{"paper_id":"322c6d7c-ab55-4958-8a15-a8cd947df86b","body_text":"Summary\nThe aim of this study is to assess the impact of atypical endometriosis on fertility as well as the effect of treatment in endometriosis-related infertility. A prospective randomized study comparing the effects of triptorelin (Arvekap, Ipsen) and danazol (Danatrol, Winthrop) was completed recently. The 103 patients (aged 30.9±4.92, range 21–41) who finished the study were divided into three comparable (infertility duration, age) groups. Group A (n=37) received danazol (600 mg/day) for 6 months, Group B (n=32) received triptorelin (3.75 mg) injections, one every 28 days for 6 months, and Group C (n=34) did not receive any kind of treatment. More pregnancies were observed in Group B (65.62%) compared with Group C (20.58%, p=0.00012) but not compared with Group A (54.05%, p=0.05857). The overall monthly fecundity rate in Group B was 0.11, and differences concerning spontaneous abortion rates were not observed. Our results indicate that danazol and triptorelin are equally effective in the treatment of atypical endometriosis-related infertility.\nSimilar content being viewed by others\nReferences\nBarlow D.M., Am. J. Obstet. Gynecol., 125 (1976) 412.\nSoules H.A., Malinak L.R., Bury R. and Poindexter A., Am. J. Obstet. Gynecol., 125 (1976) 412.\nWallace A.M., Lees D.A.R., Roberts A.D.G. and Gray C.E., Acta Endocrinol., 107 (1984) 445.\nMuse K., In Wilson E.A. (Ed.) Endometriosis, Liss, New York, NY, U.S.A., 1987, p. 94.\nBadaway S.Z., Marshall L. and Cuenca V., Int. J. Fertil., 30 (1985) 48.\nYlikorkala O., Koskimies A.I., Laatkainen T. and Penhusen A., Obstet. Gynecol., 63 (1984) 616.\nBrosens I.A., Koninckx P.R. and Corveleyn P.A., Br. J. Obstet. Gynaecol., 85 (1978) 246.\nCoutinho E.M., Am. J. Obstet. Gynecol., 144 (1982) 898.\nLemay A., Maheux R., Faure N., Jean C. and Fazekas A.T.A., Fertil. Steril., 41 (1984) 863.\nDonnez J., Nisolle M., Clerckx F. and Casanas-Roux F., Gynecol. Endocrinol., 2 (1988) 84.\nDmowski W.P. and Cohen M.R., Am. J. Obstet. Gynecol., 130 (1978) 41.\nGreenblatt R.B. and Tzingounis V.A., Fertil. Steril., 32 (1978) 518.\nGuzick D.S. and Rock J.A., Fertil. Steril., 40 (1983) 580.\nButler L., Wilson E., Belisle S., Gibson M., Albrecht B., Schiff I. and Stillman R., Fertil. Steril., 41 (1984) 373.\nButtramJr. V.C., Reiter P.-C. and Ward S., Fertil. Steril., 43 (1985) 353.\nFedele L., Parazzini F., Radici E., Bocciolone L., Bianchi S., Bianchi C. and Candiani G.B., Am. J. Obstet. Gynecol., 166 (1992) 1345.\nHenzl M.R., Cirson S.L., Maghissi K., Buttram V.A., Bergvist C. and Jacobson J., New Engl. J. Med., 318 (1988) 485.\nFedele L., Bianchi S., Arcaini L., Vercellini P. and Candian G.B., Am. J. Obstet. Gynecol., 161 (1989) 871.\nFranssen A.M.H.W., Zijlstra K.A., Kauer F.M., Rolland R. and Chadha D.R., Fertil. Steril., 51 (1989) 401.\nHughes E.G., Fedorkkow D.M. and Collins J.A., Fertil. Steril., 59 (1993) 963.\nJansen R.P. and Russel P., Am. J. Obstet. Gynecol., 155 (1986) 1154.\nThomas E.J. and Cooke I.D., Br. Med. J., 294 (1987) 117.\nBrosens I.A., Acta Obstet. Gynecol. Scand., 159 (1994) 18.\nPetersohn L., Acta Obstet. Gynecol. Scand., 49 (1970) 331.\nNaples J.D., Batt R.E. and Sadigh H., Obstet. Gynecol., 57 (1981) 509.\nOlive D.L., Franklin R.R. and Gratkins D., J. Reprod. Med., 27 (1982) 333.\nLemay A., Maheux R. and Dodin-Dewailly S., In Boutaleb Y. and Gzouli A. (Eds.) The Treatment of Endometriosis, The Parthenon Publishing Group, Casterton Hall Canforth, U.K., 1991, pp. 17–30.\nTzingounis V.A., Cardamakis E., Lioutas G.P. and Pappas A.P., J. Am. Assoc. Gynecol. Laparoscopists, 2 (1995) S.54.\nVernon M.S., Beard J.S., Graves K. and Wilson E.A., Fertil. Steril., 42 (1986) 801.\nRedwine D.B., Fertil. Steril., 47 (1987) 1062.\nTzingounis, V.A. and Cardamakis, E., 4th World Congress of Endometriosis, Salvador de Bahia, Brazil, May 25–28, 1994, Abstract FC-10.\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nTzingounis, V.A., Cardamakis, E. Danazol versus [d-Trp6]GnRH agonist for the management of infertility due to atypical endometriosis. Lett Pept Sci 3, 247–251 (1996). https://doi.org/10.1007/BF00128115\nReceived:\nAccepted:\nIssue date:\nDOI: https://doi.org/10.1007/BF00128115","source_license":"CC0","license_restricted":false}