{"paper_id":"3738ab63-eac2-4ecb-8c57-212a73b62386","body_text":"Received: 27 Aug 2025;\nRevised: 15 Nov 2025; Accepted: 20 Nov 2025; Available online: 24 Dec 2025; Published: 24 Dec 2025.\nCopyright (c) 2025 Journal of Biomedicine and Translational Research\nThis work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.\nThis work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.\nAbstract\nBackground: Endometriosis is associated with lipid peroxidation by reactive oxygen species (ROS) which causes endometrial cell DNA damage. Vitamin D is known to have good antioxidant content, so it is thought to have the ability to inhibit proliferation, invasion and production of pro-inflammatory cytokines in endometriosis.\nObjective: To analyze the differences in vitamin D levels between endometriosis cyst patients and normal women and the relationship between vitamin D levels and the size of endometriosis cysts.\nMethods: Analytical observational study with cross sectional design with 60 samples consisting of 30 endometriosis cyst patients and 30 normal women. Evaluation was carried out on vitamin 25 (OH) D serum levels using the ELISA method and endometriosis cyst size. Cyst size is evaluated by assessing the largest diameter of a single endometriosis cyst assessed through an ultrasound examination by a specialist doctor.\nResults: Vitamin D levels in the endometriosis group were significantly lower than normal women (13.23 ± 5.39 ng/mL vs 15.83 ± 5.30 ng/mL; p = 0.048). Subjects with vitamin D levels <13.45 had a 4.03x (OR 4.03; CI95% 1.37-11.83) higher risk of experiencing endometriosis compared to subjects with vitamin D levels > 13.45 ng/mL. There was no correlation between vitamin D levels and the size of endometriosis cysts (p=0.720).\nConclusion: Endometriosis patients have significantly lower serum vitamin D levels than normal women (OR 4.03; CI95% 1.37-11.83). Serum vitamin D levels do not significantly correlate with endometriosis cyst size.Note: This article has supplementary file(s).\nFulltext\nView|Download\n|\nCopyright Transfer Agreement\nConflict of Interest and CTA\nEmail colleagues\n| Subject | |\n| Type | Copyright Transfer Agreement |\n| Download (43KB) Indexing metadata |\nKeywords: Endometriosis; Endometriosis cyst size; Vitamin D\nArticle Metrics:\nArticle Info\n- Parasar P, Ozcan P, Terry KL. Endometriosis: Epidemiology, Diagnosis and Clinical Management. 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Gynecological Endocrinology. 2017 Feb 1;33(2):164–7. doi: 10.1080/09513590.2016.1239254\nLast update:\nNo citation recorded.\nLast update:\nNo citation recorded.\nCopyright (c) 2025 Journal of Biomedicine and Translational Research\nThis work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.\nThis work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.\nThe Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Journal of Biomedicine and Translational Research Diponegoro University as publisher of the journal.\nCopyright encompasses non-exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations.\nJournal of Biomedicine and Translational Research Diponegoro University, the Editors and the Advisory International Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal. 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