{"paper_id":"38780867-6d25-4f37-ad52-01386350b61b","body_text":"ECR 2020 / C-07636\nAltered resting state MR functional connectivity in women with chronic pelvic pain\nCongress:\nECR 2020\nPoster Number:\nC-07636\nType:\nScientific Exhibit\nKeywords:\nNeuro, CNS, MR, Computer Applications-General, Pelvic floor dysfunction, Prospective, Not applicable, Performed at one institution\nAuthors:\nG. Garcia-Marti1, L. Marti-Bonmati2, R. Sanz-Requena2, R. torres2; 1Valencia, València/ES, 2Valencia/ES\nDOI:\n10.26044/ecr2020/C-07636\nPurpose\nResting state functional magnetic resonance imaging (rs-fMRI) has revealed altered connectivity patterns in patients with chronic pelvic pain. Disruptions of the Default Mode Network (DMN) and Salience Network (SN) have been associated to clinical and functional effects in this disease [1].\nThe aim of this study is to use high-resolution rs-fMRI sequences to study the DMN and SN functional connectivity in a homogeneous sample of patients with chronic pelvic pain and to evaluate the effect of physiotherapy in these patients.\nMethods and materials\nFifteen patients with chronic pelvic pain (all women) with a mean age of 37.8 ± 10.1 years, were recruited for this study. All subjects were MR evaluated twice (before and after physiotherapy) on a 3T magnet (Philips Achieva, Best, the Netherlands). The following rs-fMRI BOLD sequence was acquired: echo-planar imaging, 180 dynamics, TR=2200 ms, TE=30 ms, FA=90º, 38 contiguous slices with no interslice gap, voxel size 2.88 x 2.88 x 3.60 mm, NEX=1.\nImages were improved with non-local postprocessing methods for minimizing signal inhomogeneity and...\nResults\nUsing and independent component analysis approach, the DMN and SN were extracted for all subjects. A significant increase of DMN functional connectivity was observed in chronic pelvic pain patients after physiotherapy, compared with the baseline MR (ANOVA. p=0.046; F=4.222). No differences of functional connectivity were observed in the SN (ANOVA. p=0.415; F=0.678) (Fig. 1).\nConclusion\nThere are significant alterations of the DMN connectivity associated to neuropsychological therapies in this homogeneous sample of patients with chronic pelvic pain. However, no disruptions of the SN were found. Further studies with additional clinical information and MR techniques such as diffusion tensor imaging to evaluate structural connectivity, will help to clarify the effect of the DMN and SN in chronic pelvic pain.\nPersonal information and conflict of interest\nL. Marti-Bonmati; Valencia/ES - nothing to disclose G. Garcia-Marti; Valencia, VALÈNCIA/ES - nothing to disclose R. Sanz-Requena; Valencia/ES - nothing to disclose R. Torres; Valencia/ES - nothing to disclose\nReferences\n1.Martucci KT1, Shirer WR, Bagarinao E, Johnson KA, Farmer MA, Labus JS, Apkarian AV, Deutsch G, Harris RE, Mayer EA, Clauw DJ, Greicius MD, Mackey SC. The posterior medial cortex in urologic chronic pelvic pain syndrome: detachment from default mode network-a resting-state study from the MAPP Research Network. Pain. 2015. 156(9):1755-64.","source_license":"CC0","license_restricted":false}