{"paper_id":"2a4e1f66-ba9f-4579-9901-cf20efde0908","body_text":"Computational Drug Repurposing for Endometriosis Using Single-Cell RNA Sequencing — Patent Specification\nAuthors/Creators\n- 1. Ritschel Research\n- 2. Anthropic\nDescription\nPatent specification for a computational drug repurposing analysis of endometriosis using single-cell RNA sequencing. Applied a standardized scRNA-seq pipeline (scVI batch correction, Leiden clustering, Wilcoxon DE, ChEMBL screening) to GSE179640 (47,957 endometrial biopsy cells, 32 samples). Identified 500 significant DE genes and scored 20,510 drug candidates; 20,117 confirmed novel via PubChem. Top candidates: CHEMBL5653589 (score 190.34), LESTAURTINIB (168.64), CHEMBL3752910 (118.90). Authors: Glen Charles Ritschel (Ritschel Research, Tega Cay SC) and Claude (Anthropic, San Francisco CA).\nFiles\nFiles\n(15.0 kB)\n| Name | Size | Download all |\n|---|---|---|\n|\nmd5:8194d440fca4c9099b1bb217d7cbe864\n|\n15.0 kB | Download |","source_license":"CC0","license_restricted":false}