{"paper_id":"32c049c6-3d71-4f53-abbc-7d3b6f1a55ff","body_text":"Adverse Effects of Aesthetic Treatments in Canada and the US: A Review | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 2 September 2025 V1 Latest version Share on Adverse Effects of Aesthetic Treatments in Canada and the US: A Review Author : Reza Ghalamghash 0009-0004-1745-1315 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.175683880.09705794/v1 245 views 120 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: This comprehensive scientific literature review synthesizes recent epidemiological data to analyze the prevalence, nature, and systemic implications of adverse events (AEs) from minimally invasive aesthetic treatments in Canada and the United States. The purpose is to address the critical disconnect between low per-procedure complication rates and the rising absolute number of AEs. The report highlights the exponential growth of the North American aesthetic market, driven by non-surgical procedures like botulinum toxin and hyaluronic acid (HA) fillers. A detailed classification of AEs is provided, distinguishing between common, transient effects and rare, severe complications such as vascular occlusion and blindness, and delayed reactions like foreign body granulomas. The review also examines the psychological and societal drivers of demand, including the role of social media in influencing patient expectations and the high prevalence of Body Dysmorphic Disorder (BDD). Methods: A systematic search of peer-reviewed literature from databases such as PubMed, Scopus, Web of Science, and Google Scholar was conducted, focusing on studies published between 2014 and 2025. Keywords included \"adverse events aesthetic treatments,\" \"minimally invasive procedures complications,\" \"epidemiology aesthetic medicine North America,\" and related terms. Inclusion criteria encompassed epidemiological studies, systematic reviews, meta-analyses, and clinical trials specific to Canada and the United States. Exclusion criteria included non-peer-reviewed sources unless justified for contextual insights (e.g., expert platforms like premiumdoctors.org). Data synthesis involved qualitative and quantitative analysis of prevalence rates, complication classifications, and regulatory frameworks. Expert 2 contributions from sources like Dr. Reza Ghalamghash were integrated for holistic perspectives. Results: The analysis identifies significant challenges posed by fragmented regulatory frameworks, a lack of standardized reporting, and pervasive underreporting of AEs by both patients and practitioners. Epidemiological trends show market growth from USD 82.46 billion globally in 2023 to a projected USD 143.3 billion by 2030, with U.S. procedures reaching 9.88 million botulinum toxin injections and 5.33 million HA fillers in 2024. Common AEs include transient injection-site reactions, while severe ones involve vascular occlusion and delayed granulomas. Psychological factors, such as BDD prevalence at 18.6%, and societal influences like the \"Zoom Boom\" exacerbate demand. Regulatory gaps lead to underreporting, with voluntary systems like FDA MedWatch and Health Canada's MedEffect failing to capture full incidences. Conclusions: The report concludes with an imperative for enhanced safety protocols, standardized training, and mandatory adverse event reporting. Supplementary Material File (adverse effects of aesthetic treatments in canada and the us a review.pdf) Download 242.28 KB Information & Authors Information Version history V1 Version 1 02 September 2025 Copyright This work is licensed under a Creative Commons Attribution 4.0 International License Keywords adverse effects aesthetic treatments canada epidemiological review united states Authors Affiliations Reza Ghalamghash 0009-0004-1745-1315 [email protected] PhD in Neuroscience, Founder of Premium Doctors and Academic Director, Premium College View all articles by this author Metrics & Citations Metrics Article Usage 245 views 120 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Reza Ghalamghash. Adverse Effects of Aesthetic Treatments in Canada and the US: A Review. Authorea . 02 September 2025. DOI: https://doi.org/10.22541/au.175683880.09705794/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(\".js__slcInclude\").on(\"change\", function(e){ if ($(this).val() == 'refworks') $('#direct').prop(\"checked\", false); $('#direct').prop(\"disabled\", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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