{"paper_id":"31fc2f6c-67e8-4317-9024-26869f3693be","body_text":"Abstract\nObjective\nProgestin-only contraceptives are commonly used in women with contraindications for the use of combined hormonal contraception. They are also important treatment options for medical conditions like endometriosis. Although it is well known that progestins may have a negative impact on mood, little is known on how to identify women at risk and the course of such an adverse event after discontinuation. This case series aimed to evaluate the onset and reversibility of depressive symptoms, as well as potential risk factors for the development of mood problems in new-starters of progestins.\nMethods\nCase series of patients, who reported symptoms of depression after initiating use of a synthetic progestin.\nResults\nSeven women reported depressive symptoms after newstart with desogestrel, dienogest or the LNG-IUS 52 mg. Symptom onset was within 3 months in six cases. One woman reported a family history of depression. In all users symptoms resolved soon after discontinuation. Three patients had experienced mood problems with another progestin in the past. After symptoms had resolved two patients tolerated another progestin method.\nConclusion\nDepressive symptoms after newstart of a progestin came up soon. It is promising that symptoms resolved within few weeks after discontinuation. Close follow-up of all newstarters is recommended.\nSHORT CONDENSATION\nA case series evaluating timing of symptom onset and reversibility of depressive symptoms induced by progestin use. Risk factors could not be identified in the history before prescription for most women. Therefore close follow-up and information of newstarters are relevant.\n摘要\n目的\n单孕激素避孕药常用于联合激素避孕禁忌的女性, 同时在子宫内膜异位症等疾病的治疗中具有重要作用。尽管已有证据提示孕激素可能对情绪产生不良影响, 但关于如何识别高风险人群及停药后症状转归的研究仍然有限。本研究旨在探讨新使用孕激素者抑郁症状的发生时间、可逆性及相关危险因素。\n方法\n收集并分析使用合成孕激素后出现抑郁症状患者的病例。\n结果\n共7例女性在新开始使用去氧孕酮、地诺孕酮或52 mg左炔诺孕酮宫内系统后出现抑郁症状, 其中6例在3个月内发病。1例患者有抑郁家族史。所有患者在停药后症状均迅速缓解。另有3例患者既往使用其他孕激素时亦曾出现情绪问题。症状缓解后, 2例能够耐受另一种孕激素方法。\n结论\n新使用孕激素者的抑郁症状多在早期即出现, 且在停药后可于数周内逆转。建议对孕激素新使用者进行密切监测与随访。\nEthical statement\nBy the regulation of the Cantonal Ethics Committee of Zürich, Switzerland, this research fulfils the criteria of a «practical experience report», where no additional ethical approval besides a written general consent to analyse the medical data obtained during clinical routine is required. This general consent form was obtained from all patients.\nDisclosure statement\nNo potential conflict of interest was reported by the author(s).\nData availability statement\nThe data that support the findings of this study are available from the corresponding author, [am], upon reasonable request.","source_license":"CC0","license_restricted":false}