{"paper_id":"2b20b549-c351-48ee-b96a-9448ade9e7b7","body_text":"Endometriosis is characterized by the presence of functional endometrial tissue consisting of glands and stroma outside the uterus. This disease occurs in 5%–15% of menstruating women, ileum localization is rare, and intestinal obstruction due to this pathology is even rare, up to 23% of all cases with ileum involvement.\nEndometriosis can be divided into intra and extra peritoneal sites. In decreasing order the intraperitoneal locations are ovaries, uterosacral ligaments and large ligaments, pelvic peritoneum, Douglas pouch, and gastrointestinal tract. The extra-peritoneal location includes cervix, vagina, and round ligament. Extra-abdominal organs such as lungs, urinary system, skin, and brain are rarely involved.\nIn this article, we reviewed a case with intestinal obstruction caused by ileum endometriosis.\n\nA 33-year-old woman was admitted to the emergency unit, with abdominal pain and distension, fecal vomiting, six days constipation. The patient had been complaining of lower abdominal pain for six months. She had no labor, regular menses, and no dyspareunia.\nPainkillers and antispasmodic drugs were administrated at gastroenterologist indication but the symptoms persisted.\nAbdominal X-ray showed dilated small bowel loops. Computerized tomography scan showed dilated small intestine, except for the last 30 cm of the terminal ileum, gastric distension, enlarged ovaries, hip with osteocondensant lesions ( Fig. 1 ).\nIntravenous contrast could not be performed due to elevated kidney function tests. Oral contrast wasn’t an option due to 6 days old ileus, fecal vomiting, and abdominal distension.\nAt that moment because of nonspecific symptoms, and due to the low sensitivity of standard computerized tomography, the causes for bowel obstruction were uncertain. Laparoscopy couldn’t be performed due to important abdominal distension.\nThe patient underwent emergency laparotomy. Abdominal exploration revealed dilated small bowel loops due to a stenotic ileum tumor, cecum tumors, enlarged ovaries especially the right one, multiple tumors in Douglas pouch pressing on the anterior rectum wall, multiple enlarged mesenteric lymph nodes ( Fig. 2 ).\nDue to intestinal loops distension and edema and because of the pelvic masses we didn’t perform an ileotransverso anastomosis, preferring an ileotransverso stomy (end ileostomy and transverse colon stoma acting like a mucous fistula) placed in the right hypochondrium.\nDuring hospitalization, an IRM is performed showing ovarian cysts, pathological aspect on right ovary. The postoperative course was uneventful and the patient left hospital 12 days after surgical intervention.\nHistological examination reveals bowel endometriosis (with endometriosis outbreaks in serosa and muscular layer for ileum, and endometriosis of muscular layer for cecum). Lymph nodes without atypia. The patient underwent hormonal therapy with gonadotropin releasing hormone analogue-Diphereline for 3 months.\nAfter 3 months the patient returned for a second look. No endometrial tissue was found during surgery, Douglas pouch without modification. An ileotransverso anastomosis was performed and after an uneventful hospitalization, the patient was discharged.\nPostoperative clinical and imaging evaluation at 6 and 12 months showed no signs of endometriosis recurrence.\n\nEndometriosis is a disease of uncertain etiology with many theories proposed during the time to explain it.\nSampson retrograde menstruation theory remains widely accepted. This theory is based on endometrial tissue reflux during menstruation trough the fallopian tubes, implantation in abdominal organs serosa. It doesn’t explain rare extra abdominal locations  [1] ,  [6] .\nMinh’s theory states that endometriosis is a metaplastic transformation of peritoneal mesothelium.\nOther theories imply cell migration through the blood stream or lymphatic system, nervous spread, genetic and immunological factors. It could also result in caesarean section due to decidua displacement  [1] .\nMost common become symptomatic in the reproductive period under ovarian hormones stimulation. Usually, the symptoms are nonspecific, frequently lower abdominal pain, infertility and sometimes dyspareunia  [2] ,  [3] ,  [4] .\nFor 70% of gastrointestinal endometriosis, the site is the rectosigmoid. Small bowel involvement is less than 7%, terminal ileum as an exclusive site is around 5%  [1] ,  [5] ,  [7] .\nHistological the infiltration emerges from serosa and progressively invades the muscular layer. Mucosa is rarely involved. Local lymph nodes may be affected.\nThe differential histologic diagnosis of endometroid adenocarcinoma and intestinal adenocarcinoma is difficult. Immunohistochemical CK7 and CK20 dosage are useful in separating this two malignancies.\nThe endoscopic examination has a low sensitivity because intestinal mucosa is rarely affected, or due to insufficient bioptic tissue for an accurate pathologic diagnosis. Magnetic resonance has a high sensitivity (up to 93%), multislice computerized tomography has also a high sensitivity compared with standard computerized tomography  [1] ,  [5] .\nCancer antigen CA-125 has been used to monitor the progress of endometriosis. CA-19.9 has a lower sensitivity.\nSurgery in laparoscopic or open surgery approach remains the main treatment for endometriosis. For non-symptomatic endometriosis hormone, therapy may be considered  [2] ,  [3] ,  [8] .\nFor the case presented, the existence of appropriate imaging (MRI, CT scan with oral or IV contrast) or the possibility of a microscopic examination under emergency conditions should be useful for a correct diagnosis and a proper surgical approach. In the absence of such data, the ileum and the check tumors were interpreted as malignant and therefore right hemicolectomy was performed.\nThis type of intervention hasn't affected the subsequent evolution of the case, considering even that the existence of cecum endometriosis imposed a right hemicolectomy.\n\nPreoperative ileum endometriosis distinction from other diseases is difficult in terms of symptomatology, radiological appearances, and surgical findings. Surgical approach may be challenging due to the slight line between cytoreduction, infertility, risk of recurrence and malignant potential.\n\nDan Bratu is the main author of article being along with Beli Laurentiu, and Alin Mihetiu involved in case management.\nAlin Mihetiu, Adrian Boicean, Ciprian Tanasescu participated in the intellectual content, the analysis of data and the writing of the manuscript. Radu Chicea and Dan Sabau have reviewed the manuscript, believe it represents valid work, and approved it for submission. All authors read and approved the final version of the manuscript.\nCorresponding author for this manuscript is Radu Chicea.","source_license":"CC0","license_restricted":false}