{"paper_id":"3a4de250-d965-49b5-babb-cadb81f87aa6","body_text":"Abstract\nEndometriosis and PolyCystic Ovary Syndrome (PCOS) are both oestrogen-related diseases that often occur among women of reproductive age. Both have a negative impact on fertility. To date, there is no extensive literature on the association of endometriosis with PCOS. In this chapter, we will try to highlight the possible correlation between the two disorders, as well as to examine possible common pathogenetic mechanisms, as well as to propose a strategy for the joint treatment of the two above-mentioned disorders when they coexist.\nAccess this chapter\nTax calculation will be finalised at checkout\nPurchases are for personal use only\nSimilar content being viewed by others\nReferences\nBulun SE. Endometriosis. N Engl J Med. 2009;360:268–79.\nAzziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab. 2004;89:2745–9.\nThe Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Work-shop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81:19–25.\nHager M, Wenzl R, Riesenhuber S, Marschalek J, Kuessel L, Mayrhofer D, Ristl R, Kurz C, Ott J. The prevalence of incidental endometriosis in women undergoing laparoscopic ovarian drilling for clomiphene-resistant polycystic ovary syndrome: a retrospective cohort study and meta-analysis. J Clin Med. 2019;8:1210–21.\nBurney RO. The genetics and biochemistry of endometriosis. Curr Opin Obstet Gynecol. 2013;25:280–6.\nBulun SE, Yilmaz BD, Sison C, Miyazaki K, Bernardi L, Liu S, Kohlmeier A, Yin P, Milad M, Wei J. Endometriosis. Endocr Rev. 2019;40:1048–79.\nThe Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group*. Consensus on infertility treatment related to polycystic ovary syndrome. Fertil Steril. 2008;89(3):505–22.\nLambrinoudaki IV, Augoulea A, Christodoulakos GE, Economou EV, Kaparos G, Kontoravdis A, Papadias C, Creatsas G. Measurable serum markers of oxidative stress response in women with endometriosis. Fertil Steril. 2009;91:46–50.\nAgarwal A, Aponte-Mellado A, Premkumar BJ, Shaman A, Gupta S. The effects of oxidative stress on female reproduction: a review. Reprod Biol Endocrinol. 2012;10:49–80.\nMurri M, Luque-Ramirez M, Insenser M, Ojeda-Ojeda M, Escobar-Morreale HF. Circulating markers of oxidative stress and polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2013;19:268–88.\nFichera M, Török P, Tesarik J, Della Corte L, Rizzo G, Garzon S, Carlea A, Di Angelo Antonio S, Zito G, Panella MM. Vitamin D, reproductive disorders and assisted reproduction: evidence and perspectives. Int J Food Sci Nutr. 2020;71(3):276–85. https://doi.org/10.1080/09637486.2019.1661978.\nGuo Z, Yu Q. Role of mTOR signaling in female reproduction. Front Endocrinol. 2019;10:692. https://doi.org/10.3389/fendo.2019.00692.\nVasilopoulos E, Fragkiadaki P, Kalliora C, Fragou D, Docea AO, Vakonaki E, Tsoukalas D, Calina D, Buga AM, Georgiadis G, Mamoulakis C, Makrigiannakis A, Spandidos DA, Tsatsakis A. The association of female and male infertility with telomere length (review). Int J Mol Med. 2019;44(2):375–89. https://doi.org/10.3892/ijmm.2019.4225.\nKoiou E, Tziomalos K, Katsikis I, Delkos D, Tsourdi EA, Panidis D. Disparate effects of pharmacotherapy on plasma plasminogen activator inhibitor-1 levels in women with the polycystic ovary syndrome. Hormones. 2013;12:559–66.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 2026 Springer Nature Switzerland AG\nAbout this chapter\nCite this chapter\nAntonakis, L.G., Adonakis, G.L. (2026). Endometriosis and Polycystic Ovarian Syndrome. In: Di Renzo, G.C. (eds) Obstetric and Gynecological Women's Health. Springer, Cham. https://doi.org/10.1007/978-3-032-05381-7_18\nDownload citation\nDOI: https://doi.org/10.1007/978-3-032-05381-7_18\nPublished:\nPublisher Name: Springer, Cham\nPrint ISBN: 978-3-032-05380-0\nOnline ISBN: 978-3-032-05381-7\neBook Packages: MedicineMedicine (R0)","source_license":"CC0","license_restricted":false}