{"paper_id":"2b86f670-6f51-4d68-8aa4-ff921236d821","body_text":"Abstract\nPurpose of Review\nTo critically evaluate the most recent evidence on obstetric outcomes in women with adenomyosis.\nRecent Findings\nThere is growing evidence suggesting an increased risk of obstetrical complications in women with adenomyosis.\nSummary\nAn electronic search was conducted among the databases of PubMed, Google Scholar, and Cochrane review from January 2016 to March 2021. Nine observational studies fulfilled the inclusion criteria. Limitations of eligible studies include the presence of a majority of pregnancies achieved by ART, despite ART pregnancies being reported to be associated per se with a higher risk of adverse obstetric outcome; lack of information regarding the presence or absence of endometriosis; nonhomogeneous diagnostic criteria for adenomyosis; lack of the description of the severity of adenomyosis; and different timing of the diagnosis either before or during pregnancy. All studies reported that adenomyosis is associated with preterm delivery. Moreover, available data suggest that adenomyosis is associated with lower pregnancy rates after assisted reproductive techniques (ART) and higher rates of small-for-gestational-age (SGA)/low–birth weight (LBW) infants, cesarean delivery, and hypertensive disorder of pregnancy (HDP). Further studies on naturally conceived pregnancies, accurately designed in order to consider potential confounding factors, are needed in order to estimate the actual role of adenomyosis on fertility and obstetric and neonatal outcomes. Until more accurate data are available, it seems wise to foresee, when managing pregnant women with adenomyosis, the possible need for additional obstetric and intra-partum care.\nSimilar content being viewed by others\nReferences\nPapers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance\nHarada T, Khine YM, Kaponis A, Nikellis T, Decavalas G, Taniguchi F. The Impact of Adenomyosis on Women’s Fertility. Obstet Gynecol Surv. 2016;71:557–68. https://doi.org/10.1097/OGX.0000000000000346.\n•• Nirgianakis K, Kalaitzopoulos DR, Schwartz ASK, Spaanderman M, Kramer BW, Mueller MD, et al. Pregnancy and neonatal outcomes of patients with adenomyosis: a systematic review and meta-analysis. Reprod Biomed Online. 2021;42:185–206. https://doi.org/10.1016/j.rbmo.2020.09.023. Epub 2020 Oct 4. Findings from this study suggest that adenomyosis is associated with a significantly lower clinical pregnancy rate and higher miscarriage rate after ART, especially when a short GnRH agonist or antagonist protocol is administered for ovarian stimulation.\nVan den Bosch T, Dueholm M, Leone FP, Valentin L, Rasmussen CK, Votino A, et al. Terms, definitions and measurements to describe sonographic features of myometrium and uterine masses: a consensus opinion from the Morphological Uterus Sonographic Assessment (MUSA) group. Ultrasound Obstet Gynecol. 2015;46:284–98. https://doi.org/10.1002/uog.14806. Epub 2015 Aug 10.\nBazot M, Daraï E. Role of transvaginal sonography and magnetic resonance imaging in the diagnosis of uterine adenomyosis. Fertil Steril. 2018;109:389–97. https://doi.org/10.1016/j.fertnstert.2018.01.024.\n• Hashimoto A, Iriyama T, Sayama S, Nakayama T, Komatsu A, Miyauchi A, et al. Adenomyosis and adverse perinatal outcomes: increased risk of second trimester miscarriage, preeclampsia, and placental malposition. J Matern Fetal Neonatal Med. 2018;31:364–9. https://doi.org/10.1080/14767058.2017.1285895. Epub 2017 Feb 9. In this matched, case-control study, they found that patients who had adenomyosis were more likely associated with spontaneous second trimester miscarriage, preeclampsia, placental malposition, and preterm delivery, and to delivery of a SGA infant.\nScala C, Leone Roberti Maggiore U, Racca A, Barra F, Vellone VG, Venturini PL, et al. Influence of adenomyosis on pregnancy and perinatal outcomes in women with endometriosis. Ultrasound Obstet Gynecol. 2018;52:666–671. https://doi.org/10.1002/uog.18989.\nSharma S, Bathwal S, Agarwal N, Chattopadhyay R, Saha I, Chakravarty B. Does presence of adenomyosis affect reproductive outcome in IVF cycles? A retrospective analysis of 973 patients. Reprod Biomed Online. 2019;38:13–21. https://doi.org/10.1016/j.rbmo.2018.09.014. Epub 2018 Oct 26.\nShin YJ, Kwak DW, Chung JH, Kim MY, Lee SW, Han YJ. The risk of preterm births among pregnant women with adenomyosis. J Ultrasound Med. 2018;37:1937–43. https://doi.org/10.1002/jum.14540. Epub 2018 Jan 24.\nShinohara S, Okuda Y, Hirata S, Suzuki K. Adenomyosis as a potential risk factor for adverse pregnancy outcomes: a multicenter case-control study. Tohoku J Exp Med. 2020;251:231–9. https://doi.org/10.1620/tjem.251.231.\nYamaguchi A, Kyozuka H, Fujimori K, Hosoya M, Yasumura S, Yokoyama T, et al. Japan Environment and Children’s Study Group. Risk of preterm birth, low birthweight and small-for-gestational-age infants in pregnancies with adenomyosis: a cohort study of the Japan Environment and Children’s Study. Acta Obstet Gynecol Scand. 2019 Mar;98:359–364. https://doi.org/10.1111/aogs.13498. Epub 2018 Dec 2.\nNeal S, Morin S, Werner M, Gueye NA, Pirtea P, Patounakis G, et al. Three-dimensional ultrasound diagnosis of adenomyosis is not associated with adverse pregnancy outcome following single thawed euploid blastocyst transfer: prospective cohort study. Ultrasound Obstet Gynecol. 2020;56:611–7. https://doi.org/10.1002/uog.22065.\nMavrelos D, Holland TK, O’Donovan O, Khalil M, Ploumpidis G, Jurkovic D, et al. The impact of adenomyosis on the outcome of IVF-embryo transfer. Reprod Biomed Online. 2017;35:549–54. https://doi.org/10.1016/j.rbmo.2017.06.026. Epub 2017 Jul 29.\nHou X, Xing J, Shan H, Mei J, Sun Y, Yan G, et al. The effect of adenomyosis on IVF after long or ultra-long GnRH agonist treatment. Reprod Biomed Online. 2020;41:845–53. https://doi.org/10.1016/j.rbmo.2020.07.027 (Epub 2020 Aug 1).\nPandey S, Shetty A, Hamilton M, Bhattacharya S, Maheshwari A. Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF/ICSI: a systematic review and meta-analysis. Hum Reprod Update. 2012 Sep-Oct;18:485–503. doi: https://doi.org/10.1093/humupd/dms018. Epub 2012 May 19.\nQin JB, Sheng XQ, Wu D, Gao SY, You YP, Yang TB, et al. Worldwide prevalence of adverse pregnancy outcomes among singleton pregnancies after in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis. Arch Gynecol Obstet. 2017;295:285–301. https://doi.org/10.1007/s00404-016-4250-3 (Epub 2016 Nov 28).\nJuang CM, Chou P, Yen MS, Twu NF, Horng HC, Hsu WL. Adenomyosis and risk of preterm delivery. BJOG. 2007;114:165–9. https://doi.org/10.1111/j.1471-0528.2006.01186.x. Epub 2006 Dec 4.\nBrosens I, Pijnenborg R, Benagiano G. Defective myometrial spiral artery remodeling as a cause of major obstetrical syndromes in endometriosis and adenomyosis. Placenta. 2013;34:100–5.\nVannuccini S, Clifton VL, Fraser IS, Taylor HS, Critchley H, Giudice LC, et al. Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome. Hum Reprod Update. 2016 Jan-Feb;22:104–15. doi: https://doi.org/10.1093/humupd/dmv044. Epub 2015 Sep 22.\nYounes G, Tulandi T. Effects of adenomyosis on in vitro fertilization treatment outcomes: a meta-analysis. Fertil Steril. 2017;108:483-490.e3. https://doi.org/10.1016/j.fertnstert.2017.06.025.\nVercellini P, Consonni D, Dridi D, Bracco B, Frattaruolo MP, Somigliana E. Uterine adenomyosis and in vitro fertilization outcome: a systematic review and meta-analysis. Hum Reprod. 2014;29:964–77. https://doi.org/10.1093/humrep/deu041. Epub 2014 Mar 12.\nMochimaru A, Aoki S, Oba MS, Kurasawa K, Takahashi T, Hirahara F. Adverse pregnancy outcomes associated with adenomyosis with uterine enlargement. J Obstet Gynaecol Res. 2015;41:529–33. https://doi.org/10.1111/jog.12604. Epub 2014 Nov 3.\n•• Horton J, Sterrenburg M, Lane S, Maheshwari A, Li TC, Cheong Y. Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis. Hum Reprod Update. 2019;11(25):592–632. https://doi.org/10.1093/humupd/dmz012. Findings from this study suggest that adenomyosis and endometriosis have a negative impact on oocyte yield and number of mature oocytes and they increase the risk of miscarriage, preterm birth, cesarean section delivery, and neonatal unit admission following delivery.\nVercellini P, Parazzini F, Pietropaolo G, Cipriani S, Frattaruolo MP, Fedele L. Pregnancy outcome in women with peritoneal, ovarian and rectovaginal endometriosis: a retrospective cohort study. BJOG. 2012;119:1538–43. https://doi.org/10.1111/j.1471-0528.2012.03466.x. Epub 2012 Aug 20.\nExacoustos C, Lauriola I, Lazzeri L, De Felice G, Zupi E. Complications during pregnancy and delivery in women with untreated rectovaginal deep infiltrating endometriosis. Fertil Steril. 2016;106:1129-1135.e1.\nVercellini P, Frattaruolo MP, Barbara G, Buggio L, Somigliana E. The ominous association between severe endometriosis, in vitro fertilisation, and placenta previa: raising awareness, limiting risks, informing women. BJOG. 2018;125:12–5. https://doi.org/10.1111/1471-0528.14789. Epub 2017 Jul 26.\nAuthor information\nAuthors and Affiliations\nContributions\nNB and PV were responsible for conception and design of the study and for critical revision of the article for intellectual content. Acquisition of data was performed by AD, FF, and ML. Analysis and interpretation of data was accomplished by NB and PV. All the authors approved the final version of the manuscript.\nCorresponding author\nEthics declarations\nConflict of Interest\nNicola Berlanda, Agnese Donati, Francesco Fedele, Massimo Lepri, and Paolo Vercellini declare that they have no conflict of interest.\nHuman and Animal Rights and Informed Consent\nThis article does not contain any studies with human or animal subjects performed by any of the authors.\nAdditional information\nPublisher's Note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nThis article is part of the Topical Collection on Uterine Fibroids and Endometrial Lesions\nRights and permissions\nAbout this article\nCite this article\nBerlanda, N., Donati, A., Fedele, F. et al. Adenomyosis and Obstetrical Outcome: a Narrative Mini-Review of the Latest Evidence. Curr Obstet Gynecol Rep 13, 289–300 (2024). https://doi.org/10.1007/s13669-021-00316-1\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s13669-021-00316-1","source_license":"CC0","license_restricted":false}