{"paper_id":"2ea31122-956b-47cb-9cae-98ad7eb09e06","body_text":"Biomarkers of endometriosis: How far have we come and where are we going?\nDOI:\nhttps://doi.org/10.6016/ZdravVestn.3056Keywords:\nendometriosis, diagnosis, biomarkers, proteomics, hypothesis generatingAbstract\nEndometriosis is a common gynaecological disease that is characterized by endometrium-like tissue outside the uterine cavity. Endometriosis significantly compromises the quality of life of women and is a major cause of infertility. The gold standard for diagnosis of endometriosis is visual inspection by laparoscopy, which significantly prolongs the time to final diagnosis. This lack of non-invasive diagnostic approaches is why the discovery of biomarkers for endometriosis has been defined as a research priority. In this report, we describe hypothesis-driven and hypothesis-generating approaches for biomarker discovery, along with some important potential biomarkers of endometriosis and their diagnostic characteristics, sensitivities, and specificities. Finally, we present our perspective on the discovery of biomarkers for endometriosis, and discuss some results from our previous and more recent studies. Future studies must focus on improving patient quality of life rather than on discovering significant differences, and therefore close collaboration between clinicians and pre-clinical researchers is essential.\nDownloads\nReferences\n1. Rogers PA, D’Hooghe TM, Fazleabas A, Giudice LC, Montgomery GW, Petraglia G, et al. Defining future directions for endometriosis research: workshop report from the 2011 World Congress of Endometriosis In Montpellier, France. Reprod Sci. 2013;20(5):483-9.\nDOI: 10.1177/1933719113477495\n2. Sampson JA. 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J Steroid Biochem Mol Biol. 2016;159:60-9.\nDOI: 10.1016/j.jsbmb.2016.02.023\nPMID: 26921767\nPublished\nIssue\nSection\nLicense\nThe Author transfers to the Publisher (Slovenian Medical Association) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.\nThe aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory\nThe Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.\nThe Publisher (Slovenian Medical Association) has the right to transfer the rights of acquired parties without explicit consent of the Author.\nThe Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.","source_license":"CC0","license_restricted":false}