{"paper_id":"2f43377b-4e0c-4c7c-a286-5a18e2f6ec29","body_text":"The study of relationship between the expression of VEGF and Ang-2 and Tie-2 in endometriosis\nAbstract\nObjective: To detect the expression of VEGF (vascular endothelial growth factor), Ang-2 (angiopoietin-2) and Tie-2 in endometriosis (EMs) and their correlations with menstrual cycle and clinical stage.\nMethods: Thirty specimens of normal endometrium, eutopic endometrium and ectopic endometrium tissues were collected. The expression of VEGF, Ang-2 and Tie-2 was detected by immunohistochemistry methods.\nResults: The positive rate of expression of VEGF in the normal endometrium, eutopic endometrium and ectopic endometrium tissues gradually increased (16.67%, 86.67%, 90.00%), compared three groups (p < .01). The positive rate of expression of Ang-2 in the normal endometrium, eutopic endometrium and ectopic endometrium tissues was 33.33%, 70.00%, 60.00%, respectively (p < .05). The positive rate of expression of Tie-2 in the normal endometrial, eutopic endometrium and ectopic endometrial tissues was 13.33%, 50.00%, 40.00%, respectively (p < .01). The expression of VEGF, Ang-2 and Tie-2 was closely correlated with each other (r = 0.875, r = 0.905, r = 0.898).\nConclusions: Our findings suggest that there is a close relation between VEGF, Ang-2 and Tie-2, the up-regulation of VEGF and Ang-2 may cooperatively contribute to survival and invasion of EMs. This may provide new targets for therapy of EMs.\nFull Text:\nPDFDOI: https://doi.org/10.5430/dcc.v3n2p7\nRefbacks\n- There are currently no refbacks.\nDiscussion of Clinical Cases ISSN 2375-8449(Print) ISSN 2375-8473(Online)\nCopyright © Sciedu Press\nTo make sure that you can receive messages from us, please add the 'sciedu.ca' and ‘sciedupress.com’ domains to your e-mail 'safe list'. If you do not receive e-mail in your 'inbox', please check your 'spam' or 'junk' folder.","source_license":"CC0","license_restricted":false}