{"paper_id":"3b35ff3e-f3aa-4316-8ce3-4c17ab20ceb6","body_text":"Abstract\nTelocytes (TCs) are interstitial cells characterized by a small body and long extensions known as telopodes. Identified in various tissues, including the female reproductive system, they regulate homeostasis, tissue regeneration, immune modulation, and pathological processes. TCs contribute to key reproductive functions such as embryo implantation, uterine contractility, and vascular adaptation during pregnancy. Their presence in the myometrium, endometrium, ovaries, fallopian tubes, and placenta facilitates interactions with immune cells, stem cells, and the extracellular matrix. TC density is reduced in conditions like endometriosis, uterine fibroids, and infertility-related disorders. In endometriosis, TCs modulate immune responses by interacting with macrophages and influencing cytokine secretion. In leiomyomas, their loss correlates with fibrosis and altered steroid hormone receptor expression, suggesting roles in tissue remodeling and hormonal regulation. In fallopian tubes, TCs contribute to motility, with dysfunction linked to ectopic pregnancies. Experimental models highlight TC-derived exosomes in tissue repair, suggesting therapeutic potential for intrauterine adhesions and endometrial fibrosis. Current evidence underscores the role of TCs as key regulators of reproductive physiology and pathology, positioning them as promising targets for future regenerative and gynecological therapies. 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All authors read and approved the final manuscript.\nCorresponding author\nEthics declarations\nThis article does not contain any studies with human or animal participants performed by any of the authors. The authors of this work declare that they have no conflicts of interest.\nAdditional information\nPublisher's Note. Pleiades Publishing remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. AI tools may have been used in the translation or editing of this article.\nRights and permissions\nAbout this article\nCite this article\nMarca, A.L., Lecis, S., Botticelli, L. et al. Telocytes, the New Kids on the Block. What Role do They Play in Female Reproductive System and Function? (A Review). Cell Tiss. Biol. 19, 495–503 (2025). https://doi.org/10.1134/S1990519X25600589\nReceived:\nRevised:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1134/S1990519X25600589","source_license":"CC0","license_restricted":false}