{"paper_id":"322b3a3b-1dd4-4ca1-bc1f-3e1400d24f57","body_text":"Abstract\nAdult stem cells have a major role in endometrial physiology, remodeling, and repair, but they also have a critical role in the development and progression of endometriosis. Bone marrow-derived stem cells (BMDSCs) engraft eutopic endometrium and endometriotic lesions, showing stromal and epithelial fate. Nevertheless, circulating BMDSCs are in limited supply, and the presence of endometriosis depletes stem cells from the blood circulation, preventing their homing in the uterus. Furthermore, stem cells migrate from endometriotic lesion into the uterus, leading to a dysfunctional endometrium. Stem cell trafficking is a central feature of endometriosis. Understanding molecular mechanisms regulating cell mobility and engraftment in endometriosis may reveal new targets for treatment.\nSimilar content being viewed by others\nReferences\nGargett CE, Schwab KE, Deane JA. 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Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin North Am. 2012;39(4):535–549.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nPluchino, N., Taylor, H.S. Endometriosis and Stem Cell Trafficking. Reprod. Sci. 23, 1616–1619 (2016). https://doi.org/10.1177/1933719116671219\nPublished:\nIssue date:\nDOI: https://doi.org/10.1177/1933719116671219","source_license":"CC0","license_restricted":false}