{"paper_id":"31d80676-1282-47aa-8048-fbe34bf99641","body_text":"Abstract\nIntroduction\nEndometriosis is the condition in which there are ectopic endometrial tissues outside the uterine cavity. The use of nerve sparing technique has been well established in the field of oncology, leading to better quality of life following radical oncologic procedures without compromising on the long-term survival. The objective of this study is to compare the quality of life in terms of sexual function and urinary function in women undergoing nerve sparing surgeries for endometriosis and those undergoing non-nerve sparing surgeries.\nMaterial and Methods\nData of 51 patients operated for endometriosis at Galaxy Care Laparoscopic Institute, Pune, India between 1st January 2020 till 31st December 2020 were collected and analysed. We included patients in age group between 38 and 44 years in monogamous relationship, with moderate to severe endometriosis (Revised American Society of Reproductive Medicine r-ASRM score of 16 and above 5), being operated for hysterectomy along with ureterolysis and/or bowel resection (including shaving of rectal endometriosis, discoid resection, segmental resection), and excision of large ovarian endometriomas (> 3 cm size) with cul-de-sac obliteration.\nResults\nThe patients were evaluated for the following factors: age, parity, nature of surgery done, immediate intraoperative complications (bowel injury, bladder injury, ureteric injury), operative time in minutes, average blood loss, length of hospital stay, days to removal of foley’s catheter and postoperative urinary and sexual function which were assessed on follow up visit and a 1-year follow up interview. We found that the urinary and sexual function in the group undergoing nerve sparing surgeries was significantly better than the patients undergoing non-nerve sparing surgeries.\nConclusion\nLaparoscopic nerve sparing approach for clearance of endometriosis has allowed better quality of life post surgery. Proper understanding and demonstration of pelvic neuroanatomy has made this approach feasible and achievable in carefully selected patients.\nSimilar content being viewed by others\nReferences\nVercellini P, Viganò P, Somigliana E, et al.. Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol. 2014;10(5):261–75. https://doi.org/10.1038/nrendo.2013.255.\nDunselman GA, Vermeulen N, Becker C, et al. ESHRE guideline: management of women with endometriosis. Hum Reprod. 2014;29:400–12.\nLong Y, Yao DS, Pan XW, et al. Clinical efficacy and safety of nerve-sparing radical hysterectomy for cervical cancer: a systematic review and meta-analysis. PLoS ONE. 2014;9(4):e94116.\nBallard KD, Seaman HE, de Vries CS, Wright JT. Can symptomatology help in the diagnosis of endometriosis? Findings from a national case-control study—Part 1. BJOG. 2008;115:1382–91.\nCanis M, Donnez JG, Guzick DS, Halme JK, et al. Revised American society for reproductive medicine classification of endometriosis: 1996. Fertil Steril. 1997;1997(67):817–21.\nPuntambekar S, Shetty TS, Goel A, et al. Single-centre experience of doing safe total laparoscopic hysterectomy: retrospective analysis of 1200 cases. J Obstet Gynaecol India. 2020;70(5):376–83. https://doi.org/10.1007/s13224-020-01333-5.\nPuntambekar SP, Palep RJ, Puntambekar SS, et al. Agarwal GA. Laparoscopic total radical hysterectomy by the Pune technique: our experience of 248 cases. J Minim Invasive Gynecol. 2007;14(6):682–9. https://doi.org/10.1016/j.jmig.2007.05.007.\nPuntambekar SP, Lawande A, Puntambekar S, et al. Nerve-sparing radical hysterectomy made easy by laparoscopy. J Minim Invasive Gynecol. 2014;21(5):732. https://doi.org/10.1016/j.jmig.2014.03.020.\nLemos N, Souza C, Marques RM, et al. Laparoscopic anatomy of the autonomic nerves of the pelvis and the concept of nerve-sparing surgery by direct visualization of autonomic nerve bundles. Fertil Steril. 2015;104(5):e11–2. https://doi.org/10.1016/j.fertnstert.2015.07.1138.\nCeccaroni M, Clarizia R, Roviglione G. Nerve-sparing surgery for deep infiltrating endometriosis: laparoscopic eradication of deep infiltrating endometriosis with rectal and parametrial resection according to the Negrar method. J Minim Invasive Gynecol. 2020;27(2):263–4. https://doi.org/10.1016/j.jmig.2019.09.002.\nCeccaroni M, Clarizia R, Bruni F, et al. Nerve-sparing laparoscopic eradication of deep endometriosis with segmental rectal and parametrial resection: the Negrar method. A single-center, prospective, clinical trial. Surg Endosc. 2012;26(7):2029–45. https://doi.org/10.1007/s00464-012-2153-3.\nRabischong B, Botchorishvili R, Bourdel N, et al. Les techniques de préservation nerveuse dans la chirurgie de l’endométriose profonde pour prévenir les séquelles fonctionnelles urinaires et digestives: modalités techniques et résultats. RPC Endométriose CNGOF-HAS [Nerve sparing techniques in deep endometriosis surgery to prevent urinary or digestive functional disorders: techniques and results: CNGOF-HAS Endometriosis Guidelines]. Gynecol Obstet Fertil Senol. 2018;46(3):309–13. https://doi.org/10.1016/j.gofs.2018.02.031.\nFritzer N, Hudelist G. Love is a pain? Quality of sex life after surgical resection of endometriosis review. Eur J Obstet Gynecol Reprod Biol. 2016. https://doi.org/10.1016/j.ejogrb.2016.04.036.\nKossi J, Setala M, Makinen J, et al. Quality of life and sexual function 1 year after laparoscopic rectosigmoid resection for endometriosis. Colorectal Dis. 2013;15:102–8.\nFerrero S, Abbamonte LH, Giordano M, et al. Deep dyspareunia and sex life after laparoscopic excision of endometriosis. Hum Reprod. 2007;22:1142–8.\nAbbott JA, Hawe J, Clayton RD, et al. The effects and effectiveness of laparoscopic excision of endometriosis: a prospective study with 2–5 year follow-up. Hum Reprod. 2003;18:1922–7.\nFunding\nNone.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEthics declarations\nConflict of interest\nThe authors declare no conflict of interest.\nEthical Standards\nThis is a prospective study involving human participants and was in accordance with the ethical standards of the institutional ethics committee and with the 1964 Helsinki Declaration and its later amendments.\nEthical Approval\nTaken from Institutional Ethics Committee (IEC).\nInformed consent\nTaken from all the included subjects.\nAdditional information\nPublisher's Note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nDr. Shailesh P Puntambekar (MS) is an Medical Director; Dr. Sneha Venkateswaran (MS, DNB (OBGY)) is an Fellow in Minimal Access Surgery – Gynaecology; Dr. Saranya Naidu (DGO, DNB (OBGY)) is an Fellow in Minimal Access Surgery; Dr. Maitreyee Parulekar (MS (OBGY)) is an Fellow in Minimal Access Surgery – Gynaecology; Dr. Madhavi Patil (DGO, DNB (OBGY)) is an Fellow in Minimal Access Surgery – Gynaecology; Dr. Sravya Inampudi (MS) is an Fellow in Minimal Access Surgery; Dr. Mihir Chitale (DNB, FMAS) is an Consultant Surgeon; Dr. Suyog Bharambe (MS, FMAS) is an Consultant Surgeon; Dr. Aishwarya Puntambekar (MS) is an Fellow in Minimal Access Surgery; Dr. Kshitij Manerikar (MS) is an Consultant Surgeon; Dr. Seema Puntambekar (MD, DGO) is an Consultant Gynaecologist and Chief Medical Admin.\nRights and permissions\nSpringer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.\nAbout this article\nCite this article\nPuntambekar, S.P., Venkateswaran, S., Naidu, S. et al. Endometriosis Resection Using Nerve Sparing Versus Non-nerve Sparing Surgical Techniques. J Obstet Gynecol India 73, 421–427 (2023). https://doi.org/10.1007/s13224-023-01794-4\nReceived:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s13224-023-01794-4","source_license":"CC0","license_restricted":false}