{"paper_id":"37f65456-9491-4b22-b2e7-da04516b4ebd","body_text":"Abstract\nPurpose\nThis study aims to assess the impact of endometrioma on patients who undergo ART treatment due to endometriosis.\nMethods\nA retrospective study was conducted on women ≤ 40 years of age who underwent ART treatment at an academic medical center between January 2014 and December 2020. Two-hundred-and-eight women had received IVF/ICSI treatment due to endometriosis and there were 89 patients presence of endometrioma. Patients were further divided into primary endometrioma, recurrent endometrioma and those having received cystectomy for endometrioma prior to IVF/ICSI. The control group included 624 infertile women without endometriosis.\nResults\nIn the endometrioma subgroup (B) the blastocyst formation rate was significantly lower when compared with the endometriosis (A) and control groups (C). The cumulative live birth rates (CLBRs) (60.5% versus 49.4% versus 56.9%, p = 0.194 in A versus B, p = 0.406 in A versus C, p = 0.878 in B versus C) were comparable. Multiple logistic regression analysis revealed that female age, total FSH dose and blastocyst formation rate were the significant variables in predicting CLBR (OR 0.89, CI 0.80–0.99, p < 0.025, OR 0.68 CI 0.53–0.88, p = 0.003 and OR 30.04, CI 9.93–90.9, p < 0.001, respectively). The CLBRs were comparable at 47.1%, 60% and 57.9% in the primary endometrioma, s/p cystectomy and recurrent endometrioma group.\nConclusion\nAlthough the blastocyst formation rate was lower in the endometrioma group, CLBR was not worse than those who were in the endometriosis or control group. Cystectomy for endometrioma did not alter IVF/ICSI outcomes if the ovarian reserve was comparable. Recurrent endometrioma did not worsen IVF/ICSI outcomes than primary endometrioma.\nSimilar content being viewed by others\nAvailability of data and materials\nAll data generated and analyzed during this study are included in this published article and its supplementary information files.\nData availability\nData of the study are available and can be provided upon request.\nReferences\nHoloch KJ, Lessey BA (2010) Endometriosis and infertility. Clin Obstet Gynecol 53:429–438. https://doi.org/10.1097/GRF.0b013e3181db7d71\nMacer ML, Taylor HS (2012) Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin North Am 39:535–549. https://doi.org/10.1016/j.ogc.2012.10.002\nHughesdon PE (1957) The structure of endometrial cysts of the ovary. 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Y-FC: Data analysis. S-TC: Data analysis. All authors reviewed the manuscript.\nCorresponding author\nEthics declarations\nCompeting interests\nThe authors have no relevant financial or non-financial interests to disclose.\nEthics approval and consent to participate\nInstitutional Review Board, TCVGH, No. CE21306B. Date of approval: August 30, 2021.\nInformed consent statement\nNot applicable\nConsent to publish\nAuthors are responsible for the correctness of the statements provided in the manuscript.\nAdditional information\nPublisher's Note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nRights and permissions\nSpringer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.\nAbout this article\nCite this article\nChang, JC., Yi, YC., Chen, YF. et al. Presence of endometrioma decreased blastocyst formation rate but not impair Assisted Reproductive Technology (ART) outcome. Arch Gynecol Obstet 307, 2011–2020 (2023). https://doi.org/10.1007/s00404-023-07036-2\nReceived:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-023-07036-2","source_license":"CC0","license_restricted":false}