{"paper_id":"2e8be8fa-c8e7-48d3-b123-3ee58a181e92","body_text":"ENDOMETRIOSIS: ETIOPATHOGENESIS, EPIDEMIOLOGY, DIAGNOSIS AND THE CURRENT STATE OF TREATMENT (LITERATURE REVIEW AND STATISTICAL ANALYSIS)\nAuthors/Creators\n- 1. Student of Impuls Medical Institute\nDescription\nThis article provides a systematic review and statistical analysis of contemporary scientific data on endometriosis, covering its epidemiology, etiopathogenetic theories, diagnostic approaches and treatment strategies. Statistical evidence from the Global Burden of Disease (GBD) studies, meta-analyses and major clinical trials is synthesized. Endometriosis affects approximately 10% of women of reproductive age, with a mean diagnostic delay of 6.6–9.7 years, and infertility observed in 30–40% of patients. The efficacy and limitations of hormonal therapy (progestins, GnRH agonists and antagonists), surgery and assisted reproductive technologies are compared. The detrimental impact of the disease on quality of life and the economy is substantiated by statistical data.\nFiles\n1338-1343.pdf\nFiles\n(256.9 kB)\n| Name | Size | Download all |\n|---|---|---|\n|\nmd5:cebcef39e7df194ee611d541d56594e7\n|\n256.9 kB | Preview Download |\nAdditional details\nReferences\n- 1.Harder C., et al. Assessing the true prevalence of endometriosis: A narrative review of literature data // International Journal of Gynecology & Obstetrics. — 2024.\n- 2.GBD 2021. Global, regional, and national burden of endometriosis among women of reproductive age, 1990–2021 // Frontiers in Global Women's Health. — 2025.\n- 3.Global prevalence of adenomyosis and endometriosis: a systematic review and meta-analysis // PubMed (PMID: 41257733). — 2025.\n- 4.Taylor H.S., Kotlyar A.M., Flores V.A. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations // The Lancet. — 2021. — Vol. 397. — P. 839–852.\n- 5.Zondervan K.T., Becker C.M., Missmer S.A. Endometriosis // New England Journal of Medicine. — 2020. — Vol. 382, No. 13. — P. 1244–1256.","source_license":"CC0","license_restricted":false}