{"paper_id":"2900d9bb-7afc-411f-955c-120d668dc187","body_text":"Computational Drug Repurposing for Endometriosis Using Single-Cell RNA Sequencing — Patent Specification\nAuthors/Creators\n- 1. Ritschel Research\n- 2. Anthropic\nDescription\nPatent specification for a computational drug repurposing analysis of endometriosis using single-cell RNA sequencing. Applied a standardized scRNA-seq pipeline (scVI batch correction, Leiden clustering, Wilcoxon DE, ChEMBL screening) to GSE179640 (47,957 endometrial biopsy cells, 32 samples). Identified 500 significant DE genes and scored 20,510 drug candidates; 20,117 confirmed novel via PubChem. Top candidates: CHEMBL5653589 (score 190.34), LESTAURTINIB (168.64), CHEMBL3752910 (118.90). Authors: Glen Charles Ritschel (Ritschel Research, Tega Cay SC) and Claude (Anthropic, San Francisco CA).\nFiles\nFiles\n(16.7 kB)\n| Name | Size | Download all |\n|---|---|---|\n|\nmd5:3127f2d67e1e9ee0e37f9a0361c47e3d\n|\n16.7 kB | Download |\nAdditional details\nDates\n- Updated\n-\n2026-05-04v2: Corrected inventorship attribution","source_license":"CC0","license_restricted":false}