{"paper_id":"2d6f1fb9-6c37-406e-bb0d-842c5eb9b8a2","body_text":"Summary\nTo investigate the effects of the LH-RH agonist Buserelin [D-Ser (But)6 des — Gly10 — LHRH ethylamide] on endometriosis, 64 patients were treated with 900 μg/d Buserelin intranasally over 6 months after histological verification of the disease. As shown by the follow-up operation at the end of treatment, 73% of cases showed regression of implants, whereas adhesions seemed to be unaffected. The uncorrected pregnancy rate of the 45 patients with a history of infertility was 40%, while the overall recurrence rate —confirmed by histological examination — was 9.4%. The endocrine parameters demonstrated a highly significant suppression of estradiol (E2) and a sharp decline of progesterone (Prog), indicating anovulatory cycles. Folliclestimulating hormone (FSH) was unchanged, while luteinizing hormone (LH) and prolactin (Prl) decreased significantly. The androgenic parameters testosterone (T), dehydroepiandrosterone sulfate (DHEA-S), and sex-hormone-binding globulin (SHBG) revealed no relevant changes. Influence on bone metabolism could not be detected by measuring calcitonin and parathyroid hormone fragments (PTH-C and PTH-MM). Negative metabolic effects were absent in terms of hematology, clotting system, liver enzymes, renal parameters and lipid metabolism. Remarkable was a significant increase of high-density-lipoprotein cholesterol (HDL). Subjective complaints were mostly attributed to the therapy — induced hypoestrogenism. We consider Buserelin to be an effective drug in the treatment of endometriosis, with a low incidence of relevannt side effects.\nSimilar content being viewed by others\nReferences\nAbbasi R, Hodgen GD (1986) Predicting the predisposition to osteoporosis. JAMA 255:1600–1604\nAmerican Fertility Society (1979) Classification of endometriosis. 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AFS, p 2\nWaibel S, Bremen T, Schiffl R, Scharla S, Wüster C, Ziegler R, Minne HW, Leyendecker G (1988) Bone density in patients treated with GnRH agonists for myomata and endometriosis. International Symposium on GnRH Analogues in Cancer and Human Reproduction, Geneva. (Gynecological endocrinology, vol 2) Parthenon, London, p 106\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nCirkel, U., Schweppe, K.W., Ochs, H. et al. LH-RH agonist (Buserelin): treatment of endometriosis. Arch Gynecol Obstet 246, 139–151 (1989). https://doi.org/10.1007/BF00934075\nReceived:\nAccepted:\nIssue date:\nDOI: https://doi.org/10.1007/BF00934075","source_license":"CC0","license_restricted":false}