • Scapular retraction or hyperextension, shoulder abduction, elbow flexion, forearm supination, wrist and finger flexion • Pelvic retraction • Hip flexion, abduction, external rotation, knee flexion, ankle dorsiflexion, inversion • Pectoralis major, Pectoralis minor, Latissimus dorsi, Biceps brachii, brachioradialis, Supinator muscle, Flexor digitorum profundas, Flexor digitorum superficialis and Palmaris longus • Piriformis and Thoracolumbar fascia • Gluteus minimus, Gluteus medius, Psoas major, Iliacus sartarius, Rectus femoris, Hamstring, Tibialis anterior Patient position: Supine and sitting Therapist position: Standing Mode of stretching: Manual stretching, slow repetition, continuous stretch Doses: 3 repetitions with 30 seconds hold Table 2. Strengthening exercises for upper extremities, pelvic position and lower extremities. Action of the muscles Major muscles targeted Procedure • Scapular retraction or hyperextension, shoulder abduction, elbow flexion, forearm supination, wrist and finger flexion • Pelvic retraction • Hip flexion, abduction, external rotation, knee flexion, ankle dorsiflexion, inversion. • Rhomboid, Latissimus dorsi muscle, Deltoid, Triceps, Pronator teres, Extensor digitorium, Extensor digiti minimi. • Quadratus lumborum • Adductor mangus, Adductor longus, Adductor brevis, Gracillis, Gluteus maximus, Quadriceps, Gastrocnemius Patient position: Supine and sitting Therapist position: Standing Progression: Strengthening exercises will be given with THERABAND (Yellow, Red and Green colour). Outcome measures Time frames at baseline and six weeks later. Primary outcomes 1. Change in Berg Balance Scale (BBS) The BBS is a scale with 14 items that is frequently used and is a standardized balance assessment that uses observation to quantitatively assess a patient’s capacity for balance, either statically or while engaging in a variety of planned routine daily tasks. For evaluating static and dynamic balance following a stroke, The inter-rater and intra-rater reliability of BBS for the patients with stroke is 0.97 and 0.98, respectively. 15 Each item on the scale will be given a score between 0 and 4, giving the patient an overall ranking of 56. A score of 0 means you didn’t complete the project, and a score of 4 means you did it independently. 16 2. Change in Dynamic Gait Index (DGI) The goal of the DGI is to examine dynamic balance while in motion. Eight of the tasks ask participants to keep their balance when walking normally and while doing so in various conditions (such as adjusting their speed, turning their heads to go around obstacles, pivoting around and climbing steps). Each item is given a score between 0 and 3 points, with a maximum score of 24. A higher DGI score indicates greater independent functional mobility. The DGI has been shown to yield ratios of subject variability to total variability with excellent interrater reliability 0.96 and test-retest reliability 0.98. 17 Secondary outcomes 1. Change in Trunk Impairment Scale (TIS) The TIS assesses post-stroke trunk movement, static and dynamic sitting balance, and trunk movement coordination. The TIS is used to analyse motor dysfunction of the trunk after a stroke, static and dynamic seated balance and coordination of trunk movement. Overall reliability for clinical care and research in the TIS, 0.96. 18 2. Change in Functional Reach Test (FRT) Utilising a yardstick fastened to the wall at the acromion’s height, functional reach is determined. Functional reach has been shown to exhibit test-retest reliability, interobserver consistency, criterion validity, and concurrent concept validity in earlier investigations. Additionally, it has been demonstrated that in patients undergoing rehabilitation, functional reach is sensitive to clinically significant changes in balance. 19 3. Change in 10 Meter Walk Test (10MWT) Ambulation speed is a crucial component of gait and is frequently utilised in clinical and research settings as an objective indicator of functional mobility. In healthy older adults, gait speed can also be determined using the 10MWT. Therefore, to obtain the most accurate clinical evaluation of walking speed, we advise performing the 10MWT. 20 4. Change in Fall Efficacy Scale (FES) The FES International, a tool designed to measure patient’s fears about falling, has strong psychometric qualities. The 16 items on the Persian FES were factor analysed. The Persian FES showed outstanding test-retest reliability, according to the results. In stroke patients, FES showed that the assessment of fear of fall was appropriate and acceptable. Concerns of falling during physical and social activities could be addressed using the FES. Additionally, it can be applied in a clinical context to identify individuals who have a fear of falling. 21 Sample size calculation We estimated the sample size using a power analysis with 80% power and 5% Type 1 error for the main variables. The BBS score, in comparison to the difference in mean score pre and post treatment for mCIMT group from baseline to end visits. For the study, we used the previously determined effect size difference in percentage from the RCT. 22 Formula using mean difference: n 1 = n 2 = 2 Z α + Z β 2 σ 2 δ 2 Primary Variable (BBS) Mean ± SD (Pre) result on BBS for mCIMT = 48.8 ± 4.7 Mean ± SD (Post) result on BBS for mCIMT = 52.5 ± 3.5 Difference = 3.7 Pooled std. dev. = (4.7 + 3.5)/2 = 4.1 N1 = 2 ∗ 1.64 + 0.84 2 4.1 2 / 3.7 2 = 15 Considering 10% dropout = 2 Total samples required = 15 + 2 = 17 per group. Total sample size required = 15 Notations: Z α = 1.64 bat 5% l.o.s. at both sides total 10% type I error α = Type I error at 5% Z β = 0.84 1 − β = Power at 80 % σ = std . dev = 0.5 pooled std . dev Data collection methods Before group allocation, screening of the participants as per the inclusion and exclusion criteria will be carried out. This will be followed by baseline assessment of the outcome measures as mentioned. All participants will undergo the randomization process and are allocated into either group A or Group B. The intervention will be administered for an hour daily, five days per week for six weeks. The post intervention data for the outcomes will be recorded after the last intervention session day. The data will be compiled and analysed for studying the results. The study interventions will be administered by the principal investigator under the supervision of the guide throughout the duration of the study. The patients will be instructed and reminded of the sessions in advance through messages sent to their mobile phones so that adherence to the study is ensured. Furthermore, if the patient misses their sessions due to any reason, the standby days from the week will be utilized such that the patient receives a total of 30 sessions of intervention in the six week duration. As per in the sample size calculation we have given a 10% dropout rate so that it does not interfere with the results of our study. The data collection forms can be found as Extended data. 24 Data management The evaluation data will be derived from a pre-set spreadsheet with varied baseline attributes. The research data will be stored in a safe database. Hard copies of evaluation forms, signed informed consent forms, and other non-electronic documents will be safely preserved in the study setting. Every month until the trial is over, a complete backup of the data entries will be performed. The lead investigators will supervise the data gathering and reporting processes. The accuracy of the research papers must be properly reviewed. At the end of the study, the Excel spreadsheet will be published and delivered to the statistician for the necessary analysis. A checklist can be used to avoid data loss due to ineffective staff processes. Due to the thorough follow-up assessment of this trial, participant retention and completion of follow-up assessments are anticipated to be quite high. The patients in this trial will be invited to follow-up exams after six weeks. Statistical analysis Samples taken in accordance with the protocol and recorded on a basis that includes all relevant characteristics. Dataset of outcome variables including demographic, physical, laboratory and vitals information will be collected and tabulated in Excel, and will be analysed using R-Software version 4.3. Demographic variables such as age and gender and physical examination (height, weight, BMI), laboratory parameters (haemoglobin, Erythrocyte Sedimentation Rate (ESR), Liver Function Test (LFT), Kidney Function Test (KFT)), and vitals (respiratory rate, pulse rate, systolic blood pressure, diastolic blood pressure and SpO 2 levels) will be collected. Outcome variables such as BBS, DGI, TIS, 10MWT, FRT and FES will be presented over descriptive statistics with categorical tabulation for frequency and percentage, while quantitative measurements with minimum, maximum, mean and standard deviation. The primary outcome variables will include the BBS for measuring balance and the DGI for measuring gait outcome variables, the secondary outcome variables include the TIS, FRT, 10MWT and FES. Variables as primary and secondary parameters for their measuring assessment at different time visits will be assessed to find the significance in mean at 5% level of significance at P-value < 0.05. Statistical analysis will be performed for hypothesis testing for paired pre and post analysis using a paired t-test for normal data or non-parametric test such as Wilcoxon signed-rank test for non-normal data. Similarly, an unpaired t-test will be used for two independent groups for the change in parameters readings of primary and secondary variables at two different visits. Data over the outcome variables will be analysed for normality (normal distribution) using Kolmogorov–Smirnov test. If data results over non normal distribution then alternate non parametric test will be used. Confounding variables will be analysed with generalised linear model to find the random and fixed effects over the outcome variables. Association analysis for finding significance of cofounding parameters will be examined by using Chi-squared test or Fisher’s exact test or by using multi-variant analysis. Full analysis set for the values of outcome variables will be analysed for the results missing data will be covered with imputation method by calculating the mean and median over the existing data. Monitoring Data monitoring We will have a data monitoring committee lead by the PI for maintaining and integrating of the data. Harms The whole procedure is going to held under the supervision of clinicians and departmental committee During the trial, harms and adverse event will be immediately reported to the committee. The final dataset will be uploaded to the institutional research website and will be accessible to concerned authorities. Auditing Every month, auditing of the trial is going to be conducted. Any deviation from the protocol will be documented and will be addressed. Ethics and dissemination Ethical considerations Datta Meghe Institute of Higher Education and Research, Sawangi Wardha granted ethical approval (date, 21/03/2023) (reference number, DMIHER (DU)/IEC/2023/813). This protocol has been registered on CTRI (trial registration number, CTRI/2023/05/052674 ; registration date, 16/05/2023). Protocol amendments The study has been approved by the Scrutiny Committee at the college level on 01/03/2023 and by the IEC at the university level on 21/03/2023 following which, CTRI registration was also done. As per the suggestions through these committees the study has already been modified and approved. So further changes could not be carried out. Consent Members of the trial committee will provide the consent form to the participants in the trial and will inform and explain all the potential benefits and risks to the participants. Confidentiality The study program will be elaborated to the participant and one of their relatives, and the principal investigator will take personal information as a part of procedure. The consent form will include the confidentiality statement and signatures of the principal investigator, patient and two witnesses. Whenever it’s necessary to divulge details for the study, consent will be obtained from the patient with complete assurance of their confidentiality. Access to data The Principal Investigator will have access to the final trial datasheet. Ancillary and post-trial care The whole procedure is going to held under the supervision of clinicians and the departmental committee i.e. , Guide, Head of department, Principal and member of Research Guidance Cell. After the trial session, the participations are going to be under supervision for about four weeks so that if there will be any harm, the Principal Investigator will take care of the participants. Dissemination policy We will present the work in International Conference Proceedings and publish in an indexed journal. Study status The study is yet to begin. Discussion The study’s primary objective is to determine how well mCIMT and MRP work to treat balance and gait issues. These cause a rise in the risk of falling, which further reduces the functional independence of those who had sub-acute stroke. In a previous study, the experimental group received mCIMT for two weeks, while the control group received neurodevelopmental therapy (NDT). The findings showed that mCIMT for lower limb had a superior impact on improving motor function compared with NDT. 22 Using a randomized controlled trial, the study was done to determine how well the MRP worked to improve balance and upright mobility in sub-acute stroke patients. The results suggested that MRP showed a good impact on post-stroke survivors with the experimental group receiving MRP in addition to conventional physical therapy (RPT) for a duration of five days per week for eight weeks. 23 Both interventions were found to be beneficial in hemiplegic stroke when compared with a negative control group. But there is dearth of literature reflecting the superiority of either of these interventions when compared with each other. Therefore, our study will compare the two regimes to evaluate which is more successful while looking at the effectiveness of these therapies in sub-acute stroke patients. Data availability Underlying data No data are associated with this article. Extended data Zenodo: Extended data - Nitika.docx, https://doi.org/10.5281/zenodo.8172474 . 24 This project contains the following extended data: - Model consent form - Data collection form - Schedule of enrolment, interventions and assessments. Reporting guidelines Zenodo: SPIRIT- Nitika.docx, https://doi.org/10.5281/zenodo.8172339 . 25 Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0). Acknowledgements I’d like to express my gratitude to Mr. Lakshmikant Umate, biostatistician, for data analysis planning and sample size. References 1. 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Alghadir AH, Al-Eisa ES, Anwer S, et al. : Reliability, validity, and responsiveness of three scales for measuring balance in patients with chronic stroke. BMC Neurol. 2018 Sep 13; 18 (1): 141. PubMed Abstract | Publisher Full Text | Free Full Text 17. Shumway-Cook A, Gruber W, Baldwin M, et al. : The Effect of Multidimensional Exercises on Balance, Mobility, and Fall Risk in Community-Dwelling Older Adults. Phys. Ther. 1997 Jan 1; 77 (1): 46–57. PubMed Abstract | Publisher Full Text 18. Verheyden G, Nieuwboer A, Mertin J, et al. : The Trunk Impairment Scale: a new tool to measure motor impairment of the trunk after stroke. Clin. Rehabil. 2004 May 1; 18 (3): 326–334. PubMed Abstract | Publisher Full Text 19. Duncan PW, Studenski S, Chandler J, et al. : Functional Reach: Predictive Validity in a Sample of Elderly Male Veterans. J. Gerontol. 1992 May 1; 47 (3): M93–M98. PubMed Abstract | Publisher Full Text 20. Peters DM, Fritz SL, Krotish DE: Assessing the Reliability and Validity of a Shorter Walk Test Compared With the 10-Meter Walk Test for Measurements of Gait Speed in Healthy, Older Adults. J. Geriatr. Phys. Ther. 2013 Mar; 36 (1): 24–30. Publisher Full Text 21. Azad A, Hassani Mehraban A, Mehrpour M, et al. : Clinical assessment of fear of falling after stroke: validity, reliability and responsiveness of the Persian version of the Fall Efficacy Scale-International. Med. J. Islam Repub. Iran. 2014 Nov 18; 28 : 131. PubMed Abstract 22. Candan SA, Livanelioğlu A: EFFECTS OF MODIFIED CONSTRAINT-INDUCED MOVEMENT THERAPY FOR LOWER LIMB ON MOTOR FUNCTION IN STROKE PATIENTS: A RANDOMIZED CONTROLLED STUDY. Int. J. Physiother. 2017 Oct 9; 4 : 269–277. Publisher Full Text 23. Naz A, Batool S, Ahmad A, et al. : Effectiveness of motor relearning program on balance and upright mobility in sub-acute stroke patients: A randomized control trial: Motor Relearning Program in Sub-Acute Stroke Patients. Pakistan BioMedical Journal. 2022 Jan 31; 5 : 313–317. Publisher Full Text 24. Chavan NS: Extended data - Nitika.docx (Version v1). [Dataset]. Zenodo. 2023 Jul 21 [cited 2023 Jul 21]. Publisher Full Text 25. Chavan NS: SPIRIT- Nitika.docx. [Dataset]. Zenodo. 2023 Jun 7 [cited 2023 Jul 21]. Publisher Full Text Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 01 Sep 2023 ADD YOUR COMMENT Comment Author details Author details 1 Department of Neurophysiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra, 442004, India Nitika S. Chavan Roles: Conceptualization, Writing – Original Draft Preparation Raghumahanti Raghuveer Roles: Supervision, Validation Competing interests No competing interests were disclosed. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (2) version 2 Revised Published: 28 Mar 2024, 12:1098 https://doi.org/10.12688/f1000research.138127.2 version 1 Published: 01 Sep 2023, 12:1098 https://doi.org/10.12688/f1000research.138127.1 Copyright © 2024 Chavan NS and Raghuveer R. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Chavan NS and Raghuveer R. Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . F1000Research 2024, 12 :1098 ( https://doi.org/10.12688/f1000research.138127.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 2 VERSION 2 PUBLISHED 28 Mar 2024 Revised Views 0 Cite How to cite this report: Marklund I. Reviewer Report For: Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . F1000Research 2024, 12 :1098 ( https://doi.org/10.5256/f1000research.164215.r260278 ) The direct URL for this report is: https://f1000research.com/articles/12-1098/v2#referee-response-260278 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 29 Apr 2024 Ingela Marklund , Umeå universitet, Umeå, Sweden; Centre for Clinical Research and Education, Region Värmland, Karlstad, Sweden Not Approved VIEWS 0 https://doi.org/10.5256/f1000research.164215.r260278 I have read the revised manuscript with the tracked changes marked and none of the comments I made ... Continue reading READ ALL I have read the revised manuscript with the tracked changes marked and none of the comments I made before have been answered or taken into account not even the paragraph that is duplicated has been removed. Competing Interests: No competing interests were disclosed. Reviewer Expertise: Rehabilitation Medicine and Physiotherapy I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Marklund I. Reviewer Report For: Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . F1000Research 2024, 12 :1098 ( https://doi.org/10.5256/f1000research.164215.r260278 ) The direct URL for this report is: https://f1000research.com/articles/12-1098/v2#referee-response-260278 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Souza GS. Reviewer Report For: Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . F1000Research 2024, 12 :1098 ( https://doi.org/10.5256/f1000research.164215.r260277 ) The direct URL for this report is: https://f1000research.com/articles/12-1098/v2#referee-response-260277 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 24 Apr 2024 Givago Silva Souza , Federal University of Pará, Belém, Brazil Approved VIEWS 0 https://doi.org/10.5256/f1000research.164215.r260277 No more comments. All ... Continue reading READ ALL No more comments. All my issues were addressed. Competing Interests: No competing interests were disclosed. Reviewer Expertise: Digital Health, Balance, Mobility I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Souza GS. Reviewer Report For: Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . F1000Research 2024, 12 :1098 ( https://doi.org/10.5256/f1000research.164215.r260277 ) The direct URL for this report is: https://f1000research.com/articles/12-1098/v2#referee-response-260277 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Version 1 VERSION 1 PUBLISHED 01 Sep 2023 Views 0 Cite How to cite this report: Kiran Q. Reviewer Report For: Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . F1000Research 2024, 12 :1098 ( https://doi.org/10.5256/f1000research.151304.r235562 ) The direct URL for this report is: https://f1000research.com/articles/12-1098/v1#referee-response-235562 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 16 Sep 2024 Qurba Kiran , Shalamar Institute of Health Sciences, Lahore, Pakistan Approved VIEWS 0 https://doi.org/10.5256/f1000research.151304.r235562 This study focuses on two key rehabilitation techniques: Modified Constraint-Induced Movement Therapy (mCIMT) and the Motor Relearning Program (MRP) applied to improve balance and gait in patients with sub-acute hemiplegic stroke. Hemiplegic stroke causes significant impairments in motor functions, especially ... Continue reading READ ALL This study focuses on two key rehabilitation techniques: Modified Constraint-Induced Movement Therapy (mCIMT) and the Motor Relearning Program (MRP) applied to improve balance and gait in patients with sub-acute hemiplegic stroke. Hemiplegic stroke causes significant impairments in motor functions, especially affecting one side of the body, resulting in reduced mobility and balance. The study compares the effectiveness of these two interventions in enhancing motor recovery in the lower limbs. The findings of this comparative study may have direct implications on physical therapy practices. Clinics and rehabilitation centers can adopt more targeted approaches to improve outcomes for stroke survivors based on the results. The article highlights a comparative approach to two evidence-based rehabilitation techniques, contributing to the body of knowledge on effective stroke rehabilitation strategies, particularly in improving gait and balance in sub-acute hemiplegic stroke patients. The results may guide clinicians in selecting the most appropriate intervention for patient-specific needs. • Baseline comparability need to be addressed • Revise the potential benefits and potential risks • Add some operational definitions of terminologies which are used in title • References should be revised as more than five years old references are not encouraged • Add some literature regarding your topic at national level Is the rationale for, and objectives of, the study clearly described? Partly Is the study design appropriate for the research question? Yes Are sufficient details of the methods provided to allow replication by others? Yes Are the datasets clearly presented in a useable and accessible format? Not applicable Competing Interests: No competing interests were disclosed. Reviewer Expertise: Neuromuscular Physical therapy I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Kiran Q. Reviewer Report For: Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . F1000Research 2024, 12 :1098 ( https://doi.org/10.5256/f1000research.151304.r235562 ) The direct URL for this report is: https://f1000research.com/articles/12-1098/v1#referee-response-235562 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Souza GS. Reviewer Report For: Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . F1000Research 2024, 12 :1098 ( https://doi.org/10.5256/f1000research.151304.r235555 ) The direct URL for this report is: https://f1000research.com/articles/12-1098/v1#referee-response-235555 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 20 Mar 2024 Givago Silva Souza , Federal University of Pará, Belém, Brazil Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.151304.r235555 Abstract: Please indicate the names of the groups in the abstract. Introduction: It would be important to write a paragraph about balance and mobility in hemiplegic patients ... Continue reading READ ALL Abstract: Please indicate the names of the groups in the abstract. Introduction: It would be important to write a paragraph about balance and mobility in hemiplegic patients and the consequences that their losses could bring to the patients. Methods: I suggest including the use of accelerometry to evaluate the static balance and instrumented Timed Up and Go test. Is the rationale for, and objectives of, the study clearly described? Yes Is the study design appropriate for the research question? Yes Are sufficient details of the methods provided to allow replication by others? Yes Are the datasets clearly presented in a useable and accessible format? Not applicable Competing Interests: No competing interests were disclosed. Reviewer Expertise: Digital Health, Balance, Mobility I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Souza GS. Reviewer Report For: Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . F1000Research 2024, 12 :1098 ( https://doi.org/10.5256/f1000research.151304.r235555 ) The direct URL for this report is: https://f1000research.com/articles/12-1098/v1#referee-response-235555 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Marklund I. Reviewer Report For: Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . F1000Research 2024, 12 :1098 ( https://doi.org/10.5256/f1000research.151304.r235564 ) The direct URL for this report is: https://f1000research.com/articles/12-1098/v1#referee-response-235564 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 08 Feb 2024 Ingela Marklund , Umeå universitet, Umeå, Sweden; Centre for Clinical Research and Education, Region Värmland, Karlstad, Sweden Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.151304.r235564 Thank you for the opportunity to review this study “Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study”. The authors aimed to evaluate the effect of ... Continue reading READ ALL Thank you for the opportunity to review this study “Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study”. The authors aimed to evaluate the effect of mCIMT in addition to conventional therapy on balance and gait, the effectiveness of MRP along with conventional therapy on balance and gait and compare mCIMT and the MRP in improving balance and gait in sub-acute stroke patients. The topic is interesting and there is a lack of studies regarding mCIMT. Introduction When crosschecking the references, I have doubts about whether the cited articles can really be used to make these statements (ref. 1-3, 6, 8, and 9). Please check the references and make sure that the reference really refers to a statement that can be seen as a result of the referenced work. The reference 7 and 10 are placed before the sentence instead of after and I lack a reference for conventional therapy in section three and for mCIMT and MRP in section four. Conventional therapy needs further explanation and a reference, what is it in your context, I doubt it is the same over the world. The sentence, “there are several anatomical and functional abnormalities that are followed by hemiplegia”, please explain what you mean with several anatomical abnormalities?. CIMT comprises four components: i) intensive training of the more-affected arm; ii) training with a behavioral technique called shaping; iii) the ‘transfer package’, where problem-solving is used to overcome perceived barriers to more-affected arm uses in ADL; and iv) restraint of the less-affected arm for 90% of waking hours during the treatment period (Ref 1). Shaping is also used in Lower-extremity CIMT and I miss this part in the present study. The phenomenon “learned nonuse” is more commonly used according to CIMT for the upper extremity and also used in your reference 11 and 12. Section five is a duplication of section four. The study aims are clearly described. Methods The section Protocol is clearly described but the references for extended data are not in numerical order and I can not clearly understand if it is two or three assessments for outcome measures. Two in the text but three marks (x) in figure 2 (outcomes variables). Inclusion and Exclusion criteria are well written and does not need to be adjusted. Section Interventions, please describe the size of the intervention’s groups, are all 17 receiving the intervention at the same time or in smaller groups or individual? Did the principal investigator conduct both intervention and assessment? This is not clearly described and if so how can it affect the results? The interventions mCIMT, MRP and conventional therapy needs to be explained in more details to provide the opportunity for other researchers to replicate the study. Not only which exercise but also dose and intensity. Please describe what 10 minutes of transfer package includes. I also miss in the introduction how you came to the conclusion that 30 minutes a day for six weeks is enough? CIMT is often conducted six hours a day for two weeks and in your reference mCIMT was conducted 120 minutes a day for two weeks. Section Outcome measures, please use references with validity and reliability tests for the stroke population when possible. For example, BBS (Ref 2), 10MWT (Ref 3 or Ref 4), and DGI (Ref 5). Section Sample size calculation, I don’t understand. You wrote “we used the previously determined effect size in percentage from the RCT” but in the reference you referred to has not used BBS? Please explain where the data for the BBS you use in the calculation comes from. Is 17 in each group enough to show, as you write in the discussion part \"to evaluate which is more successful while looking at the effectiveness of these therapies in sub-acute stroke patients\" In the EXCITE trial (Ref 6), there were 106 and 116 in each arm. Section Data collection methods and Data management are well written and I have no more questions except of the need of clarification if it is two or three assessments as I mention earlier. Section Statistical analysis, These variables has not been explained before, please move from statistical section to another, for example Protocol and describe the characteristics you will collect and from where, medical journals or examination? Demographic variables such as age and gender and physical examination (height, weight, BMI), laboratory parameters (haemoglobin, Erythrocyte Sedimentation Rate(ESR), Liver Function Test (LFT), Kidney Function Test (KFT)), and vitals (respiratory rate, pulse rate, systolic blood pressure, diastolic blood pressure and SpO2 levels) will be collected. I have no further questions or comments and look forward to following the results and discussion in the present study. Is the rationale for, and objectives of, the study clearly described? Partly Is the study design appropriate for the research question? Yes Are sufficient details of the methods provided to allow replication by others? No Are the datasets clearly presented in a useable and accessible format? Partly References 1. Taub E, Uswatte G, Mark VW: The functional significance of cortical reorganization and the parallel development of CI therapy. Front Hum Neurosci . 2014; 8 : 396 PubMed Abstract | Publisher Full Text 2. Berg K, Wood-Dauphinee S, Williams JI: The Balance Scale: reliability assessment with elderly residents and patients with an acute stroke. Scand J Rehabil Med . 1995; 27 (1): 27-36 PubMed Abstract 3. Collen FM, Wade DT, Bradshaw CM: Mobility after stroke: reliability of measures of impairment and disability. Int Disabil Stud . 1990; 12 (1): 6-9 PubMed Abstract | Publisher Full Text 4. Fulk GD, Echternach JL: Test-retest reliability and minimal detectable change of gait speed in individuals undergoing rehabilitation after stroke. J Neurol Phys Ther . 2008; 32 (1): 8-13 PubMed Abstract | Publisher Full Text 5. Jonsdottir J, Cattaneo D: Reliability and validity of the dynamic gait index in persons with chronic stroke. Arch Phys Med Rehabil . 2007; 88 (11): 1410-5 PubMed Abstract | Publisher Full Text 6. Wolf SL, Winstein CJ, Miller JP, Taub E, et al.: Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial. JAMA . 2006; 296 (17): 2095-104 PubMed Abstract | Publisher Full Text Competing Interests: No competing interests were disclosed. Reviewer Expertise: Rehabilitation Medicine and Physiotherapy I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Marklund I. Reviewer Report For: Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . F1000Research 2024, 12 :1098 ( https://doi.org/10.5256/f1000research.151304.r235564 ) The direct URL for this report is: https://f1000research.com/articles/12-1098/v1#referee-response-235564 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 01 Sep 2023 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 3 Version 2 (revision) 28 Mar 24 read read Version 1 01 Sep 23 read read read Ingela Marklund , Umeå universitet, Umeå, Sweden; Region Värmland, Karlstad, Sweden Givago Silva Souza , Federal University of Pará, Belém, Brazil Qurba Kiran , Shalamar Institute of Health Sciences, Lahore, Pakistan Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Marklund I. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 29 Apr 2024 | for Version 2 Ingela Marklund , Umeå universitet, Umeå, Sweden; Centre for Clinical Research and Education, Region Värmland, Karlstad, Sweden 0 Views copyright © 2024 Marklund I. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Not Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions I have read the revised manuscript with the tracked changes marked and none of the comments I made before have been answered or taken into account not even the paragraph that is duplicated has been removed. Competing Interests No competing interests were disclosed. Reviewer Expertise Rehabilitation Medicine and Physiotherapy I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. reply Respond to this report Responses (0) Marklund I. Peer Review Report For: Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . F1000Research 2024, 12 :1098 ( https://doi.org/10.5256/f1000research.164215.r260278) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/12-1098/v2#referee-response-260278 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Souza G. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 24 Apr 2024 | for Version 2 Givago Silva Souza , Federal University of Pará, Belém, Brazil 0 Views copyright © 2024 Souza G. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions No more comments. All my issues were addressed. Competing Interests No competing interests were disclosed. Reviewer Expertise Digital Health, Balance, Mobility I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Souza GS. Peer Review Report For: Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . F1000Research 2024, 12 :1098 ( https://doi.org/10.5256/f1000research.164215.r260277) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/12-1098/v2#referee-response-260277 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Kiran Q. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 16 Sep 2024 | for Version 1 Qurba Kiran , Shalamar Institute of Health Sciences, Lahore, Pakistan 0 Views copyright © 2024 Kiran Q. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions This study focuses on two key rehabilitation techniques: Modified Constraint-Induced Movement Therapy (mCIMT) and the Motor Relearning Program (MRP) applied to improve balance and gait in patients with sub-acute hemiplegic stroke. Hemiplegic stroke causes significant impairments in motor functions, especially affecting one side of the body, resulting in reduced mobility and balance. The study compares the effectiveness of these two interventions in enhancing motor recovery in the lower limbs. The findings of this comparative study may have direct implications on physical therapy practices. Clinics and rehabilitation centers can adopt more targeted approaches to improve outcomes for stroke survivors based on the results. The article highlights a comparative approach to two evidence-based rehabilitation techniques, contributing to the body of knowledge on effective stroke rehabilitation strategies, particularly in improving gait and balance in sub-acute hemiplegic stroke patients. The results may guide clinicians in selecting the most appropriate intervention for patient-specific needs. • Baseline comparability need to be addressed • Revise the potential benefits and potential risks • Add some operational definitions of terminologies which are used in title • References should be revised as more than five years old references are not encouraged • Add some literature regarding your topic at national level Is the rationale for, and objectives of, the study clearly described? Partly Is the study design appropriate for the research question? Yes Are sufficient details of the methods provided to allow replication by others? Yes Are the datasets clearly presented in a useable and accessible format? Not applicable Competing Interests No competing interests were disclosed. Reviewer Expertise Neuromuscular Physical therapy I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Kiran Q. Peer Review Report For: Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . F1000Research 2024, 12 :1098 ( https://doi.org/10.5256/f1000research.151304.r235562) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/12-1098/v1#referee-response-235562 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Souza G. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 20 Mar 2024 | for Version 1 Givago Silva Souza , Federal University of Pará, Belém, Brazil 0 Views copyright © 2024 Souza G. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Abstract: Please indicate the names of the groups in the abstract. Introduction: It would be important to write a paragraph about balance and mobility in hemiplegic patients and the consequences that their losses could bring to the patients. Methods: I suggest including the use of accelerometry to evaluate the static balance and instrumented Timed Up and Go test. Is the rationale for, and objectives of, the study clearly described? Yes Is the study design appropriate for the research question? Yes Are sufficient details of the methods provided to allow replication by others? Yes Are the datasets clearly presented in a useable and accessible format? Not applicable Competing Interests No competing interests were disclosed. Reviewer Expertise Digital Health, Balance, Mobility I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (0) Souza GS. Peer Review Report For: Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . F1000Research 2024, 12 :1098 ( https://doi.org/10.5256/f1000research.151304.r235555) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/12-1098/v1#referee-response-235555 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Marklund I. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 08 Feb 2024 | for Version 1 Ingela Marklund , Umeå universitet, Umeå, Sweden; Centre for Clinical Research and Education, Region Värmland, Karlstad, Sweden 0 Views copyright © 2024 Marklund I. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Thank you for the opportunity to review this study “Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study”. The authors aimed to evaluate the effect of mCIMT in addition to conventional therapy on balance and gait, the effectiveness of MRP along with conventional therapy on balance and gait and compare mCIMT and the MRP in improving balance and gait in sub-acute stroke patients. The topic is interesting and there is a lack of studies regarding mCIMT. Introduction When crosschecking the references, I have doubts about whether the cited articles can really be used to make these statements (ref. 1-3, 6, 8, and 9). Please check the references and make sure that the reference really refers to a statement that can be seen as a result of the referenced work. The reference 7 and 10 are placed before the sentence instead of after and I lack a reference for conventional therapy in section three and for mCIMT and MRP in section four. Conventional therapy needs further explanation and a reference, what is it in your context, I doubt it is the same over the world. The sentence, “there are several anatomical and functional abnormalities that are followed by hemiplegia”, please explain what you mean with several anatomical abnormalities?. CIMT comprises four components: i) intensive training of the more-affected arm; ii) training with a behavioral technique called shaping; iii) the ‘transfer package’, where problem-solving is used to overcome perceived barriers to more-affected arm uses in ADL; and iv) restraint of the less-affected arm for 90% of waking hours during the treatment period (Ref 1). Shaping is also used in Lower-extremity CIMT and I miss this part in the present study. The phenomenon “learned nonuse” is more commonly used according to CIMT for the upper extremity and also used in your reference 11 and 12. Section five is a duplication of section four. The study aims are clearly described. Methods The section Protocol is clearly described but the references for extended data are not in numerical order and I can not clearly understand if it is two or three assessments for outcome measures. Two in the text but three marks (x) in figure 2 (outcomes variables). Inclusion and Exclusion criteria are well written and does not need to be adjusted. Section Interventions, please describe the size of the intervention’s groups, are all 17 receiving the intervention at the same time or in smaller groups or individual? Did the principal investigator conduct both intervention and assessment? This is not clearly described and if so how can it affect the results? The interventions mCIMT, MRP and conventional therapy needs to be explained in more details to provide the opportunity for other researchers to replicate the study. Not only which exercise but also dose and intensity. Please describe what 10 minutes of transfer package includes. I also miss in the introduction how you came to the conclusion that 30 minutes a day for six weeks is enough? CIMT is often conducted six hours a day for two weeks and in your reference mCIMT was conducted 120 minutes a day for two weeks. Section Outcome measures, please use references with validity and reliability tests for the stroke population when possible. For example, BBS (Ref 2), 10MWT (Ref 3 or Ref 4), and DGI (Ref 5). Section Sample size calculation, I don’t understand. You wrote “we used the previously determined effect size in percentage from the RCT” but in the reference you referred to has not used BBS? Please explain where the data for the BBS you use in the calculation comes from. Is 17 in each group enough to show, as you write in the discussion part \"to evaluate which is more successful while looking at the effectiveness of these therapies in sub-acute stroke patients\" In the EXCITE trial (Ref 6), there were 106 and 116 in each arm. Section Data collection methods and Data management are well written and I have no more questions except of the need of clarification if it is two or three assessments as I mention earlier. Section Statistical analysis, These variables has not been explained before, please move from statistical section to another, for example Protocol and describe the characteristics you will collect and from where, medical journals or examination? Demographic variables such as age and gender and physical examination (height, weight, BMI), laboratory parameters (haemoglobin, Erythrocyte Sedimentation Rate(ESR), Liver Function Test (LFT), Kidney Function Test (KFT)), and vitals (respiratory rate, pulse rate, systolic blood pressure, diastolic blood pressure and SpO2 levels) will be collected. I have no further questions or comments and look forward to following the results and discussion in the present study. Is the rationale for, and objectives of, the study clearly described? Partly Is the study design appropriate for the research question? Yes Are sufficient details of the methods provided to allow replication by others? No Are the datasets clearly presented in a useable and accessible format? Partly References 1. Taub E, Uswatte G, Mark VW: The functional significance of cortical reorganization and the parallel development of CI therapy. Front Hum Neurosci . 2014; 8 : 396 PubMed Abstract | Publisher Full Text 2. Berg K, Wood-Dauphinee S, Williams JI: The Balance Scale: reliability assessment with elderly residents and patients with an acute stroke. Scand J Rehabil Med . 1995; 27 (1): 27-36 PubMed Abstract 3. Collen FM, Wade DT, Bradshaw CM: Mobility after stroke: reliability of measures of impairment and disability. Int Disabil Stud . 1990; 12 (1): 6-9 PubMed Abstract | Publisher Full Text 4. Fulk GD, Echternach JL: Test-retest reliability and minimal detectable change of gait speed in individuals undergoing rehabilitation after stroke. J Neurol Phys Ther . 2008; 32 (1): 8-13 PubMed Abstract | Publisher Full Text 5. Jonsdottir J, Cattaneo D: Reliability and validity of the dynamic gait index in persons with chronic stroke. Arch Phys Med Rehabil . 2007; 88 (11): 1410-5 PubMed Abstract | Publisher Full Text 6. Wolf SL, Winstein CJ, Miller JP, Taub E, et al.: Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial. JAMA . 2006; 296 (17): 2095-104 PubMed Abstract | Publisher Full Text Competing Interests No competing interests were disclosed. Reviewer Expertise Rehabilitation Medicine and Physiotherapy I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (0) Marklund I. Peer Review Report For: Lower limb rehabilitation using modified constraint-induced movement therapy and motor relearning program on balance and gait in sub-acute hemiplegic stroke: a comparative study [version 2; peer review: 2 approved, 1 not approved] . 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