{"paper_id":"2bdb52b2-83fe-4098-89fc-a8374232a03a","body_text":"A Real-Time 2D-3D Registration Algorithm for Spine Surgery Navigation Using Accelerated Gradient Optimization | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article A Real-Time 2D-3D Registration Algorithm for Spine Surgery Navigation Using Accelerated Gradient Optimization Jun-Ming Zhang, Yan-Yan Zhang, Ying-Ying Yan, Xiao-Xiao Xuan, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8380892/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 11 You are reading this latest preprint version Abstract Two-dimensional to three-dimensional (2D–3D) medical image registration plays a critical role in image-guided spinal surgery, enabling accurate alignment between intraoperative fluoroscopy and preoperative CT volumes. However, existing methods often suffer from slow convergence or high computational demands, limiting their use in time-sensitive clinical settings. To address this challenge, we propose a semi-automatic 2D–3D registration algorithm that integrates a grid-based initialization strategy with Nesterov-accelerated gradient (NAG) optimization. The method first coarsely aligns anatomical landmarks via vertebral segmentation on a grid, then refines the transformation parameters by maximizing a novel similarity metric—Normalized Cross-Correlation–Gradient Difference–Projection Distance Error (NGE)—using momentum-enhanced gradient descent. Evaluated on clinical spine datasets, our approach achieves a root mean square (RMS) registration error of 0.82 ± 0.15 mm with an average processing time of 15.2 seconds per case, outperforming conventional gradient descent (28.7 s) and Gauss–Newton (22.4 s) methods in both speed and accuracy. These results demonstrate the algorithm’s potential for real-time surgical navigation, where rapid and sub-millimeter precision is essential. 2D-3D image registration real-time 2D-3D registration GPU acceleration surgical navigation Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Revision requested 06 Mar, 2026 Reviews received at journal 04 Feb, 2026 Reviews received at journal 31 Jan, 2026 Reviewers agreed at journal 26 Jan, 2026 Reviewers agreed at journal 25 Jan, 2026 Reviewers agreed at journal 16 Jan, 2026 Reviewers invited by journal 14 Jan, 2026 Editor assigned by journal 12 Jan, 2026 Editor invited by journal 22 Dec, 2025 Submission checks completed at journal 22 Dec, 2025 First submitted to journal 22 Dec, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {\"props\":{\"pageProps\":{\"initialData\":{\"identity\":\"rs-8380892\",\"acceptedTermsAndConditions\":true,\"allowDirectSubmit\":false,\"archivedVersions\":[],\"articleType\":\"Research Article\",\"associatedPublications\":[],\"authors\":[{\"id\":575831205,\"identity\":\"d8907ec7-26e9-4ad5-966d-59f206ce4b4c\",\"order_by\":0,\"name\":\"Jun-Ming Zhang\",\"email\":\"\",\"orcid\":\"\",\"institution\":\"Jiyang College, Zhejiang A\\u0026F University\",\"correspondingAuthor\":false,\"prefix\":\"\",\"firstName\":\"Jun-Ming\",\"middleName\":\"\",\"lastName\":\"Zhang\",\"suffix\":\"\"},{\"id\":575831206,\"identity\":\"0db8a40d-4889-4480-aa14-ddd53b8719ef\",\"order_by\":1,\"name\":\"Yan-Yan Zhang\",\"email\":\"\",\"orcid\":\"\",\"institution\":\"Jiyang College, Zhejiang A\\u0026F University\",\"correspondingAuthor\":false,\"prefix\":\"\",\"firstName\":\"Yan-Yan\",\"middleName\":\"\",\"lastName\":\"Zhang\",\"suffix\":\"\"},{\"id\":575831207,\"identity\":\"0c719c90-6a89-4a10-a8eb-0276ed439362\",\"order_by\":2,\"name\":\"Ying-Ying Yan\",\"email\":\"\",\"orcid\":\"\",\"institution\":\"Jiyang College, Zhejiang A\\u0026F University\",\"correspondingAuthor\":false,\"prefix\":\"\",\"firstName\":\"Ying-Ying\",\"middleName\":\"\",\"lastName\":\"Yan\",\"suffix\":\"\"},{\"id\":575831208,\"identity\":\"285d965b-c662-40df-9e27-38ba2d094067\",\"order_by\":3,\"name\":\"Xiao-Xiao Xuan\",\"email\":\"\",\"orcid\":\"\",\"institution\":\"Jiyang College, Zhejiang A\\u0026F University\",\"correspondingAuthor\":false,\"prefix\":\"\",\"firstName\":\"Xiao-Xiao\",\"middleName\":\"\",\"lastName\":\"Xuan\",\"suffix\":\"\"},{\"id\":575831209,\"identity\":\"fd0869f9-5088-4b2a-b73c-722ff737e813\",\"order_by\":4,\"name\":\"Jin-Hai Wang\",\"email\":\"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAyUlEQVRIiWNgGAWjYBACxhkMDAfALPbGxocfSNPCc7jZWIIoa+CqJNLbBHiI0cE8u/nhAcY2uzz5yIdtQP12croNhBw255gBUEtyseHtxLYHBQzJxmYHCGmZkQDUso05cePsxHYDCYYDidsIa0n/ANRSn7hx5sE2CR7itOSAbDmcOF+CkXgtBQcY/x1P3MCTCAxkAyL8YjgjffMHhjPVifPbjz98+KHCTo6wlgZgQP8BMgzAKg0IKAcBeTijgQjVo2AUjIJRMDIBAOh1R79gOPb/AAAAAElFTkSuQmCC\",\"orcid\":\"\",\"institution\":\"Jiyang College, Zhejiang A\\u0026F University\",\"correspondingAuthor\":true,\"prefix\":\"\",\"firstName\":\"Jin-Hai\",\"middleName\":\"\",\"lastName\":\"Wang\",\"suffix\":\"\"}],\"badges\":[],\"createdAt\":\"2025-12-17 02:53:24\",\"currentVersionCode\":1,\"declarations\":\"\",\"doi\":\"10.21203/rs.3.rs-8380892/v1\",\"doiUrl\":\"https://doi.org/10.21203/rs.3.rs-8380892/v1\",\"draftVersion\":[],\"editorialEvents\":[],\"editorialNote\":\"\",\"failedWorkflow\":false,\"files\":[{\"id\":100540714,\"identity\":\"445ab985-0bca-4f71-9683-48b41790f2e3\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:56\",\"extension\":\"doc\",\"order_by\":0,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":2774016,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"AcceleratedGradientBasedAlgorithmforAutomatic2D3DMedicalImageRegistration.doc\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/e51b0138b57c161102d13c20.doc\"},{\"id\":100540709,\"identity\":\"b8be6d8e-c96a-4039-b128-8b465acb4946\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:55\",\"extension\":\"json\",\"order_by\":1,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":6424,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"231502666ebb42dca61d28629fd9e939.json\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/0a4c70a6362feb41a1f9eac1.json\"},{\"id\":100540708,\"identity\":\"e204e49b-488d-49a8-b15b-8e639c4391b0\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:55\",\"extension\":\"xml\",\"order_by\":2,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":141176,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"231502666ebb42dca61d28629fd9e9391enriched.xml\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/a61004a7c2044270d9d18b1a.xml\"},{\"id\":100549207,\"identity\":\"933721d2-3a80-4f3b-bb15-822db9f6272c\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:47\",\"extension\":\"eps\",\"order_by\":3,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":428,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"drawingimage1.eps\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/4a146246f9f4e2ec586eca08.eps\"},{\"id\":100548957,\"identity\":\"6e9b41f6-734b-436b-8e5a-a037f4fc6505\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:21:49\",\"extension\":\"jpeg\",\"order_by\":4,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":319033,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"floatimage1.jpeg\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/adcd1c6b181c53b6db9c3595.jpeg\"},{\"id\":100540726,\"identity\":\"55ddfcbf-5bb4-4f01-8e96-479850dcdf77\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:56\",\"extension\":\"jpeg\",\"order_by\":5,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":241862,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"floatimage2.jpeg\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/05feb7b6e65bf2deb9e90348.jpeg\"},{\"id\":100548492,\"identity\":\"dec48582-106f-4135-99d9-71395e89aae4\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:18:57\",\"extension\":\"png\",\"order_by\":6,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":100502,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"floatimage3.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/c3c07f6830218ac5678f5892.png\"},{\"id\":100549079,\"identity\":\"286b2895-1c24-494f-9ab1-8bedd8ef93ab\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:19\",\"extension\":\"png\",\"order_by\":7,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":83723,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"floatimage4.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/f672d1360755262ab4dfe586.png\"},{\"id\":100540706,\"identity\":\"4cbfe792-18ce-4f75-898a-40df159c0675\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:55\",\"extension\":\"png\",\"order_by\":8,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":195550,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"floatimage5.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/39de58f5e026ef135c140c39.png\"},{\"id\":100549446,\"identity\":\"c1cb10b0-acd9-4e9e-bebd-cce3f5f6c41d\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:23:20\",\"extension\":\"jpeg\",\"order_by\":9,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":773238,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"floatimage6.jpeg\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/a7ad4ca5cc748a52b53496e7.jpeg\"},{\"id\":100540710,\"identity\":\"90bbcd2c-2f0f-4871-b40b-89ff87f82641\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:55\",\"extension\":\"png\",\"order_by\":10,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":266475,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"floatimage7.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/030095ed0f8cc64c7cf3bff8.png\"},{\"id\":100540718,\"identity\":\"bb1e8ddc-439c-44e4-bc7f-56b993ecf956\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:56\",\"extension\":\"wmf\",\"order_by\":11,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":598,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image10.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/27f0d9c9f37765c865b2d4e9.wmf\"},{\"id\":100548507,\"identity\":\"c580dd1f-e800-4609-8412-c8b0ff699117\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:19:11\",\"extension\":\"wmf\",\"order_by\":12,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":640,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image12.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/ad2a9095b6a0de1e1c3a4c78.wmf\"},{\"id\":100540719,\"identity\":\"07dfe41b-064a-48e3-80df-7b1e21cccf59\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:56\",\"extension\":\"wmf\",\"order_by\":13,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":640,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image13.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/4c5eb880ffa060a5255f9436.wmf\"},{\"id\":100540736,\"identity\":\"8444da35-f0c9-4ad0-8609-32cf51bab77f\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:57\",\"extension\":\"wmf\",\"order_by\":14,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":640,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image14.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/d79b1b13d56e65ea32b63a00.wmf\"},{\"id\":100540754,\"identity\":\"861aa7c4-3af3-4e7e-84fc-61e66faefdf2\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:58\",\"extension\":\"wmf\",\"order_by\":15,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":640,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image15.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/e0575ed7a66b35fa6485f9e6.wmf\"},{\"id\":100540774,\"identity\":\"e351070e-fa9e-46cd-b0d2-757e21e239cd\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:58\",\"extension\":\"wmf\",\"order_by\":16,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1240,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image16.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/dff1fcf49b4e5eea953c7d87.wmf\"},{\"id\":100549293,\"identity\":\"cc0c47e8-a460-4637-a30a-54a3d7edf474\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:59\",\"extension\":\"wmf\",\"order_by\":17,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":444,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image17.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/ba32dd59acbec465c4621b72.wmf\"},{\"id\":100540751,\"identity\":\"866a5f25-06cc-4ffd-88ff-8e625ea91d1f\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:58\",\"extension\":\"wmf\",\"order_by\":18,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1236,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image18.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/2c63a66727f592cc86f7021c.wmf\"},{\"id\":100540768,\"identity\":\"7dec66a5-ad7e-477b-b2fd-fee096ae12dd\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:58\",\"extension\":\"wmf\",\"order_by\":19,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":442,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image19.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/fb3cc8609c8c939fac4ccf91.wmf\"},{\"id\":100540711,\"identity\":\"d5ce2875-175e-4aeb-b7b9-9522a2aa86ca\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:55\",\"extension\":\"wmf\",\"order_by\":20,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":442,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image20.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/a748d2bc35d9a2a56ffb66b5.wmf\"},{\"id\":100548684,\"identity\":\"3ab62747-1a48-439f-9c8c-f4981bb7152a\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:20:23\",\"extension\":\"wmf\",\"order_by\":21,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":444,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image21.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/7ce89784a72d22c7f1914fc2.wmf\"},{\"id\":100540730,\"identity\":\"852294a3-63d3-4f62-93d9-85f66f2576bb\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:57\",\"extension\":\"wmf\",\"order_by\":22,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":530,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image22.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/bc55290963be2880f1e1616f.wmf\"},{\"id\":100549199,\"identity\":\"21e858c0-db6e-441c-94b8-8d328dfc3822\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:45\",\"extension\":\"wmf\",\"order_by\":23,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":530,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image23.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/393ab2ff385ba12fb9efbecf.wmf\"},{\"id\":100540740,\"identity\":\"f3f53de1-623b-4722-bf15-73ae173f5f0e\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:57\",\"extension\":\"wmf\",\"order_by\":24,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":530,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image24.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/76c029d2570fcf8b8a438970.wmf\"},{\"id\":100548592,\"identity\":\"34c7909f-fac6-4093-bfdc-2ea48a7d0237\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:19:45\",\"extension\":\"wmf\",\"order_by\":25,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":426,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image25.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/1fa9ff3b77be3320637eede6.wmf\"},{\"id\":100540713,\"identity\":\"7aa2971f-712e-4ba6-bfeb-d2f19d9ad8f5\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:56\",\"extension\":\"wmf\",\"order_by\":26,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":426,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image26.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/f73ba0ff6ecdf5797ba59cff.wmf\"},{\"id\":100548940,\"identity\":\"fcaa715f-e2aa-46e7-af18-3d9449626b3a\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:21:42\",\"extension\":\"wmf\",\"order_by\":27,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":654,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image27.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/e1060615935f0e295b15bb8b.wmf\"},{\"id\":100540756,\"identity\":\"af3e67ac-5663-44e2-8a71-a46d2793a5f8\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:58\",\"extension\":\"wmf\",\"order_by\":28,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":530,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image28.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/e5fd65cef8b23de396d3434e.wmf\"},{\"id\":100549193,\"identity\":\"9d3648f5-96c4-490a-a068-db7d51e5f3ad\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:44\",\"extension\":\"wmf\",\"order_by\":29,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":530,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image29.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/728edbeeb9afedaceec877d0.wmf\"},{\"id\":100540761,\"identity\":\"d841bcb6-7719-4210-8ae6-804d23e051fd\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:58\",\"extension\":\"wmf\",\"order_by\":30,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":426,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image30.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/eece63b5a299c16cafea5fd6.wmf\"},{\"id\":100549119,\"identity\":\"e113412f-caae-4d2d-9dd7-ba820f2e3f0e\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:29\",\"extension\":\"wmf\",\"order_by\":31,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":426,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image31.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/6ef3c81cc59607f815791a69.wmf\"},{\"id\":100549030,\"identity\":\"154c9b1e-7dc1-4fc5-a39b-2342f1c53ae5\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:04\",\"extension\":\"wmf\",\"order_by\":32,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":530,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image32.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/4874ee2ce63b17150b9a7407.wmf\"},{\"id\":100540735,\"identity\":\"cb2b7376-ca9a-4ae7-863b-27de210139cb\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:57\",\"extension\":\"wmf\",\"order_by\":33,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":720,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image33.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/afdcf409a056c045a6ec8a2e.wmf\"},{\"id\":100549317,\"identity\":\"5806860f-04cd-4164-8db8-8d1cbb3f2acb\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:23:01\",\"extension\":\"wmf\",\"order_by\":34,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":336,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image34.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/d62f5c77da3db985b21347aa.wmf\"},{\"id\":100540722,\"identity\":\"d49fbad4-6c76-4a90-be9d-e4b2c5d66709\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:56\",\"extension\":\"wmf\",\"order_by\":35,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":336,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image35.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/86fef08d5244cf28879d8e25.wmf\"},{\"id\":100548320,\"identity\":\"672ece11-921f-4809-9fe3-4a968a4b2c62\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:18:13\",\"extension\":\"wmf\",\"order_by\":36,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":530,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image36.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/bd9aa470eca56807f7bd6986.wmf\"},{\"id\":100548739,\"identity\":\"ef6f61f2-80da-465b-9b7f-59c4bd7a7f07\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:20:46\",\"extension\":\"wmf\",\"order_by\":37,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":924,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image37.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/690224739399d34d3de33b32.wmf\"},{\"id\":100540729,\"identity\":\"0a892541-7b5c-42bc-ae22-afd3b3139c3f\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:56\",\"extension\":\"wmf\",\"order_by\":38,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":336,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image38.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/153b44a310d9a4ab6b12ba15.wmf\"},{\"id\":100548288,\"identity\":\"17499913-bb5f-49ea-8b4e-a457ad6c13d2\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:18:05\",\"extension\":\"wmf\",\"order_by\":39,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":336,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image39.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/a97adeca5fdf3d8f44950518.wmf\"},{\"id\":100548381,\"identity\":\"69470634-8cef-4001-bb28-c38ff3a32c45\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:18:27\",\"extension\":\"wmf\",\"order_by\":40,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":608,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image4.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/e06629af79bd74ef87e17fc4.wmf\"},{\"id\":100540786,\"identity\":\"43184f12-77cb-48f4-9239-226e460e7986\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:59\",\"extension\":\"wmf\",\"order_by\":41,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":336,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image40.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/e669ee053fe64e89fb572b7e.wmf\"},{\"id\":100540725,\"identity\":\"1a0658ea-a0b4-4b99-8453-e2c40e36a96e\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:56\",\"extension\":\"wmf\",\"order_by\":42,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":820,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image41.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/6236d549e6b11b31bcd04af9.wmf\"},{\"id\":100549443,\"identity\":\"b7461e57-b3e8-4d7a-8b00-8b0c7788d5df\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:23:19\",\"extension\":\"wmf\",\"order_by\":43,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":424,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image42.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/c08fb772ee78b893e5f5f928.wmf\"},{\"id\":100540743,\"identity\":\"0a6a7a10-dde6-4c59-bec9-665ae38f14c0\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:57\",\"extension\":\"wmf\",\"order_by\":44,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1860,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image43.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/6154b2ed7e30b903550fce12.wmf\"},{\"id\":100540742,\"identity\":\"f5c2464f-7062-403c-aa86-3929be18aed2\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:57\",\"extension\":\"wmf\",\"order_by\":45,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":3150,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image45.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/98d432206f89ed5759aec29f.wmf\"},{\"id\":100549323,\"identity\":\"7047716c-d4e7-4335-9f87-a7c8f54ae6ef\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:23:02\",\"extension\":\"wmf\",\"order_by\":46,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1216,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image46.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/cb15f22448db9cbc1e389ce7.wmf\"},{\"id\":100540734,\"identity\":\"cb34c5e7-10ec-45e7-95e7-5b5fc450e315\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:57\",\"extension\":\"wmf\",\"order_by\":47,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":544,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image47.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/c72bf4fa95d120c5da4e9dd6.wmf\"},{\"id\":100540764,\"identity\":\"a18dc5ba-b1fa-4251-bbfa-25da180ecf43\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:58\",\"extension\":\"wmf\",\"order_by\":48,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":440,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image48.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/ee535b2a94a426feb04f4ab9.wmf\"},{\"id\":100540727,\"identity\":\"8f5c8528-fba3-4a13-8b34-263ab1bbbbca\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:56\",\"extension\":\"wmf\",\"order_by\":49,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":336,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image49.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/cb54c711ef2eb31bc3425ebc.wmf\"},{\"id\":100540745,\"identity\":\"56babfff-7068-4e93-ad18-44f09005bbe3\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:57\",\"extension\":\"wmf\",\"order_by\":50,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":488,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image5.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/8941f44ec6fba290e2daccee.wmf\"},{\"id\":100540773,\"identity\":\"db31348e-5a08-4353-a12a-07a85e8e3d89\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:58\",\"extension\":\"wmf\",\"order_by\":51,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":458,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image50.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/2093891eade7a3abe015bdf8.wmf\"},{\"id\":100540796,\"identity\":\"1ce52429-907d-4211-b3eb-4d973b6f1b79\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:00\",\"extension\":\"wmf\",\"order_by\":52,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":336,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image51.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/62458ed968f317186daa5d5f.wmf\"},{\"id\":100540783,\"identity\":\"6d9c6e3f-c919-40f1-9998-119d94c9dfe2\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:59\",\"extension\":\"wmf\",\"order_by\":53,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":594,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image52.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/7b6eab68c55d014261c258cd.wmf\"},{\"id\":100548946,\"identity\":\"e0cad5f7-7473-4eba-954e-f15ec19d224a\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:21:43\",\"extension\":\"wmf\",\"order_by\":54,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1904,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image53.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/b464d27254a3a75cdcc972ff.wmf\"},{\"id\":100540824,\"identity\":\"40e1d134-44ce-4c90-a447-197cab7ff773\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:01\",\"extension\":\"wmf\",\"order_by\":55,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1536,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image54.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/3a37feb093ddf03a876fd15b.wmf\"},{\"id\":100548982,\"identity\":\"19470453-fa6a-4296-9765-910ec61b71b5\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:21:54\",\"extension\":\"wmf\",\"order_by\":56,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":552,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image55.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/9d3fd99c2908f31a4cdab4c2.wmf\"},{\"id\":100548764,\"identity\":\"146b6d2b-37c2-4e0b-ad3a-ded499d4f523\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:20:49\",\"extension\":\"wmf\",\"order_by\":57,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":544,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image56.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/b97935a16ee2ceea32ab0135.wmf\"},{\"id\":100549065,\"identity\":\"17908932-637c-48c2-89c5-5ef9b95c9070\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:17\",\"extension\":\"wmf\",\"order_by\":58,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":424,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image57.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/b3732aea93eee49c9756e522.wmf\"},{\"id\":100549017,\"identity\":\"e588eb9e-978a-4f42-88a1-027064c840e9\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:04\",\"extension\":\"wmf\",\"order_by\":59,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":512,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image58.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/0c6131e9fa8f92c4d016b0c4.wmf\"},{\"id\":100540808,\"identity\":\"fdc46495-83b0-4210-af51-38c20295f4e1\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:00\",\"extension\":\"wmf\",\"order_by\":60,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":512,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image59.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/2d2f015949b85e2e58459ad8.wmf\"},{\"id\":100549274,\"identity\":\"43d5e7c9-dee8-4856-93e3-bda5ed5672dd\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:59\",\"extension\":\"wmf\",\"order_by\":61,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":652,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image6.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/ec1c17d3795a7a4982a85473.wmf\"},{\"id\":100548846,\"identity\":\"78301843-64be-4e53-a388-f3b4f66252a9\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:21:13\",\"extension\":\"wmf\",\"order_by\":62,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":424,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image60.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/94251fae0a3e6b224b79d9a0.wmf\"},{\"id\":100540758,\"identity\":\"be648efd-f5f7-4e36-8996-5de719fa3a12\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:58\",\"extension\":\"wmf\",\"order_by\":63,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":698,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image61.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/2f5eacb0c2f86a6ff04e6e6a.wmf\"},{\"id\":100540814,\"identity\":\"15f00230-4d22-41fe-9aed-3b6092a22c19\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:01\",\"extension\":\"wmf\",\"order_by\":64,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":440,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image62.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/6636cc66c5ea8b3715d7ca40.wmf\"},{\"id\":100548757,\"identity\":\"c5a07023-2983-4825-a1f7-d697f80be22a\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:20:49\",\"extension\":\"wmf\",\"order_by\":65,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1162,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image63.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/ba3b7bd454f1b5b137d9e6b0.wmf\"},{\"id\":100540747,\"identity\":\"4234546b-8746-46c8-8b07-d592c497bc15\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:57\",\"extension\":\"wmf\",\"order_by\":66,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":592,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image64.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/15d8cef9cbd36b0871c58bf3.wmf\"},{\"id\":100540772,\"identity\":\"98969432-5d65-4923-99ec-d1cdd074dad9\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:58\",\"extension\":\"wmf\",\"order_by\":67,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":476,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image65.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/3adc8753a457e5e7a0ad02d5.wmf\"},{\"id\":100540757,\"identity\":\"a3000764-e6ea-434e-a819-fe2d8efb2e7b\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:58\",\"extension\":\"wmf\",\"order_by\":68,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1208,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image67.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/187cee110da6a9e58045d03e.wmf\"},{\"id\":100549457,\"identity\":\"ca81aa11-29c7-4b6c-962f-f73239f4e094\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:23:22\",\"extension\":\"wmf\",\"order_by\":69,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":736,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image68.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/1b83a62bbb5288042d18c159.wmf\"},{\"id\":100548824,\"identity\":\"3b55f8ac-8afc-4941-a4ff-e8c68deea8e9\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:21:04\",\"extension\":\"wmf\",\"order_by\":70,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":528,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image69.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/aa261956f1d2447c3d4b4a2e.wmf\"},{\"id\":100540750,\"identity\":\"0baeadfc-af58-4e25-9c3e-9f3852e0ddf1\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:57\",\"extension\":\"wmf\",\"order_by\":71,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":704,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image7.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/4daf3352f8b92a47c65395e3.wmf\"},{\"id\":100549054,\"identity\":\"5ec24e1b-9160-4b96-a8cc-e0b2547b8ce0\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:12\",\"extension\":\"wmf\",\"order_by\":72,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":528,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image70.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/30a64aa792191e812b723fda.wmf\"},{\"id\":100594215,\"identity\":\"67c3cc35-f40d-40a1-8ac4-a53a77a6b93e\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 13:36:59\",\"extension\":\"wmf\",\"order_by\":73,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1432,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image71.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/9f35a77dece053a464273f6d.wmf\"},{\"id\":100540820,\"identity\":\"bc0fd019-8dc0-4e4f-9751-02b48d4f9ba6\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:01\",\"extension\":\"wmf\",\"order_by\":74,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1216,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image72.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/c1e724c4b7a31f71ccca284d.wmf\"},{\"id\":100548962,\"identity\":\"0dd029d8-bc61-4284-b6be-f007d2f99cde\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:21:50\",\"extension\":\"wmf\",\"order_by\":75,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":736,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image73.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/bfc4afdb28a02f95e12f52c7.wmf\"},{\"id\":100540771,\"identity\":\"521862db-3621-4d8a-831b-265766b3cace\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:58\",\"extension\":\"wmf\",\"order_by\":76,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":528,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image74.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/d2331f22b806e5d11dd79d3c.wmf\"},{\"id\":100540860,\"identity\":\"055bc12e-44e1-4c87-bd5a-29831eed4e02\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:02\",\"extension\":\"wmf\",\"order_by\":77,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":512,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image75.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/7f4d36070918923543fe2c10.wmf\"},{\"id\":100548697,\"identity\":\"3a49d3d2-aa38-4eae-8274-9b17a20033f6\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:20:29\",\"extension\":\"wmf\",\"order_by\":78,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":528,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image76.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/fb92daeaa6feb4c87fa1815f.wmf\"},{\"id\":100549131,\"identity\":\"fdf5f256-1963-454a-b5ec-afcf5493503a\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:31\",\"extension\":\"wmf\",\"order_by\":79,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":528,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image78.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/207abd22ae6fbc6ba6701ea3.wmf\"},{\"id\":100549402,\"identity\":\"028c8565-b9f9-4d7a-ba9e-e8f1779734b8\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:23:16\",\"extension\":\"wmf\",\"order_by\":80,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":720,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image79.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/bf865034bdc0a0ca2a7f32f4.wmf\"},{\"id\":100540775,\"identity\":\"5deb157c-3c0c-450a-b1dd-69d3b50f332b\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:59\",\"extension\":\"wmf\",\"order_by\":81,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":562,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image8.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/d6f6e7d2bf1d18a3004fa817.wmf\"},{\"id\":100549041,\"identity\":\"07f0b2c2-7768-42a5-bc0a-2034d0ddb342\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:08\",\"extension\":\"wmf\",\"order_by\":82,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":752,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image80.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/18835bd73d96e0529efe17e9.wmf\"},{\"id\":100540738,\"identity\":\"776689ab-b02e-4e4e-bcc5-2cbb12a8a4e3\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:57\",\"extension\":\"wmf\",\"order_by\":83,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":840,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image81.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/21bfa493e29f38e5ff8da64a.wmf\"},{\"id\":100540811,\"identity\":\"00c006be-bedd-4faa-89f1-0273a74aa5c5\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:00\",\"extension\":\"wmf\",\"order_by\":84,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":720,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image82.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/07198708cb2a35eda522659c.wmf\"},{\"id\":100548874,\"identity\":\"90b5e471-41f8-435d-bd28-1ece3aa7dcbd\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:21:19\",\"extension\":\"wmf\",\"order_by\":85,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":720,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image83.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/67f7f5b1ae24d883e50b0277.wmf\"},{\"id\":100540802,\"identity\":\"793eed6c-d623-4183-9950-3a475b361cb6\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:00\",\"extension\":\"wmf\",\"order_by\":86,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":580,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"image9.wmf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/35473443afe8f563f631a8da.wmf\"},{\"id\":100540804,\"identity\":\"521e3e2b-e457-4da2-868b-b69cdd620865\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:00\",\"extension\":\"png\",\"order_by\":87,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":76817,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlinefloatimage1.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/a0a786038d21078993736903.png\"},{\"id\":100548318,\"identity\":\"2cab07be-2eaf-4d48-8bff-281b96944380\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:18:13\",\"extension\":\"png\",\"order_by\":88,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":53530,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlinefloatimage2.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/3c1052c8e022abbfbaf20f83.png\"},{\"id\":100540770,\"identity\":\"8e95bbf3-2e8d-40ec-88cc-041e515a2106\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:58\",\"extension\":\"png\",\"order_by\":89,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":21392,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlinefloatimage3.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/7bfb636d2532b1344356457d.png\"},{\"id\":100548457,\"identity\":\"dead7204-aadb-4b98-a2cc-44abc4bbf707\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:18:50\",\"extension\":\"png\",\"order_by\":90,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":14735,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlinefloatimage4.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/02a6e8efd5435afed2b79e07.png\"},{\"id\":100540794,\"identity\":\"92c63c1a-8960-49c9-84a0-d5a454b19f93\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:00\",\"extension\":\"png\",\"order_by\":91,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":40495,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlinefloatimage5.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/81312a9c6df62479eb9b1fc6.png\"},{\"id\":100549016,\"identity\":\"29571725-dda4-43f0-8368-625d9df82dc9\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:03\",\"extension\":\"png\",\"order_by\":92,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":212408,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlinefloatimage6.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/a9fc617b08846b794ea45348.png\"},{\"id\":100548823,\"identity\":\"d4001bd5-93c0-4b2f-9693-8bce4776a5cb\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:21:04\",\"extension\":\"png\",\"order_by\":93,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":50404,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlinefloatimage7.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/274c49ebdbd8709518a4b54e.png\"},{\"id\":100549162,\"identity\":\"f974ab0a-299f-44bc-a729-315e2b1eff7c\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:40\",\"extension\":\"png\",\"order_by\":94,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":591,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage10.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/4302eeb2a771b14b9817b7df.png\"},{\"id\":100540821,\"identity\":\"6482601c-2484-43d4-bcd5-153195588742\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:01\",\"extension\":\"png\",\"order_by\":95,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":612,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage12.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/629f2e656592d1bc6df5c3c8.png\"},{\"id\":100548445,\"identity\":\"1e855bdc-ff4a-4ae2-aecf-acee4086cb43\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:18:45\",\"extension\":\"png\",\"order_by\":96,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":645,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage13.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/0d2b257637e9e70687727ba0.png\"},{\"id\":100540777,\"identity\":\"6aa3e230-289f-4ffe-b954-2c066b290122\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:59\",\"extension\":\"png\",\"order_by\":97,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":609,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage14.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/cb3148af8cf2ed05575a920c.png\"},{\"id\":100549096,\"identity\":\"7eb0a338-a024-4b0f-a00c-4de839acef4b\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:24\",\"extension\":\"png\",\"order_by\":98,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":640,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage15.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/d2826ebc196e01eb2ecad485.png\"},{\"id\":100549205,\"identity\":\"08225951-658d-4274-a681-b8a6d9b091e0\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:46\",\"extension\":\"png\",\"order_by\":99,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1758,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage16.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/afb3f41ce6d9177f060c2bfc.png\"},{\"id\":100549220,\"identity\":\"28f00c3d-693e-4515-ae54-db515f97d3d2\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:49\",\"extension\":\"png\",\"order_by\":100,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":599,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage17.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/30bce7c9013d427b890eed60.png\"},{\"id\":100540800,\"identity\":\"42f8c4a0-fb79-4b1c-ac5d-e7c84c04388f\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:00\",\"extension\":\"png\",\"order_by\":101,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1711,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage18.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/896bece4ac2b17c9daa870a5.png\"},{\"id\":100540833,\"identity\":\"24bb3b4d-f822-4215-858d-899075a81393\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:01\",\"extension\":\"png\",\"order_by\":102,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":518,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage19.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/32f879210e454e0e60edffd9.png\"},{\"id\":100548748,\"identity\":\"50408f6a-5d6c-4ae9-a3ec-ec0f8e56f4c6\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:20:47\",\"extension\":\"png\",\"order_by\":103,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":496,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage20.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/8e8bb653438af16c1793a4bf.png\"},{\"id\":100548708,\"identity\":\"aef30906-256e-4e59-b9de-b66d3a300380\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:20:35\",\"extension\":\"png\",\"order_by\":104,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":599,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage17.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/5781eac72e89a3cf30231dc0.png\"},{\"id\":100540791,\"identity\":\"b7ecefb8-2a1a-4fa7-ba85-9645591190fd\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:59\",\"extension\":\"png\",\"order_by\":105,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":409,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage22.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/6340b0c568381e85c5e4641a.png\"},{\"id\":100540867,\"identity\":\"be9b00e4-682d-4ea3-8dc6-cb9e34c41b68\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:03\",\"extension\":\"png\",\"order_by\":106,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":424,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage23.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/ce5f07e7e2bce7e4a792a037.png\"},{\"id\":100540857,\"identity\":\"dd735f06-412a-45f7-9f9a-9562d2a0dbd2\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:02\",\"extension\":\"png\",\"order_by\":107,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":409,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage22.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/9b536326b99a662fd2dbbb0c.png\"},{\"id\":100540812,\"identity\":\"c4897d25-cf99-4033-a942-8d3ec537525f\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:00\",\"extension\":\"png\",\"order_by\":108,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":337,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage25.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/e4a8b8928a3646b3df9d56b4.png\"},{\"id\":100540849,\"identity\":\"5bec0e18-7079-4b9b-80a5-da8f6fa990a4\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:02\",\"extension\":\"png\",\"order_by\":109,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":327,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage26.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/00859cd9174ffeb244bff3de.png\"},{\"id\":100594706,\"identity\":\"7f0ba1ef-4e18-4697-ae40-cacab9005a90\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 13:44:11\",\"extension\":\"png\",\"order_by\":110,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":793,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage27.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/00d5a4411bf67c24d0e0b6a9.png\"},{\"id\":100540841,\"identity\":\"84e9db5c-fe50-4cd8-ba2a-8d242f725bd9\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:02\",\"extension\":\"png\",\"order_by\":111,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":409,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage22.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/be77919cd3267a38f7599574.png\"},{\"id\":100540813,\"identity\":\"90f1c048-afaa-48ad-8db0-818f9f6bb41e\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:00\",\"extension\":\"png\",\"order_by\":112,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":452,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage29.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/18e601cda8aa096caf972349.png\"},{\"id\":100549339,\"identity\":\"2b904ca4-1b81-4e81-a796-5dba0dd7ad0e\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:23:04\",\"extension\":\"png\",\"order_by\":113,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":327,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage26.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/2643e609dbe621ca623e3323.png\"},{\"id\":100540803,\"identity\":\"f0515fcf-8824-4c88-94db-537e4e967cde\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:00\",\"extension\":\"png\",\"order_by\":114,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":363,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage31.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/4f0805c499cb6d75606351dc.png\"},{\"id\":100540815,\"identity\":\"6b60c8fe-6a4f-465e-b399-dc64d8403fbd\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:01\",\"extension\":\"png\",\"order_by\":115,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":452,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage29.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/7f1b22b5d0af8d9138d0b290.png\"},{\"id\":100549252,\"identity\":\"bec5fcaf-0d98-4b32-8777-0b6e29482063\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:56\",\"extension\":\"png\",\"order_by\":116,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":445,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage33.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/a942f1a334eebaa72730b914.png\"},{\"id\":100540868,\"identity\":\"d6a6e9d0-44b2-432a-9f5c-0f110a77bbc3\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:03\",\"extension\":\"png\",\"order_by\":117,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":251,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage34.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/e538d0c8ae4f8b944f1f4463.png\"},{\"id\":100548914,\"identity\":\"38680594-2094-44e8-9dff-38f52dbf8bf6\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:21:29\",\"extension\":\"png\",\"order_by\":118,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":278,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage35.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/4186e9288dc517a86dcac140.png\"},{\"id\":100549014,\"identity\":\"78a3c642-5572-4f59-b50f-7d0abc990ad8\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:03\",\"extension\":\"png\",\"order_by\":119,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":452,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage29.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/f05d90094fbea0e8c2acdf82.png\"},{\"id\":100548675,\"identity\":\"0a352b29-0c52-4934-acd9-3721f6614097\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:20:20\",\"extension\":\"png\",\"order_by\":120,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1027,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage37.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/166301238bf8818170fe72e8.png\"},{\"id\":100540827,\"identity\":\"d94df1fd-3b7b-4def-b056-a3b3f8ca0a6f\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:01\",\"extension\":\"png\",\"order_by\":121,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":236,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage38.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/1345cb0e8e539bf230cf6505.png\"},{\"id\":100540781,\"identity\":\"d898c032-9a89-487b-9595-396d5acdc5ba\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:59\",\"extension\":\"png\",\"order_by\":122,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":226,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage39.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/22d239e8b24d79cf986edd90.png\"},{\"id\":100540848,\"identity\":\"85a84efa-f59c-4982-ab39-c6dd678c486c\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:02\",\"extension\":\"png\",\"order_by\":123,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":644,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage4.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/dbe0e52e76129eac8154d7ba.png\"},{\"id\":100540845,\"identity\":\"cd061bb6-e11f-4df8-b769-52325694d117\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:02\",\"extension\":\"png\",\"order_by\":124,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":245,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage40.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/a828f7ced44e81792d47eaa4.png\"},{\"id\":100540835,\"identity\":\"b4173afb-1aed-461e-8ec8-f811327d7c65\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:01\",\"extension\":\"png\",\"order_by\":125,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":859,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage41.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/182ca34ee6b72c4498010f08.png\"},{\"id\":100549217,\"identity\":\"0f43eca7-a569-48fa-89ee-a879e9f755d8\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:49\",\"extension\":\"png\",\"order_by\":126,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":242,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage42.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/054bf95cbe13dea1c713b534.png\"},{\"id\":100540877,\"identity\":\"264d8429-42dd-443c-b4d2-4da6bbb09c59\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:04\",\"extension\":\"png\",\"order_by\":127,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":2098,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage43.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/b0cf018657e572e631508f82.png\"},{\"id\":100548690,\"identity\":\"f95ff0b2-629a-4742-a8a9-7b0f43354b23\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:20:27\",\"extension\":\"png\",\"order_by\":128,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":4034,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage45.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/8cef4a5d9b94fdb00de05547.png\"},{\"id\":100549210,\"identity\":\"2bc6d419-e5fd-4619-9873-e3206686e7a4\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:48\",\"extension\":\"png\",\"order_by\":129,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1419,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage46.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/d24dd3adf9618e322f87025e.png\"},{\"id\":100549196,\"identity\":\"51244ebf-8dc4-40a0-8d0b-b28faad92934\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:45\",\"extension\":\"png\",\"order_by\":130,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":320,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage47.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/4f18643d6f2e5f954e108392.png\"},{\"id\":100540825,\"identity\":\"720971a9-05df-4639-a584-15892c73453f\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:01\",\"extension\":\"png\",\"order_by\":131,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":273,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage48.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/c9385ad5a192efb32c68d078.png\"},{\"id\":100540855,\"identity\":\"14920b8b-ed95-421a-a0dd-983f10bec54d\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:02\",\"extension\":\"png\",\"order_by\":132,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":239,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage49.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/0c6b81c36f4f4ad35654707d.png\"},{\"id\":100549341,\"identity\":\"0bbe67e5-ca95-4bb5-a66b-8cf01f9d98e3\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:23:04\",\"extension\":\"png\",\"order_by\":133,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":427,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage5.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/b65437b6dcf09747279c2558.png\"},{\"id\":100540862,\"identity\":\"563cb72d-db1e-4624-a594-63c35470edd5\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:03\",\"extension\":\"png\",\"order_by\":134,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":479,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage50.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/c67585e78fa3fc084b4264e7.png\"},{\"id\":100549068,\"identity\":\"d45d5285-9251-4ab1-8793-411cd22bf4a1\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:17\",\"extension\":\"png\",\"order_by\":135,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":239,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage49.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/49e236eaa6eb674fac30b180.png\"},{\"id\":100540831,\"identity\":\"efd960c6-03f4-4d71-a32f-d7831f3a6452\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:01\",\"extension\":\"png\",\"order_by\":136,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":531,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage52.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/7082e24ba61e6115f8a2d71b.png\"},{\"id\":100540788,\"identity\":\"a0414643-2cc1-4fb1-b0a0-ff6984d739f9\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:12:59\",\"extension\":\"png\",\"order_by\":137,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":2084,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage53.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/669ac4fa7ac35b3bc6f5f957.png\"},{\"id\":100540838,\"identity\":\"0fa0dad2-01fd-47fc-9168-541566207fb4\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:02\",\"extension\":\"png\",\"order_by\":138,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1562,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage54.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/3554cc3ac587541e637f4ec2.png\"},{\"id\":100540843,\"identity\":\"8fc99cad-9795-4a1a-869a-ec99c6e67d28\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:02\",\"extension\":\"png\",\"order_by\":139,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":542,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage55.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/95b8dcea6351263c4eacfcfc.png\"},{\"id\":100548765,\"identity\":\"77e4d159-33eb-40bb-a5aa-5a4c0f301182\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:20:49\",\"extension\":\"png\",\"order_by\":140,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":391,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage56.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/60a9ec9ee97097f0ab82bef6.png\"},{\"id\":100540837,\"identity\":\"721e9156-5e2f-48f0-a68e-5805a01beb10\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:01\",\"extension\":\"png\",\"order_by\":141,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":319,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage57.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/0268cd35bc3479a485a2b7c0.png\"},{\"id\":100548620,\"identity\":\"128afa36-c4c8-431e-b21d-977afc705e2f\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:19:55\",\"extension\":\"png\",\"order_by\":142,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":339,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage58.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/dcc286669e4e67df21f4addb.png\"},{\"id\":100549384,\"identity\":\"651374af-d77a-4476-81c9-168e19954ef1\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:23:13\",\"extension\":\"png\",\"order_by\":143,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":339,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage58.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/8861c7b8ea4c65f6882c085d.png\"},{\"id\":100540869,\"identity\":\"9162657d-f59c-486a-93d1-6e3523f37023\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:03\",\"extension\":\"png\",\"order_by\":144,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":504,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage6.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/cf24541dad43409618f17605.png\"},{\"id\":100548331,\"identity\":\"b1fe3925-c4f5-46d5-ba60-6a4208c566c3\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:18:16\",\"extension\":\"png\",\"order_by\":145,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":319,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage57.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/e0e7bfa32ec711c51f67fdf6.png\"},{\"id\":100549254,\"identity\":\"bb22424c-761f-4771-b677-0082cb92bc20\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:57\",\"extension\":\"png\",\"order_by\":146,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":661,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage61.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/0c2d9f60af98057e5c8ca831.png\"},{\"id\":100548967,\"identity\":\"373ec6c7-71fb-4e23-8aa5-4c04877c2858\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:21:50\",\"extension\":\"png\",\"order_by\":147,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":167,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage62.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/4c0c8a7ea74daeebe0da8db4.png\"},{\"id\":100540864,\"identity\":\"c3dbd9e1-1707-45ae-8228-fedece159fff\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:03\",\"extension\":\"png\",\"order_by\":148,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1548,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage63.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/57978c0a80e12c2ebf88d4ea.png\"},{\"id\":100548407,\"identity\":\"fb738e17-869b-467a-9b80-0b5c53d50bc2\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:18:33\",\"extension\":\"png\",\"order_by\":149,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":426,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage64.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/063055c25638cbccae2ef019.png\"},{\"id\":100548429,\"identity\":\"db6c007d-b731-40fa-9afd-eba9b808282a\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:18:39\",\"extension\":\"png\",\"order_by\":150,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":661,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage65.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/3979a7aaf98db56ea2337732.png\"},{\"id\":100540872,\"identity\":\"e8b62b42-ca19-446d-ba0f-0c74eeb2d7cb\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:03\",\"extension\":\"png\",\"order_by\":151,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":900,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage67.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/4df5d6a9ae867a1613500b3f.png\"},{\"id\":100549272,\"identity\":\"f41cf8ca-9bf2-4342-be25-029f4f8c8627\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:58\",\"extension\":\"png\",\"order_by\":152,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":574,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage68.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/e6c3cc4375b83704b943981f.png\"},{\"id\":100549389,\"identity\":\"1cc208fd-25d4-4022-9ddb-b4623a9153fa\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:23:14\",\"extension\":\"png\",\"order_by\":153,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":349,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage69.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/292a96a6631a423648c52204.png\"},{\"id\":100549295,\"identity\":\"35467504-7241-4f0d-875d-98aaca1fa6ed\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:23:00\",\"extension\":\"png\",\"order_by\":154,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":757,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage7.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/83618d067c8c8a30707fd9cc.png\"},{\"id\":100540840,\"identity\":\"18a2aaf8-1790-486e-b73e-3b4665860235\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:02\",\"extension\":\"png\",\"order_by\":155,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":342,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage70.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/2f1c2010dbb86aa100d1d0fd.png\"},{\"id\":100540851,\"identity\":\"e811bca2-06f6-4050-89e1-8d36423bed0b\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:02\",\"extension\":\"png\",\"order_by\":156,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1109,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage71.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/d5a6bdf7a249cf83691c3e91.png\"},{\"id\":100549088,\"identity\":\"00a60b49-87ff-471e-b156-3e622fdf6524\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:21\",\"extension\":\"png\",\"order_by\":157,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":1267,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage72.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/d9c186160c71d5a1ce68228b.png\"},{\"id\":100549073,\"identity\":\"9e639985-9ff9-4658-adfb-e801212ecc14\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:18\",\"extension\":\"png\",\"order_by\":158,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":559,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage73.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/5d9fd7aa2f63383706f9f3e6.png\"},{\"id\":100540819,\"identity\":\"872ed3b2-8b2f-4da2-b439-fe416c42fe80\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:01\",\"extension\":\"png\",\"order_by\":159,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":381,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage74.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/fd98fe43035c2b7b1e17e29e.png\"},{\"id\":100549229,\"identity\":\"99267ada-14a0-4c1d-a2e0-a13ece3cd4c1\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:51\",\"extension\":\"png\",\"order_by\":160,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":319,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage75.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/7d8b086fdacb281fa3adb835.png\"},{\"id\":100549301,\"identity\":\"7e9a095d-4fd2-4051-aac4-523600e8a0c8\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:23:00\",\"extension\":\"png\",\"order_by\":161,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":377,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage76.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/58d9ac105b4886573e4c0545.png\"},{\"id\":100540875,\"identity\":\"8fc7d002-fc52-4f02-ba11-1bc96667552f\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:03\",\"extension\":\"png\",\"order_by\":162,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":351,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage78.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/260192ceb7d478dafe37fcab.png\"},{\"id\":100548419,\"identity\":\"39666af5-c3ed-492e-8880-436719276963\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:18:36\",\"extension\":\"png\",\"order_by\":163,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":432,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage79.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/c987b8ba6901e3b69bc32d82.png\"},{\"id\":100548329,\"identity\":\"a9e742df-1d1c-485e-9d14-b28dd3642001\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:18:16\",\"extension\":\"png\",\"order_by\":164,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":562,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage8.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/faf2d5727856f03a96d8493d.png\"},{\"id\":100549219,\"identity\":\"b80a53cb-e727-499c-b947-719e0a713dff\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:49\",\"extension\":\"png\",\"order_by\":165,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":719,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage80.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/3377929a44862426374d5503.png\"},{\"id\":100549406,\"identity\":\"b5a5c8ef-c412-4b2e-bcb0-18a8236cbb89\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:23:17\",\"extension\":\"png\",\"order_by\":166,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":685,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage81.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/885a7912f930a89f5ea94e34.png\"},{\"id\":100540873,\"identity\":\"86598133-f9df-4020-aec9-19be0c4447dc\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:03\",\"extension\":\"png\",\"order_by\":167,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":478,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage82.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/96ef088d92d71918617e2f26.png\"},{\"id\":100540807,\"identity\":\"0b9c477f-099b-43d3-89a5-b481bbe6c2b7\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:00\",\"extension\":\"png\",\"order_by\":168,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":485,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage83.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/145d22cc438a6e15b50a5dcf.png\"},{\"id\":100540852,\"identity\":\"0398c04e-1923-474e-a32b-50c16c86785b\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:02\",\"extension\":\"png\",\"order_by\":169,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":576,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Onlineimage9.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/57765048e1ae58f3ee0ecbe6.png\"},{\"id\":100549027,\"identity\":\"e8e52fe0-65be-44ef-989c-14a6fbf4b66d\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 08:22:04\",\"extension\":\"xml\",\"order_by\":170,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":135504,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"231502666ebb42dca61d28629fd9e9391structuring.xml\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/22f7c11e0970493aa9695af2.xml\"},{\"id\":100540870,\"identity\":\"a9dfa351-e243-4389-8498-637b59ffc6ee\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 05:13:03\",\"extension\":\"html\",\"order_by\":171,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"acdc-reference\",\"size\":151544,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"earlyproof.html\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1/327f7fc5680288002759a539.html\"},{\"id\":100597234,\"identity\":\"da9c0097-ac09-4f82-a01a-689147f8109c\",\"added_by\":\"auto\",\"created_at\":\"2026-01-19 14:15:04\",\"extension\":\"pdf\",\"order_by\":1,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"manuscript-pdf\",\"size\":851125,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"AcceleratedGradientBasedAlgorithmforAutomatic2D3DMedicalImageRegistration.pdf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8380892/v1_covered_16abca76-1893-42e9-ae4c-8f8dfa4f6a70.pdf\"}],\"financialInterests\":\"No competing interests reported.\",\"formattedTitle\":\"A Real-Time 2D-3D Registration Algorithm for Spine Surgery Navigation Using Accelerated Gradient Optimization\",\"fulltext\":[],\"fulltextSource\":\"\",\"fullText\":\"\",\"funders\":[],\"hasAdminPriorityOnWorkflow\":false,\"hasManuscriptDocX\":false,\"hasOptedInToPreprint\":true,\"hasPassedJournalQc\":\"\",\"hasAnyPriority\":false,\"hideJournal\":false,\"highlight\":\"\",\"institution\":\"\",\"isAcceptedByJournal\":false,\"isAuthorSuppliedPdf\":true,\"isDeskRejected\":\"\",\"isHiddenFromSearch\":false,\"isInQc\":false,\"isInWorkflow\":false,\"isPdf\":true,\"isPdfUpToDate\":true,\"isWithdrawnOrRetracted\":false,\"journal\":{\"display\":true,\"email\":\"info@researchsquare.com\",\"identity\":\"bmc-medical-imaging\",\"isNatureJournal\":false,\"hasQc\":true,\"allowDirectSubmit\":false,\"externalIdentity\":\"bmim\",\"sideBox\":\"Learn more about [BMC Medical Imaging](http://bmcmedimaging.biomedcentral.com/)\",\"snPcode\":\"\",\"submissionUrl\":\"https://www.editorialmanager.com/bmim/default.aspx\",\"title\":\"BMC Medical Imaging\",\"twitterHandle\":\"BMC_series\",\"acdcEnabled\":true,\"dfaEnabled\":false,\"editorialSystem\":\"em\",\"reportingPortfolio\":\"BMC Series\",\"inReviewEnabled\":true,\"inReviewRevisionsEnabled\":true},\"keywords\":\"2D-3D image registration, real-time 2D-3D registration, GPU acceleration, surgical navigation\",\"lastPublishedDoi\":\"10.21203/rs.3.rs-8380892/v1\",\"lastPublishedDoiUrl\":\"https://doi.org/10.21203/rs.3.rs-8380892/v1\",\"license\":{\"name\":\"CC BY 4.0\",\"url\":\"https://creativecommons.org/licenses/by/4.0/\"},\"manuscriptAbstract\":\"\\u003cp\\u003eTwo-dimensional to three-dimensional (2D\\u0026ndash;3D) medical image registration plays a critical role in image-guided spinal surgery, enabling accurate alignment between intraoperative fluoroscopy and preoperative CT volumes. However, existing methods often suffer from slow convergence or high computational demands, limiting their use in time-sensitive clinical settings. To address this challenge, we propose a semi-automatic 2D\\u0026ndash;3D registration algorithm that integrates a grid-based initialization strategy with Nesterov-accelerated gradient (NAG) optimization. The method first coarsely aligns anatomical landmarks via vertebral segmentation on a grid, then refines the transformation parameters by maximizing a novel similarity metric\\u0026mdash;Normalized Cross-Correlation\\u0026ndash;Gradient Difference\\u0026ndash;Projection Distance Error (NGE)\\u0026mdash;using momentum-enhanced gradient descent. Evaluated on clinical spine datasets, our approach achieves a root mean square (RMS) registration error of 0.82\\u0026thinsp;\\u0026plusmn;\\u0026thinsp;0.15 mm with an average processing time of 15.2 seconds per case, outperforming conventional gradient descent (28.7 s) and Gauss\\u0026ndash;Newton (22.4 s) methods in both speed and accuracy. These results demonstrate the algorithm\\u0026rsquo;s potential for real-time surgical navigation, where rapid and sub-millimeter precision is essential.\\u003c/p\\u003e\",\"manuscriptTitle\":\"A Real-Time 2D-3D Registration Algorithm for Spine Surgery Navigation Using Accelerated Gradient Optimization\",\"msid\":\"\",\"msnumber\":\"\",\"nonDraftVersions\":[{\"code\":1,\"date\":\"2026-01-19 05:12:44\",\"doi\":\"10.21203/rs.3.rs-8380892/v1\",\"editorialEvents\":[{\"type\":\"communityComments\",\"content\":0},{\"type\":\"decision\",\"content\":\"Revision requested\",\"date\":\"2026-03-06T09:51:59+00:00\",\"index\":\"\",\"fulltext\":\"\"},{\"type\":\"editorInvitedReview\",\"content\":\"\",\"date\":\"2026-02-04T17:39:55+00:00\",\"index\":\"hide\",\"fulltext\":\"\"},{\"type\":\"editorInvitedReview\",\"content\":\"\",\"date\":\"2026-01-31T17:17:55+00:00\",\"index\":\"hide\",\"fulltext\":\"\"},{\"type\":\"reviewerAgreed\",\"content\":\"329554816701906542255274839718914085187\",\"date\":\"2026-01-26T07:43:50+00:00\",\"index\":\"hide\",\"fulltext\":\"\"},{\"type\":\"reviewerAgreed\",\"content\":\"239146430142528033862929848203089481017\",\"date\":\"2026-01-25T08:44:48+00:00\",\"index\":\"hide\",\"fulltext\":\"\"},{\"type\":\"reviewerAgreed\",\"content\":\"177918373246200648460299812333076081506\",\"date\":\"2026-01-16T21:15:07+00:00\",\"index\":\"hide\",\"fulltext\":\"\"},{\"type\":\"reviewersInvited\",\"content\":\"\",\"date\":\"2026-01-14T16:01:21+00:00\",\"index\":\"\",\"fulltext\":\"\"},{\"type\":\"editorAssigned\",\"content\":\"\",\"date\":\"2026-01-13T03:41:04+00:00\",\"index\":\"\",\"fulltext\":\"\"},{\"type\":\"editorInvited\",\"content\":\"\",\"date\":\"2025-12-22T11:54:02+00:00\",\"index\":\"\",\"fulltext\":\"\"},{\"type\":\"checksComplete\",\"content\":\"\",\"date\":\"2025-12-22T10:11:12+00:00\",\"index\":\"\",\"fulltext\":\"\"},{\"type\":\"submitted\",\"content\":\"BMC Medical Imaging\",\"date\":\"2025-12-22T10:03:00+00:00\",\"index\":\"\",\"fulltext\":\"\"}],\"status\":\"published\",\"journal\":{\"display\":true,\"email\":\"info@researchsquare.com\",\"identity\":\"bmc-medical-imaging\",\"isNatureJournal\":false,\"hasQc\":true,\"allowDirectSubmit\":false,\"externalIdentity\":\"bmim\",\"sideBox\":\"Learn more about [BMC Medical Imaging](http://bmcmedimaging.biomedcentral.com/)\",\"snPcode\":\"\",\"submissionUrl\":\"https://www.editorialmanager.com/bmim/default.aspx\",\"title\":\"BMC Medical Imaging\",\"twitterHandle\":\"BMC_series\",\"acdcEnabled\":true,\"dfaEnabled\":false,\"editorialSystem\":\"em\",\"reportingPortfolio\":\"BMC Series\",\"inReviewEnabled\":true,\"inReviewRevisionsEnabled\":true}}],\"origin\":\"\",\"ownerIdentity\":\"a516b1ff-f6f4-439e-982d-861712788c58\",\"owner\":[],\"postedDate\":\"January 19th, 2026\",\"published\":true,\"recentEditorialEvents\":[],\"rejectedJournal\":[],\"revision\":\"\",\"amendment\":\"\",\"status\":\"under-review\",\"subjectAreas\":[],\"tags\":[],\"updatedAt\":\"2026-04-22T13:53:14+00:00\",\"versionOfRecord\":[],\"versionCreatedAt\":\"2026-01-19 05:12:44\",\"video\":\"\",\"vorDoi\":\"\",\"vorDoiUrl\":\"\",\"workflowStages\":[]},\"version\":\"v1\",\"identity\":\"rs-8380892\",\"journalConfig\":\"researchsquare\"},\"__N_SSP\":true},\"page\":\"/article/[identity]/[[...version]]\",\"query\":{\"redirect\":\"/article/rs-8380892\",\"identity\":\"rs-8380892\",\"version\":[\"v1\"]},\"buildId\":\"XKTyCvWXoU3ODBz1xrDgd\",\"isFallback\":false,\"isExperimentalCompile\":false,\"dynamicIds\":[84888],\"gssp\":true,\"scriptLoader\":[]}","source_license":"CC-BY-4.0","license_restricted":false}