{"paper_id":"2abd3904-ad59-4c8b-bba8-dbaa3c693b48","body_text":"07 December 2016 : Clinical Research\nP53 and Murine Double Mimute 2 (MDM2) Expression Changes and Significance in Different Types of Endometrial Lesions\nZhongyong Jiang1CD, Wanqing Xu1EF, Gang Dan1FG, Yuan Liu1AB, Jie Xiong1AE*DOI: 10.12659/MSM.898616\nMed Sci Monit 2016; 22:4786-4793\nAbstract\nBACKGROUND: Endometrial lesions are common in obstetrics and gynecology, including endometrial polyps, uterine adenomyosis, and malignant endometrial adenocarcinoma. Endometrial lesions seriously affect women’s health, fertility, quality of life, and life safety. As a pro-apoptosis gene, p53 is considered to be closely related with human tumors. Murine double mimute 2 (MDM2) is an oncogene that can promote tumor occurrence and development. P53 and MDM2 expression and significance in different types of endometrial lesions have not been fully elucidated.\nMATERIAL AND METHODS: Normal endometrium, endometrial polyps, uterine adenomyosis, and endometrial adenocarcinoma tissue samples were collected. Real-time PCR was used to detect p53 and MDM2 mRNA expression. Immunohistochemical staining and Western blot analysis were applied to test p53 and MDM2 protein expression. Their correlation with clinical staging of endometrial adenocarcinoma was analyzed.\nRESULTS: P53 and MDM2 mRNA and protein expression were significantly elevated in the endometrial polyps group and the endometrial adenocarcinoma group compared with the normal control group (P<0.05). Their levels increased more obviously in endometrial adenocarcinoma compared with endometrial polyps (P<0.05). P53 and MDM2 mRNA and protein expression were slightly enhanced in uterine adenomyosis compared with normal controls, but this difference lacked statistical significance (P>0.05). P53 and MDM2 mRNA and protein level showed a positive correlation. Significantly higher expression of p53 or MDM2 was observed in patients with stage III compared to those in patients with stage II. Higher expression was also observed in patients with stage II than in patients with stage I.\nCONCLUSIONS: P53 and MDM2 mRNA and protein were elevated in endometrial polyps and endometrial adenocarcinoma and their expressions were correlated with clinical staging of endometrial adenocarcinoma. They can promote cancer occurrence and development, and can be treated to assist diagnosis and provide a reference for treatment.\nKeywords: Adenomyosis - pathology, Adenocarcinoma - pathology, Diagnosis, Differential, Endometrial Neoplasms - pathology, Polyps - pathology, Proto-Oncogene Proteins c-mdm2 - genetics, Quality of Life, RNA, Messenger - metabolism, Tumor Suppressor Protein p53 - genetics\nEditorial\n01 January 2026 : Editorial\nEditorial: Increasing Awareness of Lung Cancer in Non-Smokers and Never-Smokers Challenges Current Approaches to Prevention and ScreeningDOI: 10.12659/MSM.952454\nMed Sci Monit 2026; 32:e952454\nIn Press\nClinical Research\nInstitutional and Regional Variations in Access to Clinical Trials and Next-Generation Sequencing in Turkis...Med Sci Monit In Press; DOI: 10.12659/MSM.951027\nClinical Research\nLow-Intensity Blood Flow-Restricted Multi-Joint Exercise Improves Muscle Function in Patients With Patellof...Med Sci Monit In Press; DOI: 10.12659/MSM.950516\nReview article\nMusculoskeletal Ultrasound and MRI in the Evaluation of Chemotherapy-Induced Peripheral Neuropathy: A ReviewMed Sci Monit In Press; DOI: 10.12659/MSM.951283\nClinical Research\nSensory Processing, Dissociation, and Affective Symptoms in Misophonia: A Cross-Sectional Study of 35 AdultsMed Sci Monit In Press; DOI: 10.12659/MSM.950938\nMost Viewed Current Articles\n17 Jan 2024 : Review article 10,187,196\nVaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799\nMed Sci Monit 2024; 30:e942799\n13 Nov 2021 : Clinical Research 3,708,487\nAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788\nMed Sci Monit 2021; 27:e932788\n14 Dec 2022 : Clinical Research 2,341,643\nPrevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990\nMed Sci Monit 2022; 28:e937990\n16 May 2023 : Clinical Research 706,524\nElectrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387\nMed Sci Monit 2023; 29:e940387","source_license":"CC0","license_restricted":false}