{"paper_id":"22af571d-0109-4e4a-9a7f-664690be132f","body_text":"Globally, breast cancer is the second most frequently diagnosed malignancy after lung cancer, accounting for over two million cases annually [ 1 ]. It is also the leading cause of cancer death in women worldwide. In Japan, breast cancer was the most common cancer of women in 2018, and the fifth most common cause of cancer death in women in 2019 [ 2 ].\nFewer than one-third of women with newly diagnosed breast cancer are premenopausal [ 3 ]; however, administration of adjuvant endocrine therapy for hormone receptor-positive cancers is important regardless of menopausal status, to reduce the risk of recurrence.\nTamoxifen (TAM) is widely administered to women with hormone receptor-positive breast cancer. TAM is an established adjuvant therapeutic agent for breast cancer because of its antagonistic effect on that tissue. However, TAM is also a known risk factor for endometrial cancer because of its agonistic effects on the endometrium.\nDespite case reports regarding the relationship between endometriosis and TAM use, it remains unclear whether this agent induces or promotes endometriosis. We report here a woman with bilateral ovarian endometriomas that developed following TAM treatment.\n\nA 48-year-old premenopausal woman, gravida 1, para 1, presented with heavy menstrual bleeding. Transvaginal ultrasonography and magnetic resonance imaging (MRI) revealed one submucosal and multiple interstitial uterine fibroids. Additionally, she was anemic.\nGiven that her fibroids were symptomatic, a total laparoscopic hysterectomy with ovarian conservation was performed. Intraoperatively, the uterus was seen to be enlarged, but both ovaries were macroscopically normal. There was no macroscopic evidence of endometriosis on laparoscopy ( Fig. 1 ). Fig. 1 Laparoscopic image showing no endometriotic lesions in both ovaries (arrows) and the peritoneum. Fig. 1\nLaparoscopic image showing no endometriotic lesions in both ovaries (arrows) and the peritoneum.\nTwo years after the hysterectomy, she was diagnosed with breast cancer and underwent mastectomy followed by radiotherapy. She was prescribed oral tamoxifen (20 mg/day) as adjuvant therapy. No pelvic masses were detected on ultrasound sonography at that time. Three years after the hysterectomy, at the age of 51 years, she presented with lower abdominal pain of sudden onset. A 7-cm diameter, right pelvic, multilocular cyst and a left unilocular cyst were detected by contrast enhanced CT and MRI examination ( Fig. 2 ). Bilateral endometriotic ovarian cysts were suspected and accordingly laparoscopic bilateral salpingo-oophorectomy was performed. Fig. 2 MRI findings of (A) axial T2-weighted image and (B) axial T1-weighted image revealing a right pelvic multilocular cyst (7 cm in diameter) (arrows) and a left unilocular cyst with high-signal intensity on the T1-weighted image (arrows). Fig. 2\nMRI findings of (A) axial T2-weighted image and (B) axial T1-weighted image revealing a right pelvic multilocular cyst (7 cm in diameter) (arrows) and a left unilocular cyst with high-signal intensity on the T1-weighted image (arrows).\nAt laparoscopy, the diameter of her right ovary was 4 cm and of the left ovary 7 cm. No intraperitoneal adhesions were identified. The cysts contained chocolate-like liquid ( Fig. 3 ,  Fig. 4 ). Fig. 3 Laparoscopic findings (A) The left ovary is 7 cm. (B) The right ovary is 4 cm. No intraperitoneal adhesions were detected. Fig. 3 Fig. 4 There is chocolate-like liquid in (A) the left and (B) right ovaries. Fig. 4\nLaparoscopic findings (A) The left ovary is 7 cm. (B) The right ovary is 4 cm. No intraperitoneal adhesions were detected.\nThere is chocolate-like liquid in (A) the left and (B) right ovaries.\nShe was diagnosed as having bilateral ovarian endometriotic cysts with no histopathological evidence of malignancy. Postoperatively, anastrozole (an aromatase inhibiter) was substituted for TAM.\n\nTAM has antiestrogenic activity in breast tissue, whereas it has an estrogen-like effect on the endometrium. TAM has been associated with endometrial proliferation leading to endometrial hyperplasia, polyps, endometriosis, and carcinoma [ 4 ]. Numerous reports of endometriosis developing during treatment with tamoxifen have been published [ [5] ,  [6] ,  [7] ,  [8] ,  [9] ,  [10] ,  [11] ] ( Table 1 ). The Breast Cancer Prevention Trial by the National Surgical Adjuvant Breast and Bowel Project reported that women taking TAM have a greater incidence of endometriosis than do women taking a placebo (RR = 2.0). [ 4 ] However, little is known about the progression of endometriosis in women taking tamoxifen. This case report describes the development of benign ovarian endometriomas in a tamoxifen user whose ovaries were macroscopically normal before treatment. Table 1 Case reports of endometriosis developing during administration of tamoxifen [ [5] ,  [6] ,  [7] ,  [8] ,  [9] ,  [10] ,  [11] ]. Table 1 age pre/post menopausal region period of medication 42 premenopausal Ovary 19 months Abad de Velasco et al. [ 5 ] 37 premenopausal Ovary 13 months Morgan et al. [ 6 ] 26 premenopausal Ovary 12 months Morgan et al. [ 6 ] 54 premenopausal Douglas' pouch 5 months Ford et al. [ 7 ] 41 premenopausal Douglas' pouch 1 months Rose et al. [ 8 ] 55 postmenopausal retroperitoneum 24 months Naufel et al. [ 9 ] 60 postmenopausal Douglas' pouch, rectum 24 months Hajjar et al. [ 10 ] 66 postmenopausal Ovary 48 months Choi IH et al. [ 11 ]\nCase reports of endometriosis developing during administration of tamoxifen [ [5] ,  [6] ,  [7] ,  [8] ,  [9] ,  [10] ,  [11] ].\nGiven the risk of malignant transformation in endometriosis [ 12 , 13 ], women taking TAM should be advised to have gynecological follow-up.\n\nWe report here a case of ovarian endometriosis in a TAM user. Because TAM can stimulate endometrial tissue, women should be followed up regularly. In the present case, the ovarian endometriomas arose in a woman who had macroscopically normal ovaries before treatment.\n\nSatoshi Nishiyama contributed to patient management, data collection and analysis and drafted the manuscript.\nSotaro Hayashi, Naoki Abe, Sachino Kira, Miho Oda, Lifa Lee, Yoko To, and Maki Goto contributed to data analysis and editing of the manuscript.\nHiroshi Tsujioka contributed to patient management, data analysis, and editing of the manuscript.\nAll authors approved the final submitted article.\n\nNo funding was received for the writing of this case report.\n\nInformed consent for publication of this case report was obtained from the patient.\n\nThis article was not commissioned and was peer reviewed.\n\nThe authors declare that they have no conflict of interest regarding the publication of this case report.","source_license":"CC0","license_restricted":false}