{"paper_id":"3b3b7ad0-4749-40ac-bfd4-d4c9eeb6000b","body_text":"Risk factors for adenomyosis in women of reproductive age\nDOI:\nhttps://doi.org/10.15574/HW.2024.172.12Keywords:\nendometriosis, adenomyosis, endometrium, etiopathogenesis, womenAbstract\nThe problem of adenomyosis is of particular relevance to patients of reproductive age since these diseases are accompanied by significant violations of the menstrual and generative functions.\nAim - determine the risk factors for the development of adenomyosis in women of reproductive age in order to improve a complex pathogenetically based approach in the selection of treatment.\nMaterials and methods. Analysis of anamnestic data and examination of 90 women of reproductive age with adenomyosis, which made up the main group, was carried out. The control group - 30 gynecologically healthy non-pregnant women of reproductive age.\nResults. The article provides data on the results of clinical-statistical analysis among reproductive-age women with the adenomyosis. The risk factors of development of adenomyosis in investigated group are determined. Those are: complicated heredity, high frequency of the clinical abortions, spontaneous miscarriages, pathological deliveries in the past. The low index of health is observed in such category of women: high sick rate of gynecological or extragenital pathology, 3 times higher frequency of child's and respiratory illnesses, the surgical intervention on uterus and ovarium promotes the progress of the endometriosis. That the most frequent clinical manifestations of adenomyosis are pain and hemorrhagic syndrome.\nConclusions. The clinical and statistical analysis of the examined patients made it possible to identify risk factors for the development of adenomyosis in women of reproductive age: burdened heredity (60%), unmarried and single women (58.5%); employees with intellectual and mental and neuropsychological stress (63.3%), high infection index, accompanying extragenital pathology (37.4%), menstrual cycle disorders (93.3%) and reduced reproductive and sexual function; aggravated gynecological history: chronic inflammatory processes of the uterus and appendages (44.2%), pathology of the cervix (36.5%), artificial (66.6%) and involuntary (14.4%) abortions; intrauterine surgical interventions (76.3%).\nThe research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies.\nNo conflict of interests was declared by the authors.\nReferences\nAltibaieva DM, Kurochka VV, Petrenko TH. (2016). Osoblyvosti hormonalnoho homeostazu pry adenomiozi v poiednanni z hiperplastychnymy protsesamy endometriia u zhinok reproduktyvnoho viku. Zbirnyk naukovykh prats Asotsiatsii akusheriv Ukrainy. 2(38): 17-21.\nBenyuk VA, Altibaeva DM, Goncharenko VN, Kurochka VV. (2016). The role of immune mechanisms in the development of benign uterus pathology. Health of woman. 5(111): 30-32. https://doi.org/10.15574/HW.2016.111.30\nBenyuk VA, Kurochka VV, Benyuk SV, Altibaeva DM. (2017). Menstrual function in women with adenomiosis in combination with the hyperplastic processes of endometry on the background of hormonotherapy. Health of woman. 4(120): 115-117. https://doi.org/10.15574/HW.2017.120.115\nChapron C, Vannuccini S, Santulli P, Abrão MS, Carmona F, Fraser IS et al. (2020). Diagnosing adenomyosis: an integrated clinical and imaging approach. Hum Reprod Update. 2020 Apr 15;26(3):392-411. https://doi.org/10.1093/humupd/dmz049; PMid:32097456\nMielikhova TV. (2017). Udoskonalennia rannoi diahnostyky dlia prohnozuvannia rozvytku adenomiozu ta vyznachennia kryteriiv efektyvnosti likuvannia. Innovative technology in medicine: experience of Poland and Ukraine: Conference Proceedings, Lublin, April 28-29: 185-187.\nMurji A, Biberoğlu K, Leng J. (2020). Use of dienogest in endometriosis. A narrative literature review and expert commentary. Reproductive endocrinology. (52): 73-81. https://doi.org/10.18370/2309-4117.2020.52.73-81\nPyrohova V, Shurpiak S, Kozlovskyi I. (2023). Hinekolohichni peredumovy rozvytku syndromu khronichnoho tazovoho boliu - diahnostyka ta likuvannia (Ohliad literatury). Reproduktyvne zdorov'ia zhinky. (2): 59-66. https://doi.org/10.30841/2708-8731.2.2023.278288\nShcherbyna M, Chekhunova A. (2020). Analiz kliniko-anamnestychnykh danykh i premorbidnoho fonu pry adenomiozi. Aktualni pytannia pediatrii, akusherstva ta hinekolohii. (1): 102-107. https://doi.org/10.11603/24116-4944.2020.1.11493\nDownloads\nPublished\nIssue\nSection\nLicense\nCopyright (c) 2024 Ukrainian Journal Health of Woman\nThis work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.\nThe policy of the Journal UKRAINIAN JOURNAL «HEALTH OF WOMAN» is compatible with the vast majority of funders' of open access and self-archiving policies. The journal provides immediate open access route being convinced that everyone – not only scientists - can benefit from research results, and publishes articles exclusively under open access distribution, with a Creative Commons Attribution-Noncommercial 4.0 international license (СС BY-NC).\nAuthors transfer the copyright to the Journal UKRAINIAN JOURNAL «HEALTH OF WOMAN» when the manuscript is accepted for publication. Authors declare that this manuscript has not been published nor is under simultaneous consideration for publication elsewhere. After publication, the articles become freely available on-line to the public.\nReaders have the right to use, distribute, and reproduce articles in any medium, provided the articles and the journal are properly cited.\nThe use of published materials for commercial purposes is strongly prohibited.","source_license":"CC0","license_restricted":false}