{"paper_id":"3606d678-ee37-476c-9174-a4d9df677e6c","body_text":"Abstract\nExternal disturbances to the body are better counteracted when their nature can be predicted in advance. Here, we investigated the neural mechanisms through which probabilistic predictions shape feedback responses using functional magnetic resonance imaging (fMRI) in humans. We show that, prior to a mechanical perturbation applied to a finger, the primary motor (M1) and somatosensory (S1) cortices receive a signal that linearly encodes the expected sensory input. When perturbations reach these areas, expectations are combined with the sensory input through a simple additive mechanism, yielding motor commands that reflect a weighted sum of the two signals. At the same time, M1 and S1 receive a prediction error signal, likely from upstream regions, encoding the difference between expectations and actual sensory input. This signal is visible in fMRI data in humans and in the local field potentials in non-human primates, but not in M1-S1 spiking activity.\nCompeting Interest Statement\nThe authors have declared no competing interest.\nFootnotes\n↵* co-senior authors","source_license":"CC-BY-4.0","license_restricted":false}