{"paper_id":"3e59d707-9db2-49dd-bb23-46e340cde57b","body_text":"Abstract\nObjectives\nTo evaluate uterine artery resistance during multiovulation induction in relation to the implantation rate in patients attendingin vitro fertilization (IVF) cycles.\nPatients\nMultiovulation induction for IVF was monitored by daily determination of the pulsatility index (PI) of the uterine arteries, obtained by a transvaginal probe (6.5 MHz) implemented with color-flow imaging. Doppler data were obtained from 5 days before hCG administration to the day of follicular aspiration. One IVF cycle was monitored in 70 patients. In 17 patients, 41 IVF cycles were monitored until a successful attempt occurred.\nResults\nIn the 70 patients studied during one IVF attempt, the PI of the uterine arteries significantly varied (P < 0.001) in the different phases of the cycle. In the 24 patients who conceived, a significantly lower PI (P < 0.03) was found throughout the cycle. This result was mainly due to a highly significant difference of PI values observed the day after hCG administration (P < 0.005). In the 17 patients who conceived after 1 to 4 negativein vitro fertilizations, no significant difference in PI was observed in the uterine artery resistance in cycles in which implantation was or was not successful.\nConclusions\nUterine artery resistance varies significantly during phases of the induction therapy. Uterine artery resistance is lower throughout the course of multiovulation induction in patients with higher pregnancy rates. The PI on the day after hCG administration was the best index of pregnancy rate. Low uterine artery resistance was present even in negative attempts in patients who eventually achieved a successful implantation. PI values ⩽3 can be considered a favorable prognostic factor for future IVF cycles.\nSimilar content being viewed by others\nReferences\nFord S, Reynolds L, Farley D: Interaction of ovarian steroids and periarterial alfa 1-adrenergic receptors in altering uterine blood flow during the estrous cycle of gilts. Am J Obstet Gynecol 1984;150:480–484\nMagness RR, Rosenfeld CR: The role of steroid hormones in the control of uterine blood flow in the uterine circulation. Perinatal Press 1989;13:239–271\nLevi Setti PE, Bozzo M, Sulpizio P, Rognoni G, Ferrazzi E, Pardi G: Color flow imaging and Doppler velocimetry of the uterine arteries in conceptional and non-conceptional ovulatory cycles. J Matern Fetal Invest 1993;3:123–126\nGoswamy RK, Steptoe PC: Doppler ultrasound studies of the uterine artery in spontaneous ovarian cycles. Hum Reprod 1988;6:721–726\nSteer CV, Campbell S, Pampiglione JS: Transvaginal color flow imaging of the uterine arteries during the ovarian and menstrual cycles. Hum Reprod 1990;5:391–395\nSteer CV, Campbell S, Tan SL, Crayford T, Mills C, Bridget AM, Collins WP: The use of transvaginal color flow imaging after in vitro fertilization to identify optimum uterine conditions before embryo transfer. Fertil Steril 1192;57:372–376\nGoswamy RK, Williams G, Steptoe PC: Decreased uterine perfusion—a cause of infertility. Hum Reprod 1988;8:955–959\nSterzik K, Hutter W, Grab D, Rosenbusch B, Sasse V, Terinde R: Doppler sonographic findings and their correlation with implantation in an in vitro fertilization program. Fertil Steril 1989;52:825–828\nSteer CV, Tan SL, Mason BA, Campbell S. Mid-luteal vaginal color Doppler assessment of uterine artery impedance in a subfertile population. Fertil Steril 1994;61:53–58\nWada I, Hsu CC, Williams G, Macnamee MC, Brinsden PR: The value of low dose aspirin therapy in woman with impaired uterine perfusion during assisted conception. Hum Reprod 1994;9:1954–1957\nGlantz SA: Primer of Biostatistics. New York, McGrawHill, 1987\nDe Ziegler D, Bessis R, Frydman R: Vascular resistance of uterine arteries: physiological effects of estradiol and progesterone. Fertil Steril 1991;55:775–779\nSteer VS, Tan LS, Dillon D, Mason BA, Campbell S: Vaginal color Doppler of uterine artery impedance correlates with immunohistochemical markers of endometrial receptivity required for the implantation of an embryo. Fertil Steril 1995;63:101–108\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nLevi-Setti, P.E., Rognoni, G., Bozzo, M. et al. Color-doppler velocimetry of uterine arteries in pregnant and nonpregnant patients during multiovulation induction for IVF. J Assist Reprod Genet 12, 413–417 (1995). https://doi.org/10.1007/BF02211140\nReceived:\nAccepted:\nIssue date:\nDOI: https://doi.org/10.1007/BF02211140","source_license":"CC0","license_restricted":false}