{"paper_id":"2235d7ad-0922-4e04-b290-ad365e2bca33","body_text":"Received: 21 Feb 2018;\nPublished: 30 Jul 2018.\nAbstract\nBackground: In endometriosis there is a decrease in endometrial receptivity. Kebar and Metformin grasses are expected to improve the condition of endometrial receptivity\nObjective: To find out whether there is any effect of giving Kebar grass extract and metformin on endometrial receptivity\nMethods: The study was designed by using a simple experimental randomization. It was conducted in Obstetrics Gynecology Department - Faculty of Medicine Diponegoro University and Faculty of Veterinary Medicine Airlangga University. Sample calculation was employed. The study was done within five groups including control group with normal mice, group of endometriosis mouse models given placebo, group of endometriosis mouse models given Kebar grass extract, group of endometriosis mouse models given metformin, and group of endometriosis mouse models given the combination of Kebar grass – metformin extract. The examination materials of ανβ3 integrin and Leukemia Inhibitory Factors were taken from the uteri of the mice and measured by the Rammele Scale Index (Immuno Reactive Score), while the Superoxide Dismutase examination using ELISA was derived from mice serum. These examinations were performed by two veterinarians\nResults: The expression of ανβ3 integrin was significantly higher in the group of mouse models given Kebar grass extract as well as the combination of Kebar and metformin grass extracts (p <0.05) rather than in the group of endometriosis mouse models with no treatment, whereas LIF expression was significantly higher in the group given Kebar grass extract, metformin and combination of both extracts (p <0.05). Serum SOD levels remained the same.\nConclusion: The expressions of ανβ3 Integrin and LIF are higher due to the provision of Kebar grass extract as well as the combination of Kebar grass and metformin extracts\nNote: This article has supplementary file(s).\nFulltext\nView|Download\n|\nResearch Instrument\nGraphics and Table\nEmail colleagues\n| Subject | |\n| Type | Research Instrument |\n| Download (142KB) Indexing metadata |\nKeywords: Integrin ανβ3; Leukemia Inhibitory Factor; Superoxide Dismutase; Kebar grass; Metformin\nArticle Metrics:\nArticle Info\n- Greaves E, Cousins FL, Murray A, Esnal-Zufiaurre A, Fassbender A, Horne AW, et al. A Novel Mouse Model of Endometriosis Mimics Human Phenotype an Reveals Insights into the Inflammatory Contribution of Shed Endometrium. Am J Pathol. 2014;184:1930 - 9\n- Titrikou S, Eklu-Gadegbeku K, Mouzou A, Aklikokou K, Gbeassor M. Calcium Antagonistic Activity of Biophytum petersianum on Vascular Smooth Muscles of Wistar Rat. 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