{"paper_id":"36201b9c-a26b-4949-9b29-d4c0794fe2a3","body_text":"Abstract\nUterine adenomyosis is a benign gynecological disease that affects women’s fertility and quality of life. Infertility, miscarriage, and obstetric complications are prominent problems, which are difficult and hot spots in its research and treatment. There is an increasing evidence that adenomyosis is associated with infertility and reproductive failure [1–4]. A recent cross-sectional study of infertile women found that the incidence of adenomyosis was 29.7% in women over 40 years of age and 22% under 40 years of age. Furthermore, among people with repeated miscarriages and previous assisted reproductive technology (ART) failures, this proportion increased to 38.2% [5].\nAccess this chapter\nTax calculation will be finalised at checkout\nPurchases are for personal use only\nSimilar content being viewed by others\nReferences\nYounes G, Tulandi T. Effects of adenomyosis on in vitro fertilization treatment outcomes: a meta-analysis. Fertil Steril. 2017;108:483–490.e3.\nTomassetti C, et al. Adenomyosis and subfertility: evidence of association and causation. Semin Reprod Med. 2013;31(2):101–8.\nBenagiano, Adenomyosis and infertility. Reproductive Biomedicine Online.\nVercellini P, et al. Uterine adenomyosis and in vitro fertilization outcome: a systematic review and meta-analysis. Hum Reprod. 2014;29(5):964–77.\nGarcia-Velasco JA. Adenomyosis in infertile women: prevalence and the role of 3D ultrasound as a marker of severity of the disease. Reprod Biol Endocrinol. 2016;14(1):60.\nHarada T, et al. The Impact of Adenomyosis on Women’s fertility. Obstet Gynecol Surv. 2016;71(9):557–68.\nHabiba MA. Uterine adenomyosis is associated with ultrastructural features of altered contractility in the inner myometrium. Fertil Steril. 2009;93(7):P2130–6.\nMall G. The pathophysiology of endometriosis and adenomyosis: tissue injury and repair. Arch Gynecol Obstet. 2009;280(4):529–38.\nLieng M, Istre O, Qvigstad E. Treatment of endometrial polyps: a systematic review. J Minim Invasive Gynecol. 2010;89(8):992–1002.\nPetraglia F. Pathogenesis of adenomyosis: an update on molecular mechanisms. Reprod Biomed Online. 2017; 35(5):592–601. http://www.rbmojournal.com/article/S1472648317302961/pdf.\nJiang Y, et al. Decreased expression of NR4A nuclear receptors in adenomyosis impairs endometrial decidualization. Mhr: Basic Sci Reprod Med. 2016;22(9):655–68.\nHsu WL. Adenomyosis and risk of preterm delivery. BJOG Int J Obstet Gynaecol. 2007;114(2):165–9.\nMochimaru A, et al. Adverse pregnancy outcomes associated with adenomyosis with uterine enlargement. J Obstet Gynaecol Res. 2015;41(4):529–33.\nHashimoto A, Iriyama T, Sayama S Fujii T et al. Adenomyosis and adverse perinatal outcomes: increased risk of second trimester miscarriage, preeclampsia, and placental malposition. J Matern Fetal Neonatal Med, 2018, 31p 1–6.\nTamura H, Maekawa R, Sugino N. Complications and outcomes of pregnant women with adenomyosis in Japan. Fertil Steril. 2018;110(4):e389–90.\nExacoustos C, et al. New sonographic classification of adenomyosis: do type and degree of adenomyosis correlate to severity of symptoms? J Minim Invasive Gynecol. 2019;27(6):1308–15.\nKunz G, et al. Adenomyosis in endometriosis—prevalence and impact on fertility. Evidence from magnetic resonance imaging. Hum Reprod. 2005;20(8):2309–16.\nLisa J, Rubin I, Trinidad S. Further observations on ectopic endometrium of the fallopian tube. Surg Gynecol Obstet. 1956;103(4):469.\nNa Y-J, et al. Effects of peritoneal fluid from endometriosis patients on the release of vascular endothelial growth factor by neutrophils and monocytes. Hum Reprod. 2006;21(7):1846–55.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.\nAbout this chapter\nCite this chapter\nWang, G. (2021). Adenomyosis and Infertility. In: Xue, M., Leng, J., Wong, F. (eds) Adenomyosis. Springer, Singapore. https://doi.org/10.1007/978-981-33-4095-4_7\nDownload citation\nDOI: https://doi.org/10.1007/978-981-33-4095-4_7\nPublished:\nPublisher Name: Springer, Singapore\nPrint ISBN: 978-981-33-4094-7\nOnline ISBN: 978-981-33-4095-4\neBook Packages: MedicineMedicine (R0)","source_license":"CC0","license_restricted":false}