{"paper_id":"3f2d2cd6-b02b-4715-b865-3786e32a5365","body_text":"Genomic Evolution of Vibrio cholerae O1 El Tor Strains and Climatic Factors in Driving Cholera Surges in Dhaka, Bangladesh, 1996-2024 | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Genomic Evolution of Vibrio cholerae O1 El Tor Strains and Climatic Factors in Driving Cholera Surges in Dhaka, Bangladesh, 1996-2024 Munirul Alam, Md Mamun Monir, Khalilur Rahman, Mohammad Islam, and 11 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7203192/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted You are reading this latest preprint version Abstract Vibrio cholerae O1 El Tor strains responsible for endemic and epidemic cholera exhibit high genomic divergence in Bangladesh, although their relationship with the epidemiology and transmission of the disease has not been elucidated. Our integrated analyses results of the cholera case data of the world’s largest Diarrheal Disease Surveillance System (DDSS) of icddr,b (1996–2024) against the bacterial genomic sequence data reveal that the co-circulation of multiple lineages/sub-lineages of V. cholerae O1 El Tor strains, as well as their flux between the years with newly introduced or re-emerged lineages were significantly (p-value < = 0.05) associated with the number of cholera cases at Dhaka city. Our statistical modelling combining cholera with the climate factors such as temperature, humidity, and rainfall and the V. cholerae genome evolutionary dynamics data elucidates the interannual variation such as, high and low cholera, including the case surges in major epidemics of the disease in Bangladesh. Biological sciences/Microbiology/Policy and public health in microbiology Health sciences/Diseases/Infectious diseases/Bacterial infection Biological sciences/Computational biology and bioinformatics/Data acquisition Full Text Additional Declarations There is NO Competing Interest. Supplementary Files AdditionalInformation.docx Additional Information SupplementaryTablesMS.xlsx Supplementary Tables 1-8 Cite Share Download PDF Status: Under Review Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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