{"paper_id":"3010bae8-8c9a-4e19-8e87-c7448b5c1d7e","body_text":"Abstract\nKisspeptin is now known to be an important regulator of the hypothalamic-pituitary-gonadal axis and is the target of a range of regulators, such as steroid hormone feedback, nutritional and metabolic regulation. Kisspeptin binds to its cognate receptor, KISS1R (also called GPR54), on GnRH neurons and stimulates their activity, which in turn provides an obligatory signal for GnRH secretion—thus gating down-stream events supporting reproduction. The development of peripherally active kisspeptin antagonists could offer a unique therapeutic agent for treating hormone-dependent disorders of reproduction, including precocious puberty, endometriosis, and metastatic prostate cancer. The following chapter discusses the advances made in the search for both peptide and small molecule kisspeptin antagonists and their use in delineating the role of kisspeptin within the reproductive system. 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Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6199-9_8\nDownload citation\nDOI: https://doi.org/10.1007/978-1-4614-6199-9_8\nPublished:\nPublisher Name: Springer, New York, NY\nPrint ISBN: 978-1-4614-6198-2\nOnline ISBN: 978-1-4614-6199-9\neBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)\nKeywords\nThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.","source_license":"public-domain-us","license_restricted":false}