{"paper_id":"248a93ce-81b7-4d11-b940-afa95175a7ce","body_text":"WEKO3\nアイテム\nToll-like receptor system and endometriosis\nhttp://hdl.handle.net/10069/34520\nhttp://hdl.handle.net/10069/34520da16b222-1b40-49e5-8322-a8a9c2540434\n| 名前 / ファイル | ライセンス | アクション |\n|---|---|---|\n|\nJOGR39_1281.pdf (1.1 MB)\n|\n|\n| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||\n|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|\n| 公開日 | 2014-09-01 | |||||||||||||||\n| タイトル | ||||||||||||||||\n| タイトル | Toll-like receptor system and endometriosis | |||||||||||||||\n| 言語 | ||||||||||||||||\n| 言語 | eng | |||||||||||||||\n| キーワード | ||||||||||||||||\n| 主題Scheme | Other | |||||||||||||||\n| 主題 | bacterial endotoxin | |||||||||||||||\n| キーワード | ||||||||||||||||\n| 主題Scheme | Other | |||||||||||||||\n| 主題 | endometriosis | |||||||||||||||\n| キーワード | ||||||||||||||||\n| 主題Scheme | Other | |||||||||||||||\n| 主題 | endometrium | |||||||||||||||\n| キーワード | ||||||||||||||||\n| 主題Scheme | Other | |||||||||||||||\n| 主題 | infertility | |||||||||||||||\n| キーワード | ||||||||||||||||\n| 主題Scheme | Other | |||||||||||||||\n| 主題 | innate immunity | |||||||||||||||\n| キーワード | ||||||||||||||||\n| 主題Scheme | Other | |||||||||||||||\n| 主題 | Toll-like receptors | |||||||||||||||\n| 資源タイプ | ||||||||||||||||\n| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||\n| 資源タイプ | journal article | |||||||||||||||\n| 著者 |\nKhan, Khaleque Newaz\n× Khan, Khaleque Newaz\n× Kitajima, Michio\n× Fujishita, Akira\n× Nakashima, Masahiro\n× Masuzaki, Hideaki\n|\n|||||||||||||||\n| 抄録 | ||||||||||||||||\n| 内容記述タイプ | Abstract | |||||||||||||||\n| 内容記述 | Endometriosis is an estrogen-dependent chronic inflammatory condition associated with variable degrees of pelvic pain and infertility. Studies have showed that the growth and progression of endometriosis continue even in ovariectomized animals. This indicates that besides ovarian steroid hormones, the growth of endometriosis can be regulated by the innate immune system in the pelvic environment. As a component of innate immune system, increased infiltration of macrophages has been described in the intact tissue and peritoneal fluid of women with endometriosis. Different immune cells and dendritic cells express Toll-like receptors (TLR) and exhibit functional activity in response to microbial products. In this review article, we discuss the role of the TLR system in endometrium and endometriosis and outline the involvement of cytokines/endotoxin in causing adverse reproductive outcome. In the first part of this review article, the fundamentals of innate immune system, functional characteristics of TLR and signaling pathways of TLR4 are discussed for easy understanding by the readers. | |||||||||||||||\n| 書誌情報 |\nThe Journal of Obstetrics and Gynaecology Research 巻 39, 号 8, p. 1281-1292, 発行日 2013-08 |\n|||||||||||||||\n| 出版者 | ||||||||||||||||\n| 出版者 | 日本産科婦人科学会 | |||||||||||||||\n| 出版社別言語 | ||||||||||||||||\n| 値 | Japan Society of Obstetrics and Gynecology | |||||||||||||||\n| ISSN | ||||||||||||||||\n| 収録物識別子タイプ | ISSN | |||||||||||||||\n| 収録物識別子 | 13418076 | |||||||||||||||\n| DOI | ||||||||||||||||\n| 関連タイプ | isVersionOf | |||||||||||||||\n| 識別子タイプ | DOI | |||||||||||||||\n| 関連識別子 | 10.1111/jog.12117 | |||||||||||||||\n| 権利 | ||||||||||||||||\n| 権利情報 | c 2013 The Authors. Journal of Obstetrics and Gynaecology Research c 2013 Japan Society of Obstetrics and Gynecology | |||||||||||||||\n| 権利 | ||||||||||||||||\n| 権利情報 | The definitive version is available at Wiley Online Library , www.wileyonlinelibrary.com. | |||||||||||||||\n| 著者版フラグ | ||||||||||||||||\n| 出版タイプ | AM | |||||||||||||||\n| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||\n| 引用 | ||||||||||||||||\n| 内容記述タイプ | Other | |||||||||||||||\n| 内容記述 | The Journal of Obstetrics and Gynaecology Research, 39(8), pp.1281-1292; 2013 |","source_license":"CC0","license_restricted":false}