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Physiotherapy techniques, such as stretching and strength training, have beneficial effects on neck pain. Telerehabilitation exercise programmes could readily address the growing concern of patient adherence to home-based exercise programmes, while being time- and cost-effective. This study aimed to determine the effectiveness of telerehabilitation exercise intervention in females with chronic non-specific neck pain by measuring the pain score, disability index, cervical range of motion (CROM), cervical muscle endurance, and patient adherence. Methods In this pilot randomized controlled trial, 31 females (mean age 22.7 &plusmn; 2.1 years) were given a 6-week home-based exercise programme based on their assigned group: telerehabilitation (TR) &ndash; online software or conventional (CG) &ndash; exercise manual. Baseline measurements were collected using the Visual Analog Scale for Pain (VAS Pain), Neck Disability Index (NDI) questionnaire, CROM using the CROM instrument, and cervical muscle endurance through the Craniocervical Flexion Test (CCFT), and repeated after six weeks, in addition to adherence. SPSS version 26.0 was used for all statistical analyses. Results Based on mixed model ANOVA measures (0 week and 6 weeks), within-group comparisons for both groups showed statistical significance in favour of the exercise programme, for all variables (p&lt;0.05). Telerehabilitation group showed significantly more increase in cervical rotation ROM R (0.006) and L (0.03) post-exercise programme, and longer duration of treatment session (0.02) as compared to conventional group. Between-group comparisons showed no significant differences for all other variables. Conclusions Based on our findings, both groups showed significant improvement in neck pain, disability, cervical ROM, and cervical muscle endurance; however, no group was found superior to the other in this regard. While both groups showed good adherence to the frequency of sessions, telerehabilitation exhibited better adherence to the duration of the exercise sessions. \" } { \"@context\": \"http://schema.org\", \"@type\": \"BreadcrumbList\", \"itemListElement\": [ { \"@type\": \"ListItem\", \"position\": \"1\", \"item\": { \"@id\": \"https://f1000research.com/\", \"name\": \"Home\" } }, { \"@type\": \"ListItem\", \"position\": \"2\", \"item\": { \"@id\": \"https://f1000research.com/browse/articles\", \"name\": \"Browse\" } }, { \"@type\": \"ListItem\", \"position\": \"3\", \"item\": { \"@id\": \"https://f1000research.com/articles/14-174/v2\", \"name\": \"Effects Of 6-Week Telerehabilitation Exercise Programme On Chronic...\" } } ] } Home Browse Effects Of 6-Week Telerehabilitation Exercise Programme On Chronic... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Ahmed ZZ, Aqil Khan MN and Bairapareddy KC. Effects Of 6-Week Telerehabilitation Exercise Programme On Chronic Non-Specific Neck Pain In Women: A Pilot Randomized Controlled Trial [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2025, 14 :174 ( https://doi.org/10.12688/f1000research.160247.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Research Article Revised Effects Of 6-Week Telerehabilitation Exercise Programme On Chronic Non-Specific Neck Pain In Women: A Pilot Randomized Controlled Trial [version 2; peer review: 1 approved, 2 approved with reservations] Zaina Zahur Ahmed https://orcid.org/0009-0007-7585-4915 1 , Mohammad Nayel Aqil Khan 1 , Kalyana Chakravarthy Bairapareddy https://orcid.org/0000-0002-5159-5951 1 Zaina Zahur Ahmed https://orcid.org/0009-0007-7585-4915 1 , Mohammad Nayel Aqil Khan 1 , Kalyana Chakravarthy Bairapareddy https://orcid.org/0000-0002-5159-5951 1 PUBLISHED 22 Apr 2025 Author details Author details 1 Department of Physiotherapy, University of Sharjah, Sharjah, Sharjah, United Arab Emirates Zaina Zahur Ahmed Roles: Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Project Administration, Software, Supervision, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Mohammad Nayel Aqil Khan Roles: Data Curation, Formal Analysis, Investigation, Project Administration, Software, Visualization, Writing – Review & Editing Kalyana Chakravarthy Bairapareddy Roles: Conceptualization, Data Curation, Formal Analysis, Methodology, Resources, Software, Supervision, Validation, Writing – Review & Editing OPEN PEER REVIEW DETAILS REVIEWER STATUS Abstract Background Chronic non-specific neck pain is one of the most prevalent musculoskeletal disorders affecting work and lifestyle. Physiotherapy techniques, such as stretching and strength training, have beneficial effects on neck pain. Telerehabilitation exercise programmes could readily address the growing concern of patient adherence to home-based exercise programmes, while being time- and cost-effective. This study aimed to determine the effectiveness of telerehabilitation exercise intervention in females with chronic non-specific neck pain by measuring the pain score, disability index, cervical range of motion (CROM), cervical muscle endurance, and patient adherence. Methods In this pilot randomized controlled trial, 31 females (mean age 22.7 ± 2.1 years) were given a 6-week home-based exercise programme based on their assigned group: telerehabilitation (TR) – online software or conventional (CG) – exercise manual. Baseline measurements were collected using the Visual Analog Scale for Pain (VAS Pain), Neck Disability Index (NDI) questionnaire, CROM using the CROM instrument, and cervical muscle endurance through the Craniocervical Flexion Test (CCFT), and repeated after six weeks, in addition to adherence. SPSS version 26.0 was used for all statistical analyses. Results Based on mixed model ANOVA measures (0 week and 6 weeks), within-group comparisons for both groups showed statistical significance in favour of the exercise programme, for all variables (p<0.05). Telerehabilitation group showed significantly more increase in cervical rotation ROM R (0.006) and L (0.03) post-exercise programme, and longer duration of treatment session (0.02) as compared to conventional group. Between-group comparisons showed no significant differences for all other variables. Conclusions Based on our findings, both groups showed significant improvement in neck pain, disability, cervical ROM, and cervical muscle endurance; however, no group was found superior to the other in this regard. While both groups showed good adherence to the frequency of sessions, telerehabilitation exhibited better adherence to the duration of the exercise sessions. READ ALL READ LESS Keywords Telerehabilitation, Neck pain, Home exercises Corresponding Author(s) Kalyana Chakravarthy Bairapareddy ( [email protected] ) Close Corresponding author: Kalyana Chakravarthy Bairapareddy Competing interests: No competing interests were disclosed. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2025 Ahmed ZZ et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Ahmed ZZ, Aqil Khan MN and Bairapareddy KC. Effects Of 6-Week Telerehabilitation Exercise Programme On Chronic Non-Specific Neck Pain In Women: A Pilot Randomized Controlled Trial [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2025, 14 :174 ( https://doi.org/10.12688/f1000research.160247.2 ) First published: 07 Feb 2025, 14 :174 ( https://doi.org/10.12688/f1000research.160247.1 ) Latest published: 22 Apr 2025, 14 :174 ( https://doi.org/10.12688/f1000research.160247.2 ) Revised Amendments from Version 1 Additional information regarding the background and purpose of this study was added. Outcome measure descriptions were elaborated. Discussion was expanded, as per reviewers' comments. Additional information regarding the background and purpose of this study was added. Outcome measure descriptions were elaborated. Discussion was expanded, as per reviewers' comments. See the authors' detailed response to the review by İsmet Tümtürk READ REVIEWER RESPONSES Introduction Chronic non-specific neck pain is a growing problem affecting almost 50% of adults in the general population. According to Goode et al. (2010), the majority of individuals with this musculoskeletal illness either never respond to treatment or never find a way to manage their pain, which has a detrimental effect on their ability to work and lead a normal life. 1 Several studies have identified multiple risk factors for neck pain. These include causes such as excessive physical demands at work, unsuitable workplace conditions, psychosocial factors (including stress and anxiety), sleep deprivation, recurrent chronic low back pain, and female sex. 2 , 3 In general, females are associated with a higher prevalence of pain when compared to males. This has been linked to various psychosocial influences, including views and approaches concerning health, feeling more disagreeable towards pain, greater exposure to psychological distress, and unintentional prejudice among healthcare providers. 3 , 4 Moreover, the global burden of neck pain, in terms of years lived with a disability, is far greater in women than in men. 5 The benefits of physical therapy on the intensity of pain experienced, degree of disability, and cervical range of motion (CROM) are becoming increasingly evident. Strengthening exercises, endurance exercises, stretching, and postural education are types of training included in these exercise programmes. 6 Moreover, active exercise training has been shown to improve the strength of the neck musculature. 7 Considering that a large part of the exercise programme consists of self-management, in terms of administering the exercises themselves, education, awareness, and lifestyle changes, 8 home-based exercises are recommended, particularly in those who suffer from chronic pain. 9 The exercises are taught to the patient, and they are encouraged to follow all the advice provided by the physiotherapist; however, the adherence of patients to these programmes often poses an obstacle to relief from chronic pain. 10 Home-based exercise programmes have shown similar improvements in pain, disability, and cervical muscle endurance compared with supervised exercise programmes. 11 , 12 In recent decades, exercise programmes that are patient-suitable, time-efficient, and cost-effective have become much greater in demand. 13 Moreover, in light of the global circumstances raised by the COVID-19 pandemic, telerehabilitation interventions—which are currently getting widely popular—have been chosen in this context. 14 The advantages of this method of delivering healthcare have been demonstrated in numerous studies with a particular focus on patient adherence to treatment. 12 CareSpace software, in collaboration with the Connect2MyDoctor application, was adopted as a means of telerehabilitation in this study. CareSpace Inc. 15 is a US-based multinational digital health company that offers an online platform for patient care management. The facility of this platform to digitize musculoskeletal care via a mobile or webcam powered by visual (AI-powered) learning to measure, record, and recommend personalized care pathways to improve outcomes on the population health scale was utilized based on the requirements of this study for recording exercise sessions. A potential solution to patients not adhering to prescribed exercise regimens could be telerehabilitation. Due to its advantages in terms of patient adherence, cost-effectiveness, and convenience, healthcare professionals are encouraged to implement this type of intervention, which might be extended to in-patient care. For individuals suffering from chronic non-specific neck pain, telerehabilitation can guarantee the effectiveness of following exercise sessions and, consequently, of the treatment programme itself. The purpose of this study is to determine the effectiveness of telerehabilitation exercise intervention is in females with chronic non-specific neck pain, via measuring the pain score, disability index, CROM, cervical muscle endurance and their adherence to the exercise programme. It is hypothesised that there would be notable improvements in pain score, disability index, CROM, cervical muscle endurance in both groups suffering from chronic non-specific neck pain, but telerehabilitation exercise programme would result in greater improvements in all outcome measures, and particularly better patient adherence, as compared to conventional exercise programme. Methods Study design The present pilot randomized controlled trial investigated the effectiveness of 6-week telerehabilitation programme in women with chronic non-specific neck pain. The study participants were randomized by the researcher into two groups: telerehabilitation (TR) or conventional (CG) using the permuted block randomization method. Five permuted blocks were used, each with a block size of six (ABABAB, BABABA, AAABBB, AABBAB, and BBAABA). The co-researcher (KR) administered treatment allocation using sealed and opaque envelopes that were sequentially numbered. Data for the outcome measures (pretest and posttest) were obtained by the lead researcher (ZA) both at the beginning and end of the 6-week period. Due to the nature of the study, blinding of the researchers or participants was not possible. Sample Convenience sampling was selected for this study. Based on the effect size of 0.95 utilizing the VAS mean and standard deviation values, alpha error of 5%, study power of 80%, and allocation ratio of 1, a total sample size of 30 participants was deemed suitable. 12 Considering that this was a pilot study, 30 participants were anticipated (15 for each group). The final study sample included 31 participants (15 in the TR and 16 in the CG), as shown in Figure 1 . Recruited participants were included in this study based on the following criteria: (1) residents of the UAE, only females; (2) aged between 18 and 45 years; (3) had normal BMI: 18.5 – 24.9 kg/m 2 16 ; (4) referred to physiotherapy by an orthopedic surgeon for chronic non-specific neck pain; (5) a minimum pain score of 3 cm on the VAS Pain (Visual Analog Scale for Pain); (6) pain onset at least 3 months ago; and (7) provided informed verbal and written consent for voluntary participation. The exclusion criteria were as follows: (1) diagnosis by an orthopedic surgeon with any pathological condition as the cause of chronic neck pain; (2) presently undergoing any physical treatment or taking any medication for said pain; (3) comorbidities such as diabetes and hypertension; (4) conditions such as migraine and cervicogenic headache; (5) vertigo and/or vertebrobasilar insufficiency; (6) physically disabled or recently immobilizing injury; (7) orthopaedic conditions, such as spondylosis, spondylolisthesis, wryneck; (8) current pregnancy; and (9) history of neurological conditions. Figure 1. Consolidated standards of reporting trials flow diagram. Measures Pain Pain intensity was self-reported on the VAS Pain, which is a continuous scale presented as a 10 cm line, 0 represents ‘no pain’ and 10 represents ‘worst possible pain’. The scale is ideal for use in this study because it has shown acceptable reliability (0.94) and validity for chronic diseases, ranging from 0.62 to 0.91. 17 Pain score was considered the primary outcome. Disability The NDI (Neck Disability Index) questionnaire was chosen because it is commonly used in research studies to measure neck pain and disability experienced from said pain. Each item is scored out of 5 (where 0 indicates no disability), giving a total of 50 for 10 items, which can be doubled for a percentage score. A higher score represents greater disability. The alpha coefficient was found to be 0.08, denoting acceptable reliability and validity of this questionnaire for assessing neck pain and disability. 18 Cervical ROM Active ROM of the cervical region was assessed using a CROM instrument. Measurements were obtained using this tool for ROM of cervical flexion, extension, lateral flexion, and rotation to both sides. The CROM instrument consists of compasses for each plane (sagittal, frontal, and horizontal), which are secured to a firm headgear. The participant is required to be in an upright, seated position, while wearing a magnetic necklace to aid calibration of the inclinometers. Hence, this tool was chosen because it shows acceptable reliability and validity for active cervical ROM measurement. 19 Endurance For the craniocervical flexion test (CCFT), the participant was tested in the supine position with the head neutral. A pressure biofeedback device was placed under the patient’s neck, with a starting pressure of 20 mmHg. The participant was then asked to perform a chin tuck, which was explained as a gentle head nod. They were instructed to hold the chin tuck for 10 s at five different pressure levels, gradually increasing from 22 to 30 mmHg. 20 The highest pressure level maintained by each participant was recorded. Intra- and inter-examiner reliability for this test based on the intraclass coefficient (ICC) was found to be moderate (0.63-0.86). 21 Adherence Adherence is a measure of how well a patient can follow professional advice for a home-based exercise programme, including how often (frequency per week) and how long each session is conducted (duration). 10 The CG used an exercise diary for self-report adherence. 22 For TR, since each session was recorded and stored on the cloud, it was checked and confirmed by the researcher to be reviewed in the biweekly review sessions. Exercise programme Over the course of six weeks, participants were instructed to perform the given exercises on their own at home three times a week, for a total of 18 sessions, 30 minutes each. TR used the CareSpace programme to follow a pre-recorded video. This software enabled them to record and save the entire session on the cloud, so that the therapist could review it. CG were given an exercise manual with clear written instructions, guiding the participant through each exercise, as well as an exercise diary to record the details of each session. Procedure Upon receiving ethical approval from the UOS Research Ethics Committee (REC-23-02-27-01-PG) and registration with ClinicalTrials.gov (US) (NCT06076174), data collection commenced. E-posters with study details were sent out to announce the recruitment of participants, and those who voluntarily offered their participation, met the requirements of the inclusion criteria and gave verbal and written consent were recruited. Prior to the start of the exercise programme, baseline measurements were obtained from all participants in person at the University of Sharjah. These included the pain score on the VAS Pain scale, 23 score on the NDI questionnaire, 18 CROM measurement using the CROM instrument 14 and cervical muscle endurance assessed by the CCFT. 20 After collecting the baseline measurements and before starting the programme, the physiotherapist conducted an in-person session at the University of Sharjah, with each participant performing all the exercises. The physiotherapist had received the required training to conduct the demonstration of exercises and monitor and follow up with the participants. The first review session was held by the physiotherapist after two weeks, one-on-one with each participant. For TR, this was done virtually in real time using the Connect2MyDoctor application, and for CG, it was conducted over the phone. Similarly, the second review session took place after four weeks. During both review sessions, the participants performed exercise progressions. Following completion of the 6-week exercise programme, posttest measures were obtained. All assessments were conducted in a private room at the University of Sharjah, and all data were stored on a secure account on a secure computer. Recorded videos of participant sessions of TR were stored in the cloud, and only the lead researcher (female) had access to these recordings. The software provider company or anyone in the university department, other than the lead researcher, did not have access to these data. All patient information and data were kept confidential. No participant name was used for publication or presentation. Statistical analysis The dependent variables were pain score, disability index, CROM, and cervical muscle endurance. These outcome measures were collected from all participants at baseline and upon completion of all exercise sessions, in addition to data regarding adherence to the treatment programme. All statistical analyses were performed using the SPSS (Statistical Package for the Social Sciences) version 26.0. The Shapiro-Wilk test determined that the data had a normal distribution. Frequencies, means, and standard deviations (SD) were calculated using descriptive statistics. An independent samples t-test was conducted to determine baseline differences between the groups. For all within-group and between-group analyses, repeated-measures ANOVA was used at two distinct time points: 0 weeks and 6 weeks. Statistical significance was set at p < 0.05. The effect size statistics for the pretest and posttest mean values for all variables in both groups were calculated using paired sample t-tests. Cohen’s d value benchmark was considered for effect size as small (d = 0.2), medium (d = 0.5), or large (d = 0.8). 24 The interpretation of effect size, for between-groups comparisons, was done utilizing the partial eta squared, with thresholds defined as follows: values greater than 0.01 are considered small, those exceeding 0.06 are deemed moderate, and those surpassing 0.14 are classified as large. 25 Results All participants (females) completed the 6-week intervention (15 in the TR and 16 in the CG). Table 1 presents baseline demographics and participant characteristics. The mean age was 22.7 ± 2.1 years and all participants had a normal BMI (mean 22.3 ± 2.8 kg/m 2 ). Both groups showed no significant differences in the baseline values of demographic data and all outcome measures, as concluded from the independent sample t-tests (p < 0.05). The mean pain score on VAS Pain was 5.2 ± 1.7 cm (5.1 ± 1.9 cm for TR and 5.3 ± 1.5 cm for CG). The mean NDI was 6.3 ± 2.0 (5.7 ± 1.9 for TR and 6.9 ± 1.9 for CG). The Shapiro–Wilk’s test (p<0.05) was performed to confirm the normal distribution of the data. Table 1. Baseline characteristics of the participants (mean ± SD). Variable Total sample (N = 31) TR (N = 15) CG (N = 16) P value (p<0.05) Age (years) 22.7 ± 2.1 22.3 ± 2.5 23 ± 1.7 0.36 Height (cm) 165.4 ± 6.3 164.7 ± 6.3 166.1± 6.4 0.99 Weight (kg) 61.3 ± 10.2 59.5 ± 9.7 63.0 ± 10.6 0.85 BMI (kg/m 2 ) 22.3 ± 2.8 21.9 ± 2.8 22.7 ± 2.7 1.00 VAS Pain (cm) 5.2 ± 1.7 5.1 ± 1.9 5.3 ± 1.5 0.33 NDI 6.3 ± 2.0 5.7 ± 1.9 6.9 ± 1.9 0.91 Cervical Flexion ROM ( o ) 42.7 ± 5.9 41.8 ± 5.2 43.6 ± 6.6 0.19 Cervical Extension ROM ( o ) 52.1 ± 8.1 49.6 ± 6.4 54.7 ± 9.1 0.22 Cervical R Lateral Flexion ROM ( o ) 34.2 ± 5.9 34.9 ± 6.2 33.5 ± 5.6 0.62 Cervical L Lateral Flexion ROM ( o ) 38.0 ± 6.2 39.0 ± 4.7 36.9 ± 7.4 0.03 Cervical R Rotation ROM ( o ) 51.5 ± 6.9 49.5 ± 5.2 53.6 ± 8.0 0.07 Cervical L Rotation ROM ( o ) 53.3 ± 7.0 52.9 ± 6.1 53.7 ± 8.0 0.48 CCFT (mmHg) 25.5 ± 1.8 25.5 ± 1.5 25.5 ± 2.1 0.37 To compare the adherence of the participants to the exercise programme, independent samples t-tests (p < 0.05) were carried out based on the mean changes in the number of sessions completed and the average duration of each session. While the number of sessions completed was not significantly different between the groups, it was found that TR followed through for a significantly longer duration of each session (p = 0.02) than CG ( Table 2 ). Table 2. Adherence variables between-groups comparison (mean ± SD and 95% confidence interval). TR (N = 15) CG (N = 16) Between-groups P value (p<0.05) Number of sessions completed 16.7 ± 2.1 16.5 ± 2.0 0.85 Average duration of each session 23.7 ± 2.4 20.2 ± 4.6 0.02 Based on mixed-model ANOVA measures, statistical significance was found in both within-group comparisons, in favor of the exercise programme, for all variables (p < 0.05). TR showed a significantly greater increase in cervical rotation ROM R (0.006) and L (0.03) post-exercise programmes than CG. Between-group comparisons of all other variables showed no significant differences. A large, significant effect on pain score, disability index, cervical flexion, right lateral flexion, and right rotation ROM was found in both groups post-treatment, whereas medium effects on cervical extension, left lateral flexion and left rotation ROM, and cervical muscle endurance were observed. When looking at between-groups values, large effect on pain score (0.14) and disability index (0.17) was found in favor of telerehabilitation ( Table 3 ). Line graphs depicting the profile plots of the estimated marginal means for all the variables are shown in Figure 2 . Table 3. Within-group and between-groups changes for outcome measures (mean ± SD and 95% confidence interval) post-treatment. Pretest Posttest Effect size (Cohen’s d, 95% CI) Within-group Effect size (ηp2 a ) Between-groups P value (p<0.05) Within-group Between-groups VAS Pain (cm) TR 5.1 ± 1.9 1.2 ± 1.0 2.20 (1.23, 3.14) 0.14 <.001 0.47 CG 5.3 ± 1.5 1.8 ± 2.0 2.33 (1.36, 3.28) <.001 NDI TR 5.7 ± 1.9 0.8 ± 0.7 3.02 (1.80, 4.22) 0.17 <.001 0.84 CG 6.9 ± 1.9 2.1 ± 2.0 2.02 (1.14, 2.87) <.001 Cervical Flexion ROM ( o ) TR 41.8 ± 5.2 48.5 ± 5.9 -1.10 (-1.71, -0.46) 0.03 <.001 0.14 CG 43.6 ± 6.6 47.7 ± 5.9 -1.44 (-2.16, -0.69) 0.003 Cervical Extension ROM ( o ) TR 49.6 ± 6.4 54.6 ± 11.1 -0.49 (-1.00,0.34) 0.05 0.01 0.35 CG 54.7 ± 9.1 57.1 ± 55.8 -0.79 (-1.36, -0.19) 0.23 Cervical R Lateral Flexion ROM ( o ) TR 34.9 ± 6.2 40.8 ± 7.1 -1.92 (-2.75, -1.07) 0.03 <.001 0.54 CG 33.5 ± 5.6 38.5 ± 5.2 -1.20 (-1.87, -0.52) <.001 Cervical L Lateral Flexion ROM ( o ) TR 39.0 ± 4.7 43.6 ± 9.4 -0.76 (-1.31, -0.19) 0.01 0.03 0.58 CG 36.9 ± 7.4 43.2 ± 7.9 -0.63 (-1.18, -0.07) 0.006 Cervical R Rotation ROM ( o ) TR 49.5 ± 5.2 56.0 ± 6.8 -1.24 (-1.89, -0.57) 0.02 <.001 0.006 CG 53.6 ± 8.0 55.6 ± 7.4 -0.76 (-1.33, -0.17) 0.07 Cervical L Rotation ROM ( o ) TR 52.9 ± 6.1 58.25 ± 7.3 -0.81 (-1.37, -0.23) 0.01 <.001 0.03 CG 53.7 ± 8.0 54.9 ± 9.0 -0.40 (-0.92, -0.13) 0.38 CCFT (mmHg) TR 25.5 ± 1.5 26.8 ± 1.9 -0.73 (-1.27, -0.16) <.001 0.01 0.95 CG 25.5 ± 2.1 26.8 ± 1.8 -0.64 (-1.18, -0.07) 0.02 a Partial eta squared. Figure 2. Line graphs depicting profile plots of estimated marginal means. (A) VAS Pain. (B) NDI score. (C) Cervical flexion ROM. (D) Cervical extension ROM. (E) Cervical R lateral flexion ROM. (F) Cervical L lateral flexion ROM. (G) Cervical R rotation ROM. (H) Cervical L rotation ROM. (I) CCFT. Discussion This study aimed to investigate the effects of home-based exercise programmes for chronic non-specific neck pain, based on the mode of delivery. Comparisons were made based on neck pain, disability, cervical ROM, cervical muscle endurance, and adherence to the exercise programme. It is known that physiotherapy interventions consisting of strengthening and stretching exercises result in the reduction of neck pain and disability, as well as an enhancement in cervical ROM and cervical muscle endurance. 26 – 28 Based on our findings, both groups showed significant improvements in neck pain upon successful completion of the prescribed home-based exercise programme. In addition to improvement in self-reported pain, disability experienced as assessed by the NDI also reduced, similar to the findings of previous studies conducted on individuals with chronic non-specific neck pain, by utilizing telerehabilitation. 11 , 29 Moreover, when comparisons were drawn between the results of both groups, the telerehabilitation group proved to be non-inferior to the conventional group in positively influencing neck pain and disability, in addition to large effect size for pain score and disability index in favour of telerehabilitation. 30 , 31 Cervical ROM was assessed in terms of cervical flexion, extension, lateral flexion, and rotation on both sides. 32 Post-exercise measurements for both groups exhibited an increase in all values of cervical ROM, similar to findings from other studies. 3 , 33 Both groups presented a significant increase in cervical muscle endurance based on the findings of CCFT; however, no group was found superior to the other in this regard. This finding is in line with that of a study conducted by Ozer et al. (2021). Notably when it comes to improving posture and relieving chronic neck pain, exercises that target the activation of the deep flexor muscle of the neck (such as chin tucks and chin tucks with overpressure) have demonstrated superior outcomes compared to general strengthening exercises. 34 This is explained by findings that reveal that cervical muscles that have undergone strength training in addition to endurance training and stretching demonstrate increases in motor unit recruitment, firing rate per unit, and capillarization, all of which result in an increase in the strength and endurance of the cervical musculature. 7 , 35 Our findings suggest that telerehabilitation provides meaningful clinical improvement in patient symptoms, unlike previous studies. 13 Healthcare providers and patients alike can be encouraged to consider this mode of treatment delivery when access, time, and costs pose difficulties. 8 , 31 Regarding adherence to the exercise programme, both methods of treatment delivery were feasible since, overall, both groups showed good compliance with the frequency of sessions (3 times a week for 6 weeks). When looking at adherence to session duration, our study found that TR had longer sessions on average than CG. This may be owed to the video recording and monitoring facilities available from the telerehabilitation software that enable the therapist to review the entire session. 10 , 36 , 37 However, both groups exhibited shorter exercise durations than the recommended duration of 30 minutes, 38 possibly due to time constraints, busy lifestyles, or experiencing improvement in symptoms even with a shorter session duration. The effect of confounders cannot be ignored when comparing all variables, particularly pain, as it was the main outcome measure in this study. The diet of an individual is a variable confounding factor that can affect the neck pain experienced by them, which was not anticipated. 39 , 40 Another such factor is sleeping position, as it is known to greatly affect the intensity of pain, especially waking pain and perceived severity of disability. 41 , 42 Additionally, anxiety and depression have been identified as psychosocial factors that alter the pain perception of those affected by it. 43 , 44 Physical activity and chronic pain sensitivity have also been associated in recent studies, particularly in women. 45 , 46 Moreover, some participants may have used a cervical collar without informing the researcher, which may have influenced the amount of pain felt. Raising awareness of healthy and active lifestyles is key to a person’s general well-being and is crucial in managing any type of chronic pain. Particularly in cases where people find healthcare inaccessible owing to distance, time, or high costs, telerehabilitation-based care can prove to be quite effective and long-lasting. 12 , 47 All participants were given general advice after completing the 6-week exercise programme. These included ergonomic training, education about sleeping and sitting posture, and advice to continue with recommended exercises from the home programme, along with general fitness topics. 9 , 47 Considering that a large proportion of participants in this age group spent long hours using a computer, sitting at a desk posture was explained to them, such as the use of a spinal support chair, distance between eye and monitor, adjusting the desk height so that the forearms could rest on the surface, adjusting the chair height so that the feet could rest on the floor, etc. 48 , 49 Moreover, the importance of comfortable sleeping posture in either supine or side-lying, with appropriate neck support, was elaborated, in addition to the use of a good pillow with the right amount of thickness (10-12 cm) and firmness. 42 , 50 For those suffering from chronic non-specific neck pain, especially females, this mode of exercise delivery brings about the success of exercise sessions in terms of symptom improvement as well as increased cervical muscle ROM and endurance. Based on these results, especially considering adherence, treatment is favourable for TR. Telerehabilitation, due to its benefits of increased patient adherence, cost-effectiveness, and providing convenience, gives medical professionals with a robust means to providing healthcare. Although it proves to be a useful tool for home-based exercises, it is crucial to remember that telerehabilitation is recommended as an extension to in-person care and not a replacement for hands-on clinical sessions, such as manual therapy, provided by a physiotherapist. Blinding of neither participants nor researchers was done, which presents a limitation. Because all participants in this study were females, the results cannot be generalized to the entire population. Moreover, all participants who were randomized into the telerehabilitation group were expected to have software-compatible devices, such as laptops or mobile phones, as well as a stable internet connection. The duration of treatment may be another potential limitation. Considering that this is a pilot study, a larger sample size, longer duration of treatment, and extended follow-up periods for randomized controlled trials are recommended for the future. Studies can build on the methods used in this study, and in addition to its findings, by including both gender comparisons, exploring the effects of varying treatment durations is recommended. Furthermore, the influence of factors such as diet, physical activity, sleeping position, and stress should also be studied. In conclusion, home-based exercises for chronic non-specific neck pain showed significant improvement in neck pain, disability, cervical ROM, and cervical muscle endurance for both groups, when followed for six weeks, in addition to large effect size for pain score and disability index in favour of telerehabilitation. While both groups showed good adherence to the frequency of sessions, telerehabilitation group exhibited better adherence to the duration of the exercise sessions. Ethics and consent Upon receiving ethical approval from the UOS Research Ethics Committee (REC-23-02-27-01-PG) and registration with ClinicalTrials.gov (US) (NCT06076174), data collection commenced. E-posters with study details were sent out to announce the recruitment of participants, and those who voluntarily offered their participation, met the requirements of the inclusion criteria and gave verbal and written consent were recruited. Data availability Dataset and extended date are available in Harvard Dataverse repository, under the title “Effects of 6-Week Exercise Programme On Chronic Non-Specific Neck Pain In Women”, DOI: https://doi.org/10.7910/DVN/ZMC9DU , under the CC0 1.0 license. 51 Acknowledgements The authors would like to thank the University of Sharjah Department of Physiotherapy and the Care Space and ConnectToMyDoctor teams for their support. References 1. Goode AP, Freburger J, Carey T: Prevalence, practice patterns, and evidence for chronic neck pain. Arthritis Care Res (Hoboken). 2010; 62 (11): 1594–1601. PubMed Abstract | Publisher Full Text | Free Full Text 2. Kääriä S, Laaksonen M, Rahkonen O, et al. : Risk factors of chronic neck pain: A prospective study among middle-aged employees. Eur. J. Pain (United Kingdom). 2012; 16 (6): 911–920. Publisher Full Text 3. Kazeminasab S, Nejadghaderi SA, Amiri P, et al. : Neck pain: global epidemiology, trends and risk factors. BMC Musculoskelet. 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Johnston V, Chen X, Welch A, et al. : A cluster-randomized trial of workplace ergonomics and neck-specific exercise versus ergonomics and health promotion for office workers to manage neck pain – a secondary outcome analysis. BMC Musculoskelet. Disord. 2021; 22 (1): 1–12. 50. Yamada S, Hoshi T, Toda M, et al. : Changes in neck pain and somatic symptoms before and after the adjustment of the pillow height. J. Phys. Ther. Sci. 2023; 35 (2): 106–113. PubMed Abstract | Publisher Full Text | Free Full Text 51. Ahmed Z: Effects of 6-Week Exercise Programme On Chronic Non-Specific Neck Pain In Women. Harvard Dataverse. 2024. Publisher Full Text Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 07 Feb 2025 ADD YOUR COMMENT Comment Author details Author details 1 Department of Physiotherapy, University of Sharjah, Sharjah, Sharjah, United Arab Emirates Zaina Zahur Ahmed Roles: Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Project Administration, Software, Supervision, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Mohammad Nayel Aqil Khan Roles: Data Curation, Formal Analysis, Investigation, Project Administration, Software, Visualization, Writing – Review & Editing Kalyana Chakravarthy Bairapareddy Roles: Conceptualization, Data Curation, Formal Analysis, Methodology, Resources, Software, Supervision, Validation, Writing – Review & Editing Competing interests No competing interests were disclosed. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (2) version 2 Revised Published: 22 Apr 2025, 14:174 https://doi.org/10.12688/f1000research.160247.2 version 1 Published: 07 Feb 2025, 14:174 https://doi.org/10.12688/f1000research.160247.1 Copyright © 2025 Ahmed ZZ et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Ahmed ZZ, Aqil Khan MN and Bairapareddy KC. Effects Of 6-Week Telerehabilitation Exercise Programme On Chronic Non-Specific Neck Pain In Women: A Pilot Randomized Controlled Trial [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2025, 14 :174 ( https://doi.org/10.12688/f1000research.160247.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 1 VERSION 1 PUBLISHED 07 Feb 2025 Views 0 Cite How to cite this report: Hao J. Reviewer Report For: Effects Of 6-Week Telerehabilitation Exercise Programme On Chronic Non-Specific Neck Pain In Women: A Pilot Randomized Controlled Trial [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2025, 14 :174 ( https://doi.org/10.5256/f1000research.176111.r377585 ) The direct URL for this report is: https://f1000research.com/articles/14-174/v1#referee-response-377585 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 02 May 2025 Jie Hao , University of Nebraska Medical Center, Omaha, USA Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.176111.r377585 The authors have conducted a well-structured pilot randomized controlled trial comparing a telerehabilitation intervention with a conventional home-based exercise program. The study design is clearly described, and the manuscript includes appropriate outcome measures such as pain, disability, cervical ROM, muscle ... Continue reading READ ALL The authors have conducted a well-structured pilot randomized controlled trial comparing a telerehabilitation intervention with a conventional home-based exercise program. The study design is clearly described, and the manuscript includes appropriate outcome measures such as pain, disability, cervical ROM, muscle endurance, and adherence. While the manuscript is overall well-written, several issues should be addressed to enhance the clarity of the study. The manuscript refers to this as a \"pilot study,\" but it lacks a clear rationale or reference for the selected sample size of 30 participants. Even in pilot trials, providing justification for the sample size is essential to contextualize findings. The rationale for studying only female participants should be better justified. Please explicitly state the research hypotheses and expected outcomes. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: physical therapy, digital health, rehabilitation I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Hao J. Reviewer Report For: Effects Of 6-Week Telerehabilitation Exercise Programme On Chronic Non-Specific Neck Pain In Women: A Pilot Randomized Controlled Trial [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2025, 14 :174 ( https://doi.org/10.5256/f1000research.176111.r377585 ) The direct URL for this report is: https://f1000research.com/articles/14-174/v1#referee-response-377585 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Hazari A. Reviewer Report For: Effects Of 6-Week Telerehabilitation Exercise Programme On Chronic Non-Specific Neck Pain In Women: A Pilot Randomized Controlled Trial [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2025, 14 :174 ( https://doi.org/10.5256/f1000research.176111.r365949 ) The direct URL for this report is: https://f1000research.com/articles/14-174/v1#referee-response-365949 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 11 Apr 2025 Animesh Hazari , Gulf Medical University, Ajman, United Arab Emirates Approved VIEWS 0 https://doi.org/10.5256/f1000research.176111.r365949 Strengths of the Manuscript: The use of randomized controlled trial (RCT) design strengthens the validity of findings. A detailed methodology section ensures reproducibility. Telerehabilitation is an emerging field, and the study addresses a timely issue, especially given the post-pandemic ... Continue reading READ ALL Strengths of the Manuscript: The use of randomized controlled trial (RCT) design strengthens the validity of findings. A detailed methodology section ensures reproducibility. Telerehabilitation is an emerging field, and the study addresses a timely issue, especially given the post-pandemic shift towards digital healthcare. Areas for Improvement and Suggestions: 1. Abstract: The conclusion states that no group was found superior to the other, & yet partial eta squared values indicate a large effect in favor of telerehabilitation for pain and disability. 2. Introduction: The manuscript mentions that females have a higher prevalence of neck pain, but additional justification is needed. Expand on sex-specific physiological differences that might influence treatment response. 3. Methods: The study mentions a permuted block randomization method but does not specify how the block sizes were determined. The manuscript states that this is a pilot study but does not provide a rationale for selecting 30 participants. 4. Results: The between-group p-values for VAS Pain and NDI are non-significant (0.47, 0.84), yet partial eta-squared values suggest a meaningful effect. Consider discussing whether the study was underpowered to detect between- group differences. 5. Discussion: The discussion mostly reiterates results but should provide more actionable insights for clinicians. While the discussion mentions diet, sleep, and psychological factors as confounders, the study does not account for these variables. Suggested to acknowledge this as a limitation and propose future research to explore these effects. 6. Conclusion: The conclusion states that telerehabilitation is a viable alternative but does not emphasize its benefits in adherence. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Partly Are all the source data underlying the results available to ensure full reproducibility? Partly Are the conclusions drawn adequately supported by the results? Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: Biomechanics I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Hazari A. Reviewer Report For: Effects Of 6-Week Telerehabilitation Exercise Programme On Chronic Non-Specific Neck Pain In Women: A Pilot Randomized Controlled Trial [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2025, 14 :174 ( https://doi.org/10.5256/f1000research.176111.r365949 ) The direct URL for this report is: https://f1000research.com/articles/14-174/v1#referee-response-365949 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Tümtürk İ. Reviewer Report For: Effects Of 6-Week Telerehabilitation Exercise Programme On Chronic Non-Specific Neck Pain In Women: A Pilot Randomized Controlled Trial [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2025, 14 :174 ( https://doi.org/10.5256/f1000research.176111.r367541 ) The direct URL for this report is: https://f1000research.com/articles/14-174/v1#referee-response-367541 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 25 Feb 2025 İsmet Tümtürk , Antalya Bilim University, Antalya, Turkey Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.176111.r367541 First of all, I congratulate the authors for this valuable work. However, I would like to make some suggestions. Introduction 1- Please state the purpose and hypotheses of the study. 2- Elaborate the introduction a little ... Continue reading READ ALL First of all, I congratulate the authors for this valuable work. However, I would like to make some suggestions. Introduction 1- Please state the purpose and hypotheses of the study. 2- Elaborate the introduction a little more, e.g. with a description of the advantages of tele rehabilitation and the importance of the study method among these advantages. Indicate the contribution of the study to the literature. Methods 1- Check the manuscript with regard to English. Write sentences more clearly and simply. For example, “This study compared the effectiveness of two different methods of administering the same 6-week home-based exercise program for chronic nonspecific neck pain. This was a pilot randomized controlled trial.” can be corrected to \"The present pilot randomized controlled trial investigated the effectiveness of 6-week tele rehabilitation program in women with chronic nonspecific neck pain\". 2- How did you determine the sample size? If you used a method similar to G*Power, please specify this in detail. 3- Give the explanations for abbreviations such as VAS, ROM, etc. at the first mention in the manuscript. 4- Detail the measurement procedures. For example, indicate what kind of questions the NDI contains and what its high scores mean, how CROM is measured and cite the procedure used from the literature. 5- Please detail the procedure section. What was the sequence of the measurements? Were rest periods given between measurements? What were the exercises given? Which outcome measures were evaluated in the interim assessments and how? Why did the participants in the TR group take videos of themselves during the exercise and in which assessment were these recorded videos used? The procedure section should be detailed enough to adequately inform the readers. 6- In the statistical analysis part, did the distributions follow a normal distribution (parametric or non-parametric)? It seems that the number of participants in the groups is small, but the statistical methods used are the statistical methods used in parametric distributions. Please clarify this. 7- ANOVA was used in the statistical analysis, but there are only two groups in the study, and you have specified two measurement points as measurement points (pretest and posttest). ANOVA is mostly used for three or more groups or measurement points. Explain why you preferred ANOVA in this study. Results 1-“All 31 participants (females) completed the 6-week intervention (15 in the TR and 16 in the CG).” in the sentence ‘31’ is redundant. 2- The baseline characteristics of the participants did not include information such as smoking and symptom duration. If these assessments are available, please add them to Table 1. If not available, discuss in the limitations section. Discussion 1- In the discussion section, discuss the results, including effect sizes. 2- Write the conclusion as the last paragraph. 3- Briefly discuss also the results that are not significantly different. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Partly If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: Orthopedic rehabilitation I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Tümtürk İ. Reviewer Report For: Effects Of 6-Week Telerehabilitation Exercise Programme On Chronic Non-Specific Neck Pain In Women: A Pilot Randomized Controlled Trial [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2025, 14 :174 ( https://doi.org/10.5256/f1000research.176111.r367541 ) The direct URL for this report is: https://f1000research.com/articles/14-174/v1#referee-response-367541 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 08 Mar 2025 Zaina Ahmed , Department of Physiotherapy, University of Sharjah, Sharjah, United Arab Emirates 08 Mar 2025 Author Response Introduction 1- Please state the purpose and hypotheses of the study. The following text will be added to the introduction: “The purpose of this study is to determine ... Continue reading Introduction 1- Please state the purpose and hypotheses of the study. The following text will be added to the introduction: “The purpose of this study is to determine the effectiveness of telerehabilitation exercise intervention is in females with chronic non-specific neck pain, via measuring the pain score, disability index, CROM, cervical muscle endurance and their adherence to the exercise programme. It is hypothesised that there would be notable improvements in pain score, disability index, CROM, cervical muscle endurance in both groups suffering from chronic non-specific neck pain, but telerehabilitation exercise programme would result in greater improvements in all outcome measures, and particularly better patient adherence, as compared to conventional exercise programme.” 2- Elaborate the introduction a little more, e.g. with a description of the advantages of tele rehabilitation and the importance of the study method among these advantages. Indicate the contribution of the study to the literature. The following text will be added to the introduction: “A potential solution to patients not adhering to prescribed exercise regimens could be telerehabilitation. Due to its advantages in terms of patient adherence, cost-effectiveness, and convenience, healthcare professionals are encouraged to implement this type of intervention, which might be extended to in-patient care. For individuals suffering from chronic non-specific neck pain, telerehabilitation can guarantee the effectiveness of following exercise sessions and, consequently, of the treatment programme itself.” Methods 1- Check the manuscript with regard to English. Write sentences more clearly and simply. For example, “This study compared the effectiveness of two different methods of administering the same 6-week home-based exercise program for chronic nonspecific neck pain. This was a pilot randomized controlled trial.” can be corrected to \"The present pilot randomized controlled trial investigated the effectiveness of 6-week tele rehabilitation program in women with chronic nonspecific neck pain\". Thank you for your comment, agreed. 2- How did you determine the sample size? If you used a method similar to G*Power, please specify this in detail. The following text will be added to the methods - sample: “Based on the effect size of 0.95 utilizing the VAS mean and standard deviation values, alpha error of 5%, study power of 80%, and allocation ratio of 1, a total sample size of 30 participants was deemed suitable (Ozer et al., 2021).” 3- Give the explanations for abbreviations such as VAS, ROM, etc. at the first mention in the manuscript. These abbreviations have been expanded wherever they first appear in the manuscript. 4- Detail the measurement procedures. For example, indicate what kind of questions the NDI contains and what its high scores mean, how CROM is measured and cite the procedure used from the literature. Sure, will add what the scores mean. 5- Please detail the procedure section. What was the sequence of the measurements? Were rest periods given between measurements? What were the exercises given? Which outcome measures were evaluated in the interim assessments and how? Why did the participants in the TR group take videos of themselves during the exercise and in which assessment were these recorded videos used? The procedure section should be detailed enough to adequately inform the readers. The sequence of measures is as they appear in text. Regarding, the exercise manual, with descriptions for all exercises, are provided as an additional document. 6- In the statistical analysis part, did the distributions follow a normal distribution (parametric or non-parametric)? It seems that the number of participants in the groups is small, but the statistical methods used are the statistical methods used in parametric distributions. Please clarify this. It is mentioned in the manuscript that “The Shapiro-Wilk test determined that the data had a normal distribution”. 7- ANOVA was used in the statistical analysis, but there are only two groups in the study, and you have specified two measurement points as measurement points (pretest and posttest). ANOVA is mostly used for three or more groups or measurement points. Explain why you preferred ANOVA in this study. The mixed model ANOVA was chosen as it is more flexible and allows us to analyze the effects of continuous within- and between-subjects variables. Results 1-“All 31 participants (females) completed the 6-week intervention (15 in the TR and 16 in the CG).” in the sentence ‘31’ is redundant. Sure, will change that. 2- The baseline characteristics of the participants did not include information such as smoking and symptom duration. If these assessments are available, please add them to Table 1. If not available, discuss in the limitations section. Symptom duration has been mentioned in the inclusion criteria. Discussion 1- In the discussion section, discuss the results, including effect sizes. Thank you for your comment, will add that. 2- Write the conclusion as the last paragraph. Okay, will separate the text into a separate paragraph. 3- Briefly discuss also the results that are not significantly different. This has been discussed in the second and third paragraphs of the discussion. Introduction 1- Please state the purpose and hypotheses of the study. The following text will be added to the introduction: “The purpose of this study is to determine the effectiveness of telerehabilitation exercise intervention is in females with chronic non-specific neck pain, via measuring the pain score, disability index, CROM, cervical muscle endurance and their adherence to the exercise programme. It is hypothesised that there would be notable improvements in pain score, disability index, CROM, cervical muscle endurance in both groups suffering from chronic non-specific neck pain, but telerehabilitation exercise programme would result in greater improvements in all outcome measures, and particularly better patient adherence, as compared to conventional exercise programme.” 2- Elaborate the introduction a little more, e.g. with a description of the advantages of tele rehabilitation and the importance of the study method among these advantages. Indicate the contribution of the study to the literature. The following text will be added to the introduction: “A potential solution to patients not adhering to prescribed exercise regimens could be telerehabilitation. Due to its advantages in terms of patient adherence, cost-effectiveness, and convenience, healthcare professionals are encouraged to implement this type of intervention, which might be extended to in-patient care. For individuals suffering from chronic non-specific neck pain, telerehabilitation can guarantee the effectiveness of following exercise sessions and, consequently, of the treatment programme itself.” Methods 1- Check the manuscript with regard to English. Write sentences more clearly and simply. For example, “This study compared the effectiveness of two different methods of administering the same 6-week home-based exercise program for chronic nonspecific neck pain. This was a pilot randomized controlled trial.” can be corrected to \"The present pilot randomized controlled trial investigated the effectiveness of 6-week tele rehabilitation program in women with chronic nonspecific neck pain\". Thank you for your comment, agreed. 2- How did you determine the sample size? If you used a method similar to G*Power, please specify this in detail. The following text will be added to the methods - sample: “Based on the effect size of 0.95 utilizing the VAS mean and standard deviation values, alpha error of 5%, study power of 80%, and allocation ratio of 1, a total sample size of 30 participants was deemed suitable (Ozer et al., 2021).” 3- Give the explanations for abbreviations such as VAS, ROM, etc. at the first mention in the manuscript. These abbreviations have been expanded wherever they first appear in the manuscript. 4- Detail the measurement procedures. For example, indicate what kind of questions the NDI contains and what its high scores mean, how CROM is measured and cite the procedure used from the literature. Sure, will add what the scores mean. 5- Please detail the procedure section. What was the sequence of the measurements? Were rest periods given between measurements? What were the exercises given? Which outcome measures were evaluated in the interim assessments and how? Why did the participants in the TR group take videos of themselves during the exercise and in which assessment were these recorded videos used? The procedure section should be detailed enough to adequately inform the readers. The sequence of measures is as they appear in text. Regarding, the exercise manual, with descriptions for all exercises, are provided as an additional document. 6- In the statistical analysis part, did the distributions follow a normal distribution (parametric or non-parametric)? It seems that the number of participants in the groups is small, but the statistical methods used are the statistical methods used in parametric distributions. Please clarify this. It is mentioned in the manuscript that “The Shapiro-Wilk test determined that the data had a normal distribution”. 7- ANOVA was used in the statistical analysis, but there are only two groups in the study, and you have specified two measurement points as measurement points (pretest and posttest). ANOVA is mostly used for three or more groups or measurement points. Explain why you preferred ANOVA in this study. The mixed model ANOVA was chosen as it is more flexible and allows us to analyze the effects of continuous within- and between-subjects variables. Results 1-“All 31 participants (females) completed the 6-week intervention (15 in the TR and 16 in the CG).” in the sentence ‘31’ is redundant. Sure, will change that. 2- The baseline characteristics of the participants did not include information such as smoking and symptom duration. If these assessments are available, please add them to Table 1. If not available, discuss in the limitations section. Symptom duration has been mentioned in the inclusion criteria. Discussion 1- In the discussion section, discuss the results, including effect sizes. Thank you for your comment, will add that. 2- Write the conclusion as the last paragraph. Okay, will separate the text into a separate paragraph. 3- Briefly discuss also the results that are not significantly different. This has been discussed in the second and third paragraphs of the discussion. Competing Interests: Authors declare no competing interests. Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 08 Mar 2025 Zaina Ahmed , Department of Physiotherapy, University of Sharjah, Sharjah, United Arab Emirates 08 Mar 2025 Author Response Introduction 1- Please state the purpose and hypotheses of the study. The following text will be added to the introduction: “The purpose of this study is to determine ... Continue reading Introduction 1- Please state the purpose and hypotheses of the study. The following text will be added to the introduction: “The purpose of this study is to determine the effectiveness of telerehabilitation exercise intervention is in females with chronic non-specific neck pain, via measuring the pain score, disability index, CROM, cervical muscle endurance and their adherence to the exercise programme. It is hypothesised that there would be notable improvements in pain score, disability index, CROM, cervical muscle endurance in both groups suffering from chronic non-specific neck pain, but telerehabilitation exercise programme would result in greater improvements in all outcome measures, and particularly better patient adherence, as compared to conventional exercise programme.” 2- Elaborate the introduction a little more, e.g. with a description of the advantages of tele rehabilitation and the importance of the study method among these advantages. Indicate the contribution of the study to the literature. The following text will be added to the introduction: “A potential solution to patients not adhering to prescribed exercise regimens could be telerehabilitation. Due to its advantages in terms of patient adherence, cost-effectiveness, and convenience, healthcare professionals are encouraged to implement this type of intervention, which might be extended to in-patient care. For individuals suffering from chronic non-specific neck pain, telerehabilitation can guarantee the effectiveness of following exercise sessions and, consequently, of the treatment programme itself.” Methods 1- Check the manuscript with regard to English. Write sentences more clearly and simply. For example, “This study compared the effectiveness of two different methods of administering the same 6-week home-based exercise program for chronic nonspecific neck pain. This was a pilot randomized controlled trial.” can be corrected to \"The present pilot randomized controlled trial investigated the effectiveness of 6-week tele rehabilitation program in women with chronic nonspecific neck pain\". Thank you for your comment, agreed. 2- How did you determine the sample size? If you used a method similar to G*Power, please specify this in detail. The following text will be added to the methods - sample: “Based on the effect size of 0.95 utilizing the VAS mean and standard deviation values, alpha error of 5%, study power of 80%, and allocation ratio of 1, a total sample size of 30 participants was deemed suitable (Ozer et al., 2021).” 3- Give the explanations for abbreviations such as VAS, ROM, etc. at the first mention in the manuscript. These abbreviations have been expanded wherever they first appear in the manuscript. 4- Detail the measurement procedures. For example, indicate what kind of questions the NDI contains and what its high scores mean, how CROM is measured and cite the procedure used from the literature. Sure, will add what the scores mean. 5- Please detail the procedure section. What was the sequence of the measurements? Were rest periods given between measurements? What were the exercises given? Which outcome measures were evaluated in the interim assessments and how? Why did the participants in the TR group take videos of themselves during the exercise and in which assessment were these recorded videos used? The procedure section should be detailed enough to adequately inform the readers. The sequence of measures is as they appear in text. Regarding, the exercise manual, with descriptions for all exercises, are provided as an additional document. 6- In the statistical analysis part, did the distributions follow a normal distribution (parametric or non-parametric)? It seems that the number of participants in the groups is small, but the statistical methods used are the statistical methods used in parametric distributions. Please clarify this. It is mentioned in the manuscript that “The Shapiro-Wilk test determined that the data had a normal distribution”. 7- ANOVA was used in the statistical analysis, but there are only two groups in the study, and you have specified two measurement points as measurement points (pretest and posttest). ANOVA is mostly used for three or more groups or measurement points. Explain why you preferred ANOVA in this study. The mixed model ANOVA was chosen as it is more flexible and allows us to analyze the effects of continuous within- and between-subjects variables. Results 1-“All 31 participants (females) completed the 6-week intervention (15 in the TR and 16 in the CG).” in the sentence ‘31’ is redundant. Sure, will change that. 2- The baseline characteristics of the participants did not include information such as smoking and symptom duration. If these assessments are available, please add them to Table 1. If not available, discuss in the limitations section. Symptom duration has been mentioned in the inclusion criteria. Discussion 1- In the discussion section, discuss the results, including effect sizes. Thank you for your comment, will add that. 2- Write the conclusion as the last paragraph. Okay, will separate the text into a separate paragraph. 3- Briefly discuss also the results that are not significantly different. This has been discussed in the second and third paragraphs of the discussion. Introduction 1- Please state the purpose and hypotheses of the study. The following text will be added to the introduction: “The purpose of this study is to determine the effectiveness of telerehabilitation exercise intervention is in females with chronic non-specific neck pain, via measuring the pain score, disability index, CROM, cervical muscle endurance and their adherence to the exercise programme. It is hypothesised that there would be notable improvements in pain score, disability index, CROM, cervical muscle endurance in both groups suffering from chronic non-specific neck pain, but telerehabilitation exercise programme would result in greater improvements in all outcome measures, and particularly better patient adherence, as compared to conventional exercise programme.” 2- Elaborate the introduction a little more, e.g. with a description of the advantages of tele rehabilitation and the importance of the study method among these advantages. Indicate the contribution of the study to the literature. The following text will be added to the introduction: “A potential solution to patients not adhering to prescribed exercise regimens could be telerehabilitation. Due to its advantages in terms of patient adherence, cost-effectiveness, and convenience, healthcare professionals are encouraged to implement this type of intervention, which might be extended to in-patient care. For individuals suffering from chronic non-specific neck pain, telerehabilitation can guarantee the effectiveness of following exercise sessions and, consequently, of the treatment programme itself.” Methods 1- Check the manuscript with regard to English. Write sentences more clearly and simply. For example, “This study compared the effectiveness of two different methods of administering the same 6-week home-based exercise program for chronic nonspecific neck pain. This was a pilot randomized controlled trial.” can be corrected to \"The present pilot randomized controlled trial investigated the effectiveness of 6-week tele rehabilitation program in women with chronic nonspecific neck pain\". Thank you for your comment, agreed. 2- How did you determine the sample size? If you used a method similar to G*Power, please specify this in detail. The following text will be added to the methods - sample: “Based on the effect size of 0.95 utilizing the VAS mean and standard deviation values, alpha error of 5%, study power of 80%, and allocation ratio of 1, a total sample size of 30 participants was deemed suitable (Ozer et al., 2021).” 3- Give the explanations for abbreviations such as VAS, ROM, etc. at the first mention in the manuscript. These abbreviations have been expanded wherever they first appear in the manuscript. 4- Detail the measurement procedures. For example, indicate what kind of questions the NDI contains and what its high scores mean, how CROM is measured and cite the procedure used from the literature. Sure, will add what the scores mean. 5- Please detail the procedure section. What was the sequence of the measurements? Were rest periods given between measurements? What were the exercises given? Which outcome measures were evaluated in the interim assessments and how? Why did the participants in the TR group take videos of themselves during the exercise and in which assessment were these recorded videos used? The procedure section should be detailed enough to adequately inform the readers. The sequence of measures is as they appear in text. Regarding, the exercise manual, with descriptions for all exercises, are provided as an additional document. 6- In the statistical analysis part, did the distributions follow a normal distribution (parametric or non-parametric)? It seems that the number of participants in the groups is small, but the statistical methods used are the statistical methods used in parametric distributions. Please clarify this. It is mentioned in the manuscript that “The Shapiro-Wilk test determined that the data had a normal distribution”. 7- ANOVA was used in the statistical analysis, but there are only two groups in the study, and you have specified two measurement points as measurement points (pretest and posttest). ANOVA is mostly used for three or more groups or measurement points. Explain why you preferred ANOVA in this study. The mixed model ANOVA was chosen as it is more flexible and allows us to analyze the effects of continuous within- and between-subjects variables. Results 1-“All 31 participants (females) completed the 6-week intervention (15 in the TR and 16 in the CG).” in the sentence ‘31’ is redundant. Sure, will change that. 2- The baseline characteristics of the participants did not include information such as smoking and symptom duration. If these assessments are available, please add them to Table 1. If not available, discuss in the limitations section. Symptom duration has been mentioned in the inclusion criteria. Discussion 1- In the discussion section, discuss the results, including effect sizes. Thank you for your comment, will add that. 2- Write the conclusion as the last paragraph. Okay, will separate the text into a separate paragraph. 3- Briefly discuss also the results that are not significantly different. This has been discussed in the second and third paragraphs of the discussion. Competing Interests: Authors declare no competing interests. Close Report a concern COMMENT ON THIS REPORT Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 07 Feb 2025 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 3 Version 2 (revision) 22 Apr 25 Version 1 07 Feb 25 read read read İsmet Tümtürk , Antalya Bilim University, Antalya, Turkey Animesh Hazari , Gulf Medical University, Ajman, United Arab Emirates Jie Hao , University of Nebraska Medical Center, Omaha, USA Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2025 Hao J. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 02 May 2025 | for Version 1 Jie Hao , University of Nebraska Medical Center, Omaha, USA 0 Views copyright © 2025 Hao J. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The authors have conducted a well-structured pilot randomized controlled trial comparing a telerehabilitation intervention with a conventional home-based exercise program. The study design is clearly described, and the manuscript includes appropriate outcome measures such as pain, disability, cervical ROM, muscle endurance, and adherence. While the manuscript is overall well-written, several issues should be addressed to enhance the clarity of the study. The manuscript refers to this as a \"pilot study,\" but it lacks a clear rationale or reference for the selected sample size of 30 participants. Even in pilot trials, providing justification for the sample size is essential to contextualize findings. The rationale for studying only female participants should be better justified. Please explicitly state the research hypotheses and expected outcomes. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes Competing Interests No competing interests were disclosed. Reviewer Expertise physical therapy, digital health, rehabilitation I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (0) Hao J. Peer Review Report For: Effects Of 6-Week Telerehabilitation Exercise Programme On Chronic Non-Specific Neck Pain In Women: A Pilot Randomized Controlled Trial [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2025, 14 :174 ( https://doi.org/10.5256/f1000research.176111.r377585) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/14-174/v1#referee-response-377585 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2025 Hazari A. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 11 Apr 2025 | for Version 1 Animesh Hazari , Gulf Medical University, Ajman, United Arab Emirates 0 Views copyright © 2025 Hazari A. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Strengths of the Manuscript: The use of randomized controlled trial (RCT) design strengthens the validity of findings. A detailed methodology section ensures reproducibility. Telerehabilitation is an emerging field, and the study addresses a timely issue, especially given the post-pandemic shift towards digital healthcare. Areas for Improvement and Suggestions: 1. Abstract: The conclusion states that no group was found superior to the other, & yet partial eta squared values indicate a large effect in favor of telerehabilitation for pain and disability. 2. Introduction: The manuscript mentions that females have a higher prevalence of neck pain, but additional justification is needed. Expand on sex-specific physiological differences that might influence treatment response. 3. Methods: The study mentions a permuted block randomization method but does not specify how the block sizes were determined. The manuscript states that this is a pilot study but does not provide a rationale for selecting 30 participants. 4. Results: The between-group p-values for VAS Pain and NDI are non-significant (0.47, 0.84), yet partial eta-squared values suggest a meaningful effect. Consider discussing whether the study was underpowered to detect between- group differences. 5. Discussion: The discussion mostly reiterates results but should provide more actionable insights for clinicians. While the discussion mentions diet, sleep, and psychological factors as confounders, the study does not account for these variables. Suggested to acknowledge this as a limitation and propose future research to explore these effects. 6. Conclusion: The conclusion states that telerehabilitation is a viable alternative but does not emphasize its benefits in adherence. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Partly Are all the source data underlying the results available to ensure full reproducibility? Partly Are the conclusions drawn adequately supported by the results? Yes Competing Interests No competing interests were disclosed. Reviewer Expertise Biomechanics I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Hazari A. Peer Review Report For: Effects Of 6-Week Telerehabilitation Exercise Programme On Chronic Non-Specific Neck Pain In Women: A Pilot Randomized Controlled Trial [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2025, 14 :174 ( https://doi.org/10.5256/f1000research.176111.r365949) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/14-174/v1#referee-response-365949 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2025 Tümtürk İ. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 25 Feb 2025 | for Version 1 İsmet Tümtürk , Antalya Bilim University, Antalya, Turkey 0 Views copyright © 2025 Tümtürk İ. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions First of all, I congratulate the authors for this valuable work. However, I would like to make some suggestions. Introduction 1- Please state the purpose and hypotheses of the study. 2- Elaborate the introduction a little more, e.g. with a description of the advantages of tele rehabilitation and the importance of the study method among these advantages. Indicate the contribution of the study to the literature. Methods 1- Check the manuscript with regard to English. Write sentences more clearly and simply. For example, “This study compared the effectiveness of two different methods of administering the same 6-week home-based exercise program for chronic nonspecific neck pain. This was a pilot randomized controlled trial.” can be corrected to \"The present pilot randomized controlled trial investigated the effectiveness of 6-week tele rehabilitation program in women with chronic nonspecific neck pain\". 2- How did you determine the sample size? If you used a method similar to G*Power, please specify this in detail. 3- Give the explanations for abbreviations such as VAS, ROM, etc. at the first mention in the manuscript. 4- Detail the measurement procedures. For example, indicate what kind of questions the NDI contains and what its high scores mean, how CROM is measured and cite the procedure used from the literature. 5- Please detail the procedure section. What was the sequence of the measurements? Were rest periods given between measurements? What were the exercises given? Which outcome measures were evaluated in the interim assessments and how? Why did the participants in the TR group take videos of themselves during the exercise and in which assessment were these recorded videos used? The procedure section should be detailed enough to adequately inform the readers. 6- In the statistical analysis part, did the distributions follow a normal distribution (parametric or non-parametric)? It seems that the number of participants in the groups is small, but the statistical methods used are the statistical methods used in parametric distributions. Please clarify this. 7- ANOVA was used in the statistical analysis, but there are only two groups in the study, and you have specified two measurement points as measurement points (pretest and posttest). ANOVA is mostly used for three or more groups or measurement points. Explain why you preferred ANOVA in this study. Results 1-“All 31 participants (females) completed the 6-week intervention (15 in the TR and 16 in the CG).” in the sentence ‘31’ is redundant. 2- The baseline characteristics of the participants did not include information such as smoking and symptom duration. If these assessments are available, please add them to Table 1. If not available, discuss in the limitations section. Discussion 1- In the discussion section, discuss the results, including effect sizes. 2- Write the conclusion as the last paragraph. 3- Briefly discuss also the results that are not significantly different. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Partly If applicable, is the statistical analysis and its interpretation appropriate? Yes Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes Competing Interests No competing interests were disclosed. Reviewer Expertise Orthopedic rehabilitation I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (1) Author Response 08 Mar 2025 Zaina Ahmed, Department of Physiotherapy, University of Sharjah, Sharjah, United Arab Emirates Introduction 1- Please state the purpose and hypotheses of the study. The following text will be added to the introduction: “The purpose of this study is to determine the effectiveness of telerehabilitation exercise intervention is in females with chronic non-specific neck pain, via measuring the pain score, disability index, CROM, cervical muscle endurance and their adherence to the exercise programme. It is hypothesised that there would be notable improvements in pain score, disability index, CROM, cervical muscle endurance in both groups suffering from chronic non-specific neck pain, but telerehabilitation exercise programme would result in greater improvements in all outcome measures, and particularly better patient adherence, as compared to conventional exercise programme.” 2- Elaborate the introduction a little more, e.g. with a description of the advantages of tele rehabilitation and the importance of the study method among these advantages. Indicate the contribution of the study to the literature. The following text will be added to the introduction: “A potential solution to patients not adhering to prescribed exercise regimens could be telerehabilitation. Due to its advantages in terms of patient adherence, cost-effectiveness, and convenience, healthcare professionals are encouraged to implement this type of intervention, which might be extended to in-patient care. For individuals suffering from chronic non-specific neck pain, telerehabilitation can guarantee the effectiveness of following exercise sessions and, consequently, of the treatment programme itself.” Methods 1- Check the manuscript with regard to English. Write sentences more clearly and simply. For example, “This study compared the effectiveness of two different methods of administering the same 6-week home-based exercise program for chronic nonspecific neck pain. This was a pilot randomized controlled trial.” can be corrected to \"The present pilot randomized controlled trial investigated the effectiveness of 6-week tele rehabilitation program in women with chronic nonspecific neck pain\". Thank you for your comment, agreed. 2- How did you determine the sample size? If you used a method similar to G*Power, please specify this in detail. The following text will be added to the methods - sample: “Based on the effect size of 0.95 utilizing the VAS mean and standard deviation values, alpha error of 5%, study power of 80%, and allocation ratio of 1, a total sample size of 30 participants was deemed suitable (Ozer et al., 2021).” 3- Give the explanations for abbreviations such as VAS, ROM, etc. at the first mention in the manuscript. These abbreviations have been expanded wherever they first appear in the manuscript. 4- Detail the measurement procedures. For example, indicate what kind of questions the NDI contains and what its high scores mean, how CROM is measured and cite the procedure used from the literature. Sure, will add what the scores mean. 5- Please detail the procedure section. What was the sequence of the measurements? Were rest periods given between measurements? What were the exercises given? Which outcome measures were evaluated in the interim assessments and how? Why did the participants in the TR group take videos of themselves during the exercise and in which assessment were these recorded videos used? The procedure section should be detailed enough to adequately inform the readers. The sequence of measures is as they appear in text. Regarding, the exercise manual, with descriptions for all exercises, are provided as an additional document. 6- In the statistical analysis part, did the distributions follow a normal distribution (parametric or non-parametric)? It seems that the number of participants in the groups is small, but the statistical methods used are the statistical methods used in parametric distributions. Please clarify this. It is mentioned in the manuscript that “The Shapiro-Wilk test determined that the data had a normal distribution”. 7- ANOVA was used in the statistical analysis, but there are only two groups in the study, and you have specified two measurement points as measurement points (pretest and posttest). ANOVA is mostly used for three or more groups or measurement points. Explain why you preferred ANOVA in this study. The mixed model ANOVA was chosen as it is more flexible and allows us to analyze the effects of continuous within- and between-subjects variables. Results 1-“All 31 participants (females) completed the 6-week intervention (15 in the TR and 16 in the CG).” in the sentence ‘31’ is redundant. Sure, will change that. 2- The baseline characteristics of the participants did not include information such as smoking and symptom duration. If these assessments are available, please add them to Table 1. If not available, discuss in the limitations section. Symptom duration has been mentioned in the inclusion criteria. Discussion 1- In the discussion section, discuss the results, including effect sizes. Thank you for your comment, will add that. 2- Write the conclusion as the last paragraph. Okay, will separate the text into a separate paragraph. 3- Briefly discuss also the results that are not significantly different. This has been discussed in the second and third paragraphs of the discussion. View more View less Competing Interests Authors declare no competing interests. reply Respond Report a concern Tümtürk İ. Peer Review Report For: Effects Of 6-Week Telerehabilitation Exercise Programme On Chronic Non-Specific Neck Pain In Women: A Pilot Randomized Controlled Trial [version 2; peer review: 1 approved, 2 approved with reservations] . F1000Research 2025, 14 :174 ( https://doi.org/10.5256/f1000research.176111.r367541) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/14-174/v1#referee-response-367541 Alongside their report, reviewers assign a status to the article: Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions Adjust parameters to alter display View on desktop for interactive features Includes Interactive Elements View on desktop for interactive features Competing Interests Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. 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