{"paper_id":"2bac0599-e426-465e-8e43-0a7d73541b84","body_text":"Abstract\nObjective To delineate the evolutionary trajectory of immunomodulatory biomaterials in implant osseointegration through bibliometric analysis, identifying pivotal theoretical breakthroughs and technological advancements.\nMethods A total of 419 articles (2005–2025) from the Web of Science Core Collection were analyzed using a multi-tool framework. Current research status and hotspots were evaluated by co-occurrence analysis of keywords and institutions using VOSviewer. The evolution and bursts of the knowledge base were assessed through co-citation analysis of references, authors, and journals via CiteSpace. Thematic evolution and keyword trends were mapped using the bibliometrix package in R.\nResults The field exhibited “intermittent-explosive” growth (32.7% annual increment), with China leading global contributions (69.4%). The osteoimmunomodulation (OIM) theory emerged as the cornerstone, emphasizing spatiotemporal macrophage polarization (M1/M2 balance) and multi-signal crosstalk (BMP-2/VEGF/OSM). Key technological pathways included: ① Surface engineering (nanotopography, ion-doped coatings); ② Smart materials (3D-printed scaffolds, pH/ROS-responsive carriers); ③ Antibacterial-immunomodulatory synergy. Burst detection revealed shifting frontiers toward clinical translation (2023-2025 burst: “3D printing”, strength=4.05) and precision modulation (“macrophage polarization”, strength=9.02).\nConclusion Immunomodulatory biomaterials are transitioning from mechanistic exploration to clinical adaptation. Future development requires integrating dynamic microenvironment-responsive designs with multi-omics validation to address macrophage heterogeneity, ultimately enabling personalized osseointegration therapies.\nCompeting Interest Statement\nThe authors have declared no competing interest.","source_license":"CC-BY-4.0","license_restricted":false}