{"paper_id":"3dff1caf-3bda-4a0e-bb8d-2f2c01a3b2ae","body_text":"Abstract\nAt present, many studies have confirmed that HIFU is a safe, effective, and non- invasive method for treating adenomyosis. Still, at the same time, we also realize that this HIFU treatment also has certain limitations. One of them is similar to all other uterine preservation treatment for adenomyosis; patients will face problems of poor results and recurrence. Clinical studies have confirmed that the effective rate of HIFU alone in treating adenomyosis is about 80%–90%, and there are still 10%–20% of patients whose symptoms do not improve significantly. Besides, there are still some patients with symptoms soon recur after treatment. Liu et al. [1] reported that 45 of the 173 patients with adenomyosis after HIFU treatment had symptoms recurred; the recurrence rate was about 26%, and the median time to relapse is 12 months.\nAccess this chapter\nTax calculation will be finalised at checkout\nPurchases are for personal use only\nSimilar content being viewed by others\nReferences\nLiu X, et al. Clinical predictors of long-term success in ultrasound-guided high-intensity focused ultrasound ablation treatment for adenomyosis: a retrospective study. Medicine. 2016;95(3):e2443.\nWang P-H, et al. Comparison of surgery alone and combined surgical-medical treatment in the management of symptomatic uterine adenomyoma. Fertil Steril. 2009;92(3):876–85.\nJiang D, Liu X. High-intensity focused ultrasound combined with mifepristone to treat uterine adenomyosis and the effects on pain. Chin Commun Phys. 2019;30:23.\nMao Shihua TX, Ling F, Zongguo T, Tao Z, Lian Z. High-intensity focused ultrasound combined with mifesterone to treat uterine adenomyosis. Chin Family Planning Obstet Gynecol. 2014;6(5):29–31.\nGuo Q, et al. High intensity focused ultrasound treatment of adenomyosis: a comparative study. Int J Hyperth. 2018;35(1):505–9.\nTan Yutao LZ. High-intensity focused ultrasound noninvasive therapy combined with gonadotropin release hormone agonists to treat uterine adenomyosis – an observation. Chin Mater Child Health. 2019;34(20):4811–5.\nXiao-Ying Z, et al. Effect of pre-treatment with gonadotropin-releasing hormone analogue GnRH-α on high-intensity focussed ultrasound ablation for diffuse adenomyosis: a preliminary study. Int J Hyperth. 2018;34(8):1289–97.\nHuang Xia YB, Hong Z, Denghua J. The clinical efficacy analysis of high-intensity focused ultrasound in combination with Mirena IUD in the treatment of uterine adenomyosis. Pract Gynaecol Endocrinol Elect J. 2018;15:33–5.\nWu Ziyu PZ, Xiuping L, Yueyue D, Mingjie J. Clinical observation of high-intensity focused ultrasound in combination with LNG-IUS treatment of uterine adenomyosis. Shandong Med. 2018;58(3):65–7.\nLuo Shuang WY, Jia H. Evaluation of the efficacy of high-intensity focused ultrasound ablation combined Gestrinone to treat uterine adenomyosis. Chongqing Med. 2018;47(2):170–2.\nDing G. Clinical study of high-intensity focused ultrasound combined with aqueous ethanol to treat uterine adenomyosis. Zhonghua Fu Chan Ke Za Zhi. 2017;51(9):643–9.\nXiangjie L Clinical study of ultrasound ablation combined herbal analgesic capsules for the treatment of uterine adenomyosis. New Town Medical College; 2015.\nHou Y, et al. Combination therapeutic effects of high intensity focused ultrasound and metformin for the treatment of adenomyosis. Exp Ther Med. 2018;15(2):2104–8.\nHaiyan S, et al. High-intensity focused ultrasound (HIFU) combined with gonadotropin-releasing hormone analogs (GnRHa) and levonorgestrel-releasing intrauterine system (LNG-IUS) for adenomyosis: a case series with long-term follow up. Int J Hyperth. 2019;36(1):1179–85.\nYang X, et al. Combined therapeutic effects of HIFU, GnRH-a and LNG-IUS for the treatment of severe adenomyosis. Int J Hyperth. 2019;36(1):485–91.\nYe Mingzhu DX, Xiaogang Z, Min X. High-intensity focused ultrasound ablation combined GnRH-a and LNG-IUS in the treatment of uterine adenomyosis. Chin J Obstet Gynecol. 2016;5:1–9.\nAuthor information\nAuthors and Affiliations\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.\nAbout this chapter\nCite this chapter\nYe, M. (2021). Adjuvant Therapy of HIFU Ablation for Adenomyosis. In: Xue, M., Leng, J., Wong, F. (eds) Adenomyosis. Springer, Singapore. https://doi.org/10.1007/978-981-33-4095-4_16\nDownload citation\nDOI: https://doi.org/10.1007/978-981-33-4095-4_16\nPublished:\nPublisher Name: Springer, Singapore\nPrint ISBN: 978-981-33-4094-7\nOnline ISBN: 978-981-33-4095-4\neBook Packages: MedicineMedicine (R0)","source_license":"CC0","license_restricted":false}